Aliases for TMEM106C Gene

Aliases for TMEM106C Gene

  • Transmembrane Protein 106C 2 3 4 5
  • Endoplasmic Reticulum Membrane Protein Overexpressed In Cancer 3 4
  • EMOC 4

External Ids for TMEM106C Gene

Previous GeneCards Identifiers for TMEM106C Gene

  • GC12P046645
  • GC12P048357
  • GC12P045389

Summaries for TMEM106C Gene

GeneCards Summary for TMEM106C Gene

TMEM106C (Transmembrane Protein 106C) is a Protein Coding gene. Diseases associated with TMEM106C include Asphyxia Neonatorum and Placenta Praevia.

Additional gene information for TMEM106C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM106C Gene

Genomics for TMEM106C Gene

GeneHancer (GH) Regulatory Elements for TMEM106C Gene

Promoters and enhancers for TMEM106C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM106C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM106C

Top Transcription factor binding sites by QIAGEN in the TMEM106C gene promoter:
  • AREB6
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • E47
  • NF-Y
  • NF-YA
  • NF-YB
  • Tal-1

Genomic Locations for TMEM106C Gene

Genomic Locations for TMEM106C Gene
chr12:47,963,547-47,968,878
(GRCh38/hg38)
Size:
5,332 bases
Orientation:
Plus strand
chr12:48,357,330-48,362,661
(GRCh37/hg19)
Size:
5,332 bases
Orientation:
Plus strand

Genomic View for TMEM106C Gene

Genes around TMEM106C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106C Gene

Proteins for TMEM106C Gene

  • Protein details for TMEM106C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVX2-T106C_HUMAN
    Recommended name:
    Transmembrane protein 106C
    Protein Accession:
    Q9BVX2
    Secondary Accessions:
    • B2R998
    • B7Z5M4
    • Q3B761

    Protein attributes for TMEM106C Gene

    Size:
    250 amino acids
    Molecular mass:
    27875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM106C Gene

Post-translational modifications for TMEM106C Gene

  • Glycosylation at Asn186 and Asn173
  • Ubiquitination at Lys17
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM106C Gene

Domains & Families for TMEM106C Gene

Gene Families for TMEM106C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM106C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM106C Gene

GenScript: Design optimal peptide antigens:
  • Endoplasmic reticulum membrane protein overexpressed in cancer (T106C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BVX2

UniProtKB/Swiss-Prot:

T106C_HUMAN :
  • Belongs to the TMEM106 family.
Family:
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106C: view

Function for TMEM106C Gene

Phenotypes From GWAS Catalog for TMEM106C Gene

Gene Ontology (GO) - Molecular Function for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM106C: view
genes like me logo Genes that share phenotypes with TMEM106C: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM106C Gene

Localization for TMEM106C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM106C gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
endosome 1
lysosome 1
extracellular 0
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM106C Gene

Pathways & Interactions for TMEM106C Gene

PathCards logo

SuperPathways for TMEM106C Gene

No Data Available

Interacting Proteins for TMEM106C Gene

;

Gene Ontology (GO) - Biological Process for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM106C Gene

Drugs & Compounds for TMEM106C Gene

No Compound Related Data Available

Transcripts for TMEM106C Gene

mRNA/cDNA for TMEM106C Gene

6 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - -
SP14: - - - - - - - - - - - -
SP15: -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for TMEM106C Gene

GeneLoc Exon Structure for
TMEM106C

Expression for TMEM106C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM106C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM106C Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM106C Gene



Protein tissue co-expression partners for TMEM106C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM106C

SOURCE GeneReport for Unigene cluster for TMEM106C Gene:

Hs.596726

Evidence on tissue expression from TISSUES for TMEM106C Gene

  • Skin(4.6)
  • Lung(4.3)
  • Nervous system(4.2)
  • Intestine(3.5)
  • Pancreas(2.8)
  • Blood(2.5)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with TMEM106C: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM106C Gene

Orthologs for TMEM106C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM106C 31 30
  • 99.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM106C 31 30
  • 91.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM106C 31 30
  • 84.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem106c 17 31 30
  • 82.05 (n)
rat
(Rattus norvegicus)
Mammalia Tmem106c 30
  • 81.32 (n)
chicken
(Gallus gallus)
Aves TMEM106C 31 30
  • 71.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM106C 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106c 30
  • 64.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53571 30
zebrafish
(Danio rerio)
Actinopterygii zgc:153351 30
  • 63.06 (n)
TMEM106C (2 of 2) 31
  • 50 (a)
OneToMany
TMEM106C (1 of 2) 31
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
Species where no ortholog for TMEM106C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106C Gene

ENSEMBL:
Gene Tree for TMEM106C (if available)
TreeFam:
Gene Tree for TMEM106C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM106C: view image

Paralogs for TMEM106C Gene

(2) SIMAP similar genes for TMEM106C Gene using alignment to 10 proteins:

  • T106C_HUMAN
  • C9JUY7_HUMAN
  • F8VVN7_HUMAN
  • F8VWX5_HUMAN
  • F8VZW0_HUMAN
  • F8W001_HUMAN
  • F8W098_HUMAN
  • F8W120_HUMAN
  • H0YHU2_HUMAN
  • H0YIA4_HUMAN
genes like me logo Genes that share paralogs with TMEM106C: view

No data available for Paralogs for TMEM106C Gene

Variants for TMEM106C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM106C Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs2286025 - p.Ser175Phe
rs35000511 - p.Val103Phe

Additional dbSNP identifiers (rs#s) for TMEM106C Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM106C Gene

Variant ID Type Subtype PubMed ID
esv3580262 CNV loss 25503493
nsv519174 CNV loss 19592680
nsv832401 CNV loss 17160897

Variation tolerance for TMEM106C Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM106C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM106C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106C Gene

Disorders for TMEM106C Gene

MalaCards: The human disease database

(7) MalaCards diseases for TMEM106C Gene - From: DISEASES

Disorder Aliases PubMed IDs
asphyxia neonatorum
  • asphyxia - birth
placenta praevia
  • placenta previa
nemaline myopathy 5
  • nem5
ophthalmia neonatorum
  • gonococcal conjunctivitis
tetanus neonatorum
  • neonatal tetanus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM106C

genes like me logo Genes that share disorders with TMEM106C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM106C Gene

Publications for TMEM106C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  3. Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. (PMID: 25544563) Davis ZH … Glaunsinger BA (Molecular cell 2015) 3 54
  4. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M … Tate EW (Angewandte Chemie (International ed. in English) 2015) 4 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for TMEM106C Gene

Sources for TMEM106C Gene