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Aliases for TMEM106C Gene

Aliases for TMEM106C Gene

  • Transmembrane Protein 106C 2 3 5
  • Endoplasmic Reticulum Membrane Protein Overexpressed In Cancer 4
  • EMOC 4

External Ids for TMEM106C Gene

Previous GeneCards Identifiers for TMEM106C Gene

  • GC12P046645
  • GC12P048357
  • GC12P045389

Summaries for TMEM106C Gene

GeneCards Summary for TMEM106C Gene

TMEM106C (Transmembrane Protein 106C) is a Protein Coding gene. An important paralog of this gene is TMEM106B.

Additional gene information for TMEM106C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106C Gene

Genomics for TMEM106C Gene

GeneHancer (GH) Regulatory Elements for TMEM106C Gene

Promoters and enhancers for TMEM106C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I047962 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 567.7 +1.1 1081 3.3 HDGF MLX ARID4B SIN3A ZNF2 SLC30A9 ZNF207 ZNF143 DEK SP3 TMEM106C ENSG00000279840 DDX23 CCNT1 RPL37P19 LOC390314 HDAC7 KANSL2 SENP1 COL2A1
GH12I047804 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -145.8 -145799 25.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 HDAC7 ENSG00000274737 LOC390314 KANSL2 CCNT1 RAPGEF3 ASB8 VDR SENP1 SLC48A1
GH12I047887 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -74.7 -74749 2.1 CTCF RFX1 GABPA GATA3 POLR2A GABPB1 CREM SPI1 NR2C2 VDR TMEM106C HDAC7 RAPGEF3 SLC48A1 ENSG00000257433 ENSG00000197376 ZNF641 ASB8 ENSG00000205537
GH12I048156 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.1 +193.9 193908 2.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF143 ASB8 PFKM RPL37P19 ZNF641 H1FNT SENP1 RNU6-1203P CCDC184 TMEM106C ENSG00000274124
GH12I048104 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +142.7 142743 4.1 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SENP1 PFKM DDX23 KMT2D CCNT1 LOC390314 KANSL2 RPL37P19 OR5BK1P HDAC7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM106C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM106C gene promoter:

Genomic Locations for TMEM106C Gene

Genomic Locations for TMEM106C Gene
5,332 bases
Plus strand

Genomic View for TMEM106C Gene

Genes around TMEM106C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106C Gene

Proteins for TMEM106C Gene

  • Protein details for TMEM106C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 106C
    Protein Accession:
    Secondary Accessions:
    • B2R998
    • B7Z5M4
    • Q3B761

    Protein attributes for TMEM106C Gene

    250 amino acids
    Molecular mass:
    27875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106C Gene


neXtProt entry for TMEM106C Gene

Post-translational modifications for TMEM106C Gene

  • Ubiquitination at isoforms=217
  • Glycosylation at isoforms=173 and isoforms=2186

No data available for DME Specific Peptides for TMEM106C Gene

Domains & Families for TMEM106C Gene

Gene Families for TMEM106C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM106C Gene

Suggested Antigen Peptide Sequences for TMEM106C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM106 family.
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106C: view

Function for TMEM106C Gene

Phenotypes From GWAS Catalog for TMEM106C Gene

Gene Ontology (GO) - Molecular Function for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM106C: view

Phenotypes for TMEM106C Gene

GenomeRNAi human phenotypes for TMEM106C:
genes like me logo Genes that share phenotypes with TMEM106C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM106C Gene

Localization for TMEM106C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM106C gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM106C Gene

Pathways & Interactions for TMEM106C Gene

SuperPathways for TMEM106C Gene

No Data Available

Interacting Proteins for TMEM106C Gene

Gene Ontology (GO) - Biological Process for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM106C Gene

Drugs & Compounds for TMEM106C Gene

No Compound Related Data Available

Transcripts for TMEM106C Gene

Unigene Clusters for TMEM106C Gene

Transmembrane protein 106C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - -
SP14: - - - - - - - - - - - -
SP15: -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j

Relevant External Links for TMEM106C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM106C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM106C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM106C Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM106C Gene

Protein tissue co-expression partners for TMEM106C Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM106C Gene:


SOURCE GeneReport for Unigene cluster for TMEM106C Gene:


Evidence on tissue expression from TISSUES for TMEM106C Gene

  • Skin(4.6)
  • Lung(4.3)
  • Nervous system(4.2)
  • Intestine(3.5)
  • Pancreas(2.8)
  • Blood(2.4)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with TMEM106C: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM106C Gene

Orthologs for TMEM106C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM106C 33 34
  • 99.87 (n)
(Canis familiaris)
Mammalia TMEM106C 33 34
  • 91.3 (n)
(Bos Taurus)
Mammalia TMEM106C 33 34
  • 84.41 (n)
(Mus musculus)
Mammalia Tmem106c 33 16 34
  • 82.05 (n)
(Rattus norvegicus)
Mammalia Tmem106c 33
  • 81.32 (n)
(Gallus gallus)
Aves TMEM106C 33 34
  • 71.58 (n)
(Anolis carolinensis)
Reptilia TMEM106C 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106c 33
  • 64.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53571 33
(Danio rerio)
Actinopterygii zgc:153351 33
  • 63.06 (n)
TMEM106C (2 of 2) 34
  • 50 (a)
TMEM106C (1 of 2) 34
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for TMEM106C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106C Gene

Gene Tree for TMEM106C (if available)
Gene Tree for TMEM106C (if available)

Paralogs for TMEM106C Gene

Paralogs for TMEM106C Gene

genes like me logo Genes that share paralogs with TMEM106C: view

Variants for TMEM106C Gene

Sequence variations from dbSNP and Humsavar for TMEM106C Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000187599 -- 47,965,511(+) TG/ intron_variant
rs1000621232 -- 47,965,882(+) C/G coding_sequence_variant, missense_variant
rs1000742016 -- 47,965,577(+) A/G intron_variant
rs1001324104 -- 47,964,254(+) C/T coding_sequence_variant, synonymous_variant
rs1002305185 -- 47,962,650(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM106C Gene

Variant ID Type Subtype PubMed ID
esv3580262 CNV loss 25503493
nsv519174 CNV loss 19592680
nsv832401 CNV loss 17160897

Variation tolerance for TMEM106C Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM106C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106C Gene

Disorders for TMEM106C Gene

Additional Disease Information for TMEM106C

No disorders were found for TMEM106C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM106C Gene

Publications for TMEM106C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M … Tate EW (Angewandte Chemie (International ed. in English) 2015) 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for TMEM106C Gene

Sources for TMEM106C Gene

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