Aliases for TMEM104 Gene

Aliases for TMEM104 Gene

  • Transmembrane Protein 104 2 3 4 5
  • FLJ20255 2
  • FLJ00021 2
  • TMEM104 5

External Ids for TMEM104 Gene

Previous GeneCards Identifiers for TMEM104 Gene

  • GC17P070285
  • GC17P072772
  • GC17P068182

Summaries for TMEM104 Gene

GeneCards Summary for TMEM104 Gene

TMEM104 (Transmembrane Protein 104) is a Protein Coding gene.

Additional gene information for TMEM104 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM104 Gene

Genomics for TMEM104 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM104 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM104 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM104

Top Transcription factor binding sites by QIAGEN in the TMEM104 gene promoter:
  • ARP-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Lmo2
  • POU2F1
  • POU2F1a
  • RREB-1

Genomic Locations for TMEM104 Gene

Genomic Locations for TMEM104 Gene
chr17:74,776,499-74,839,783
(GRCh38/hg38)
Size:
63,285 bases
Orientation:
Plus strand
chr17:72,772,622-72,835,922
(GRCh37/hg19)
Size:
63,301 bases
Orientation:
Plus strand

Genomic View for TMEM104 Gene

Genes around TMEM104 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM104 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM104 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM104 Gene

Proteins for TMEM104 Gene

  • Protein details for TMEM104 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE00-TM104_HUMAN
    Recommended name:
    Transmembrane protein 104
    Protein Accession:
    Q8NE00
    Secondary Accessions:
    • Q8TEU1
    • Q9NT56
    • Q9NXH1

    Protein attributes for TMEM104 Gene

    Size:
    496 amino acids
    Molecular mass:
    55679 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM104 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM104 Gene

Post-translational modifications for TMEM104 Gene

  • Glycosylation at Asn193
  • Ubiquitination at Lys381
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM104 Gene

Domains & Families for TMEM104 Gene

Gene Families for TMEM104 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM104 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM104 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51226 (B4DKL7_HUMAN)
  • Transmembrane protein 104 (TM104_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NE00

UniProtKB/Swiss-Prot:

TM104_HUMAN :
  • Belongs to the TMEM104 family.
Family:
  • Belongs to the TMEM104 family.
genes like me logo Genes that share domains with TMEM104: view

Function for TMEM104 Gene

Phenotypes From GWAS Catalog for TMEM104 Gene

Gene Ontology (GO) - Molecular Function for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM104: view
genes like me logo Genes that share phenotypes with TMEM104: view

Animal Models for TMEM104 Gene

MGI Knock Outs for TMEM104:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM104

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM104

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM104 Gene

Localization for TMEM104 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM104 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM104 gene
Compartment Confidence
plasma membrane 3
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM104: view

Pathways & Interactions for TMEM104 Gene

PathCards logo

SuperPathways for TMEM104 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM104: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM104 Gene

Drugs & Compounds for TMEM104 Gene

No Compound Related Data Available

Transcripts for TMEM104 Gene

mRNA/cDNA for TMEM104 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM104

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM104 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TMEM104 Gene

GeneLoc Exon Structure for
TMEM104

Expression for TMEM104 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM104 Gene

Protein differential expression in normal tissues from HIPED for TMEM104 Gene

This gene is overexpressed in Adrenal (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM104 Gene



Protein tissue co-expression partners for TMEM104 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM104

SOURCE GeneReport for Unigene cluster for TMEM104 Gene:

Hs.370262

Evidence on tissue expression from TISSUES for TMEM104 Gene

  • Intestine(4.1)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with TMEM104: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM104 Gene

Orthologs for TMEM104 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM104 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM104 30 31
  • 99.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM104 30 31
  • 90.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem104 30
  • 87.9 (n)
Mouse
(Mus musculus)
Mammalia Tmem104 30 17 31
  • 87.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMEM104 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM104 31
  • 78 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM104 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM104 30 31
  • 77.51 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM104 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem104 30
  • 72.17 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmem104 30 31
  • 71.69 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002099 30
  • 56.37 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5262 30 31
  • 51.36 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C03A3.2 30 31
  • 49.07 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.897 30
Species where no ortholog for TMEM104 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMEM104 Gene

ENSEMBL:
Gene Tree for TMEM104 (if available)
TreeFam:
Gene Tree for TMEM104 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM104: view image

Paralogs for TMEM104 Gene

(1) SIMAP similar genes for TMEM104 Gene using alignment to 3 proteins:

  • TM104_HUMAN
  • B4DKL7_HUMAN
  • J3QQK2_HUMAN
genes like me logo Genes that share paralogs with TMEM104: view

No data available for Paralogs for TMEM104 Gene

Variants for TMEM104 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM104 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
773593 Benign: not provided 74,790,238(+) C/T SYNONYMOUS_VARIANT
782159 Benign: not provided 74,795,600(+) C/G MISSENSE_VARIANT
rs2016126 - p.Val58Met
rs3803784 - p.Ala439Thr

Additional dbSNP identifiers (rs#s) for TMEM104 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM104 Gene

Variant ID Type Subtype PubMed ID
esv1000943 CNV insertion 20482838
esv1113079 CNV insertion 17803354
esv2716233 CNV deletion 23290073
esv2716234 CNV deletion 23290073
esv3554778 CNV deletion 23714750
esv8400 CNV gain 19470904
nsv457907 CNV loss 19166990
nsv518292 CNV loss 19592680
nsv576025 CNV loss 21841781
nsv833540 CNV loss 17160897
nsv952367 CNV deletion 24416366

Variation tolerance for TMEM104 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM104 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM104

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM104 Gene

Disorders for TMEM104 Gene

No disorders were found for TMEM104 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM104 Gene

Publications for TMEM104 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for TMEM104 Gene

Sources for TMEM104 Gene