External Ids for TMEM100 Gene
Previous GeneCards Identifiers for TMEM100 Gene
GeneCards Summary for TMEM100 Gene
TMEM100 (Transmembrane Protein 100) is a Protein Coding gene. An important paralog of this gene is PIRT.
UniProtKB/Swiss-Prot Summary for TMEM100 Gene
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.