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Aliases for TMED8 Gene

Aliases for TMED8 Gene

  • Transmembrane P24 Trafficking Protein Family Member 8 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 8 2 3
  • Family With Sequence Similarity 15, Member B 2 3
  • Transmembrane Emp24 Domain Containing 8 2 3
  • FAM15B 3 4
  • Protein TMED8 3

External Ids for TMED8 Gene

Previous HGNC Symbols for TMED8 Gene

  • FAM15B

Previous GeneCards Identifiers for TMED8 Gene

  • GC14M076872
  • GC14M077808
  • GC14M057974

Summaries for TMED8 Gene

GeneCards Summary for TMED8 Gene

TMED8 (Transmembrane P24 Trafficking Protein Family Member 8) is a Protein Coding gene. An important paralog of this gene is ACBD3.

Additional gene information for TMED8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED8 Gene

Genomics for TMED8 Gene

GeneHancer (GH) Regulatory Elements for TMED8 Gene

Promoters and enhancers for TMED8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I077375 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 572.4 +0.6 586 2.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ELK1 ZNF143 TMED8 SAMD15 GSTZ1 LOC100422225
GH14I077456 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.9 -80.8 -80844 3.1 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 IRF4 VIPAS39 AHSA1 TMED8 ADCK1 ENSG00000212371
GH14I077312 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +61.6 61638 5.7 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZNF2 ZNF143 FOS YY2 REST TMED8 GSTZ1 NGB ZDHHC22 ENSG00000201384 SAMD15 AHSA1 VIPAS39 TMEM63C POMT2
GH14I077406 Enhancer 1 Ensembl ENCODE 24.1 -30.2 -30192 1.4 HDAC1 MEIS2 LEF1 TEAD4 TAL1 CEBPG TCF12 ZFHX2 ZNF766 GATA3 SAMD15 TMED8 AHSA1 VIPAS39 GSTZ1 POMT2 GC14M077403 NOXRED1
GH14I077371 Enhancer 1 Ensembl ENCODE 22.5 +4.2 4184 3.3 PKNOX1 FOXA2 INSM2 NEUROD1 KLF5 ZNF366 ATF7 FOS RCOR1 IKZF2 TMED8 POMT2 GSTZ1 ENSG00000259081 AHSA1 VIPAS39 SAMD15 LOC100422225
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMED8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMED8 Gene

Genomic Locations for TMED8 Gene
chr14:77,335,021-77,377,109
(GRCh38/hg38)
Size:
42,089 bases
Orientation:
Minus strand
chr14:77,801,364-77,843,452
(GRCh37/hg19)

Genomic View for TMED8 Gene

Genes around TMED8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED8 Gene

Proteins for TMED8 Gene

  • Protein details for TMED8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PL24-TMED8_HUMAN
    Recommended name:
    Protein TMED8
    Protein Accession:
    Q6PL24
    Secondary Accessions:
    • B3KTI6
    • Q3MJB0
    • Q9P1V9

    Protein attributes for TMED8 Gene

    Size:
    325 amino acids
    Molecular mass:
    35740 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF62560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMED8 Gene

Post-translational modifications for TMED8 Gene

  • Ubiquitination at posLast=304304
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED8 Gene

No data available for DME Specific Peptides for TMED8 Gene

Domains & Families for TMED8 Gene

Gene Families for TMED8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMED8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMED8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMED8: view

No data available for UniProtKB/Swiss-Prot for TMED8 Gene

Function for TMED8 Gene

Phenotypes From GWAS Catalog for TMED8 Gene

Phenotypes for TMED8 Gene

GenomeRNAi human phenotypes for TMED8:
genes like me logo Genes that share phenotypes with TMED8: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED8 Gene

Localization for TMED8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMED8 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TMED8 Gene

Pathways & Interactions for TMED8 Gene

SuperPathways for TMED8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMED8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMED8 Gene

Drugs & Compounds for TMED8 Gene

No Compound Related Data Available

Transcripts for TMED8 Gene

Unigene Clusters for TMED8 Gene

Transmembrane emp24 protein transport domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED8 Gene

No ASD Table

Relevant External Links for TMED8 Gene

GeneLoc Exon Structure for
TMED8
ECgene alternative splicing isoforms for
TMED8

Expression for TMED8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMED8 Gene

Protein differential expression in normal tissues from HIPED for TMED8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3) and Plasma (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMED8 Gene



Protein tissue co-expression partners for TMED8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMED8 Gene:

TMED8

SOURCE GeneReport for Unigene cluster for TMED8 Gene:

Hs.26403
genes like me logo Genes that share expression patterns with TMED8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED8 Gene

Orthologs for TMED8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMED8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED8 34 33
  • 99.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMED8 34 33
  • 91.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMED8 34 33
  • 87.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed8 16 34 33
  • 86.26 (n)
rat
(Rattus norvegicus)
Mammalia LOC681943 33
  • 83.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMED8 34
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMED8 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMED8 34 33
  • 75.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMED8 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145041 33
  • 63.3 (n)
zebrafish
(Danio rerio)
Actinopterygii tmed8 34
  • 44 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6331 33
fruit fly
(Drosophila melanogaster)
Insecta CG14232 34
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.7 34
  • 25 (a)
OneToMany
Species where no ortholog for TMED8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED8 Gene

ENSEMBL:
Gene Tree for TMED8 (if available)
TreeFam:
Gene Tree for TMED8 (if available)

Paralogs for TMED8 Gene

Paralogs for TMED8 Gene

genes like me logo Genes that share paralogs with TMED8: view

Variants for TMED8 Gene

Sequence variations from dbSNP and Humsavar for TMED8 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000026777 -- 77,355,147(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000092607 -- 77,348,002(-) C/A intron_variant
rs1000311493 -- 77,345,498(-) C/T intron_variant
rs1000423278 -- 77,347,611(-) G/A intron_variant
rs1000536753 -- 77,352,828(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMED8 Gene

Variant ID Type Subtype PubMed ID
esv2659963 CNV deletion 23128226
esv2678214 CNV deletion 23128226
esv3635001 CNV loss 21293372
esv3635002 CNV loss 21293372
nsv1143755 CNV deletion 24896259
nsv472613 CNV novel sequence insertion 20440878

Variation tolerance for TMED8 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.98; 97.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMED8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED8 Gene

Disorders for TMED8 Gene

Additional Disease Information for TMED8

No disorders were found for TMED8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED8 Gene

Publications for TMED8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMED8 Gene

Sources for TMED8 Gene

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