This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individ... See more...

Aliases for TMED7-TICAM2 Gene

Aliases for TMED7-TICAM2 Gene

  • TMED7-TICAM2 Readthrough 2 3 5
  • Toll/Interleukin-1 Receptor Domain-Containing Protein 3
  • Putative NF-Kappa-B-Activating Protein 502 3
  • TIR Domain-Containing Adapter Molecule 2 3
  • TMED7-TICAM2 Read-Through Transcript 3
  • Toll-Like Receptor Adaptor Protein 3 3
  • TRAM Adaptor With GOLD Domain 3
  • Protein TMED7-TICAM2 13
  • TMED7-TICAM2 5
  • MyD88-4 3
  • TICAM-2 3
  • TICAM2 3
  • TIRAP3 3
  • TIRP 3
  • TRAM 3

External Ids for TMED7-TICAM2 Gene

Previous GeneCards Identifiers for TMED7-TICAM2 Gene

  • GC00U926151
  • GC05M114914
  • GC05M110095

Summaries for TMED7-TICAM2 Gene

Entrez Gene Summary for TMED7-TICAM2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

GeneCards Summary for TMED7-TICAM2 Gene

TMED7-TICAM2 (TMED7-TICAM2 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway. An important paralog of this gene is TMED7.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMED7-TICAM2 Gene

Genomics for TMED7-TICAM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMED7-TICAM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMED7-TICAM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMED7-TICAM2

Genomic Locations for TMED7-TICAM2 Gene

Latest Assembly
chr5:115,578,496-115,626,161
(GRCh38/hg38)
Size:
47,666 bases
Orientation:
Minus strand

Previous Assembly
chr5:114,914,193-114,961,733
(GRCh37/hg19 by Entrez Gene)
Size:
47,541 bases
Orientation:
Minus strand

chr5:114,914,339-114,961,858
(GRCh37/hg19 by Ensembl)
Size:
47,520 bases
Orientation:
Minus strand

Genomic View for TMED7-TICAM2 Gene

Genes around TMED7-TICAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED7-TICAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED7-TICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED7-TICAM2 Gene

Proteins for TMED7-TICAM2 Gene

  • Protein details for TMED7-TICAM2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYA0-A0A0A6YYA0_HUMAN
    Recommended name:
    Protein TMED7-TICAM2
    Protein Accession:
    A0A0A6YYA0

    Protein attributes for TMED7-TICAM2 Gene

    Size:
    188 amino acids
    Molecular mass:
    21233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMED7-TICAM2 Gene

Post-translational modifications for TMED7-TICAM2 Gene

No Post-translational modifications

Other Protein References for TMED7-TICAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED7-TICAM2 Gene

Domains & Families for TMED7-TICAM2 Gene

Gene Families for TMED7-TICAM2 Gene

Unknown:
  • Belongs to the EMP24/GP25L family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMED7-TICAM2 Gene

Suggested Antigen Peptide Sequences for TMED7-TICAM2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ90737 fis, clone PLACE1010827, moderately similar to Membrane protein p24B (Q8NBU8_HUMAN)
genes like me logo Genes that share domains with TMED7-TICAM2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Function for TMED7-TICAM2 Gene

Phenotypes From GWAS Catalog for TMED7-TICAM2 Gene

Gene Ontology (GO) - Molecular Function for TMED7-TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TMED7-TICAM2: view

Phenotypes for TMED7-TICAM2 Gene

genes like me logo Genes that share phenotypes with TMED7-TICAM2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMED7-TICAM2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED7-TICAM2 Gene

Localization for TMED7-TICAM2 Gene

Gene Ontology (GO) - Cellular Components for TMED7-TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMED7-TICAM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMED7-TICAM2 Gene

Pathways & Interactions for TMED7-TICAM2 Gene

PathCards logo

SuperPathways for TMED7-TICAM2 Gene

SuperPathway Contained pathways
1 IL-1 signaling pathway
genes like me logo Genes that share pathways with TMED7-TICAM2: view

Pathways by source for TMED7-TICAM2 Gene

1 BioSystems pathway for TMED7-TICAM2 Gene

Interacting Proteins for TMED7-TICAM2 Gene

Gene Ontology (GO) - Biological Process for TMED7-TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TMED7-TICAM2: view

No data available for SIGNOR curated interactions for TMED7-TICAM2 Gene

Drugs & Compounds for TMED7-TICAM2 Gene

No Compound Related Data Available

Transcripts for TMED7-TICAM2 Gene

mRNA/cDNA for TMED7-TICAM2 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMED7-TICAM2

Alternative Splicing Database (ASD) splice patterns (SP) for TMED7-TICAM2 Gene

No ASD Table

Relevant External Links for TMED7-TICAM2 Gene

GeneLoc Exon Structure for
TMED7-TICAM2

Expression for TMED7-TICAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMED7-TICAM2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for TMED7-TICAM2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMED7-TICAM2

genes like me logo Genes that share expression patterns with TMED7-TICAM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED7-TICAM2 Gene

Orthologs for TMED7-TICAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED7-TICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TICAM2 30
  • 93 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia TMED7 30
  • 85 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 79 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TICAM2 30
  • 77 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ticam2 30
  • 72 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 70 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 76 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 40 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii tmed7 30
  • 69 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta p24-1 30
  • 43 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F57B10.5 30
  • 49 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 30
  • 21 (a)
OneToMany
ERP4 32
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9127 30
  • 48 (a)
OneToMany
Species where no ortholog for TMED7-TICAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TMED7-TICAM2 Gene

ENSEMBL:
Gene Tree for TMED7-TICAM2 (if available)
TreeFam:
Gene Tree for TMED7-TICAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMED7-TICAM2: view image
Alliance of Genome Resources:
Additional Orthologs for TMED7-TICAM2

Paralogs for TMED7-TICAM2 Gene

Paralogs for TMED7-TICAM2 Gene

genes like me logo Genes that share paralogs with TMED7-TICAM2: view

Variants for TMED7-TICAM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMED7-TICAM2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs113049216 Benign: not provided 115,581,066(-) C/T
NM_021649.7(TICAM2):c.191G>A (p.Ser64Asn)
MISSENSE_VARIANT,THREE_PRIME_UTR
rs7705473 Benign: not provided 115,580,654(-) T/G
NM_021649.7(TICAM2):c.603A>C (p.Gly201=)
SYNONYMOUS_VARIANT,THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMED7-TICAM2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMED7-TICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv830455 CNV gain 17160897

Variation tolerance for TMED7-TICAM2 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMED7-TICAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED7-TICAM2
Leiden Open Variation Database (LOVD)
TMED7-TICAM2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Disorders for TMED7-TICAM2 Gene

Additional Disease Information for TMED7-TICAM2

No disorders were found for TMED7-TICAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED7-TICAM2 Gene

Publications for TMED7-TICAM2 Gene

  1. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  5. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PMID: 19412184) Palsson-McDermott EM … O'Neill LA (Nature immunology 2009) 3

Products for TMED7-TICAM2 Gene

Sources for TMED7-TICAM2 Gene