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This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
TMED7-TICAM2 (TMED7-TICAM2 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway. An important paralog of this gene is TMED7.
Genomic Neighborhood
• Exon Structure
• Gene Density
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-1 signaling pathway | ||
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TICAM2 30 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | TMED7 30 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | TICAM2 30 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Ticam2 30 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | tmed7 30 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | p24-1 30 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F57B10.5 30 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EMP24 30 |
|
OneToMany | |
| ERP4 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9127 30 |
|
OneToMany |
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs113049216 | Benign: not provided | 115,581,066(-) |
C/T NM_021649.7(TICAM2):c.191G>A (p.Ser64Asn) |
MISSENSE_VARIANT,THREE_PRIME_UTR | |
| rs7705473 | Benign: not provided | 115,580,654(-) |
T/G NM_021649.7(TICAM2):c.603A>C (p.Gly201=) |
SYNONYMOUS_VARIANT,THREE_PRIME_UTR |
No disorders were found for TMED7-TICAM2 Gene.