Aliases for TMED6 Gene

Aliases for TMED6 Gene

  • Transmembrane P24 Trafficking Protein 6 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 6 2 3
  • Transmembrane Emp24 Domain-Containing Protein 6 3 4
  • P24 Family Protein Gamma-5 3 4
  • P24gamma5 3 4
  • PRO34237 3
  • SPLL9146 3
  • P24g5 3

External Ids for TMED6 Gene

Previous GeneCards Identifiers for TMED6 Gene

  • GC16M067935
  • GC16M069377
  • GC16M055254

Summaries for TMED6 Gene

GeneCards Summary for TMED6 Gene

TMED6 (Transmembrane P24 Trafficking Protein 6) is a Protein Coding gene. An important paralog of this gene is ENSG00000259900.

Additional gene information for TMED6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMED6 Gene

Genomics for TMED6 Gene

GeneHancer (GH) Regulatory Elements for TMED6 Gene

Promoters and enhancers for TMED6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMED6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMED6

Top Transcription factor binding sites by QIAGEN in the TMED6 gene promoter:
  • c-Myb
  • IRF-7A
  • LCR-F1
  • Nkx2-2
  • p53
  • POU3F1
  • POU6F1 (c2)
  • RP58

Genomic Locations for TMED6 Gene

Genomic Locations for TMED6 Gene
8,564 bases
Minus strand
8,564 bases
Minus strand

Genomic View for TMED6 Gene

Genes around TMED6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED6 Gene

Proteins for TMED6 Gene

  • Protein details for TMED6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane emp24 domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6UXN5

    Protein attributes for TMED6 Gene

    240 amino acids
    Molecular mass:
    27631 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMED6 Gene

Post-translational modifications for TMED6 Gene

  • Glycosylation at Asn107 and Asn156
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED6 Gene

Domains & Families for TMED6 Gene

Gene Families for TMED6 Gene

Protein Domains for TMED6 Gene

  • emp24/gp25L/p24 family

Suggested Antigen Peptide Sequences for TMED6 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane emp24 domain-containing protein 6 (TMED6_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EMP24/GP25L family.
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED6: view

Function for TMED6 Gene

Phenotypes From GWAS Catalog for TMED6 Gene

genes like me logo Genes that share phenotypes with TMED6: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMED6 Gene

Localization for TMED6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED6 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMED6 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 1
extracellular 1
lysosome 0

Gene Ontology (GO) - Cellular Components for TMED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IBA 21873635
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMED6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMED6 Gene

Pathways & Interactions for TMED6 Gene

PathCards logo

SuperPathways for TMED6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport IBA 21873635
GO:0007030 Golgi organization IBA 21873635
genes like me logo Genes that share ontologies with TMED6: view

No data available for Pathways by source and SIGNOR curated interactions for TMED6 Gene

Drugs & Compounds for TMED6 Gene

No Compound Related Data Available

Transcripts for TMED6 Gene

mRNA/cDNA for TMED6 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED6 Gene

No ASD Table

Relevant External Links for TMED6 Gene

GeneLoc Exon Structure for

Expression for TMED6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMED6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMED6 Gene

This gene is overexpressed in Pancreas (x29.5) and Stomach (x10.5).

Protein differential expression in normal tissues from HIPED for TMED6 Gene

This gene is overexpressed in Pancreas (56.8) and Islet of Langerhans (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMED6 Gene

Protein tissue co-expression partners for TMED6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMED6

SOURCE GeneReport for Unigene cluster for TMED6 Gene:


Evidence on tissue expression from TISSUES for TMED6 Gene

  • Liver(4.1)
  • Pancreas(2.5)
genes like me logo Genes that share expression patterns with TMED6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED6 Gene

Orthologs for TMED6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMED6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
TMED6 30
  • 99.58 (n)
(Canis familiaris)
Mammalia -- 31
  • 90 (a)
TMED6 30
  • 89.03 (n)
(Bos Taurus)
Mammalia TMED6 31 30
  • 88.47 (n)
(Rattus norvegicus)
Mammalia Tmed6 30
  • 81.79 (n)
(Mus musculus)
Mammalia Tmed6 17 31 30
  • 81.45 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 74 (a)
(Gallus gallus)
Aves TMED6 30
  • 69.15 (n)
-- 31
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed6 30
  • 66.22 (n)
(Danio rerio)
Actinopterygii LOC101884766 30
  • 57.62 (n)
TMED6 31
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta loj 31
  • 25 (a)
Species where no ortholog for TMED6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMED6 Gene

Gene Tree for TMED6 (if available)
Gene Tree for TMED6 (if available)
Evolutionary constrained regions (ECRs) for TMED6: view image

Paralogs for TMED6 Gene

genes like me logo Genes that share paralogs with TMED6: view

Variants for TMED6 Gene

Additional dbSNP identifiers (rs#s) for TMED6 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMED6 Gene

Variant ID Type Subtype PubMed ID
nsv476041 CNV novel sequence insertion 20440878

Variation tolerance for TMED6 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMED6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMED6 Gene

Disorders for TMED6 Gene

Additional Disease Information for TMED6

No disorders were found for TMED6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED6 Gene

Publications for TMED6 Gene

  1. Transmembrane emp24 protein transport domain 6 is selectively expressed in pancreatic islets and implicated in insulin secretion and diabetes. (PMID: 22129529) Wang X … Gong DW (Pancreas 2012) 2 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. TMED6-COG8 is a novel molecular marker of TFE3 translocation renal cell carcinoma. (PMID: 26045774) Xu Y … Zhou X (International journal of clinical and experimental pathology 2015) 3 54

Products for TMED6 Gene

Sources for TMED6 Gene