Aliases for TMED5 Gene

Aliases for TMED5 Gene

  • Transmembrane P24 Trafficking Protein 5 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 5 2 3
  • Transmembrane Emp24 Domain-Containing Protein 5 3 4
  • P24 Family Protein Gamma-2 3 4
  • P24gamma2 3 4
  • P28 3 4
  • CGI-100 3
  • P24g2 3

External Ids for TMED5 Gene

Previous GeneCards Identifiers for TMED5 Gene

  • GC01M093330
  • GC01M093615
  • GC01M091736

Summaries for TMED5 Gene

GeneCards Summary for TMED5 Gene

TMED5 (Transmembrane P24 Trafficking Protein 5) is a Protein Coding gene. Among its related pathways are WNT ligand biogenesis and trafficking and Signaling by GPCR. An important paralog of this gene is TMED1.

UniProtKB/Swiss-Prot Summary for TMED5 Gene

  • Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.

Additional gene information for TMED5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMED5 Gene

Genomics for TMED5 Gene

GeneHancer (GH) Regulatory Elements for TMED5 Gene

Promoters and enhancers for TMED5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMED5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMED5 gene promoter:
  • CREB
  • deltaCREB
  • HNF-3beta
  • HSF2
  • IRF-1
  • MEF-2A
  • Pax-5
  • RFX1
  • STAT1
  • YY1

Genomic Locations for TMED5 Gene

Genomic Locations for TMED5 Gene
chr1:93,149,742-93,180,689
(GRCh38/hg38)
Size:
30,948 bases
Orientation:
Minus strand
chr1:93,615,299-93,646,285
(GRCh37/hg19)
Size:
30,987 bases
Orientation:
Minus strand

Genomic View for TMED5 Gene

Genes around TMED5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED5 Gene

Proteins for TMED5 Gene

  • Protein details for TMED5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3A6-TMED5_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 5
    Protein Accession:
    Q9Y3A6
    Secondary Accessions:
    • B1AKT4
    • B2R703
    • D3DT38
    • Q96AX8

    Protein attributes for TMED5 Gene

    Size:
    229 amino acids
    Molecular mass:
    26005 Da
    Quaternary structure:
    • Interacts with TMED9 and TMED10.

    Alternative splice isoforms for TMED5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMED5 Gene

Post-translational modifications for TMED5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMED5 Gene

No data available for DME Specific Peptides for TMED5 Gene

Domains & Families for TMED5 Gene

Gene Families for TMED5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMED5 Gene

Suggested Antigen Peptide Sequences for TMED5 Gene

GenScript: Design optimal peptide antigens:
  • TMED5 protein (Q49AG2_HUMAN)
  • Transmembrane emp24 domain-containing protein 5 (TMED5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3A6

UniProtKB/Swiss-Prot:

TMED5_HUMAN :
  • Belongs to the EMP24/GP25L family.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED5: view

Function for TMED5 Gene

Molecular function for TMED5 Gene

UniProtKB/Swiss-Prot Function:
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.

Phenotypes From GWAS Catalog for TMED5 Gene

Gene Ontology (GO) - Molecular Function for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with TMED5: view
genes like me logo Genes that share phenotypes with TMED5: view

Animal Model Products

CRISPR Products

miRNA for TMED5 Gene

miRTarBase miRNAs that target TMED5

Clone Products

  • Addgene plasmids for TMED5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED5 Gene

Localization for TMED5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED5 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Probably cycles between compartments of the early secretatory pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMED5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IBA 21873635
GO:0005801 cis-Golgi network IDA 19948005
genes like me logo Genes that share ontologies with TMED5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMED5 Gene

Pathways & Interactions for TMED5 Gene

genes like me logo Genes that share pathways with TMED5: view

Pathways by source for TMED5 Gene

Gene Ontology (GO) - Biological Process for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport IBA 21873635
GO:0007030 Golgi organization IBA 21873635
GO:0015031 protein transport IEA --
GO:0090161 Golgi ribbon formation IMP,IBA 19948005
genes like me logo Genes that share ontologies with TMED5: view

No data available for SIGNOR curated interactions for TMED5 Gene

Drugs & Compounds for TMED5 Gene

No Compound Related Data Available

Transcripts for TMED5 Gene

mRNA/cDNA for TMED5 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for TMED5

Alternative Splicing Database (ASD) splice patterns (SP) for TMED5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for TMED5 Gene

GeneLoc Exon Structure for
TMED5
ECgene alternative splicing isoforms for
TMED5

Expression for TMED5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMED5 Gene

Protein differential expression in normal tissues from HIPED for TMED5 Gene

This gene is overexpressed in Islet of Langerhans (10.2) and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMED5 Gene



Protein tissue co-expression partners for TMED5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMED5 Gene:

TMED5

SOURCE GeneReport for Unigene cluster for TMED5 Gene:

Hs.482873

Evidence on tissue expression from TISSUES for TMED5 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with TMED5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED5 Gene

Orthologs for TMED5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED5 33 32
  • 99.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMED5 33 32
  • 92.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMED5 33 32
  • 92.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmed5 32
  • 89.52 (n)
mouse
(Mus musculus)
Mammalia Tmed5 17 33 32
  • 89.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMED5 33
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMED5 33
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMED5 33 32
  • 85.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMED5 33
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed5 32
  • 70.13 (n)
Str.2055 32
zebrafish
(Danio rerio)
Actinopterygii tmed5 33 32
  • 67.32 (n)
OneToOne
zgc63936 32
fruit fly
(Drosophila melanogaster)
Insecta opm 33 32
  • 52.18 (n)
ManyToMany
CG31787 33
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001505 32
  • 50.44 (n)
worm
(Caenorhabditis elegans)
Secernentea K08E4.6 33 32
  • 49.91 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 33
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10421 33
  • 51 (a)
OneToMany
Species where no ortholog for TMED5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED5 Gene

ENSEMBL:
Gene Tree for TMED5 (if available)
TreeFam:
Gene Tree for TMED5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMED5: view image

Paralogs for TMED5 Gene

(3) SIMAP similar genes for TMED5 Gene using alignment to 4 proteins:

  • TMED5_HUMAN
  • B1AKT3_HUMAN
  • M0R072_HUMAN
  • Q49AG2_HUMAN
genes like me logo Genes that share paralogs with TMED5: view

Variants for TMED5 Gene

Sequence variations from dbSNP and Humsavar for TMED5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000097733 -- 93,166,418(-) C/T intron_variant
rs1000173993 -- 93,171,555(-) T/C intron_variant
rs1000270723 -- 93,179,014(-) C/G intron_variant
rs1000439516 -- 93,157,742(-) C/T intron_variant
rs1000444604 -- 93,164,988(-) G/A/C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMED5 Gene

Variant ID Type Subtype PubMed ID
nsv1008602 CNV gain 25217958
nsv830614 CNV loss 17160897
nsv830625 CNV loss 17160897

Variation tolerance for TMED5 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.78; 96.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMED5 Gene

Human Gene Mutation Database (HGMD)
TMED5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED5 Gene

Disorders for TMED5 Gene

Additional Disease Information for TMED5

No disorders were found for TMED5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED5 Gene

Publications for TMED5 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 56
  2. p28, a novel ERGIC/cis Golgi protein, required for Golgi ribbon formation. (PMID: 19948005) Koegler E … Hauri HP (Traffic (Copenhagen, Denmark) 2010) 3 4 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56

Products for TMED5 Gene

Sources for TMED5 Gene