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TMED2 (Transmembrane P24 Trafficking Protein 2) is a Protein Coding gene. Diseases associated with TMED2 include Cardiomyopathy, Dilated, 1M and Cardiomyopathy, Familial Hypertrophic, 7. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. An important paralog of this gene is TMED7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 10359607 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005783 | endoplasmic reticulum | IBA,IDA | 12237308 |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA | 12237308 |
GO:0005794 | Golgi apparatus | IBA,IDA | 12237308 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Golgi-to-ER retrograde transport | ||
3 | Vesicle-mediated transport | ||
4 | Metabolism of proteins | ||
5 | Pre-NOTCH Expression and Processing |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001701 | in utero embryonic development | IEA | -- |
GO:0001756 | somitogenesis | IEA | -- |
GO:0001843 | neural tube closure | IEA | -- |
GO:0001892 | embryonic placenta development | IEA | -- |
GO:0001893 | maternal placenta development | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||
SP2: | |||||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | TMED2 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | TMED2 30 |
|
||
Dog (Canis familiaris) |
Mammalia | TMED2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TMED2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tmed2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tmed2 30 17 31 |
|
OneToOne | |
Tmed2b 17 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | TMED2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TMED2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TMED2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tmed2 30 |
|
||
Str.8778 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | rnp24-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tmed2 30 31 |
|
OneToOne | |
wufb18g06 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11035 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CHOp24 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004743 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | sel-9 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EMP24 30 31 33 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F12518g 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5670 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU08339 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | emp24 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1779 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv523e212 | CNV | loss | 25503493 |
esv2422416 | CNV | duplication | 17116639 |
nsv1042181 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cardiomyopathy, dilated, 1m |
|
|
cardiomyopathy, familial hypertrophic, 7 |
|
|
epiphyseal dysplasia, multiple, 3 |
|
|
cardiomyopathy, dilated, 1p |
|
|
epiphyseal dysplasia, multiple, 1 |
|
|