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Aliases for TMED2 Gene
Aliases for TMED2 Gene
External Ids for TMED2 Gene
- HGNC: 16996
- NCBI Entrez Gene: 10959
- Ensembl: ENSG00000086598
- UniProtKB/Swiss-Prot: Q15363
Previous GeneCards Identifiers for TMED2 Gene
- GC12P122595
- GC12P124069
- GC12P121030
Summaries for TMED2 Gene
GeneCards Summary for TMED2 Gene
TMED2 (Transmembrane P24 Trafficking Protein 2) is a Protein Coding gene. Diseases associated with TMED2 include Cardiomyopathy, Dilated, 1M and Cardiomyopathy, Familial Hypertrophic, 7. Among its related pathways are Pre-NOTCH Expression and Processing and Signaling by GPCR. An important paralog of this gene is TMED7.
UniProtKB/Swiss-Prot Summary for TMED2 Gene
-
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
Additional gene information for TMED2 Gene
- HGNC (16996)
- NCBI Entrez Gene (10959)
- Ensembl (ENSG00000086598)
- UniProtKB/Swiss-Prot (Q15363)
- Open Targets Platform(ENSG00000086598)
- Alliance of Genome Resources
- Search for TMED2 at DataMed
- Search for TMED2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMED2 Gene
Genomics for TMED2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TMED2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMED2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMED2
- Top Transcription factor binding sites by QIAGEN in the TMED2 gene promoter:
-
- AP-1
- COMP1
- CUTL1
- Evi-1
- GATA-1
- MIF-1
- NF-kappaB
- NF-kappaB1
- STAT1
- STAT5B
Genomic Locations for TMED2 Gene
Latest Assembly
- chr12:123,584,533-123,598,582
- (GRCh38/hg38)
- Size:
- 14,050 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:124,069,099-124,083,129
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 14,031 bases
- Orientation:
- Plus strand
Genomic View for TMED2 Gene
Genes around TMED2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
TMED2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMED2 Gene
Proteins for TMED2 Gene
-
Protein details for TMED2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15363-TMED2_HUMAN
- Recommended name:
- Transmembrane emp24 domain-containing protein 2
- Protein Accession:
- Q15363
Protein attributes for TMED2 Gene
- Size:
- 201 amino acids
- Molecular mass:
- 22761 Da
- Quaternary structure:
-
- Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10. Interacts (via GOLD domain) with TMED10 (via GOLD domain). Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED2. Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat. Interacts with ARF1 and ARFGAP1 (By similarity). Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1. Interacts with KDELR1; the interaction is decreased by KDEL ligand (By similarity). Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with CASR (immaturely glycosylated form); the interaction occurs in the endoplasmic reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2 (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10.
- Miscellaneous:
-
- Ectopic expression of TMED2 alone does not result in its proper cis-Golgi network localization. Coexpression of TMED10 is necessary, and coexpression of TMED3 and/or TMED9 is facilitating localization. Down-regulation of TMED10 expression reduces TMED2 protein level.
Protein Expression for TMED2 Gene
Post-translational modifications for TMED2 Gene
Other Protein References for TMED2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for TMED2
-
Abcam antibodies for TMED2
- Invitrogen Antibodies for TMED2 (AFLGC-Tmed2)
- antibodies-online: Show 13 available TMED2 Antibodies ranked by validation data
-
Custom Antibody ServicesProSci Antibodies for TMED2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TMED2
- Sino Biological Antibodies for TMED2
Protein products for research
-
OriGene Purified Proteins for TMED2
- Search Origene for MassSpec and Protein Over-expression Lysates for TMED2
- Origene Custom Protein Services for TMED2
-
Abcam proteins for TMED2
Assay products for research
No data available for DME Specific Peptides for TMED2 Gene
Domains & Families for TMED2 Gene
Gene Families for TMED2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for TMED2 Gene
- InterPro:
- Blocks:
-
- emp24/gp25L/p24 family
Suggested Antigen Peptide Sequences for TMED2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52153, highly similar to Transmembrane emp24 domain-containing protein 2 (B4DP27_HUMAN)
- cDNA, FLJ93436, Homo sapiens coated vesicle membrane protein (RNP24), mRNA (Q6FHT8_HUMAN)
- Membrane protein p24A (TMED2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15363- Family:
-
- Belongs to the EMP24/GP25L family.
Function for TMED2 Gene
Molecular function for TMED2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
Phenotypes From GWAS Catalog for TMED2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10359607 |
Phenotypes for TMED2 Gene
- MGI mutant phenotypes for TMED2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TMED2:
-
- no effect
- Decreased viability ratio
- Decreased viability
- Decreased shRNA abundance
- Decreased p24 protein expression
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased cell number in S and G2M
- Decreased Tat-dependent transcription
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TMED2 - Starting at $85 >
- * TMED2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TMED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMED2
miRNA for TMED2 Gene
- miRTarBase miRNAs that target TMED2
-
- hsa-miR-30a-5p (MIRT005187)
- hsa-miR-193b-3p (MIRT016541)
- hsa-miR-615-3p (MIRT039998)
- hsa-miR-7-5p (MIRT047764)
- hsa-miR-30c-5p (MIRT270739)
- hsa-miR-30d-5p (MIRT270740)
- hsa-miR-30b-5p (MIRT270741)
- hsa-miR-30e-5p (MIRT270742)
- hsa-miR-186-5p (MIRT270749)
- hsa-miR-4452 (MIRT335703)
- hsa-miR-219a-2-3p (MIRT405178)
- hsa-miR-3123 (MIRT565349)
- hsa-miR-4699-3p (MIRT565350)
- hsa-miR-892c-3p (MIRT565351)
- hsa-miR-4676-3p (MIRT565352)
- hsa-miR-452-5p (MIRT565353)
- hsa-miR-6513-5p (MIRT698379)
- hsa-miR-5089-5p (MIRT698380)
- hsa-miR-6728-5p (MIRT698381)
- hsa-miR-769-3p (MIRT698382)
- hsa-miR-450b-3p (MIRT698383)
- hsa-miR-4303 (MIRT698384)
- hsa-miR-4425 (MIRT698385)
- hsa-miR-638 (MIRT698386)
- hsa-miR-4713-3p (MIRT698387)
- hsa-miR-571 (MIRT698388)
- hsa-miR-219a-1-3p (MIRT698389)
- hsa-miR-4682 (MIRT698390)
- hsa-miR-4259 (MIRT698391)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMED2
- Browse OriGene Inhibitory RNA Products For TMED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMED2
Clone products for research
- Applied Biological Materials (abm): Clones for TMED2 - Starting at $45 >
- * TMED2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TMED2
- Addgene plasmids for TMED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMED2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED2 Gene
Localization for TMED2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMED2 Gene
- Cytoplasmic vesicle membrane. Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane. Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane. Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269 PubMed:12237308}.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 12237308 |
| GO:0005789 | endoplasmic reticulum membrane | IEA,TAS | -- |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA | 12237308 |
| GO:0005794 | Golgi apparatus | IEA,IDA | 12237308 |
Pathways & Interactions for TMED2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Vesicle-mediated transport | ||
| 4 | Metabolism of proteins | ||
| 5 | Pre-NOTCH Expression and Processing | ||
Pathways by source for TMED2 Gene
Interacting Proteins for TMED2 Gene
Selected Interacting proteins:
Q15363-TMED2_HUMAN
ENSP00000262225
for TMED2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TMED2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001756 | somitogenesis | IEA | -- |
| GO:0001843 | neural tube closure | IEA | -- |
| GO:0001892 | embryonic placenta development | IEA | -- |
| GO:0001893 | maternal placenta development | IEA | -- |
No data available for SIGNOR curated interactions for TMED2 Gene
Transcripts for TMED2 Gene
mRNA/cDNA for TMED2 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262225 2544 nts (view in UCSC)
- ENST00000438031 603 nts (view in UCSC)
- ENST00000509052 1975 nts (view in UCSC)
- ENST00000543425 1350 nts (view in UCSC)
- ENST00000544188 433 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TMED2 - Starting at $85 >
- * TMED2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TMED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMED2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMED2
- Browse OriGene Inhibitory RNA Products For TMED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMED2
Clone products for research
- Applied Biological Materials (abm): Clones for TMED2 - Starting at $45 >
- * TMED2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TMED2
- Addgene plasmids for TMED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMED2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: |
Relevant External Links for TMED2 Gene
- GeneLoc Exon Structure for
- TMED2
Expression for TMED2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMED2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMED2
SOURCE GeneReport for Unigene cluster for TMED2 Gene:
Hs.733403Evidence on tissue expression from TISSUES for TMED2 Gene
- Nervous system(5)
- Liver(4.7)
- Muscle(4.4)
- Skin(4.2)
- Pancreas(4)
- Intestine(3.7)
- Kidney(3.6)
- Lung(3.5)
- Eye(3)
- Stomach(2.4)
- Heart(2.2)
- Spleen(2.1)
- Thyroid gland(2.1)
- Lymph node(2)
Primer products for research
-
OriGene qPCR primer pairs for TMED2
-
OriGene qPCR primer pairs and template standards for TMED2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED2 Gene
Orthologs for TMED2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TMED2 30 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | TMED2 29 |
|
||
| Dog (Canis familiaris) |
Mammalia | TMED2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TMED2 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tmed2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tmed2 29 16 30 |
|
OneToOne | |
| Tmed2b 16 |
|
|
|||
| Oppossum (Monodelphis domestica) |
Mammalia | TMED2 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TMED2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TMED2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tmed2 29 |
|
||
| Str.8778 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | rnp24-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tmed2 29 30 |
|
OneToOne | |
| wufb18g06 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11035 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CHOp24 29 30 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004743 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | sel-9 29 30 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EMP24 29 30 32 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F12518g 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5670 30 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU08339 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | emp24 29 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1779 29 |
|
- Species where no ortholog for TMED2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TMED2 Gene
- ENSEMBL:
- Gene Tree for TMED2 (if available)
- TreeFam:
- Gene Tree for TMED2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMED2: view image
- Alliance of Genome Resources:
- Additional Orthologs for TMED2
Paralogs for TMED2 Gene
Paralogs for TMED2 Gene
(5) SIMAP similar genes for TMED2 Gene using alignment to 3 proteins:
- TMED2_HUMAN
- E7EQ72_HUMAN
- F5GX39_HUMAN
Pseudogenes.org Pseudogenes for TMED2 Gene
Variants for TMED2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv523e212 | CNV | loss | 25503493 |
| esv2422416 | CNV | duplication | 17116639 |
| nsv1042181 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMED2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMED2 Gene
Disorders for TMED2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cardiomyopathy, dilated, 1m |
|
|
| cardiomyopathy, familial hypertrophic, 7 |
|
|
| epiphyseal dysplasia, multiple, 1 |
|
|
| cardiomyopathy, dilated, 1p |
|
|
| ovarian mucinous adenocarcinoma |
|
|
Search TMED2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TMED2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TMED2 Gene
Publications for TMED2 Gene
- Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PMID: 8663407) Blum R … Schulz I (The Journal of biological chemistry 1996) 2 3 4 22
- 3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport. (PMID: 27569046) Nagae M … Yamaguchi Y (Journal of molecular biology 2016) 3 4
- Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PMID: 21219331) Luo W … Reiser G (Journal of neurochemistry 2011) 3 4
- Selective export of human GPI-anchored proteins from the endoplasmic reticulum. (PMID: 20427317) Bonnon C … Hauri HP (Journal of cell science 2010) 3 4
- The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway. (PMID: 20361938) Stepanchick A … Breitwieser GE (Biochemical and biophysical research communications 2010) 3 4
ExternalLinks
Products for TMED2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TMED2
- Search Origene for MassSpec and Protein Over-expression Lysates for TMED2
- Origene Custom Protein Services for TMED2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMED2
- Browse OriGene Inhibitory RNA Products For TMED2
- OriGene qPCR primer pairs for TMED2
- OriGene qPCR primer pairs and template standards for TMED2
- OriGene CRISPR knockouts for TMED2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMED2
- Sino Biological Human cDNA Clone for TMED2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for TMED2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TMED2
- Novus Biologicals proteins and lysates for TMED2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TMED2
- Abcam proteins for TMED2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for TMED2 (AFLGC-Tmed2)
- VectorBuilder Custom and pre-made DNA vectors for TMED2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TMED2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TMED2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TMED2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TMED2
- Addgene plasmids for TMED2
- antibodies-online: Show 13 available TMED2 Antibodies ranked by validation data
- antibodies-online: Search results for available TMED2 related products ranked by validation data
- antibodies-online: Search results for available TMED2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for TMED2
- Search Santa Cruz Biotechnology (SCBT) for TMED2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TMED2
- Custom Antibody ServicesProSci Antibodies for TMED2
- Search for TMED2 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMED2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TMED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMED2
Sources for TMED2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources