Aliases for TMCO2 Gene

Aliases for TMCO2 Gene

  • Transmembrane And Coiled-Coil Domains 2 2 3 5
  • Transmembrane And Coiled-Coil Domain-Containing Protein 2 3 4
  • DJ39G22.2 2 3
  • Testis Tissue Sperm-Binding Protein Li 35a 3
  • DJ39G22.2 (Novel Protein) 3
  • TMCO2 5

External Ids for TMCO2 Gene

Previous GeneCards Identifiers for TMCO2 Gene

  • GC01P040384
  • GC01P040486
  • GC01P040711
  • GC01P038832

Summaries for TMCO2 Gene

GeneCards Summary for TMCO2 Gene

TMCO2 (Transmembrane And Coiled-Coil Domains 2) is a Protein Coding gene.

Additional gene information for TMCO2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMCO2 Gene

Genomics for TMCO2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMCO2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J040247 Promoter/Enhancer 1 EPDnew Ensembl 600.7 +2.1 2089 0.7 GATAD2A SP1 SOX13 ZBTB11 CREB1 FOSL1 CREM TBP ZGPAT FOSL2 HSALNG0002853 TMCO2 ZMPSTE24
GH01J040246 Enhancer 0.3 Ensembl 600.7 +0.9 854 0.4 CEBPB ZNF384 HSALNG0002853 TMCO2 ZMPSTE24
GH01J040372 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +129.9 129906 5.9 ARHGAP35 CREB1 PRDM10 ZNF629 RFX1 LEF1 IKZF1 NFKBIZ POLR2A ZNF692 SMAP2 piR-50443-014 PPIEL PPIE TRIT1 EXO5 ENSG00000259943 NFYC-AS1 RLF NFYC
GH01J040783 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +538.1 538054 2.4 ARHGAP35 IKZF1 ZNF692 BACH1 PRDM1 MTA2 PHF21A ZIC2 ZNF776 ZSCAN4 KCNQ4 TRIT1 EXO5 ENSG00000259943 NFYC-AS1 SLFNL1 RLF NFYC TMCO2 RIMS3
GH01J040690 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +446.8 446754 4.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 RIMS3 NFYC-AS1 NFYC NONHSAG001168.2 ENSG00000259943 EXO5 TRIT1 ENSG00000237899 ZFP69 SLFNL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMCO2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMCO2

Top Transcription factor binding sites by QIAGEN in the TMCO2 gene promoter:
  • CUTL1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx6-1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TMCO2 Gene

Genomic Locations for TMCO2 Gene
5,738 bases
Plus strand
5,747 bases
Plus strand

Genomic View for TMCO2 Gene

Genes around TMCO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO2 Gene

Proteins for TMCO2 Gene

  • Protein details for TMCO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 2
    Protein Accession:

    Protein attributes for TMCO2 Gene

    182 amino acids
    Molecular mass:
    20071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCO2 Gene

Post-translational modifications for TMCO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMCO2 Gene

Domains & Families for TMCO2 Gene

Gene Families for TMCO2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMCO2 Gene


Suggested Antigen Peptide Sequences for TMCO2 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane and coiled-coil domain-containing protein 2 (TMCO2_HUMAN)
genes like me logo Genes that share domains with TMCO2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMCO2 Gene

Function for TMCO2 Gene

Phenotypes From GWAS Catalog for TMCO2 Gene

genes like me logo Genes that share phenotypes with TMCO2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMCO2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMCO2 Gene

Localization for TMCO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO2 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCO2 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMCO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMCO2 Gene

Pathways & Interactions for TMCO2 Gene

PathCards logo

SuperPathways for TMCO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCO2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCO2 Gene

Drugs & Compounds for TMCO2 Gene

No Compound Related Data Available

Transcripts for TMCO2 Gene

mRNA/cDNA for TMCO2 Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMCO2

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO2 Gene

No ASD Table

Relevant External Links for TMCO2 Gene

GeneLoc Exon Structure for

Expression for TMCO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMCO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TMCO2 Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for TMCO2 Gene

This gene is overexpressed in Testis (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMCO2 Gene

Protein tissue co-expression partners for TMCO2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMCO2

SOURCE GeneReport for Unigene cluster for TMCO2 Gene:


Evidence on tissue expression from TISSUES for TMCO2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMCO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCO2 Gene

Orthologs for TMCO2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMCO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMCO2 30 31
  • 99.63 (n)
(Canis familiaris)
Mammalia TMCO2 30 31
  • 87.72 (n)
(Bos Taurus)
Mammalia TMCO2 30 31
  • 85.98 (n)
(Rattus norvegicus)
Mammalia Tmco2 30
  • 85.85 (n)
(Mus musculus)
Mammalia Tmco2 30 17 31
  • 85.85 (n)
(Monodelphis domestica)
Mammalia TMCO2 31
  • 43 (a)
Species where no ortholog for TMCO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMCO2 Gene

Gene Tree for TMCO2 (if available)
Gene Tree for TMCO2 (if available)
Evolutionary constrained regions (ECRs) for TMCO2: view image

Paralogs for TMCO2 Gene

No data available for Paralogs for TMCO2 Gene

Variants for TMCO2 Gene

Additional dbSNP identifiers (rs#s) for TMCO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMCO2 Gene

Variant ID Type Subtype PubMed ID
nsv829660 CNV gain+loss 17160897

Variation tolerance for TMCO2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMCO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMCO2 Gene

Disorders for TMCO2 Gene

No disorders were found for TMCO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO2 Gene

Publications for TMCO2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for TMCO2 Gene

Sources for TMCO2 Gene