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Aliases for TMCO2 Gene

Aliases for TMCO2 Gene

  • Transmembrane And Coiled-Coil Domains 2 2 3 5
  • Transmembrane And Coiled-Coil Domain-Containing Protein 2 3
  • Testis Tissue Sperm-Binding Protein Li 35a 3
  • DJ39G22.2 (Novel Protein) 3
  • DJ39G22.2 3

External Ids for TMCO2 Gene

Previous GeneCards Identifiers for TMCO2 Gene

  • GC01P040384
  • GC01P040486
  • GC01P040711
  • GC01P038832

Summaries for TMCO2 Gene

GeneCards Summary for TMCO2 Gene

TMCO2 (Transmembrane And Coiled-Coil Domains 2) is a Protein Coding gene.

Additional gene information for TMCO2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO2 Gene

Genomics for TMCO2 Gene

GeneHancer (GH) Regulatory Elements for TMCO2 Gene

Promoters and enhancers for TMCO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I040247 Promoter 0.9 EPDnew 550.8 +2.0 1971 0.1 SOX5 SOX13 ZNF644 NFIL3 CREB1 HNF4A HOMEZ CREM TMCO2 GC01P040244 ENSG00000259943
GH01I040372 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +129.9 129906 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 SMAP2 PPIEL EXO5 PPIE TRIT1 ENSG00000259943 ENSG00000182109 NFYC-AS1 RLF NFYC
GH01I039779 Enhancer 0.3 FANTOM5 85.2 -466.1 -466053 0.2 LOC105378666 TMCO2 OXCT2 PPIE HEYL BMP8B
GH01I040690 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +446.8 446754 4.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D RIMS3 NFYC-AS1 NFYC ENSG00000259943 EXO5 TRIT1 LOC105378674 ZFP69 SLFNL1 MIR30C1
GH01I040338 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +93.6 93554 1.8 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 IRF4 ZNF48 SLC30A9 PPIE COL9A2 ENSG00000231296 ZMPSTE24 TMCO2 EXO5 SMAP2 PPT1 RLF RPL21P20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMCO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMCO2 gene promoter:

Genomic Locations for TMCO2 Gene

Genomic Locations for TMCO2 Gene
chr1:40,245,947-40,251,693
(GRCh38/hg38)
Size:
5,747 bases
Orientation:
Plus strand
chr1:40,711,619-40,717,365
(GRCh37/hg19)

Genomic View for TMCO2 Gene

Genes around TMCO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO2 Gene

Proteins for TMCO2 Gene

  • Protein details for TMCO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6W1-TMCO2_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 2
    Protein Accession:
    Q7Z6W1

    Protein attributes for TMCO2 Gene

    Size:
    182 amino acids
    Molecular mass:
    20071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCO2 Gene

Post-translational modifications for TMCO2 Gene

No Post-translational modifications

Other Protein References for TMCO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMCO2 Gene

Domains & Families for TMCO2 Gene

Gene Families for TMCO2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMCO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMCO2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMCO2: view

No data available for UniProtKB/Swiss-Prot for TMCO2 Gene

Function for TMCO2 Gene

Phenotypes for TMCO2 Gene

genes like me logo Genes that share phenotypes with TMCO2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMCO2 Gene

Localization for TMCO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCO2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMCO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMCO2 Gene

Pathways & Interactions for TMCO2 Gene

SuperPathways for TMCO2 Gene

No Data Available

Interacting Proteins for TMCO2 Gene

Gene Ontology (GO) - Biological Process for TMCO2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMCO2 Gene

Drugs & Compounds for TMCO2 Gene

No Compound Related Data Available

Transcripts for TMCO2 Gene

mRNA/cDNA for TMCO2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMCO2 Gene

Transmembrane and coiled-coil domains 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO2 Gene

No ASD Table

Relevant External Links for TMCO2 Gene

GeneLoc Exon Structure for
TMCO2
ECgene alternative splicing isoforms for
TMCO2

Expression for TMCO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCO2 Gene

mRNA differential expression in normal tissues according to GTEx for TMCO2 Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for TMCO2 Gene

This gene is overexpressed in Testis (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMCO2 Gene



Protein tissue co-expression partners for TMCO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMCO2 Gene:

TMCO2

SOURCE GeneReport for Unigene cluster for TMCO2 Gene:

Hs.406265

Evidence on tissue expression from TISSUES for TMCO2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMCO2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCO2 Gene

Orthologs for TMCO2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMCO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCO2 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia TMCO2 33 34
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia TMCO2 33 34
  • 85.98 (n)
mouse
(Mus musculus)
Mammalia Tmco2 33 16 34
  • 85.85 (n)
rat
(Rattus norvegicus)
Mammalia Tmco2 33
  • 85.85 (n)
oppossum
(Monodelphis domestica)
Mammalia TMCO2 34
  • 43 (a)
OneToOne
Species where no ortholog for TMCO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMCO2 Gene

ENSEMBL:
Gene Tree for TMCO2 (if available)
TreeFam:
Gene Tree for TMCO2 (if available)

Paralogs for TMCO2 Gene

No data available for Paralogs for TMCO2 Gene

Variants for TMCO2 Gene

Sequence variations from dbSNP and Humsavar for TMCO2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000115265 -- 40,247,417(+) T/C upstream_transcript_variant
rs1000230667 -- 40,247,833(+) T/C upstream_transcript_variant
rs1000643180 -- 40,251,069(+) G/A intron_variant
rs1001122010 -- 40,246,010(+) C/T upstream_transcript_variant
rs1001525655 -- 40,251,980(+) G/A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMCO2 Gene

Variant ID Type Subtype PubMed ID
nsv829660 CNV gain+loss 17160897

Variation tolerance for TMCO2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMCO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMCO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCO2 Gene

Disorders for TMCO2 Gene

Additional Disease Information for TMCO2

No disorders were found for TMCO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO2 Gene

Publications for TMCO2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMCO2 Gene

Sources for TMCO2 Gene

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