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Aliases for TMCC1 Gene

Aliases for TMCC1 Gene

  • Transmembrane And Coiled-Coil Domain Family 1 2 3 5
  • Transmembrane And Coiled-Coil Domains 1 2
  • KIAA0779 4

External Ids for TMCC1 Gene

Previous GeneCards Identifiers for TMCC1 Gene

  • GC03M130851
  • GC03M129366
  • GC03M126749

Summaries for TMCC1 Gene

GeneCards Summary for TMCC1 Gene

TMCC1 (Transmembrane And Coiled-Coil Domain Family 1) is a Protein Coding gene. An important paralog of this gene is TMCC2.

Additional gene information for TMCC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC1 Gene

Genomics for TMCC1 Gene

GeneHancer (GH) Regulatory Elements for TMCC1 Gene

Promoters and enhancers for TMCC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I129888 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +2.1 2124 6.3 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 FOS SP3 TMCC1 RNY3P13 TMCC1-AS1 ENSG00000203644 GC03P129794
GH03I129828 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 561 +63.7 63732 1.9 CTCF PKNOX1 SAP130 DNMT3B RAD21 YY1 ARID2 ZNF143 SMC3 FOSL2 TMCC1 RHO ENSG00000283509 ENSG00000203644 GC03P129794
GH03I129880 Promoter 0.5 EPDnew 550.4 +13.1 13138 0.1 TMCC1 ENSG00000203644 GC03P129794
GH03I129824 Enhancer 0.7 FANTOM5 24.8 +68.8 68790 0.2 CTCF PKNOX1 SAP130 ARID4B RAD21 CC2D1A MIER3 ZNF24 CUX1 ZNF444 TMCC1 MBD4 H1FOO ENSG00000283509 ENSG00000203644 GC03P129794
GH03I129917 Enhancer 0.6 FANTOM5 27.6 -23.8 -23784 0.3 ZEB2 KLF5 MITF ZNF280A RAD51 CBX1 MTA3 SKIL ZNF143 TRIM24 TMCC1 RNY3P13 MBD4 ENSG00000203644 TMCC1-AS1 ENSG00000250643 GC03P129794
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMCC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMCC1 gene promoter:

Genomic Locations for TMCC1 Gene

Genomic Locations for TMCC1 Gene
245,806 bases
Minus strand

Genomic View for TMCC1 Gene

Genes around TMCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC1 Gene

Proteins for TMCC1 Gene

  • Protein details for TMCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domains protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K5Y3
    • B4DE04
    • Q68E06
    • Q8IXM8

    Protein attributes for TMCC1 Gene

    653 amino acids
    Molecular mass:
    72083 Da
    Quaternary structure:
    • May form homo- or heterodimers with other TMCC proteins via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6.

    Alternative splice isoforms for TMCC1 Gene


neXtProt entry for TMCC1 Gene

Post-translational modifications for TMCC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMCC1 Gene

Domains & Families for TMCC1 Gene

Gene Families for TMCC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMCC1 Gene


Suggested Antigen Peptide Sequences for TMCC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TEX28 family.
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC1: view

Function for TMCC1 Gene

Phenotypes From GWAS Catalog for TMCC1 Gene

Gene Ontology (GO) - Molecular Function for TMCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24454821
GO:0042803 protein homodimerization activity IMP 24454821
GO:0046982 protein heterodimerization activity IMP 24454821
genes like me logo Genes that share ontologies with TMCC1: view
genes like me logo Genes that share phenotypes with TMCC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC1 Gene

Localization for TMCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCC1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TMCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005791 rough endoplasmic reticulum IMP 24454821
GO:0005829 cytosol IMP 24454821
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMCC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMCC1 Gene

Pathways & Interactions for TMCC1 Gene

SuperPathways for TMCC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007029 endoplasmic reticulum organization IMP 24454821
GO:0051260 protein homooligomerization IMP 24454821
GO:0051291 protein heterooligomerization IMP 24454821
genes like me logo Genes that share ontologies with TMCC1: view

No data available for Pathways by source and SIGNOR curated interactions for TMCC1 Gene

Drugs & Compounds for TMCC1 Gene

No Compound Related Data Available

Transcripts for TMCC1 Gene

Unigene Clusters for TMCC1 Gene

Transmembrane and coiled-coil domain family 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - -

Relevant External Links for TMCC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCC1 Gene

Protein differential expression in normal tissues from HIPED for TMCC1 Gene

This gene is overexpressed in Adrenal (26.5), Fetal Brain (10.7), Testis (9.8), Retina (9.0), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCC1 Gene

Protein tissue co-expression partners for TMCC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMCC1 Gene:


SOURCE GeneReport for Unigene cluster for TMCC1 Gene:


Evidence on tissue expression from TISSUES for TMCC1 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TMCC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCC1 Gene

Orthologs for TMCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMCC1 33 34
  • 99.69 (n)
(Bos Taurus)
Mammalia TMCC1 34
  • 96 (a)
(Canis familiaris)
Mammalia TMCC1 33 34
  • 95.13 (n)
(Monodelphis domestica)
Mammalia TMCC1 34
  • 92 (a)
(Mus musculus)
Mammalia Tmcc1 33 16 34
  • 90.86 (n)
(Rattus norvegicus)
Mammalia Tmcc1 33
  • 90.65 (n)
(Ornithorhynchus anatinus)
Mammalia TMCC1 34
  • 85 (a)
(Gallus gallus)
Aves TMCC1 33 34
  • 81.74 (n)
(Anolis carolinensis)
Reptilia TMCC1 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc1 33
  • 67.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25587 33
(Danio rerio)
Actinopterygii tmcc1b 33 34
  • 69.78 (n)
TMCC1 (2 of 2) 34
  • 62 (a)
wufd44g06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1926 33
fruit fly
(Drosophila melanogaster)
Insecta CG1021 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea C15H9.4 33 34
  • 42.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 34
  • 51 (a)
Species where no ortholog for TMCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC1 Gene

Gene Tree for TMCC1 (if available)
Gene Tree for TMCC1 (if available)

Paralogs for TMCC1 Gene

Paralogs for TMCC1 Gene

(4) SIMAP similar genes for TMCC1 Gene using alignment to 6 proteins: Pseudogenes for TMCC1 Gene

genes like me logo Genes that share paralogs with TMCC1: view

Variants for TMCC1 Gene

Sequence variations from dbSNP and Humsavar for TMCC1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000003865 -- 129,754,511(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000010079 -- 129,708,526(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000018136 -- 129,795,093(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000022178 -- 129,707,271(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000034064 -- 129,692,188(-) T/A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC1 Gene

Variant ID Type Subtype PubMed ID
nsv956830 CNV deletion 24416366
nsv591676 CNV loss 21841781
nsv516538 CNV gain 19592680
nsv508953 CNV insertion 20534489
nsv475803 CNV novel sequence insertion 20440878
nsv238037 CNV deletion 16902084
nsv237038 CNV deletion 16902084
nsv1074623 CNV deletion 25765185
esv3597750 CNV loss 21293372
esv3597747 CNV gain 21293372
esv3597746 CNV loss 21293372
esv3597745 CNV loss 21293372
esv2725905 CNV deletion 23290073
esv2725904 CNV deletion 23290073
esv2543950 CNV deletion 19546169
esv2075495 CNV deletion 18987734
esv1519846 CNV deletion 17803354
esv1008617 CNV deletion 20482838

Variation tolerance for TMCC1 Gene

Residual Variation Intolerance Score: 8.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC1 Gene

Disorders for TMCC1 Gene

Additional Disease Information for TMCC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC1 Gene

Publications for TMCC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. (PMID: 24454821) Zhang C … Qi RZ (PloS one 2014) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMCC1 Gene

Sources for TMCC1 Gene

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