Aliases for TMC8 Gene
External Ids for TMC8 Gene
Previous HGNC Symbols for TMC8 Gene
Previous GeneCards Identifiers for TMC8 Gene
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
GeneCards Summary for TMC8 Gene
TMC8 (Transmembrane Channel Like 8) is a Protein Coding gene. Diseases associated with TMC8 include Epidermodysplasia Verruciformis 2 and Epidermodysplasia Verruciformis 1. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is TMC4.
UniProtKB/Swiss-Prot Summary for TMC8 Gene
Probable ion channel.