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Aliases for TMC6 Gene

Aliases for TMC6 Gene

  • Transmembrane Channel Like 6 2 3 5
  • Epidermodysplasia Verruciformis Protein 1 3 4
  • Epidermodysplasia Verruciformis 1 2 3
  • Protein LAK-4 3 4
  • EVER1 3 4
  • EVIN1 3 4
  • Expressed In Activated T/LAK Lymphocytes 3
  • Transmembrane Channel-Like Protein 6 3
  • LAK-4P 3
  • EV1 3

External Ids for TMC6 Gene

Previous HGNC Symbols for TMC6 Gene

  • EVER1

Previous GeneCards Identifiers for TMC6 Gene

  • GC17M073619
  • GC17M076108
  • GC17M071533

Summaries for TMC6 Gene

Entrez Gene Summary for TMC6 Gene

  • Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMC6 Gene

TMC6 (Transmembrane Channel Like 6) is a Protein Coding gene. Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis. Among its related pathways are Innate Immune System. An important paralog of this gene is TMC5.

UniProtKB/Swiss-Prot for TMC6 Gene

  • Probable ion channel.

Gene Wiki entry for TMC6 Gene

Additional gene information for TMC6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC6 Gene

Genomics for TMC6 Gene

GeneHancer (GH) Regulatory Elements for TMC6 Gene

Promoters and enhancers for TMC6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J078120 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 670.9 +4.5 4457 14.8 MLX ZFP64 YBX1 FEZF1 DMAP1 SLC30A9 ZNF143 SP3 NFYC MEF2D TMC8 TMC6 USP36 SYNGR2 AFMID TK1 TNRC6C-AS1 ENGASE PGS1 TNRC6C
GH17J078250 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -120.5 -120458 4.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ENSG00000279886 THA1P USP36 TMC8 SEPT9 TK1 AFMID TMC6 TMEM235 TNRC6C
GH17J078268 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.6 -139.2 -139165 5.6 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A ZNF766 E2F8 REST ZNF592 USP36 PGS1 TMEM235 ENSG00000200063 TMC8 TMC6 SOCS3 TNRC6C LINC01993 THA1P
GH17J078143 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 6.6 -13.8 -13793 5.8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B DMAP1 SP5 MXD4 C17orf99 TMC8 TMC6 EIF5AP2
GH17J077887 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +244.5 244538 1.6 PKNOX1 ATF1 ARID4B ZNF2 GLIS2 ATF7 SP3 RXRA ZHX2 ZNF592 TMC8 TNRC6C TMC6 PGS1 SOCS3 LINC01973 GC17P077921
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMC6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMC6 gene promoter:
  • c-Ets-1

Genomic Locations for TMC6 Gene

Genomic Locations for TMC6 Gene
21,950 bases
Minus strand
21,950 bases
Minus strand

Genomic View for TMC6 Gene

Genes around TMC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC6 Gene

Proteins for TMC6 Gene

  • Protein details for TMC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 6
    Protein Accession:
    Secondary Accessions:
    • O43284
    • Q45VJ2
    • Q8IU98
    • Q8IUI7
    • Q8IWU8
    • Q8TEQ7
    • Q9HAG5

    Protein attributes for TMC6 Gene

    805 amino acids
    Molecular mass:
    90045 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35648.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24179.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84891.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC6 Gene


neXtProt entry for TMC6 Gene

Post-translational modifications for TMC6 Gene

  • Glycosylation at isoforms=2, 4312 and posLast=103103
  • Ubiquitination at posLast=409409 and isoforms=2151
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMC6 Gene

Domains & Families for TMC6 Gene

Gene Families for TMC6 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMC6 Gene


Suggested Antigen Peptide Sequences for TMC6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC6: view

Function for TMC6 Gene

Molecular function for TMC6 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.

Phenotypes From GWAS Catalog for TMC6 Gene

Gene Ontology (GO) - Molecular Function for TMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18158319
genes like me logo Genes that share ontologies with TMC6: view
genes like me logo Genes that share phenotypes with TMC6: view

Human Phenotype Ontology for TMC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMC6 Gene

MGI Knock Outs for TMC6:
  • Tmc6 Tmc6<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for TMC6 Gene

miRTarBase miRNAs that target TMC6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMC6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMC6 Gene

Localization for TMC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMC6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 2

Gene Ontology (GO) - Cellular Components for TMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12426567
GO:0005783 endoplasmic reticulum IEA,IDA 12426567
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA 18158319
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TMC6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMC6 Gene

Pathways & Interactions for TMC6 Gene

genes like me logo Genes that share pathways with TMC6: view

Pathways by source for TMC6 Gene

3 Reactome pathways for TMC6 Gene

Interacting Proteins for TMC6 Gene

Selected Interacting proteins: Q7Z403-TMC6_HUMAN for TMC6 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0008150 biological_process ND --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with TMC6: view

No data available for SIGNOR curated interactions for TMC6 Gene

Drugs & Compounds for TMC6 Gene

No Compound Related Data Available

Transcripts for TMC6 Gene

Unigene Clusters for TMC6 Gene

Transmembrane channel-like 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMC6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMC6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP6: - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - -
SP11: - - - - - -
SP13: - - -
SP14: - -
SP16: - - - - -
SP17: - - - -

ExUns: 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - -
SP7: - - -

Relevant External Links for TMC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC6 Gene

This gene is overexpressed in Whole Blood (x6.2) and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for TMC6 Gene

This gene is overexpressed in Monocytes (22.6), Plasma (12.6), Peripheral blood mononuclear cells (10.5), NK cells (6.9), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMC6 Gene

Protein tissue co-expression partners for TMC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMC6 Gene:


SOURCE GeneReport for Unigene cluster for TMC6 Gene:


mRNA Expression by UniProt/SwissProt for TMC6 Gene:

Tissue specificity: Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.

Evidence on tissue expression from TISSUES for TMC6 Gene

  • Spleen(4.4)
  • Nervous system(4.4)
  • Blood(3)
  • Skin(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TMC6 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • immune
  • integumentary
  • digit
  • foot
  • lower limb
  • toe
  • blood
  • blood vessel
  • hair
  • skin
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with TMC6: view

Orthologs for TMC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMC6 34 33
  • 99.55 (n)
(Bos Taurus)
Mammalia TMC6 34 33
  • 84.17 (n)
(Canis familiaris)
Mammalia TMC6 34 33
  • 83.93 (n)
(Mus musculus)
Mammalia Tmc6 16 34 33
  • 78.95 (n)
(Monodelphis domestica)
Mammalia TMC6 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TMC6 34
  • 42 (a)
(Gallus gallus)
Aves LOC100859142 33
  • 66.31 (n)
TMC6 34
  • 56 (a)
(Anolis carolinensis)
Reptilia TMC6 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmc6 33
  • 56.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6120 33
(Danio rerio)
Actinopterygii tmc6b 33
  • 59.22 (n)
TMC6 (1 of 2) 34
  • 44 (a)
tmc6a 34
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3280 34
  • 8 (a)
(Caenorhabditis elegans)
Secernentea tmc-2 34
  • 12 (a)
tmc-1 34
  • 11 (a)
Species where no ortholog for TMC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMC6 Gene

Gene Tree for TMC6 (if available)
Gene Tree for TMC6 (if available)
Evolutionary constrained regions (ECRs) for TMC6: view image

Paralogs for TMC6 Gene

Paralogs for TMC6 Gene

(1) SIMAP similar genes for TMC6 Gene using alignment to 7 proteins:

  • Q7L2M4_HUMAN
  • Q96I77_HUMAN Pseudogenes for TMC6 Gene

genes like me logo Genes that share paralogs with TMC6: view

Variants for TMC6 Gene

Sequence variations from dbSNP and Humsavar for TMC6 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs114853749 benign, EPIDERMODYSPLASIA VERRUCIFORMIS 78,121,077(-) G/A coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs121908327 pathogenic, EPIDERMODYSPLASIA VERRUCIFORMIS 78,125,876(-) G/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, stop_gained, upstream_transcript_variant
rs121908328 pathogenic, EPIDERMODYSPLASIA VERRUCIFORMIS 78,119,382(-) C/A/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant, stop_gained
rs121908329 pathogenic, EPIDERMODYSPLASIA VERRUCIFORMIS 78,124,671(-) G/T coding_sequence_variant, intron_variant, non_coding_transcript_variant, stop_gained
rs139557408 likely-benign, EPIDERMODYSPLASIA VERRUCIFORMIS 78,125,841(-) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMC6 Gene

Variant ID Type Subtype PubMed ID
esv2716301 CNV deletion 23290073
esv2716302 CNV deletion 23290073
esv2716303 CNV deletion 23290073
esv2716304 CNV deletion 23290073
nsv1113890 CNV deletion 24896259
nsv470607 CNV loss 18288195
nsv515500 CNV loss 19592680
nsv833554 CNV gain+loss 17160897

Variation tolerance for TMC6 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.76; 94.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMC6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC6 Gene

Disorders for TMC6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TMC6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epidermodysplasia verruciformis
  • ev
superficial mycosis
  • piedra
pityriasis versicolor
  • infection by pityrosporum furfur
hepatitis e
- elite association - COSMIC cancer census association via MalaCards
Search TMC6 in MalaCards View complete list of genes associated with diseases


  • Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. {ECO:0000269 PubMed:12426567, ECO:0000269 PubMed:15042430}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TMC6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMC6: view

No data available for Genatlas for TMC6 Gene

Publications for TMC6 Gene

  1. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. (PMID: 12426567) Ramoz N … Favre M (Nature genetics 2002) 2 3 4 22 58
  2. Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. (PMID: 15042430) Tate G … Mitsuya T (Journal of human genetics 2004) 3 4 22 58
  3. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K … Griffith AJ (Genomics 2003) 3 4 22 58
  4. Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation. (PMID: 19706093) McDermott DF … Hwang ST (Pediatric dermatology 2009) 3 22 58
  5. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. (PMID: 18158319) Lazarczyk M … Favre M (The Journal of experimental medicine 2008) 3 22 58

Products for TMC6 Gene

Sources for TMC6 Gene

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