Aliases for TMC5 Gene

Aliases for TMC5 Gene

  • Transmembrane Channel Like 5 2 3 5
  • Transmembrane Channel-Like Protein 5 3 4
  • FLJ13593 2
  • TMC5 5

External Ids for TMC5 Gene

Previous GeneCards Identifiers for TMC5 Gene

  • GC16P019379
  • GC16P019434
  • GC16P019375
  • GC16P019329
  • GC16P017959

Summaries for TMC5 Gene

GeneCards Summary for TMC5 Gene

TMC5 (Transmembrane Channel Like 5) is a Protein Coding gene. An important paralog of this gene is TMC6.

UniProtKB/Swiss-Prot Summary for TMC5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMC5 Gene

Genomics for TMC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J019409 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 614.6 +0.6 603 2.2 ATF7 PRDM10 KDM1A CTCF ZNF692 ZIC2 PATZ1 REST EZH2 ZNF600 TMC5 ENSG00000260681 lnc-TMC5-2 SYT17 ENSG00000259925 KNOP1 GDE1
GH16J019392 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 615.3 -15.4 -15408 5.5 CEBPG RFX1 LEF1 IKZF1 JUND FOXA1 PRDM1 MTA2 MTA1 SP1 TMC5 ENSG00000280265 LOC105371114 SYT17 RNU4-46P COQ7 ENSG00000259925 CLEC19A
GH16J019416 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 611.7 +8.1 8090 4.2 IKZF1 KDM1A REST FOXJ2 SCRT2 CEBPB MGA SP1 CTCF BRCA1 TMC5 SYT17 ENSG00000259925 ENSG00000260681 lnc-TMC5-2 piR-32214-246 GDE1
GH16J019456 Promoter 0.3 EPDnew 600.3 +45.9 45949 0.1 TMC5 piR-32214-246 ENSG00000260681 GDE1
GH16J019381 Enhancer 0.9 Ensembl ENCODE 34.7 -26.8 -26797 3.8 GATAD2A PRDM10 FOXA1 ZIC2 PATZ1 CEBPA SOX13 ZXDB ESR1 CTBP1 TMC5 SYT17 KNOP1 GDE1 piR-31199-125 piR-42694-059 LOC105371114 ENSG00000259925 CLEC19A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMC5

Top Transcription factor binding sites by QIAGEN in the TMC5 gene promoter:
  • AREB6
  • FOXI1
  • Gfi-1
  • HFH-3
  • PPAR-gamma1
  • PPAR-gamma2
  • SRY
  • XBP-1

Genomic Locations for TMC5 Gene

Genomic Locations for TMC5 Gene
88,618 bases
Plus strand
88,618 bases
Plus strand

Genomic View for TMC5 Gene

Genes around TMC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC5 Gene

Proteins for TMC5 Gene

  • Protein details for TMC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q68DK8
    • Q8IY20
    • Q8NHV6
    • Q9H8I7

    Protein attributes for TMC5 Gene

    1006 amino acids
    Molecular mass:
    114797 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14629.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC5 Gene


neXtProt entry for TMC5 Gene

Post-translational modifications for TMC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMC5 Gene

Domains & Families for TMC5 Gene

Gene Families for TMC5 Gene

Protein Domains for TMC5 Gene

  • TMC

Suggested Antigen Peptide Sequences for TMC5 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane channel-like protein 5 (TMC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC5: view

Function for TMC5 Gene

Molecular function for TMC5 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.

Phenotypes From GWAS Catalog for TMC5 Gene

Gene Ontology (GO) - Molecular Function for TMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IBA --
GO:0008381 mechanosensitive ion channel activity IBA 21873635
genes like me logo Genes that share ontologies with TMC5: view
genes like me logo Genes that share phenotypes with TMC5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMC5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMC5 Gene

Localization for TMC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC5 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMC5 gene
Compartment Confidence
plasma membrane 4
extracellular 4
peroxisome 2
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with TMC5: view

Pathways & Interactions for TMC5 Gene

PathCards logo

SuperPathways for TMC5 Gene

No Data Available

Interacting Proteins for TMC5 Gene

Selected Interacting proteins: Q6UXY8-TMC5_HUMAN for TMC5 Gene via IID

Gene Ontology (GO) - Biological Process for TMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMC5: view

No data available for Pathways by source and SIGNOR curated interactions for TMC5 Gene

Drugs & Compounds for TMC5 Gene

No Compound Related Data Available

Transcripts for TMC5 Gene

mRNA/cDNA for TMC5 Gene

15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMC5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - -

Relevant External Links for TMC5 Gene

GeneLoc Exon Structure for

Expression for TMC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC5 Gene

This gene is overexpressed in Minor Salivary Gland (x11.3), Small Intestine - Terminal Ileum (x9.0), Colon - Transverse (x6.9), Stomach (x6.6), and Lung (x5.1).

Protein differential expression in normal tissues from HIPED for TMC5 Gene

This gene is overexpressed in Nasal epithelium (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMC5 Gene

Protein tissue co-expression partners for TMC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMC5

SOURCE GeneReport for Unigene cluster for TMC5 Gene:


Evidence on tissue expression from TISSUES for TMC5 Gene

  • Intestine(2.7)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with TMC5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMC5 Gene

Orthologs for TMC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMC5 30 31
  • 98.94 (n)
(Canis familiaris)
Mammalia TMC5 30 31
  • 85.19 (n)
(Bos Taurus)
Mammalia TMC5 30 31
  • 84.41 (n)
(Mus musculus)
Mammalia Tmc5 30 17 31
  • 80.3 (n)
(Rattus norvegicus)
Mammalia Tmc5 30
  • 79.57 (n)
(Ornithorhynchus anatinus)
Mammalia TMC5 31
  • 54 (a)
(Monodelphis domestica)
Mammalia TMC5 31
  • 52 (a)
(Gallus gallus)
Aves TMC5 30 31
  • 60.06 (n)
(Anolis carolinensis)
Reptilia TMC5 31
  • 54 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmc5 30
  • 57.48 (n)
(Danio rerio)
Actinopterygii LOC561497 30
  • 57.63 (n)
TMC5 31
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000578 30
  • 45.8 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG3280 31
  • 8 (a)
(Caenorhabditis elegans)
Secernentea tmc-2 31
  • 13 (a)
tmc-1 31
  • 11 (a)
Species where no ortholog for TMC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMC5 Gene

Gene Tree for TMC5 (if available)
Gene Tree for TMC5 (if available)
Evolutionary constrained regions (ECRs) for TMC5: view image

Paralogs for TMC5 Gene

Paralogs for TMC5 Gene

(1) SIMAP similar genes for TMC5 Gene using alignment to 5 proteins:

  • H3BN68_HUMAN
  • I3L0P3_HUMAN
  • I3L469_HUMAN
genes like me logo Genes that share paralogs with TMC5: view

Variants for TMC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMC5 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs16972013 - p.Ser328Asn
rs36019638 - p.Ala355Thr

Additional dbSNP identifiers (rs#s) for TMC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMC5 Gene

Variant ID Type Subtype PubMed ID
dgv1312n106 CNV deletion 24896259
esv2116787 CNV deletion 18987734
esv2678457 CNV deletion 23128226
esv2714051 CNV deletion 23290073
esv2714053 CNV deletion 23290073
esv2714054 CNV deletion 23290073
esv27832 CNV loss 19812545
esv3553202 CNV deletion 23714750
esv3553203 CNV deletion 23714750
esv3553207 CNV deletion 23714750
esv3582073 CNV loss 25503493
esv3792 CNV loss 18987735
nsv1070339 CNV deletion 25765185
nsv1070501 CNV deletion 25765185
nsv1071275 CNV deletion 25765185
nsv1113765 CNV deletion 24896259
nsv1116118 CNV deletion 24896259
nsv436835 CNV insertion 17901297
nsv478473 CNV novel sequence insertion 20440878
nsv571582 CNV gain 21841781
nsv833162 CNV loss 17160897
nsv833163 CNV gain 17160897
nsv958193 CNV deletion 24416366

Variation tolerance for TMC5 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC5 Gene

Disorders for TMC5 Gene

Additional Disease Information for TMC5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for TMC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMC5 Gene

Publications for TMC5 Gene

  1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K … Griffith AJ (Genomics 2003) 2 3 4
  2. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G … Heller S (BMC genomics 2003) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D … Taylor PR (International journal of cancer 2008) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for TMC5 Gene

Sources for TMC5 Gene