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Aliases for TMC4 Gene

Aliases for TMC4 Gene

  • Transmembrane Channel Like 4 2 3 5

External Ids for TMC4 Gene

Previous GeneCards Identifiers for TMC4 Gene

  • GC19M059339
  • GC19M059355
  • GC19M054663
  • GC19M050980

Summaries for TMC4 Gene

GeneCards Summary for TMC4 Gene

TMC4 (Transmembrane Channel Like 4) is a Protein Coding gene. An important paralog of this gene is TMC7.

UniProtKB/Swiss-Prot for TMC4 Gene

  • Probable ion channel.

Additional gene information for TMC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC4 Gene

Genomics for TMC4 Gene

GeneHancer (GH) Regulatory Elements for TMC4 Gene

Promoters and enhancers for TMC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054172 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 603.7 +0.3 294 1.8 ZNF76 SIN3A ZBTB40 ETS1 ZEB1 POLR2B ZNF143 THAP11 SMARCA5 SP3 TMC4 LENG1 MBOAT7
GH19I054136 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 36.1 +35.1 35074 4.2 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 YY1 POLR2B ZNF207 CNOT3 GC19P054140 GC19P054141 TMC4 ZNF765 LENG1 LENG8-AS1 PRPF31 ZNF525 ZNF845
GH19I054158 Promoter/Enhancer 1.6 Ensembl ENCODE 36.8 +13.5 13494 3.1 HDGF PKNOX1 FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 LENG1 CNOT3 TMC4 PRPF31 LENG8-AS1 ZNF765 LENG8 ENSG00000235681 ENSG00000269001 ZNF845
GH19I054161 Promoter/Enhancer 1.2 Ensembl ENCODE 34 +10.6 10647 1.4 CTCF HDAC1 USF1 MAX SIN3A FOXK2 POLR2A VEZF1 KLF8 ZNF740 TMC4 CNOT3 ENSG00000237017 PRPF31 RPS9 ENSG00000223660 NDUFA3 LENG1
GH19I054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -32.5 -32460 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 LENG8-AS1 CNOT3 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMC4 gene promoter:

Genomic Locations for TMC4 Gene

Genomic Locations for TMC4 Gene
chr19:54,160,095-54,173,250
(GRCh38/hg38)
Size:
13,156 bases
Orientation:
Minus strand
chr19:54,663,833-54,676,944
(GRCh37/hg19)

Genomic View for TMC4 Gene

Genes around TMC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC4 Gene

Proteins for TMC4 Gene

  • Protein details for TMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z404-TMC4_HUMAN
    Recommended name:
    Transmembrane channel-like protein 4
    Protein Accession:
    Q7Z404
    Secondary Accessions:
    • Q7Z5M3
    • Q8N5E4
    • Q8TBS7

    Protein attributes for TMC4 Gene

    Size:
    712 amino acids
    Molecular mass:
    79208 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMC4 Gene

Post-translational modifications for TMC4 Gene

  • Glycosylation at isoforms=2101
  • Modification sites at PhosphoSitePlus

Other Protein References for TMC4 Gene

No data available for DME Specific Peptides for TMC4 Gene

Domains & Families for TMC4 Gene

Gene Families for TMC4 Gene

Protein Domains for TMC4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z404

UniProtKB/Swiss-Prot:

TMC4_HUMAN :
  • Belongs to the TMC family.
Family:
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC4: view

Function for TMC4 Gene

Molecular function for TMC4 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.

Phenotypes From GWAS Catalog for TMC4 Gene

genes like me logo Genes that share phenotypes with TMC4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMC4 Gene

Localization for TMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMC4 gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for TMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with TMC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMC4 Gene

Pathways & Interactions for TMC4 Gene

No Data Available

Interacting Proteins for TMC4 Gene

Selected Interacting proteins: Q7Z404-TMC4_HUMAN for TMC4 Gene via IID

Symbol External ID(s) Details
FLT1

Gene Ontology (GO) - Biological Process for TMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with TMC4: view

No data available for Pathways by source and SIGNOR curated interactions for TMC4 Gene

Drugs & Compounds for TMC4 Gene

No Compound Related Data Available

Transcripts for TMC4 Gene

Unigene Clusters for TMC4 Gene

Transmembrane channel-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMC4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: -
SP6: -
SP7:
SP8:

ExUns: 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TMC4 Gene

GeneLoc Exon Structure for
TMC4
ECgene alternative splicing isoforms for
TMC4

Expression for TMC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC4 Gene

This gene is overexpressed in Colon - Transverse (x6.9) and Pancreas (x5.5).

Protein differential expression in normal tissues from HIPED for TMC4 Gene

This gene is overexpressed in Nasal epithelium (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMC4 Gene



Protein tissue co-expression partners for TMC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMC4 Gene:

TMC4

SOURCE GeneReport for Unigene cluster for TMC4 Gene:

Hs.355126

Evidence on tissue expression from TISSUES for TMC4 Gene

  • Intestine(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with TMC4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMC4 Gene

Orthologs for TMC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMC4 33 34
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia TMC4 33 34
  • 83.47 (n)
cow
(Bos Taurus)
Mammalia TMC4 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmc4 33 16 34
  • 79.7 (n)
oppossum
(Monodelphis domestica)
Mammalia TMC4 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMC4 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMC4 34
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmc4 34
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
Species where no ortholog for TMC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMC4 Gene

ENSEMBL:
Gene Tree for TMC4 (if available)
TreeFam:
Gene Tree for TMC4 (if available)

Paralogs for TMC4 Gene

Paralogs for TMC4 Gene

(2) SIMAP similar genes for TMC4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMC4 Gene

genes like me logo Genes that share paralogs with TMC4: view

Variants for TMC4 Gene

Sequence variations from dbSNP and Humsavar for TMC4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs79199039 likely-benign, not provided 54,174,099(-) C/T upstream_transcript_variant
rs1000096184 -- 54,170,655(-) A/T intron_variant
rs1000142983 -- 54,161,482(-) G/A intron_variant
rs1000249856 -- 54,167,297(-) C/T intron_variant
rs1000292410 -- 54,173,303(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMC4 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718857 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
nsv1072898 CNV deletion 25765185
nsv428371 CNV gain+loss 18775914
nsv510774 CNV deletion 20534489
nsv515623 CNV loss 19592680
nsv953613 CNV deletion 24416366
nsv9751 CNV gain 18304495

Variation tolerance for TMC4 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.76; 91.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMC4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC4 Gene

Disorders for TMC4 Gene

Additional Disease Information for TMC4

No disorders were found for TMC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMC4 Gene

Publications for TMC4 Gene

  1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K … Griffith AJ (Genomics 2003) 2 3 4 22 58
  2. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G … Heller S (BMC genomics 2003) 2 3 4 58
  3. The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent. (PMID: 26850495) Mancina RM … Romeo S (Gastroenterology 2016) 3 58
  4. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 58
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58

Products for TMC4 Gene

Sources for TMC4 Gene

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