Aliases for TMBIM4 Gene
Aliases for TMBIM4 Gene
External Ids for TMBIM4 Gene
- HGNC: 24257
- Entrez Gene: 51643
- Ensembl: ENSG00000155957
- OMIM: 616874
- UniProtKB: Q9HC24
Previous GeneCards Identifiers for TMBIM4 Gene
- GC12M064818
- GC12M066531
- GC12M063581
- GC12M066518
Summaries for TMBIM4 Gene
GeneCards Summary for TMBIM4 Gene
TMBIM4 (Transmembrane BAX Inhibitor Motif Containing 4) is a Protein Coding gene. Diseases associated with TMBIM4 include Venezuelan Hemorrhagic Fever. An important paralog of this gene is ENSG00000228144.
UniProtKB/Swiss-Prot for TMBIM4 Gene
-
Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
Additional gene information for TMBIM4 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMBIM4 Gene
Genomics for TMBIM4 Gene
GeneHancer (GH) Regulatory Elements for TMBIM4 Gene
Promoters and enhancers for TMBIM4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TMBIM4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TMBIM4 gene promoter:
Regulatory Element Products
Genomic Locations for TMBIM4 Gene
Genomic Locations for TMBIM4 Gene
- chr12:66,135,846-66,170,072
- (GRCh38/hg38)
- Size:
- 34,227 bases
- Orientation:
- Minus strand
- chr12:66,517,709-66,563,852
- (GRCh37/hg19)
Genomic View for TMBIM4 Gene
Genes around TMBIM4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q14.3 by Ensembl
- 12q14.3 by Entrez Gene
- 12q14.3 by HGNC
TMBIM4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMBIM4 Gene
Proteins for TMBIM4 Gene
-
Protein details for TMBIM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HC24-LFG4_HUMAN
- Recommended name:
- Protein lifeguard 4
- Protein Accession:
- Q9HC24
- Q542Z6
- Q9UHY5
- Q9Y3C2
Protein attributes for TMBIM4 Gene
- Size:
- 238 amino acids
- Molecular mass:
- 26971 Da
- Quaternary structure:
-
- Interacts with ITPR3.
- SequenceCaution:
-
- Sequence=AAD34114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for TMBIM4 Gene
Post-translational modifications for TMBIM4 Gene
No Post-translational modifications
Other Protein References for TMBIM4 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TMBIM4
- Novus Biologicals Antibodies for TMBIM4
- Invitrogen Antibodies for TMBIM4
- Search GeneTex for Antibodies for TMBIM4
Protein Products
-
OriGene Purified Proteins for TMBIM4
- Search Origene for MassSpec and Protein Over-expression Lysates for TMBIM4
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- Search GeneTex for Proteins for TMBIM4
Assay Products
No data available for DME Specific Peptides for TMBIM4 Gene
Domains & Families for TMBIM4 Gene
Gene Families for TMBIM4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for TMBIM4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMBIM4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HC24- Family:
-
- Belongs to the BI1 family. LFG subfamily.
Function for TMBIM4 Gene
Molecular function for TMBIM4 Gene
- UniProtKB/Swiss-Prot Function:
- Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
Phenotypes From GWAS Catalog for TMBIM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19553469 |
Phenotypes for TMBIM4 Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
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- genomics-online: gRNA clones - Search results for available TMBIM4 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMBIM4
- GenScript: Design CRISPR guide RNA sequences for TMBIM4
miRNA for TMBIM4 Gene
- miRTarBase miRNAs that target TMBIM4
-
- hsa-mir-138-1-3p (MIRT441647)
- hsa-mir-330-3p (MIRT441648)
- hsa-mir-551b-5p (MIRT441649)
- hsa-mir-6892-5p (MIRT454043)
- hsa-mir-4746-3p (MIRT454044)
- hsa-mir-4518 (MIRT454045)
- hsa-mir-6777-3p (MIRT454046)
- hsa-mir-1266-5p (MIRT454047)
- hsa-mir-6823-5p (MIRT454048)
- hsa-mir-1246 (MIRT454049)
- hsa-mir-3141 (MIRT454050)
- hsa-mir-510-5p (MIRT454051)
- hsa-mir-522-3p (MIRT454052)
- hsa-mir-224-3p (MIRT454053)
- hsa-mir-4694-3p (MIRT454054)
- hsa-mir-6858-5p (MIRT570960)
- hsa-mir-4689 (MIRT570961)
- hsa-mir-4784 (MIRT570962)
- hsa-mir-4749-3p (MIRT570963)
- hsa-mir-3150b-3p (MIRT570964)
- hsa-mir-1225-3p (MIRT570965)
- hsa-mir-6770-5p (MIRT570966)
- hsa-mir-1253 (MIRT570967)
- hsa-mir-6761-5p (MIRT570968)
- hsa-mir-4329 (MIRT570969)
- hsa-mir-4251 (MIRT570970)
- hsa-mir-1470 (MIRT570971)
- hsa-mir-6769a-3p (MIRT570972)
- hsa-mir-6887-3p (MIRT570973)
- hsa-mir-4314 (MIRT713105)
- hsa-mir-5196-5p (MIRT713106)
- hsa-mir-6506-5p (MIRT713107)
- hsa-mir-4747-5p (MIRT713108)
- hsa-mir-619-5p (MIRT713109)
- hsa-mir-4646-5p (MIRT713110)
- hsa-mir-3192-5p (MIRT713111)
- hsa-mir-204-3p (MIRT713112)
- hsa-mir-4691-3p (MIRT713113)
- hsa-mir-1298-3p (MIRT713114)
- hsa-mir-1908-3p (MIRT716867)
- hsa-mir-6850-3p (MIRT716868)
miRNA Products
- Search ViGene Biosciences for TMBIM4
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for TMBIM4 gene
Clone Products
- Sino Biological Human cDNA Clone for TMBIM4
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TMBIM4 gene related products
- orf clones - Search results for available TMBIM4 gene related products
- Applied Biological Materials Clones for TMBIM4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TMBIM4
-
ViGene Biosciences adenoviral particle packaged cDNA for TMBIM4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMBIM4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMBIM4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMBIM4 Gene
Localization for TMBIM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMBIM4 Gene
- Golgi apparatus membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| nucleus | 1 |
- Golgi apparatus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005795 | Golgi stack | IDA | 17319741 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TMBIM4 Gene
No Data Available
Interacting Proteins for TMBIM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0043066 | negative regulation of apoptotic process | IMP | 17319741 |
| GO:0050848 | regulation of calcium-mediated signaling | IDA | 19553469 |
No data available for Pathways by source and SIGNOR curated interactions for TMBIM4 Gene
Transcripts for TMBIM4 Gene
mRNA/cDNA for TMBIM4 Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (279) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMBIM4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMBIM4
- genomics-online: gRNA clones - Search results for available TMBIM4 gene related products
- Applied Biological Materials CRISPR for TMBIM4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMBIM4
- GenScript: Design CRISPR guide RNA sequences for TMBIM4
miRNA Products
- Search ViGene Biosciences for TMBIM4
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for TMBIM4
- Browse OriGene Inhibitory RNA Products For TMBIM4
- genomics-online: shRNA clones - Search results for available TMBIM4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TMBIM4 gene
Clone Products
- Sino Biological Human cDNA Clone for TMBIM4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TMBIM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMBIM4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TMBIM4 gene related products
- orf clones - Search results for available TMBIM4 gene related products
- Applied Biological Materials Clones for TMBIM4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TMBIM4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Testis (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMBIM4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TMBIM4 Gene:
TMBIM4SOURCE GeneReport for Unigene cluster for TMBIM4 Gene:
Hs.505934Evidence on tissue expression from TISSUES for TMBIM4 Gene
- Adrenal gland(4.4)
- Nervous system(3.5)
- Liver(2.9)
- Kidney(2.4)
- Intestine(2.3)
- Lung(2.2)
- Muscle(2.1)
- Skin(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for TMBIM4
- genomics-online: primer clones - Search results for available TMBIM4 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMBIM4 Gene
Orthologs for TMBIM4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMBIM4 33 |
|
||
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | TMBIM4 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | TMBIM4 33 |
|
||
| CGI-119 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Tmbim4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tmbim4 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| TMBIM4 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmbim4 33 |
|
||
| Str.11131 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6302 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmbim4 33 34 |
|
||
| zgc66343 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG30379 34 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | tmbi-4 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BXI1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G15470 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0402300 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | bxi1 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8799 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02463 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4667 33 |
|
- Species where no ortholog for TMBIM4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TMBIM4 Gene
(4) SIMAP similar genes for TMBIM4 Gene using alignment to 10 proteins:
Variants for TMBIM4 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000082605 | -- | 66,147,570(-) | A/G | intron_variant | |
| rs1000147157 | -- | 66,149,259(-) | A/G | intron_variant | |
| rs1000286727 | -- | 66,167,609(-) | A/C | intron_variant | |
| rs1000430720 | -- | 66,138,604(-) | T/C | intron_variant | |
| rs1000431831 | -- | 66,147,164(-) | AGAGA/AGA | intron_variant |
Residual Variation Intolerance Score:
53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.54;
86.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMBIM4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMBIM4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMBIM4 Gene
Disorders for TMBIM4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| venezuelan hemorrhagic fever |
|
|
Search TMBIM4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TMBIM4
No data available for UniProtKB/Swiss-Prot and Genatlas for TMBIM4 Gene
Publications for TMBIM4 Gene
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
- Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. (PMID: 22418439) Carrara G … Smith GL (The Journal of biological chemistry 2012) 3 4 58
- Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. (PMID: 19553469) de Mattia F … van Kuppeveld FJ (Molecular biology of the cell 2009) 3 4 58
- A new inhibitor of apoptosis from vaccinia virus and eukaryotes. (PMID: 17319741) Gubser C … Smith GL (PLoS pathogens 2007) 3 4 58
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
Products for TMBIM4 Gene
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- VectorBuilder custom plasmid, inducible vectors for TMBIM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMBIM4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 31 available TMBIM4 Antibodies ranked by validation data
- Compare Top TMBIM4 Antibodies
- antibodies-online: Search results for available TMBIM4 related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for TMBIM4 gene
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Sources for TMBIM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
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