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Aliases for TMA7 Gene

Aliases for TMA7 Gene

  • Translation Machinery Associated 7 Homolog 2 3 5
  • Coiled-Coil Domain-Containing Protein 72 3 4
  • Coiled-Coil Domain Containing 72 2 3
  • CCDC72 3 4
  • Translation Machinery Associated 7 Homolog (S. Cerevisiae) 2
  • Translational Machinery Associated 7 Homolog 3
  • Translation Machinery-Associated Protein 7 3
  • HSPC016 3

External Ids for TMA7 Gene

Previous HGNC Symbols for TMA7 Gene

  • CCDC72

Previous GeneCards Identifiers for TMA7 Gene

  • GC03P048481

Summaries for TMA7 Gene

GeneCards Summary for TMA7 Gene

TMA7 (Translation Machinery Associated 7 Homolog) is a Protein Coding gene. An important paralog of this gene is ENSG00000225528.

Additional gene information for TMA7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMA7 Gene

Genomics for TMA7 Gene

GeneHancer (GH) Regulatory Elements for TMA7 Gene

Promoters and enhancers for TMA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I048439 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 613.1 +0.5 492 3.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 TMA7 CCDC51 ATRIP QRICH1 USP19 CCDC36 ENSG00000225399 NME6 SHISA5 PRKAR2A
GH03I048424 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 62.7 -9.6 -9630 12.1 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 LOC105377077 PLXNB1 TMA7 SHISA5 FBXW12 NME6 SPINK8 CDC25A RNU7-128P NDUFB1P1
GH03I048464 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 67.9 +29.8 29832 11.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SHISA5 TREX1 TMA7 ATRIP NME6 QRICH1 USP19 MRPS18AP1 TMEM89 RHOA-IT1
GH03I048445 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 61.3 +6.5 6534 2.6 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF207 ZNF143 ZNF263 ATRIP ENSG00000244380 ENSG00000282827 TMA7
GH03I048551 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.6 +119.0 119013 15.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PFKFB4 UCN2 TMA7 NME6 QRICH1 ATRIP USP19 ZNF589 WDR6 TMEM89
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMA7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMA7 Gene

Genomic Locations for TMA7 Gene
chr3:48,440,257-48,444,208
(GRCh38/hg38)
Size:
3,952 bases
Orientation:
Plus strand
chr3:48,481,667-48,485,616
(GRCh37/hg19)

Genomic View for TMA7 Gene

Genes around TMA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMA7 Gene

Proteins for TMA7 Gene

  • Protein details for TMA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2S6-TMA7_HUMAN
    Recommended name:
    Translation machinery-associated protein 7
    Protein Accession:
    Q9Y2S6
    Secondary Accessions:
    • Q9P052

    Protein attributes for TMA7 Gene

    Size:
    64 amino acids
    Molecular mass:
    7066 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMA7 Gene

Post-translational modifications for TMA7 Gene

No Post-translational modifications

Other Protein References for TMA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMA7 Gene

Domains & Families for TMA7 Gene

Gene Families for TMA7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMA7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2S6

UniProtKB/Swiss-Prot:

TMA7_HUMAN :
  • Belongs to the TMA7 family.
Family:
  • Belongs to the TMA7 family.
genes like me logo Genes that share domains with TMA7: view

Function for TMA7 Gene

Phenotypes From GWAS Catalog for TMA7 Gene

genes like me logo Genes that share phenotypes with TMA7: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMA7 Gene

Localization for TMA7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMA7 gene
Compartment Confidence
nucleus 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TMA7 Gene

Pathways & Interactions for TMA7 Gene

No Data Available

Interacting Proteins for TMA7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000397843%0d%0a9606.ENSP00000324792%0d%0a
Selected Interacting proteins: ENSP00000397843 Q9Y2S6-TMA7_HUMAN for TMA7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMA7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMA7 Gene

Drugs & Compounds for TMA7 Gene

No Compound Related Data Available

Transcripts for TMA7 Gene

Unigene Clusters for TMA7 Gene

Translation machinery associated 7 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMA7 Gene

No ASD Table

Relevant External Links for TMA7 Gene

GeneLoc Exon Structure for
TMA7
ECgene alternative splicing isoforms for
TMA7

Expression for TMA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMA7 Gene

Protein differential expression in normal tissues from HIPED for TMA7 Gene

This gene is overexpressed in Ovary (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMA7 Gene



Protein tissue co-expression partners for TMA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMA7 Gene:

TMA7

SOURCE GeneReport for Unigene cluster for TMA7 Gene:

Hs.356440

mRNA Expression by UniProt/SwissProt for TMA7 Gene:

Q9Y2S6-TMA7_HUMAN
Tissue specificity: Expressed in dermal papilla cells with aggregative behavior.

Evidence on tissue expression from TISSUES for TMA7 Gene

  • Nervous system(3.6)
  • Blood(2.3)
  • Spleen(2.3)
  • Lung(2.2)
  • Eye(2)
  • Heart(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with TMA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMA7 Gene

Orthologs for TMA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMA7 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMA7 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMA7 33 34
  • 99.48 (n)
rat
(Rattus norvegicus)
Mammalia Tma7 33
  • 95.31 (n)
mouse
(Mus musculus)
Mammalia Tma7 33 16 34
  • 94.27 (n)
cow
(Bos Taurus)
Mammalia TMA7 33 34
  • 92.71 (n)
lizard
(Anolis carolinensis)
Reptilia TMA7 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6296 33
zebrafish
(Danio rerio)
Actinopterygii tma7 34
  • 83 (a)
OneToOne
Dr.13334 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10125 33
Species where no ortholog for TMA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMA7 Gene

ENSEMBL:
Gene Tree for TMA7 (if available)
TreeFam:
Gene Tree for TMA7 (if available)

Paralogs for TMA7 Gene

Paralogs for TMA7 Gene

genes like me logo Genes that share paralogs with TMA7: view

Variants for TMA7 Gene

Sequence variations from dbSNP and Humsavar for TMA7 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000260863 -- 48,441,221(+) T/C intron_variant
rs1000335407 -- 48,441,432(+) C/T intron_variant
rs1000591725 -- 48,442,585(+) G/A/T intron_variant
rs1000666637 -- 48,442,715(+) G/C intron_variant
rs1001453941 -- 48,438,988(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMA7 Gene

Variant ID Type Subtype PubMed ID
nsv965164 CNV duplication 23825009
nsv834684 CNV gain 17160897
nsv834683 CNV gain 17160897
nsv590242 CNV loss 21841781
nsv508917 CNV insertion 20534489

Variation tolerance for TMA7 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMA7 Gene

Disorders for TMA7 Gene

Additional Disease Information for TMA7

No disorders were found for TMA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMA7 Gene

Publications for TMA7 Gene

  1. Apoptosis of the dermal papilla cells of hair follicle associated with the expression of gene HSPCO16 in vitro. (PMID: 15740594) Yang WB … Ni B (Experimental dermatology 2005) 2 3 22 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. Identification of differentially expressed genes HSPC016 in dermal papilla cells with aggregative behavior. (PMID: 16096800) Zhiqiang S … Chunlan L (Archives of dermatological research 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 4 58

Products for TMA7 Gene

Sources for TMA7 Gene

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