Aliases for TMA16 Gene

Aliases for TMA16 Gene

  • Translation Machinery Associated 16 Homolog 2 3 5
  • Translation Machinery-Associated Protein 16 3 4
  • C4orf43 3 4
  • Translation Machinery Associated 16 Homolog (S. Cerevisiae) 2
  • Chromosome 4 Open Reading Frame 43 2
  • UPF0534 Protein C4orf43 3

External Ids for TMA16 Gene

Previous HGNC Symbols for TMA16 Gene

  • C4orf43

Previous GeneCards Identifiers for TMA16 Gene

  • GC04P164416

Summaries for TMA16 Gene

GeneCards Summary for TMA16 Gene

TMA16 (Translation Machinery Associated 16 Homolog) is a Protein Coding gene.

Additional gene information for TMA16 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMA16 Gene

Genomics for TMA16 Gene

GeneHancer (GH) Regulatory Elements for TMA16 Gene

Promoters and enhancers for TMA16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J163493 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 503 +0.5 542 3.5 RXRA FOXK2 ZBTB40 ZNF217 SIN3A TCF12 MYC USF1 POLR2G SP1 TMA16 MARCHF1 ENSG00000273449 TKTL2 HSALNG0038297
GH04J163540 Enhancer 0.6 Ensembl ENCODE 46.2 +47.3 47312 2.8 FOS ZNF10 RBM22 JUND CEBPB MARCHF1 TMA16 TKTL2 ENSG00000273449 RF01061-134
GH04J163550 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 12.4 +56.1 56143 0.2 CTCF USF1 REST USF2 TOE1 RAD21 TRIM22 RAD51 SMC3 ZNF384 TMA16 TKTL2 ENSG00000273449 RF01061-134 MARCHF1
GH04J163544 Enhancer 0.9 ENCODE dbSUPER 12.3 +50.7 50654 1.4 CTCF NRF1 REST RAD21 MYC TRIM22 SMC3 NBN POU2F2 ZNF654 MARCHF1 TMA16 TKTL2 ENSG00000273449 RF01061-134
GH04J163481 Enhancer 0.9 Ensembl ENCODE 12.1 -10.5 -10488 5.2 CTCF USF1 REST RAD21 TRIM22 SMC3 NCOR1 PBX2 SPI1 GATA3 TMA16 MARCHF1 TKTL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMA16 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMA16

Genomic Locations for TMA16 Gene

Genomic Locations for TMA16 Gene
chr4:163,494,289-163,520,539
(GRCh38/hg38)
Size:
26,251 bases
Orientation:
Plus strand
chr4:164,415,594-164,441,691
(GRCh37/hg19)
Size:
26,098 bases
Orientation:
Plus strand

Genomic View for TMA16 Gene

Genes around TMA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMA16 Gene

Proteins for TMA16 Gene

  • Protein details for TMA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EY4-TMA16_HUMAN
    Recommended name:
    Translation machinery-associated protein 16
    Protein Accession:
    Q96EY4
    Secondary Accessions:
    • Q0P6E4
    • Q0P6J1
    • Q9NUR7

    Protein attributes for TMA16 Gene

    Size:
    203 amino acids
    Molecular mass:
    23864 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMA16 Gene

Post-translational modifications for TMA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMA16 Gene

No data available for DME Specific Peptides for TMA16 Gene

Domains & Families for TMA16 Gene

Gene Families for TMA16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMA16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMA16 Gene

GenScript: Design optimal peptide antigens:
  • UPF0534 protein C4orf43 (CD043_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96EY4

UniProtKB/Swiss-Prot:

TMA16_HUMAN :
  • Belongs to the UPF0534 family.
Family:
  • Belongs to the UPF0534 family.
genes like me logo Genes that share domains with TMA16: view

Function for TMA16 Gene

Phenotypes From GWAS Catalog for TMA16 Gene

Gene Ontology (GO) - Molecular Function for TMA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMA16: view
genes like me logo Genes that share phenotypes with TMA16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMA16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMA16 Gene

Localization for TMA16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMA16 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with TMA16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TMA16 Gene

Pathways & Interactions for TMA16 Gene

PathCards logo

SuperPathways for TMA16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMA16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMA16 Gene

Drugs & Compounds for TMA16 Gene

No Compound Related Data Available

Transcripts for TMA16 Gene

mRNA/cDNA for TMA16 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMA16

Alternative Splicing Database (ASD) splice patterns (SP) for TMA16 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TMA16 Gene

GeneLoc Exon Structure for
TMA16

Expression for TMA16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMA16 Gene

Protein differential expression in normal tissues from HIPED for TMA16 Gene

This gene is overexpressed in Pancreas (16.8), Breast (11.7), and Lung (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMA16 Gene



Protein tissue co-expression partners for TMA16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMA16

SOURCE GeneReport for Unigene cluster for TMA16 Gene:

Hs.267446

Evidence on tissue expression from TISSUES for TMA16 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TMA16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMA16 Gene

Orthologs for TMA16 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMA16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMA16 31 30
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMA16 31 30
  • 90.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMA16 31 30
  • 86.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tma16 17 31 30
  • 83.5 (n)
rat
(Rattus norvegicus)
Mammalia Tma16 30
  • 83 (n)
oppossum
(Monodelphis domestica)
Mammalia TMA16 31
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMA16 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves C4H4ORF43 30
  • 69.46 (n)
TMA16 31
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMA16 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tma16 30
  • 66.84 (n)
Str.10731 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11691 30
zebrafish
(Danio rerio)
Actinopterygii tma16 31 30
  • 65.26 (n)
OneToOne
Dr.17669 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003543 30
  • 48.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15027 31 30
  • 47.56 (n)
OneToOne
Species where no ortholog for TMA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMA16 Gene

ENSEMBL:
Gene Tree for TMA16 (if available)
TreeFam:
Gene Tree for TMA16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMA16: view image

Paralogs for TMA16 Gene

Pseudogenes.org Pseudogenes for TMA16 Gene

genes like me logo Genes that share paralogs with TMA16: view

No data available for Paralogs for TMA16 Gene

Variants for TMA16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMA16 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
715601 Benign: not provided 163,515,469(+) C/T INTRON_VARIANT
776028 Benign: not provided 163,515,363(+) G/A MISSENSE_VARIANT
rs1561736 - p.Ile176Thr
rs2304802 - p.Gln65Pro
rs34907234 - p.Arg12Gln

Additional dbSNP identifiers (rs#s) for TMA16 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMA16 Gene

Variant ID Type Subtype PubMed ID
esv2728665 CNV deletion 23290073
esv3564913 CNV deletion 23714750
nsv1015505 CNV gain 25217958
nsv1028437 CNV gain 25217958
nsv1030184 CNV loss 25217958

Variation tolerance for TMA16 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMA16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMA16 Gene

Disorders for TMA16 Gene

Additional Disease Information for TMA16

No disorders were found for TMA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMA16 Gene

Publications for TMA16 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. Insights into the ubiquitin-proteasome system of human embryonic stem cells. (PMID: 29511261) Saez I … Vilchez D (Scientific reports 2018) 3 54
  4. PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation. (PMID: 30209976) Choi J … Busino L (Cell cycle (Georgetown, Tex.) 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TMA16 Gene

Sources for TMA16 Gene