Aliases for TM7SF2 Gene
External Ids for TM7SF2 Gene
Previous GeneCards Identifiers for TM7SF2 Gene
GeneCards Summary for TM7SF2 Gene
TM7SF2 (Transmembrane 7 Superfamily Member 2) is a Protein Coding gene. Diseases associated with TM7SF2 include Greenberg Dysplasia and Pelger-Huet Anomaly. Among its related pathways are cholesterol biosynthesis III (via desmosterol) and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor and delta14-sterol reductase activity. An important paralog of this gene is LBR.
UniProtKB/Swiss-Prot Summary for TM7SF2 Gene
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.