Aliases for TM7SF2 Gene
External Ids for TM7SF2 Gene
Previous GeneCards Identifiers for TM7SF2 Gene
GeneCards Summary for TM7SF2 Gene
TM7SF2 (Transmembrane 7 Superfamily Member 2) is a Protein Coding gene. Diseases associated with TM7SF2 include Greenberg Dysplasia and Pelger-Huet Anomaly. Among its related pathways are cholesterol biosynthesis III (via desmosterol) and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor and delta14-sterol reductase activity. An important paralog of this gene is LBR.
UniProtKB/Swiss-Prot Summary for TM7SF2 Gene
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.