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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
TM4SF4 (Transmembrane 4 L Six Family Member 4) is a Protein Coding gene. An important paralog of this gene is TM4SF1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0042246 | tissue regeneration | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TM4SF4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TM4SF4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tm4sf4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tm4sf4 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TM4SF4 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TM4SF4 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TM4SF4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TM4SF4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TM4SF4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tm4sf4 30 |
|
||
MGC75723 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | tm4sf4-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tm4sf4 30 31 |
|
OneToOne | |
Dr.3563 30 |
|
No disorders were found for TM4SF4 Gene.