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Aliases for TM4SF4 Gene

Aliases for TM4SF4 Gene

  • Transmembrane 4 L Six Family Member 4 2 3 5
  • Intestine And Liver Tetraspan Membrane Protein 3 4
  • Transmembrane 4 Superfamily Member 4 2 3
  • Il-TMP 3 4
  • ILTMP 3 4
  • Intestinal And Liver (Il) Tetraspan Membrane Protein 3
  • Transmembrane 4 L6 Family Member 4 3

External Ids for TM4SF4 Gene

Previous GeneCards Identifiers for TM4SF4 Gene

  • GC03P146120
  • GC03P150076
  • GC03P150473
  • GC03P150512
  • GC03P150674
  • GC03P149191
  • GC03P146564

Summaries for TM4SF4 Gene

Entrez Gene Summary for TM4SF4 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

GeneCards Summary for TM4SF4 Gene

TM4SF4 (Transmembrane 4 L Six Family Member 4) is a Protein Coding gene. An important paralog of this gene is TM4SF1.

UniProtKB/Swiss-Prot for TM4SF4 Gene

  • Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

Additional gene information for TM4SF4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF4 Gene

Genomics for TM4SF4 Gene

GeneHancer (GH) Regulatory Elements for TM4SF4 Gene

Promoters and enhancers for TM4SF4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I149471 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 564.1 -0.3 -290 4.8 PKNOX1 CLOCK NFIB BRCA1 RAD21 RFX5 YY1 SMARCC2 RCOR1 FOS TM4SF4 COMMD2 ENSG00000239408
GH03I149476 Enhancer 1 FANTOM5 Ensembl dbSUPER 24.6 +2.6 2643 0.4 RXRA TAF1 MAX REST RAD21 YY1 JUND ATF3 HNF4G HNF4A TM4SF4 CP LOC100421817
GH03I149381 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -87.3 -87312 10.9 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B ENSG00000243885 TM4SF4 TM4SF18 TM4SF1 COMMD2 TM4SF1-AS1 LOC105374151
GH03I149479 Enhancer 1.3 Ensembl ENCODE dbSUPER 13.8 +6.2 6177 2 ARID4B SIN3A IRF4 ZNF48 ZNF143 RUNX3 DEK RXRA MIER2 REST TM4SF4 WWTR1 LOC100421817
GH03I149506 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +33.4 33445 2.8 ESRRA FOXA2 JUN MAX EBF1 RARA ETS1 ZNF335 CTBP1 GATA3 COMMD2 WWTR1 TM4SF4 WWTR1-AS1 RNF13 LOC100421817 RNU6-1098P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TM4SF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TM4SF4 gene promoter:

Genomic Locations for TM4SF4 Gene

Genomic Locations for TM4SF4 Gene
29,421 bases
Plus strand

Genomic View for TM4SF4 Gene

Genes around TM4SF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF4 Gene

Proteins for TM4SF4 Gene

  • Protein details for TM4SF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 4
    Protein Accession:
    Secondary Accessions:
    • B2RDA4

    Protein attributes for TM4SF4 Gene

    202 amino acids
    Molecular mass:
    21396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF4 Gene

Post-translational modifications for TM4SF4 Gene

  • N-glycosylated. Glycosylation is required for the growth inhibitory effect.
  • Glycosylation at posLast=124124 and isoforms=156

Other Protein References for TM4SF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TM4SF4 Gene

Domains & Families for TM4SF4 Gene

Gene Families for TM4SF4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TM4SF4 Gene


Suggested Antigen Peptide Sequences for TM4SF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF4: view

Function for TM4SF4 Gene

Molecular function for TM4SF4 Gene

UniProtKB/Swiss-Prot Function:
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

Phenotypes From GWAS Catalog for TM4SF4 Gene

Gene Ontology (GO) - Molecular Function for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TM4SF4: view
genes like me logo Genes that share phenotypes with TM4SF4: view

Animal Models for TM4SF4 Gene

MGI Knock Outs for TM4SF4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TM4SF4 Gene

Localization for TM4SF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM4SF4 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with TM4SF4: view

Pathways & Interactions for TM4SF4 Gene

SuperPathways for TM4SF4 Gene

No Data Available

Interacting Proteins for TM4SF4 Gene

Gene Ontology (GO) - Biological Process for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042246 tissue regeneration IEA --
genes like me logo Genes that share ontologies with TM4SF4: view

No data available for Pathways by source and SIGNOR curated interactions for TM4SF4 Gene

Drugs & Compounds for TM4SF4 Gene

No Compound Related Data Available

Transcripts for TM4SF4 Gene

mRNA/cDNA for TM4SF4 Gene

Unigene Clusters for TM4SF4 Gene

Transmembrane 4 L six family member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF4 Gene

No ASD Table

Relevant External Links for TM4SF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TM4SF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF4 Gene

This gene is overexpressed in Liver (x37.3), Pancreas (x8.3), and Small Intestine - Terminal Ileum (x4.8).

Protein differential expression in normal tissues from HIPED for TM4SF4 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TM4SF4 Gene

Protein tissue co-expression partners for TM4SF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TM4SF4 Gene:


SOURCE GeneReport for Unigene cluster for TM4SF4 Gene:


mRNA Expression by UniProt/SwissProt for TM4SF4 Gene:

Tissue specificity: Jejunum and liver.

Evidence on tissue expression from TISSUES for TM4SF4 Gene

  • Intestine(4.6)
  • Liver(4.6)
  • Pancreas(4.4)
  • Gall bladder(2.6)
genes like me logo Genes that share expression patterns with TM4SF4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TM4SF4 Gene

Orthologs for TM4SF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM4SF4 33 34
  • 99.24 (n)
(Canis familiaris)
Mammalia TM4SF4 33 34
  • 89.44 (n)
(Mus musculus)
Mammalia Tm4sf4 33 16 34
  • 86.8 (n)
(Rattus norvegicus)
Mammalia Tm4sf4 33
  • 86.8 (n)
(Bos Taurus)
Mammalia TM4SF4 33 34
  • 85.66 (n)
(Ornithorhynchus anatinus)
Mammalia TM4SF4 34
  • 73 (a)
(Monodelphis domestica)
Mammalia TM4SF4 34
  • 57 (a)
(Gallus gallus)
Aves TM4SF4 33 34
  • 68.65 (n)
(Anolis carolinensis)
Reptilia TM4SF4 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm4sf4 33
  • 67.49 (n)
MGC75723 33
African clawed frog
(Xenopus laevis)
Amphibia tm4sf4-prov 33
(Danio rerio)
Actinopterygii tm4sf4 33 34
  • 63.08 (n)
Dr.3563 33
Species where no ortholog for TM4SF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF4 Gene

Gene Tree for TM4SF4 (if available)
Gene Tree for TM4SF4 (if available)

Paralogs for TM4SF4 Gene

Paralogs for TM4SF4 Gene

(4) SIMAP similar genes for TM4SF4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TM4SF4: view

Variants for TM4SF4 Gene

Sequence variations from dbSNP and Humsavar for TM4SF4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000045441 -- 149,502,213(+) T/A intron_variant
rs1000154229 -- 149,480,987(+) G/A intron_variant
rs1000323737 -- 149,475,205(+) T/A intron_variant
rs1000519063 -- 149,503,570(+) G/A downstream_transcript_variant
rs1000797714 -- 149,492,508(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF4 Gene

Variant ID Type Subtype PubMed ID
esv29983 CNV gain 17803354
nsv1131736 CNV deletion 24896259
nsv4056 CNV deletion 18451855
nsv979887 CNV duplication 23825009

Variation tolerance for TM4SF4 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TM4SF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF4 Gene

Disorders for TM4SF4 Gene

Additional Disease Information for TM4SF4

No disorders were found for TM4SF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF4 Gene

Publications for TM4SF4 Gene

  1. A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. (PMID: 7665614) Wice BM … Gordon JI (The Journal of biological chemistry 1995) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment. (PMID: 28129652) Cheong JG … Lee JW (Oncotarget 2017) 3 58
  5. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai FF … Wheeler MB (The Journal of biological chemistry 2015) 3 58

Products for TM4SF4 Gene

Sources for TM4SF4 Gene

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