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Aliases for TM4SF19 Gene

Aliases for TM4SF19 Gene

  • Transmembrane 4 L Six Family Member 19 2 3 5
  • Osteoclast Maturation-Associated Gene 4 Protein 3 4
  • Tetraspan Membrane Protein OCTM4 3 4
  • OCTM4 3 4
  • Transmembrane 4 L6 Family Member 19 3

External Ids for TM4SF19 Gene

Previous GeneCards Identifiers for TM4SF19 Gene

  • GC03M197508
  • GC03M197531
  • GC03M196042
  • GC03M193348
  • GC03M196049

Summaries for TM4SF19 Gene

Entrez Gene Summary for TM4SF19 Gene

  • The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

GeneCards Summary for TM4SF19 Gene

TM4SF19 (Transmembrane 4 L Six Family Member 19) is a Protein Coding gene. An important paralog of this gene is TM4SF19-TCTEX1D2.

Additional gene information for TM4SF19 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF19 Gene

Genomics for TM4SF19 Gene

GeneHancer (GH) Regulatory Elements for TM4SF19 Gene

Promoters and enhancers for TM4SF19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I196337 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 588.6 -0.9 -897 4.4 HDGF PKNOX1 ARNT SIN3A YY1 POLR2B ZNF766 E2F8 FOS SMARCB1 TM4SF19 TM4SF19-TCTEX1D2 SDHAP1 LINC00969 UBXN7 SDHAP2 ENSG00000230732 ACAP2 ENSG00000260261 ENSG00000231443
GH03I196285 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.8 +51.2 51234 3.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PCYT1A TM4SF19 WDR53 RNF168 ACAP2 ENSG00000260261 NCBP2 SLC51A ENSG00000231443 ENSG00000228028
GH03I196316 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19 +20.4 20422 2.8 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B E2F8 ZNF143 ZNF207 TCTEX1D2 ENSG00000272741 TM4SF19-AS1 SDHAP1 SDHAP2 UBXN7 LINC00969 RNU6ATAC24P RNF168 ENSG00000271662
GH03I196335 Enhancer 1.1 Ensembl ENCODE dbSUPER 24 +2.1 2102 1.2 BRD4 HDAC1 PKNOX1 ATF1 BACH1 POLR2A BRD9 ATF7 CREM ZNF639 TM4SF19 TM4SF19-AS1 TM4SF19-TCTEX1D2 GC03P196178
GH03I196272 Enhancer 1.1 FANTOM5 ENCODE 23 +64.5 64471 3.2 HDAC1 PKNOX1 ATF1 TAF9B NFIB SIN3A ZBTB40 BATF FOS ATF7 PCYT1A TM4SF19 ENSG00000228028 RNU6-910P TCTEX1D2 RNF168 NRROS UBXN7 ENSG00000272741 GC03P196178
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TM4SF19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TM4SF19 gene promoter:

Genomic Locations for TM4SF19 Gene

Genomic Locations for TM4SF19 Gene
19,162 bases
Minus strand

Genomic View for TM4SF19 Gene

Genes around TM4SF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF19 Gene

Proteins for TM4SF19 Gene

  • Protein details for TM4SF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 19
    Protein Accession:
    Secondary Accessions:
    • B2RV20
    • E9PH22
    • Q336K7

    Protein attributes for TM4SF19 Gene

    209 amino acids
    Molecular mass:
    22433 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM4SF19 Gene


neXtProt entry for TM4SF19 Gene

Post-translational modifications for TM4SF19 Gene

Other Protein References for TM4SF19 Gene

No data available for DME Specific Peptides for TM4SF19 Gene

Domains & Families for TM4SF19 Gene

Gene Families for TM4SF19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TM4SF19 Gene


Suggested Antigen Peptide Sequences for TM4SF19 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF19: view

Function for TM4SF19 Gene

Phenotypes From GWAS Catalog for TM4SF19 Gene

Phenotypes for TM4SF19 Gene

genes like me logo Genes that share phenotypes with TM4SF19: view

Animal Model Products

miRNA for TM4SF19 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF19 Gene

Localization for TM4SF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM4SF19 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TM4SF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TM4SF19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TM4SF19 Gene

Pathways & Interactions for TM4SF19 Gene

SuperPathways for TM4SF19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TM4SF19 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF19 Gene

Drugs & Compounds for TM4SF19 Gene

No Compound Related Data Available

Transcripts for TM4SF19 Gene

Unigene Clusters for TM4SF19 Gene

Transmembrane 4 L six family member 19:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF19 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP4: -
SP5: -

Relevant External Links for TM4SF19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TM4SF19 Gene

mRNA differential expression in normal tissues according to GTEx for TM4SF19 Gene

This gene is overexpressed in Adipose - Subcutaneous (x8.0), Testis (x7.4), Minor Salivary Gland (x5.0), and Esophagus - Mucosa (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of TM4SF19 Gene:


SOURCE GeneReport for Unigene cluster for TM4SF19 Gene:


Evidence on tissue expression from TISSUES for TM4SF19 Gene

  • Bone(4)
genes like me logo Genes that share expression patterns with TM4SF19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TM4SF19 Gene

Orthologs for TM4SF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM4SF19 33
  • 99.68 (n)
-- 34
  • 99 (a)
(Bos Taurus)
Mammalia TM4SF19 33
  • 88.46 (n)
-- 34
  • 83 (a)
(Canis familiaris)
Mammalia TM4SF19 33
  • 86.44 (n)
-- 34
  • 83 (a)
(Mus musculus)
Mammalia Tm4sf19 33 16 34
  • 83.93 (n)
(Rattus norvegicus)
Mammalia Tm4sf19 33
  • 81.63 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
(Gallus gallus)
Aves TM4SF19 34
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
(Danio rerio)
Actinopterygii LOC101885866 33
  • 47.93 (n)
zgc:172079 34
  • 29 (a)
CABZ01033205.2 34
  • 28 (a)
Species where no ortholog for TM4SF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF19 Gene

Gene Tree for TM4SF19 (if available)
Gene Tree for TM4SF19 (if available)

Paralogs for TM4SF19 Gene

Variants for TM4SF19 Gene

Sequence variations from dbSNP and Humsavar for TM4SF19 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs147419407 uncertain-significance, not specified 196,327,503(-) C/G coding_sequence_variant, missense_variant
rs1000008545 -- 196,331,431(-) T/C intron_variant
rs1000136578 -- 196,338,286(-) G/C 5_prime_UTR_variant
rs1000803125 -- 196,324,768(-) T/C intron_variant
rs1000875130 -- 196,338,221(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF19 Gene

Variant ID Type Subtype PubMed ID
dgv8849n54 CNV gain 21841781
esv1444129 CNV insertion 17803354
esv2370851 CNV deletion 18987734
esv26108 CNV gain 19812545
nsv997797 CNV gain 25217958
nsv950311 CNV deletion 24416366
nsv593085 CNV gain+loss 21841781
nsv593084 CNV gain 21841781
nsv593083 CNV gain 21841781
nsv593082 CNV gain+loss 21841781
nsv593079 CNV loss 21841781
nsv593071 CNV gain 21841781
nsv513108 CNV loss 21212237
nsv509878 OTHER sequence alteration 20534489
nsv4183 CNV deletion 18451855
nsv1136374 CNV deletion 24896259
nsv1074120 CNV deletion 25765185
nsv1009811 CNV gain 25217958
esv4542 CNV loss 18987735
esv3599281 CNV loss 21293372
esv3563177 CNV deletion 23714750
esv2759213 CNV gain+loss 17122850
esv2677485 CNV deletion 23128226

Variation tolerance for TM4SF19 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TM4SF19 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF19 Gene

Disorders for TM4SF19 Gene

Additional Disease Information for TM4SF19

No disorders were found for TM4SF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF19 Gene

Publications for TM4SF19 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for TM4SF19 Gene

Sources for TM4SF19 Gene

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