Aliases for TM4SF18 Gene

Aliases for TM4SF18 Gene

  • Transmembrane 4 L Six Family Member 18 2 3 5
  • Transmembrane 4 L6 Family Member 18 3 4
  • L6D 3

External Ids for TM4SF18 Gene

Previous GeneCards Identifiers for TM4SF18 Gene

  • GC03M150520
  • GC03M149036
  • GC03M146407

Summaries for TM4SF18 Gene

GeneCards Summary for TM4SF18 Gene

TM4SF18 (Transmembrane 4 L Six Family Member 18) is a Protein Coding gene. An important paralog of this gene is TM4SF1.

Additional gene information for TM4SF18 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TM4SF18 Gene

Genomics for TM4SF18 Gene

GeneHancer (GH) Regulatory Elements for TM4SF18 Gene

Promoters and enhancers for TM4SF18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J149331 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 500.7 +1.7 1692 4.2 CTCF ZNF316 MAFF POLR2A FOSL2 MAFK FOS RAD21 SMC3 JUND TM4SF18 lnc-TM4SF1-3 piR-51855-024 ENSG00000244468
GH03J149365 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -38.1 -38109 14.3 EP300 TCF12 POLR2G NCOR1 PHF8 FOS CTCF POLR2A KDM6A TCF7 TM4SF1 WWTR1-IT1 HPS3 TM4SF18 TM4SF1-AS1 RPS25P5
GH03J149128 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +203.5 203501 4.6 ZNF217 EP300 SIN3A NRF1 TCF12 USF1 POLR2G SP1 PHF8 ZFX HPS3 lnc-CP-5 HLTF TM4SF18 CPHL1P RF00994-690
GH03J149381 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -54.7 -54737 16.5 EP300 FOXK2 ZNF217 CTCF TCF12 POLR2G NCOR1 JUND FOS TEAD4 NONHSAG036358.2 lnc-TM4SF4-4 WWTR1-IT1 TM4SF4 HPS3 TM4SF18 TM4SF1 COMMD2 ENSG00000243885 TM4SF1-AS1
GH03J149297 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.7 +34.9 34946 5.3 ZNF217 TCF12 JUND FOS ZIC2 POLR2A TCF7 TRIM28 CUX1 ZBTB25 TM4SF18 TM4SF1 TM4SF1-AS1 CP CPHL1P piR-51855-024 lnc-TM4SF18-1 ENSG00000244468
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TM4SF18 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TM4SF18

Top Transcription factor binding sites by QIAGEN in the TM4SF18 gene promoter:
  • CUTL1
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-1
  • HFH-3
  • HNF-3beta
  • IRF-1
  • Pbx1a

Genomic Locations for TM4SF18 Gene

Genomic Locations for TM4SF18 Gene
15,917 bases
Minus strand
15,917 bases
Minus strand

Genomic View for TM4SF18 Gene

Genes around TM4SF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF18 Gene

Proteins for TM4SF18 Gene

  • Protein details for TM4SF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 18
    Protein Accession:
    Secondary Accessions:
    • B2R8K0
    • D3DNH5

    Protein attributes for TM4SF18 Gene

    201 amino acids
    Molecular mass:
    22277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF18 Gene

Post-translational modifications for TM4SF18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TM4SF18 Gene

No data available for DME Specific Peptides for TM4SF18 Gene

Domains & Families for TM4SF18 Gene

Gene Families for TM4SF18 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TM4SF18 Gene

  • Beta and gamma crystallin
  • L6 membrane

Suggested Antigen Peptide Sequences for TM4SF18 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane 4 L6 family member 18 (T4S18_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF18: view

Function for TM4SF18 Gene

Phenotypes From GWAS Catalog for TM4SF18 Gene

genes like me logo Genes that share phenotypes with TM4SF18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TM4SF18

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF18 Gene

Localization for TM4SF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM4SF18 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TM4SF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM4SF18: view

Pathways & Interactions for TM4SF18 Gene

PathCards logo

SuperPathways for TM4SF18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TM4SF18 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF18 Gene

Drugs & Compounds for TM4SF18 Gene

No Compound Related Data Available

Transcripts for TM4SF18 Gene

mRNA/cDNA for TM4SF18 Gene

7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TM4SF18

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF18 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for TM4SF18 Gene

GeneLoc Exon Structure for

Expression for TM4SF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TM4SF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF18 Gene

This gene is overexpressed in Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for TM4SF18 Gene

This gene is overexpressed in Bone (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TM4SF18 Gene

Protein tissue co-expression partners for TM4SF18 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TM4SF18

SOURCE GeneReport for Unigene cluster for TM4SF18 Gene:


Evidence on tissue expression from TISSUES for TM4SF18 Gene

  • Kidney(4.4)
genes like me logo Genes that share expression patterns with TM4SF18: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TM4SF18 Gene

Orthologs for TM4SF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM4SF18 31 30
  • 99.83 (n)
(Canis familiaris)
Mammalia TM4SF18 31 30
  • 89.72 (n)
(Bos Taurus)
Mammalia TM4SF18 31 30
  • 88.89 (n)
(Monodelphis domestica)
Mammalia TM4SF18 31
  • 81 (a)
(Gallus gallus)
Aves TM4SF18 31 30
  • 65.01 (n)
(Anolis carolinensis)
Reptilia TM4SF18 31
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm4sf18 30
  • 60.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3108 30
(Danio rerio)
Actinopterygii tm4sf18 31
  • 36 (a)
Species where no ortholog for TM4SF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF18 Gene

Gene Tree for TM4SF18 (if available)
Gene Tree for TM4SF18 (if available)
Evolutionary constrained regions (ECRs) for TM4SF18: view image

Paralogs for TM4SF18 Gene

Paralogs for TM4SF18 Gene

(3) SIMAP similar genes for TM4SF18 Gene using alignment to 2 proteins:

  • T4S18_HUMAN
  • C9J6Q4_HUMAN
genes like me logo Genes that share paralogs with TM4SF18: view

Variants for TM4SF18 Gene

Additional dbSNP identifiers (rs#s) for TM4SF18 Gene

Structural Variations from Database of Genomic Variants (DGV) for TM4SF18 Gene

Variant ID Type Subtype PubMed ID
nsv998572 CNV loss 25217958

Variation tolerance for TM4SF18 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TM4SF18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TM4SF18 Gene

Disorders for TM4SF18 Gene

Additional Disease Information for TM4SF18

No disorders were found for TM4SF18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF18 Gene

Publications for TM4SF18 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The L6 membrane proteins--a new four-transmembrane superfamily. (PMID: 10975581) Wright MD … Rudy GB (Protein science : a publication of the Protein Society 2000) 2 3 54
  4. TM4SF18 is aberrantly expressed in pancreatic cancer and regulates cell growth. (PMID: 30897168) Singhal M … Grimaldo SR (PloS one 2019) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TM4SF18 Gene

Sources for TM4SF18 Gene