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The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
TM2D1 (TM2 Domain Containing 1) is a Protein Coding gene. Diseases associated with TM2D1 include Alzheimer Disease and Mast Syndrome. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and amyloid-beta binding. An important paralog of this gene is TM2D3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001540 | amyloid-beta binding | IBA | 21873635 |
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005887 | integral component of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0097190 | apoptotic signaling pathway | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TM2D1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TM2D1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TM2D1 31 |
|
OneToOne | |
LOC479551 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | TM2D1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tm2d1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tm2d1 30 |
|
||
Chicken (Gallus gallus) |
Aves | TM2D1 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tm2d1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16476 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tm2d1 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007485 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10795 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y66D12A.21 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6883 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8088 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
alzheimer disease |
|
|
mast syndrome |
|
|
chromosome 1p36 deletion syndrome |
|
|