Aliases for TM2D1 Gene
External Ids for TM2D1 Gene
Previous GeneCards Identifiers for TM2D1 Gene
The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
GeneCards Summary for TM2D1 Gene
TM2D1 (TM2 Domain Containing 1) is a Protein Coding gene. Diseases associated with TM2D1 include Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and amyloid-beta binding. An important paralog of this gene is TM2D3.
UniProtKB/Swiss-Prot for TM2D1 Gene
May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.