The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015] See more...

Aliases for TLX3 Gene

Aliases for TLX3 Gene

  • T Cell Leukemia Homeobox 3 2 3 5
  • T-Cell Leukemia Homeobox Protein 3 3 4
  • Homeobox Protein Hox-11L2 3 4
  • Homeo Box 11-Like 2 2 3
  • HOX11L2 3 4
  • T-Cell Leukemia, Homeobox 3 2
  • T-Cell Leukemia Homeobox 3 2
  • RNX 3

External Ids for TLX3 Gene

Previous HGNC Symbols for TLX3 Gene

  • HOX11L2

Previous GeneCards Identifiers for TLX3 Gene

  • GC05P170971
  • GC05P171438
  • GC05P170671
  • GC05P170717
  • GC05P170668
  • GC05P170736
  • GC05P165834

Summaries for TLX3 Gene

Entrez Gene Summary for TLX3 Gene

  • The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]

GeneCards Summary for TLX3 Gene

TLX3 (T Cell Leukemia Homeobox 3) is a Protein Coding gene. Diseases associated with TLX3 include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are Transcriptional misregulation in cancer and Cell Differentiation - Index. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is TLX1.

Gene Wiki entry for TLX3 Gene

Additional gene information for TLX3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLX3 Gene

Genomics for TLX3 Gene

GeneHancer (GH) Regulatory Elements for TLX3 Gene

Promoters and enhancers for TLX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J171308 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 750.6 +0.3 253 3 ZNF785 ZBTB6 POLR2A ZNF121 SP1 ZNF473 ZNF384 SP7 ZSCAN21 KLF14 ENSG00000275038 TLX3 KLF3P1 SMIM23 EFCAB9 RF00017-5091
GH05J171269 Enhancer 0.9 Ensembl ENCODE 11.7 -39.4 -39366 1.2 SP7 PRDM10 BRCA1 ZEB2 ZNF629 PATZ1 CEBPB ZNF692 NFE2 ZBTB20 TLX3 RF01210-320 ENSG00000253213 lnc-TLX3-2 RF00017-5091 RANBP17
GH05J171271 Enhancer 0.7 Ensembl ENCODE 11.6 -37.8 -37847 1.2 MAFK CEBPG POLR2A CEBPB ZNF316 EP300 ZNF580 JUND ZNF146 MAFF TLX3 RPL10P8 RPSAP71 SNORA70J ENSG00000253966 RF01210-320 ENSG00000253213 lnc-TLX3-2 RF00017-5091 RANBP17
GH05J171342 Enhancer 0.5 Ensembl 11.6 +33.5 33453 0.2 CTCF RAD21 PKNOX1 REST SMARCA5 SMC3 ZNF143 ZNF2 SNORA70J RPL10P8 RPSAP71 TLX3 FGF18 ENSG00000213393 lnc-FBXW11-9 lnc-TLX3-1 RF00017-5091
GH05J171275 Enhancer 0.4 Ensembl 11.2 -33.4 -33447 0.8 OSR2 POLR2A RCOR1 ATF2 TLX3 RF01210-320 ENSG00000253213 lnc-TLX3-2 RF00017-5091 RANBP17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLX3 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Nkx2-5

Genomic Locations for TLX3 Gene

Genomic Locations for TLX3 Gene
chr5:171,309,248-171,312,139
(GRCh38/hg38)
Size:
2,892 bases
Orientation:
Plus strand
chr5:170,736,288-170,739,138
(GRCh37/hg19)
Size:
2,851 bases
Orientation:
Plus strand

Genomic View for TLX3 Gene

Genes around TLX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX3 Gene

Proteins for TLX3 Gene

  • Protein details for TLX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43711-TLX3_HUMAN
    Recommended name:
    T-cell leukemia homeobox protein 3
    Protein Accession:
    O43711
    Secondary Accessions:
    • Q96AD3

    Protein attributes for TLX3 Gene

    Size:
    291 amino acids
    Molecular mass:
    31867 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLX3 Gene

Post-translational modifications for TLX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLX3 Gene

Domains & Families for TLX3 Gene

Gene Families for TLX3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TLX3 Gene

Suggested Antigen Peptide Sequences for TLX3 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox protein Hox-11L2 (TLX3_HUMAN)
genes like me logo Genes that share domains with TLX3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TLX3 Gene

Function for TLX3 Gene

Phenotypes From GWAS Catalog for TLX3 Gene

Gene Ontology (GO) - Molecular Function for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 22516263
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TLX3: view
genes like me logo Genes that share phenotypes with TLX3: view

Animal Models for TLX3 Gene

MGI Knock Outs for TLX3:

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLX3 Gene

Localization for TLX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLX3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLX3 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TLX3: view

Pathways & Interactions for TLX3 Gene

genes like me logo Genes that share pathways with TLX3: view

Pathways by source for TLX3 Gene

SIGNOR curated interactions for TLX3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification IEA --
GO:0001764 neuron migration IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with TLX3: view

Drugs & Compounds for TLX3 Gene

No Compound Related Data Available

Transcripts for TLX3 Gene

mRNA/cDNA for TLX3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLX3 Gene

No ASD Table

Relevant External Links for TLX3 Gene

GeneLoc Exon Structure for
TLX3
ECgene alternative splicing isoforms for
TLX3

Expression for TLX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLX3 Gene

This gene is overexpressed in Brain - Cerebellum (x25.5) and Brain - Cerebellar Hemisphere (x23.4).

NURSA nuclear receptor signaling pathways regulating expression of TLX3 Gene:

TLX3

SOURCE GeneReport for Unigene cluster for TLX3 Gene:

Hs.249125

Evidence on tissue expression from TISSUES for TLX3 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TLX3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLX3 Gene

Orthologs for TLX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLX3 33
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLX3 33
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLX3 33 32
  • 96.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlx3 32
  • 95.53 (n)
cow
(Bos Taurus)
Mammalia TLX3 33 32
  • 95.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tlx3 17 33 32
  • 95.19 (n)
oppossum
(Monodelphis domestica)
Mammalia TLX3 33
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLX3 33
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLX3 33
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlx3 32
  • 74.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia tlx3-A-prov 32
zebrafish
(Danio rerio)
Actinopterygii tlx3b 33 32 32
  • 68.36 (n)
OneToMany
CABZ01067175.1 33
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta C15 33 34
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cog-1 33
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 30 (a)
OneToMany
Species where no ortholog for TLX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLX3 Gene

ENSEMBL:
Gene Tree for TLX3 (if available)
TreeFam:
Gene Tree for TLX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLX3: view image

Paralogs for TLX3 Gene

(2) SIMAP similar genes for TLX3 Gene using alignment to 1 proteins:

  • TLX3_HUMAN
genes like me logo Genes that share paralogs with TLX3: view

Variants for TLX3 Gene

Sequence variations from dbSNP and Humsavar for TLX3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000015048 -- 171,307,254(+) G/A upstream_transcript_variant
rs1000129038 -- 171,310,250(+) C/T coding_sequence_variant, synonymous_variant
rs1001521091 -- 171,311,314(+) A/G intron_variant
rs1001792934 -- 171,308,172(+) G/A upstream_transcript_variant
rs1002140507 -- 171,307,900(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TLX3 Gene

Variant ID Type Subtype PubMed ID
nsv600262 CNV gain 21841781

Variation tolerance for TLX3 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLX3 Gene

Human Gene Mutation Database (HGMD)
TLX3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLX3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLX3 Gene

Disorders for TLX3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TLX3 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
t-cell leukemia
  • leukemia t-cell
drug-induced lupus erythematosus
  • dil
acute t cell leukemia
  • precursor t lymphoblastic leukemia
central hypoventilation syndrome, congenital
  • cchs
- elite association - COSMIC cancer census association via MalaCards
Search TLX3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLX3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TLX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLX3 Gene

Publications for TLX3 Gene

  1. Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping. (PMID: 11435718) Lee-Kirsch MA … Gahr M (Cytogenetics and cell genetics 2001) 2 3 23 56
  2. Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. (PMID: 18368072) Baak U … German Multicenter ALL Study Group (Leukemia 2008) 3 23 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (PMID: 15240857) Weese-Mayer DE … Marazita ML (Pediatric research 2004) 3 43 56
  5. Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. (PMID: 15334547) Su XY … Bernard OA (Genes, chromosomes & cancer 2004) 3 23 56

Products for TLX3 Gene

Sources for TLX3 Gene