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This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
TLX1 (T Cell Leukemia Homeobox 1) is a Protein Coding gene. Diseases associated with TLX1 include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Transcriptional misregulation in cancer and Cell Differentiation - Index. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is TLX3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,IBA | 21873635 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transcriptional misregulation in cancer | ||
2 | Cell Differentiation - Index |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IEA | -- |
GO:0048513 | animal organ development | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||
SP2: | - | ||||||||||||||
SP3: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TLX1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TLX1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TLX1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tlx1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tlx1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TLX1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TLX1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TLX1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TLX1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tlx1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | tlx1-A-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tlx1 30 31 |
|
OneToOne | |
tlx3a 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | C15 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ceh-9 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1269 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
precursor t-cell acute lymphoblastic leukemia |
|
|
t-cell acute lymphoblastic leukemia |
|
|
leukemia |
|
|
t-cell lymphoblastic leukemia/lymphoma |
|
|
lymphoblastic lymphoma |
|
|