This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain ... See more...

Aliases for TLX1 Gene

Aliases for TLX1 Gene

  • T Cell Leukemia Homeobox 1 2 3 5
  • Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To Drosophila Notch) 2 3
  • T-Cell Leukemia Homeobox Protein 1 3 4
  • T-Cell Leukemia/Lymphoma Protein 3 3 4
  • Homeobox Protein Hox-11 3 4
  • Proto-Oncogene TCL-3 3 4
  • HOX11 3 4
  • TCL3 3 4
  • Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint) 2
  • T-Cell Leukemia, Homeobox 1 2
  • T-Cell Leukemia Homeobox 1 2
  • TLX1 5

External Ids for TLX1 Gene

Previous HGNC Symbols for TLX1 Gene

  • TCL3
  • HOX11

Previous GeneCards Identifiers for TLX1 Gene

  • GC10P101783
  • GC10P102123
  • GC10P103021
  • GC10P102554
  • GC10P102880
  • GC10P096520
  • GC10P102889

Summaries for TLX1 Gene

Entrez Gene Summary for TLX1 Gene

  • This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for TLX1 Gene

TLX1 (T Cell Leukemia Homeobox 1) is a Protein Coding gene. Diseases associated with TLX1 include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Transcriptional misregulation in cancer and Cell Differentiation - Index. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is TLX3.

UniProtKB/Swiss-Prot Summary for TLX1 Gene

  • Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Gene Wiki entry for TLX1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLX1 Gene

Genomics for TLX1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J101132 Promoter/Enhancer 1.4 EPDnew Ensembl dbSUPER 600.7 +0.4 428 0.4 PRDM10 ZNF629 PRDM1 ZIC2 PKNOX1 PATZ1 ZNF501 EZH2 ZNF341 ZNF561 TLX1 TLX1NB lnc-LBX1-2 LBX1
GH10J101133 Promoter/Enhancer 1 Ensembl dbSUPER 600.7 +0.9 928 0.2 ZNF629 ZNF692 ZIC2 PATZ1 EZH2 ZNF341 ZNF561 ZBTB20 ZNF524 ZNF10 TLX1 TLX1NB lnc-LBX1-2 LBX1
GH10J101030 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -97.5 -97526 6.4 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 ZNF692 BACH1 FOS PDZD7 MRPL43 TWNK KAZALD1 TLX1 TLX1NB SEMA4G ENSG00000236662 MIR608 PHBP9
GH10J101485 Enhancer 1.6 VISTA UCNEbase ENCODE CraniofacialAtlas 10.3 +355.3 355280 1.6 PRDM10 ZNF629 ZNF692 PRDM1 ZIC2 ZSCAN4 PATZ1 SP1 ZNF501 ZNF600 RNU2-43P DPCD TLX1 POLL KCNIP2-AS1 MFSD13A lnc-POLL-4 lnc-DPCD-4 BTRC
GH10J101451 Enhancer 1.4 UCNEbase Ensembl ENCODE 10.1 +322.0 322028 6.8 PRDM10 ZNF629 LEF1 IKZF1 ZNF692 PRDM1 MTA2 ZSCAN4 PKNOX1 POLR2A BTRC DPCD RNU2-43P TLX1 POLL lnc-POLL-6 lnc-DPCD-6 NONHSAG006723.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLX1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLX1

Top Transcription factor binding sites by QIAGEN in the TLX1 gene promoter:
  • Nkx2-5
  • p300
  • Pbx1a
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for TLX1 Gene

Genomic Locations for TLX1 Gene
chr10:101,130,773-101,137,789
(GRCh38/hg38)
Size:
7,017 bases
Orientation:
Plus strand
chr10:102,889,257-102,897,546
(GRCh37/hg19)
Size:
8,290 bases
Orientation:
Plus strand

Genomic View for TLX1 Gene

Genes around TLX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX1 Gene

Proteins for TLX1 Gene

  • Protein details for TLX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31314-TLX1_HUMAN
    Recommended name:
    T-cell leukemia homeobox protein 1
    Protein Accession:
    P31314
    Secondary Accessions:
    • A1L4G3
    • O75699
    • Q5VXP2
    • Q9HCA0
    • Q9UD59

    Protein attributes for TLX1 Gene

    Size:
    330 amino acids
    Molecular mass:
    34365 Da
    Quaternary structure:
    • Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3.
    Miscellaneous:
    • TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.

    Alternative splice isoforms for TLX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLX1 Gene

Post-translational modifications for TLX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLX1 Gene

Antibody Products

  • Abcam antibodies for TLX1
  • Boster Bio Antibodies for TLX1

No data available for DME Specific Peptides for TLX1 Gene

Domains & Families for TLX1 Gene

Gene Families for TLX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TLX1 Gene

InterPro:
Blocks:
  • 'Homeobox' engrailed-type protein
ProtoNet:

Suggested Antigen Peptide Sequences for TLX1 Gene

GenScript: Design optimal peptide antigens:
  • TLX1 protein (A1L4G3_HUMAN)
  • T-cell leukemia/lymphoma protein 3 (TLX1_HUMAN)
genes like me logo Genes that share domains with TLX1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TLX1 Gene

Function for TLX1 Gene

Molecular function for TLX1 Gene

UniProtKB/Swiss-Prot Function:
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Phenotypes From GWAS Catalog for TLX1 Gene

Gene Ontology (GO) - Molecular Function for TLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA,IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with TLX1: view
genes like me logo Genes that share phenotypes with TLX1: view

Animal Models for TLX1 Gene

MGI Knock Outs for TLX1:
  • Tlx1 Tlx1<tm1Sjk>
  • Tlx1 Tlx1<tm1.1(cre/ERT2)Rygo>
  • Tlx1 Tlx1<tm1Thr>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLX1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLX1 Gene

Localization for TLX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLX1 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with TLX1: view

Pathways & Interactions for TLX1 Gene

genes like me logo Genes that share pathways with TLX1: view

Pathways by source for TLX1 Gene

1 BioSystems pathway for TLX1 Gene
1 KEGG pathway for TLX1 Gene

SIGNOR curated interactions for TLX1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0048513 animal organ development IBA 21873635
genes like me logo Genes that share ontologies with TLX1: view

Drugs & Compounds for TLX1 Gene

(3) Drugs for TLX1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TLX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TLX1: view

Transcripts for TLX1 Gene

mRNA/cDNA for TLX1 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLX1

Alternative Splicing Database (ASD) splice patterns (SP) for TLX1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4
SP1: - -
SP2: -
SP3: -

Relevant External Links for TLX1 Gene

GeneLoc Exon Structure for
TLX1

Expression for TLX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLX1 Gene

This gene is overexpressed in Spleen (x42.9) and Minor Salivary Gland (x7.5).

Protein differential expression in normal tissues from HIPED for TLX1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLX1 Gene



Protein tissue co-expression partners for TLX1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLX1

SOURCE GeneReport for Unigene cluster for TLX1 Gene:

Hs.89583

Evidence on tissue expression from TISSUES for TLX1 Gene

  • Blood(4.4)
  • Bone marrow(4.4)
  • Spleen(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TLX1 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with TLX1: view

No data available for mRNA Expression by UniProt/SwissProt for TLX1 Gene

Orthologs for TLX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLX1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TLX1 30 31
  • 98.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TLX1 30 31
  • 91.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TLX1 30 31
  • 91.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tlx1 30
  • 89.39 (n)
Mouse
(Mus musculus)
Mammalia Tlx1 30 17 31
  • 89.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TLX1 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TLX1 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TLX1 30 31
  • 77.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TLX1 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tlx1 30
  • 70.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia tlx1-A-prov 30
Zebrafish
(Danio rerio)
Actinopterygii tlx1 30 31
  • 67.95 (n)
OneToOne
tlx3a 30
Fruit Fly
(Drosophila melanogaster)
Insecta C15 31 32
  • 36 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ceh-9 31
  • 35 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 31 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1269 30
Species where no ortholog for TLX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TLX1 Gene

ENSEMBL:
Gene Tree for TLX1 (if available)
TreeFam:
Gene Tree for TLX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLX1: view image

Paralogs for TLX1 Gene

(2) SIMAP similar genes for TLX1 Gene using alignment to 2 proteins:

  • TLX1_HUMAN
  • G3V1B7_HUMAN
genes like me logo Genes that share paralogs with TLX1: view

Variants for TLX1 Gene

Additional dbSNP identifiers (rs#s) for TLX1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLX1 Gene

Variant ID Type Subtype PubMed ID
esv3624369 CNV gain 21293372
nsv508603 CNV deletion 20534489
nsv831966 CNV gain 17160897

Variation tolerance for TLX1 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLX1 Gene

Disorders for TLX1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TLX1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
t-cell acute lymphoblastic leukemia
  • acute t cell leukaemia
leukemia
  • leukemias
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
- elite association - COSMIC cancer census association via MalaCards
Search TLX1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TLX1_HUMAN
  • Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. {ECO:0000269 PubMed:1676542, ECO:0000269 PubMed:1681546, ECO:0000269 PubMed:1717256}.
genes like me logo Genes that share disorders with TLX1: view

No data available for Genatlas for TLX1 Gene

Publications for TLX1 Gene

  1. MEIS proteins as partners of the TLX1/HOX11 oncoprotein. (PMID: 19559479) Milech N … Watt PM (Leukemia research 2010) 3 4 23
  2. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PMID: 17303350) Greene WK … Bellgard MI (Gene 2007) 3 4 23
  3. Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line. (PMID: 10393251) Watt PM … Kees UR (Gene 1999) 3 4 23
  4. Multiple negative elements contribute to repression of the HOX11 proto-oncogene. (PMID: 9778044) Brake RL … Watt PM (Oncogene 1998) 3 4 23
  5. Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells. (PMID: 1352396) Lu M … Ho AD (Oncogene 1992) 3 4 23

Products for TLX1 Gene

Sources for TLX1 Gene