Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, ... See more...
Aliases for TLR9 Gene
External Ids for TLR9 Gene
- HGNC: 15633
- Entrez Gene: 54106
- Ensembl: ENSG00000239732
- OMIM: 605474
- UniProtKB: Q9NR96
Previous GeneCards Identifiers for TLR9 Gene
- GC03M051347
- GC03M051507
- GC03M052111
- GC03M052213
- GC03M052230
- GC03M052255
Summaries for TLR9 Gene
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]
GeneCards Summary for TLR9 Gene
TLR9 (Toll Like Receptor 9) is a Protein Coding gene. Diseases associated with TLR9 include Meningococcal Meningitis and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome. Among its related pathways are Th1 Differentiation Pathway and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and siRNA binding. An important paralog of this gene is ENSG00000173366.
UniProtKB/Swiss-Prot Summary for TLR9 Gene
-
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR9 Gene
Genomics for TLR9 Gene
GeneHancer (GH) Regulatory Elements for TLR9 Gene
Promoters and enhancers for TLR9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TLR9 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR9
- Top Transcription factor binding sites by QIAGEN in the TLR9 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- C/EBPalpha
- CREB
- deltaCREB
- STAT1
Genomic Locations for TLR9 Gene
Genomic Locations for TLR9 Gene
- chr3:52,221,080-52,226,163
- (GRCh38/hg38)
- Size:
- 5,084 bases
- Orientation:
- Minus strand
- chr3:52,255,096-52,273,183
- (GRCh37/hg19)
- Size:
- 18,088 bases
- Orientation:
- Minus strand
Genomic View for TLR9 Gene
Genes around TLR9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.2 by HGNC
- 3p21.2 by Entrez Gene
- 3p21.2 by Ensembl
TLR9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLR9 Gene
Proteins for TLR9 Gene
-
Protein details for TLR9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NR96-TLR9_HUMAN
- Recommended name:
- Toll-like receptor 9
- Protein Accession:
- Q9NR96
- B3Y661
- D1CS56
- Q6UVZ2
- Q9HD68
- Q9HD69
- Q9HD70
- Q9NYC2
- Q9NYC3
Protein attributes for TLR9 Gene
- Size:
- 1032 amino acids
- Molecular mass:
- 115860 Da
- Quaternary structure:
-
- Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (PubMed:17932028). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:20865800). Interacts with SMPDL3B (By similarity).
Protein Expression for TLR9 Gene
Post-translational modifications for TLR9 Gene
- Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.
-
Glycosylation at Asn64, Asn129, Asn200, Asn210, Asn242, Asn300, Asn340, Asn469, Asn474, Asn513, Asn567, Asn694, and Asn731
- NX_Q9NR96 (NX_Q9NR96-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TLR9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TLR9 Antibody
- NSJ Bioreagents TLR9 Antibody
- Creative Diagnostics Anti-TLR9 monoclonal antibody, clone 83-2776
- Novus Biologicals Antibodies for TLR9
-
Abcam antibodies for TLR9
- Invitrogen Antibodies for TLR9 (AFLGC-TLR9)
- antibodies-online: Show 94 available TLR9 Antibodies ranked by validation data
- Compare Top TLR9 Antibodies
-
Recommended
- 184 WB Antibodies (anti-human)
- 35 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 108 WB Antibodies (anti-mouse)
- 19 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 50 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for TLR9
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR9
- Sino Biological Antibodies for TLR9
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TLR9
- Origene Custom Protein Services for TLR9
-
Signalway Proteins for TLR9
-
Abcam proteins for TLR9
Assay Products
- Novus Biologicals ELISA Kits for TLR9
- antibodies-online: Show 67 available TLR9 Elisa Kits ranked by validation data
- Compare Top TLR9 Elisa Kits
-
Quality Products:
- ABIN1117531
- ABIN414673
- ABIN367238
- ABIN1030014
- ABIN5523020
- ABIN5669062
- ABIN1081908
- ABIN5593573
- ABIN456642
- ABIN809098
- ABIN1117529
- ABIN367695
- ABIN424150
- ABIN5523021
- ABIN628238
- ABIN456643
- ABIN511126
- ABIN5659369
- ABIN6254558
- ABIN2951935
- ABIN1117530
- ABIN5523022
- ABIN368321
- ABIN5670717
- ABIN1059346
- ABIN2951936
- ABIN5069798
- ABIN2539775
- ABIN1059339
- ABIN1161929
No data available for DME Specific Peptides for TLR9 Gene
Domains & Families for TLR9 Gene
Gene Families for TLR9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- FDA approved drug targets
- Predicted membrane proteins
Protein Domains for TLR9 Gene
- Blocks:
-
- TIR domain
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TLR9 Gene
- GenScript: Design optimal peptide antigens:
-
- Toll-like receptor 9 (B6CH46_HUMAN)
- TLR9 (C3W5P5_HUMAN)
- TLR9 (D1CS56_HUMAN)
- TLR9 (D1CS61_HUMAN)
- TLR9 (D1CS62_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NR96- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR9 Gene
Molecular function for TLR9 Gene
- UniProtKB/Swiss-Prot Function:
- Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).
Phenotypes From GWAS Catalog for TLR9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005149 | interleukin-1 receptor binding | IPI | 12925853 |
| GO:0005515 | protein binding | IEA | -- |
| GO:0008329 | signaling pattern recognition receptor activity | IBA | 21873635 |
| GO:0035197 | siRNA binding | IMP | 15723075 |
Phenotypes for TLR9 Gene
- MGI mutant phenotypes for TLR9:
- inferred from 10 alleles
- GenomeRNAi human phenotypes for TLR9:
Animal Models for TLR9 Gene
- MGI Knock Outs for TLR9:
-
- Tlr9 Tlr9<tm1Aki>
Animal Model Products
-
Taconic Biosciences Mouse Models for TLR9
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TLR9 - Select products 50% OFF >
- * TLR9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TLR9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR9
- genomics-online: gRNA clones - Search for available TLR9 gRNA products
- Overview of 126 available TLR9 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR9
- Browse OriGene Inhibitory RNA Products For TLR9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR9
- genomics-online: shRNA clones - Search for available TLR9 shRNA products
- Overview of 126 available TLR9 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TLR9 - Select products 50% OFF >
- * TLR9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TLR9
- Addgene plasmids for TLR9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR9
- genomics-online: cdna clones - Search for available TLR9 CDNA products
- Overview of 126 available TLR9 gene related products
- orf clones - Search for available TLR9 ORF products
- Overview of 126 available TLR9 gene related products
Cell Line Products
-
Horizon Cell Lines for TLR9
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TLR9 Gene
Localization for TLR9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR9 Gene
- Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. {ECO:0000250 UniProtKB:Q9EQU3}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| endosome | 5 |
| lysosome | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
| peroxisome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005576 | extracellular region | NAS | 11130078 |
| GO:0005737 | cytoplasm | IDA | 19740627 |
| GO:0005764 | lysosome | ISS | -- |
| GO:0005768 | endosome | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR9 Gene
Pathways & Interactions for TLR9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | RET signaling | ||
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | Th1 Differentiation Pathway | ||
| 5 | NF-KappaB Family Pathway |
NF-KappaB (p50-p65) Pathway
.72
|
NF-KappaB Family Pathway
.72
|
Pathways by source for TLR9 Gene
4 BioSystems pathways for TLR9 Gene
17 Reactome pathways for TLR9 Gene
8 KEGG pathways for TLR9 Gene
1 GeneGo (Thomson Reuters) pathway for TLR9 Gene
- Immune response TLR signaling pathways
1 Tocris pathway for TLR9 Gene
8 Qiagen pathways for TLR9 Gene
- Colorectal Cancer Metastasis
- NF-KappaB (p50-p65) Pathway
- NF-KappaB Family Pathway
- Phagocytosis of Microbes
- Tec Kinases Signaling
1 Cell Signaling Technology pathway for TLR9 Gene
1 GeneTex pathway for TLR9 Gene
Interacting Proteins for TLR9 Gene
GPS-Prot Interaction Network for TLR9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002237 | response to molecule of bacterial origin | TAS | 15356140 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002639 | positive regulation of immunoglobulin production | IDA | 23857366 |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for TLR9 Gene
Drugs & Compounds for TLR9 Gene
(41) Drugs for TLR9 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hydroxychloroquine | Approved | Pharma | Target, antagonist, inhibitor | Autophagy inhibitor | 207 | |
| chloroquine | Approved, Investigational, Vet_approved | Pharma | Agonist, Target | 164 | ||
| Cetuximab | Approved | Pharma | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 852 | ||
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3311 | ||
| Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 2258 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| CpG |
|
Agonist |
|
(2) ApexBio Compounds for TLR9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Hydroxychloroquine Sulfate | 747-36-4 | |
| Resiquimod (R-848) | Immune response modifier | 144875-48-9 |
Transcripts for TLR9 Gene
mRNA/cDNA for TLR9 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360658 3870 bps (ENST00000360658.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TLR9 - Select products 50% OFF >
- * TLR9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TLR9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR9
- genomics-online: gRNA clones - Search for available TLR9 gRNA products
- Overview of 126 available TLR9 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR9
- Browse OriGene Inhibitory RNA Products For TLR9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR9
- genomics-online: shRNA clones - Search for available TLR9 shRNA products
- Overview of 126 available TLR9 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TLR9 - Select products 50% OFF >
- * TLR9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TLR9
- Addgene plasmids for TLR9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR9
- genomics-online: cdna clones - Search for available TLR9 CDNA products
- Overview of 126 available TLR9 gene related products
- orf clones - Search for available TLR9 ORF products
- Overview of 126 available TLR9 gene related products
Relevant External Links for TLR9 Gene
- GeneLoc Exon Structure for
- TLR9
Expression for TLR9 Gene
This gene is overexpressed in Heart (26.8), Adrenal (20.5), Blymphocyte (13.4), and Adipocyte (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR9 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR9
SOURCE GeneReport for Unigene cluster for TLR9 Gene:
Hs.87968mRNA Expression by UniProt/SwissProt for TLR9 Gene:
Q9NR96-TLR9_HUMAN
Tissue specificity:
Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Evidence on tissue expression from TISSUES for TLR9 Gene
- Blood(3.6)
- Spleen(3.6)
- Lymph node(3.5)
- Bone marrow(2.7)
- Intestine(2.6)
- Lung(2.6)
- Liver(2.5)
- Kidney(2.4)
- Skin(2.4)
- Heart(2.3)
- Nervous system(2.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for TLR9
-
OriGene qPCR primer pairs and template standards for TLR9
- genomics-online: primer clones - Search for available TLR9 Primer products
- Overview of 126 available TLR9 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR9 Gene
Orthologs for TLR9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TLR9 31 30 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | TLR9 31 30 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | TLR9 31 30 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Tlr9 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tlr9 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | TLR21 31 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100494387 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tlr9 31 30 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG7896 32 |
|
|
- Species where no ortholog for TLR9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TLR9 Gene
- ENSEMBL:
- Gene Tree for TLR9 (if available)
- TreeFam:
- Gene Tree for TLR9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TLR9: view image
Paralogs for TLR9 Gene
Paralogs for TLR9 Gene
(2) SIMAP similar genes for TLR9 Gene using alignment to 7 proteins:
- TLR9_HUMAN
- B6CH46_HUMAN
- C3W5P5_HUMAN
- D1CS61_HUMAN
- D1CS62_HUMAN
- L0R5D6_HUMAN
- L8E8B9_HUMAN
Variants for TLR9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR9 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709661 | Benign: not provided | 52,223,875(-) | G/T | SYNONYMOUS_VARIANT | |
| 710317 | Likely Benign: not provided | 52,222,165(-) | G/T | SYNONYMOUS_VARIANT | |
| 712459 | Likely Benign: not provided | 52,222,605(-) | C/T | MISSENSE_VARIANT | |
| 712985 | Likely Benign: not provided | 52,224,124(-) | A/G | SYNONYMOUS_VARIANT | |
| 713902 | Benign: not provided | 52,221,223(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv460537 | CNV | loss | 19166990 |
| nsv470572 | CNV | loss | 18288195 |
| nsv482084 | CNV | gain | 20164927 |
| nsv508218 | CNV | deletion | 20534489 |
| nsv508926 | CNV | insertion | 20534489 |
| nsv519445 | CNV | gain+loss | 19592680 |
| nsv590301 | CNV | loss | 21841781 |
| nsv834694 | CNV | gain | 17160897 |
| nsv834695 | CNV | loss | 17160897 |
| nsv954858 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
3.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.67;
31.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLR9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR9 Gene
Disorders for TLR9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| meningococcal meningitis |
|
|
| stevens-johnson syndrome/toxic epidermal necrolysis overlap syndrome |
|
|
| malaria |
|
|
| herpes simplex |
|
|
| septic arthritis |
|
|
Search TLR9 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TLR9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TLR9 Gene
Publications for TLR9 Gene
- TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression. (PMID: 19284650) Campino S … Kwiatkowski DP (Malaria journal 2009) 3 23 41 54
- Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. (PMID: 19130296) Xu CJ … Ye DQ (Molecular biology reports 2009) 3 23 41 54
- Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. (PMID: 17344245) Tao K … Yasutomo K (Annals of the rheumatic diseases 2007) 3 23 41 54
- Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity. (PMID: 16849519) Merrell MA … Selander KS (Molecular cancer research : MCR 2006) 3 23 26 54
- Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. (PMID: 16125159) Hamann L … Schumann RR (Clinica chimica acta; international journal of clinical chemistry 2006) 3 23 41 54
ExternalLinks
Products for TLR9 Gene
- Custom Antibody ServicesOriGene Antibodies for TLR9
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TLR9
- Origene Custom Protein Services for TLR9
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR9
- Browse OriGene Inhibitory RNA Products For TLR9
- OriGene qPCR primer pairs for TLR9
- OriGene qPCR primer pairs and template standards for TLR9
- OriGene CRISPR knockouts for TLR9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TLR9
- Sino Biological Human cDNA Clone for TLR9
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for TLR9
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TLR9
- Novus Biologicals proteins and lysates for TLR9
- Novus Biologicals ELISA Kits for TLR9
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TLR9
- Abcam proteins for TLR9
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for TLR9
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TLR9 (AFLGC-TLR9)
- ApexBio compounds for TLR9
- VectorBuilder Custom and pre-made DNA vectors for TLR9 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TLR9 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TLR9 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TLR9 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TLR9
- Addgene plasmids for TLR9
- antibodies-online: Show 94 available TLR9 Antibodies ranked by validation data
- Compare Top TLR9 Antibodies
- Recommended
- 184 WB Antibodies (anti-human)
- 35 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 108 WB Antibodies (anti-mouse)
- 19 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 50 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- antibodies-online: Show 67 available TLR9 Elisa Kits ranked by validation data
- Compare Top TLR9 Elisa Kits
- Quality Products:
- ABIN1117531
- ABIN414673
- ABIN367238
- ABIN1030014
- ABIN5523020
- ABIN5669062
- ABIN1081908
- ABIN5593573
- ABIN456642
- ABIN809098
- ABIN1117529
- ABIN367695
- ABIN424150
- ABIN5523021
- ABIN628238
- ABIN456643
- ABIN511126
- ABIN5659369
- ABIN6254558
- ABIN2951935
- ABIN1117530
- ABIN5523022
- ABIN368321
- ABIN5670717
- ABIN1059346
- ABIN2951936
- ABIN5069798
- ABIN2539775
- ABIN1059339
- ABIN1161929
- antibodies-online: Show 12 available TLR9 Proteins ranked by validation data
- Compare Top TLR9 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TLR9
- Search Santa Cruz Biotechnology (SCBT) for TLR9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TLR9
- Custom Antibody ServicesProSci Antibodies for TLR9
- Search for TLR9 Proteins at ProSci
- Horizon Cell Lines for TLR9
- genomics-online: cdna clones - Search for available TLR9 CDNA products
- Overview of 126 available TLR9 gene related products
- orf clones - Search for available TLR9 ORF products
- Overview of 126 available TLR9 gene related products
- genomics-online: gRNA clones - Search for available TLR9 gRNA products
- Overview of 126 available TLR9 gene related products
- genomics-online: primer clones - Search for available TLR9 Primer products
- Overview of 126 available TLR9 gene related products
- genomics-online: shRNA clones - Search for available TLR9 shRNA products
- Overview of 126 available TLR9 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR9
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TLR9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR9
Sources for TLR9 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody