Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, a... See more...
Aliases for TLR8 Gene
Aliases for TLR8 Gene
External Ids for TLR8 Gene
- HGNC: 15632
- NCBI Entrez Gene: 51311
- Ensembl: ENSG00000101916
- OMIM®: 300366
- UniProtKB/Swiss-Prot: Q9NR97
Previous GeneCards Identifiers for TLR8 Gene
- GC0XP012117
- GC0XP011690
- GC0XP012221
- GC0XP012286
- GC0XP012684
- GC0XP012834
- GC0XP010691
Summaries for TLR8 Gene
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
GeneCards Summary for TLR8 Gene
TLR8 (Toll Like Receptor 8) is a Protein Coding gene. Diseases associated with TLR8 include Superficial Basal Cell Carcinoma and Anogenital Venereal Wart. Among its related pathways are Phagocytosis of Microbes and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include RNA binding and drug binding. An important paralog of this gene is TLR7.
UniProtKB/Swiss-Prot Summary for TLR8 Gene
-
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).
Additional gene information for TLR8 Gene
- HGNC (15632)
- NCBI Entrez Gene (51311)
- Ensembl (ENSG00000101916)
- OMIM® (300366)
- UniProtKB/Swiss-Prot (Q9NR97)
- Open Targets Platform(ENSG00000101916)
- Monarch Initiative
- Search for TLR8 at DataMed
- Search for TLR8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR8 Gene
Genomics for TLR8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TLR8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TLR8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR8
- Top Transcription factor binding sites by QIAGEN in the TLR8 gene promoter:
-
- C/EBPalpha
- CHOP-10
- FAC1
- IRF-7A
- Sox5
- STAT1
Genomic Locations for TLR8 Gene
Latest Assembly
- chrX:12,906,620-12,923,169
- (GRCh38/hg38)
- Size:
- 16,550 bases
- Orientation:
- Plus strand
Previous Assembly
- chrX:12,924,739-12,941,288
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 16,550 bases
- Orientation:
- Plus strand
- chrX:12,924,739-12,941,288
- (GRCh37/hg19 by Ensembl)
- Size:
- 16,550 bases
- Orientation:
- Plus strand
Genomic View for TLR8 Gene
Genes around TLR8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by HGNC
- Xp22.2 by Entrez Gene
- Xp22.2 by Ensembl
TLR8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLR8 Gene
Proteins for TLR8 Gene
-
Protein details for TLR8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NR97-TLR8_HUMAN
- Recommended name:
- Toll-like receptor 8
- Protein Accession:
- Q9NR97
- B3Y654
- D1CS70
- D1CS76
- Q495P4
- Q6UXL6
- Q9NYG9
Protein attributes for TLR8 Gene
- Size:
- 1041 amino acids
- Molecular mass:
- 119828 Da
- Quaternary structure:
-
- Homodimer (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:29155428). Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (By similarity). Interacts with BTK (PubMed:17932028). Interacts with SMPDL3B (By similarity).
Three dimensional structures from OCA and Proteopedia for TLR8 Gene
Protein Expression for TLR8 Gene
Post-translational modifications for TLR8 Gene
- Ubiquitinated by RNF216; leading to degradation by the proteasome.
- Proteolytic processing occurs in monocytes and monocyte-derived macrophages by both furin-like proprotein convertase and cathepsins (PubMed:25297876). The cleavage is necessary for dimer formation and subsequent activation (PubMed:26929371).
-
Glycosylation at Asn29, Asn42, Asn80, Asn88, Asn115, Asn160, Asn247, Asn285, Asn293, Asn358, Asn362, Asn395, Asn416, Asn443, Asn511, Asn546, Asn582, Asn590, Asn640, Asn680, and Asn752
- NX_Q9NR97 (NX_Q9NR97-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TLR8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences TLR8 Antibody and TLR8 Monoclonal Antibody
- G Biosciences Immunotag™ TLR8 Antibody
- BioLegend CD288 (TLR8) Antibody
-
Custom Antibody ServicesOriGene Antibodies for TLR8
- AM08388PU-N
- AP07372PU-N
- AP07644PU-N
- CF810174
- CF810175
- CF810191
- DDX0480A488-100
- DDX0480A546-100
- DDX0480A647-100
- DDX0480B-100
- DDX0480P-100
- DDX0481A488-100
- DDX0481A546-100
- DDX0481P-100
- DDX0482A488-100
- DDX0482P-100
- DDX0483A488-100
- DDX0483A546-100
- DDX0483A647-100
- DDX0483B-100
- DDX0483P-100
- SP2079P
- TA306159
- TA319918
- TA319919
- TA322065
- TA322066
- TA327055
- TA349553
- TA810174
- TA810174S
- TA810175
- TA810175S
- TA810191
- TA810191S
- Novus Biologicals Antibodies for TLR8
-
Abcam antibodies for TLR8
- Invitrogen Antibodies for TLR8 (AFLGC-TLR8)
- antibodies-online: Show 70 available TLR8 Antibodies ranked by validation data
- Compare Top TLR8 Antibodies
-
Recommended
- 142 WB Antibodies (anti-human)
- 26 FACS Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 89 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR8
- Sino Biological Antibodies for TLR8
Protein products for research
-
OriGene Purified Proteins for TLR8
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR8
- Origene Custom Protein Services for TLR8
-
Abcam proteins for TLR8
No data available for DME Specific Peptides for TLR8 Gene
Domains & Families for TLR8 Gene
Gene Families for TLR8 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted membrane proteins
Protein Domains for TLR8 Gene
- InterPro:
- Blocks:
-
- Cysteine-rich flanking region, C-terminal
- TIR domain
- ProtoNet:
Suggested Antigen Peptide Sequences for TLR8 Gene
- GenScript: Design optimal peptide antigens:
-
- TLR8 (D1CS76_HUMAN)
- Toll-like receptor 8 (Q495P6_HUMAN)
- Toll-like receptor 8 (Q495P7_HUMAN)
- Toll-like receptor 8 (TLR8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NR97- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR8 Gene
Molecular function for TLR8 Gene
- UniProtKB/Swiss-Prot Function:
- Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by RNAs having enough uridines.
Phenotypes From GWAS Catalog for TLR8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | 16123302 |
| GO:0003723 | RNA binding | TAS | 16123302 |
| GO:0003725 | double-stranded RNA binding | IDA | 16111635 |
| GO:0003727 | single-stranded RNA binding | IDA | 14976262 |
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
Phenotypes for TLR8 Gene
- MGI mutant phenotypes for TLR8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TLR8:
Animal Models for TLR8 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for TLR8
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TLR8 - Starting at $85 >
- * TLR8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TLR8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR8
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR8
miRNA for TLR8 Gene
- miRTarBase miRNAs that target TLR8
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR8
- Browse OriGene Inhibitory RNA Products For TLR8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR8
Clone products for research
- Applied Biological Materials (abm): Clones for TLR8 - Starting at $45 >
- * TLR8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TLR8
- Addgene plasmids for TLR8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR8
Cell Lines for research
-
Horizon Cell Lines for TLR8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR8 Gene
Localization for TLR8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR8 Gene
- Endosome membrane. Single-pass type I membrane protein. Note=Endosomal localization confers distinctive proteolytic processing. {ECO:0000269 PubMed:25297876}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| lysosome | 5 |
| golgi apparatus | 4 |
| extracellular | 3 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0009897 | external side of plasma membrane | IDA | 24942581 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR8 Gene
Pathways & Interactions for TLR8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-like Receptor Signaling Pathway | ||
| 3 | Toll-Like receptor Signaling Pathways | ||
| 4 | NF-KappaB Family Pathway |
NF-KappaB (p50-p65) Pathway
.72
|
NF-KappaB Family Pathway
.72
|
| 5 | TRAF Pathway |
TRAF Pathway
.42
|
Toll-Like Receptors Pathway
.41
|
Pathways by source for TLR8 Gene
4 BioSystems pathways for TLR8 Gene
9 Reactome pathways for TLR8 Gene
3 KEGG pathways for TLR8 Gene
1 GeneGo (Thomson Reuters) pathway for TLR8 Gene
- Immune response TLR signaling pathways
1 Tocris pathway for TLR8 Gene
8 Qiagen pathways for TLR8 Gene
- Colorectal Cancer Metastasis
- NF-KappaB (p50-p65) Pathway
- NF-KappaB Family Pathway
- Phagocytosis of Microbes
- Tec Kinases Signaling
1 Cell Signaling Technology pathway for TLR8 Gene
1 GeneTex pathway for TLR8 Gene
Interacting Proteins for TLR8 Gene
Selected Interacting proteins:
Q9NR97-TLR8_HUMAN
ENSP00000312082
for TLR8 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TLR8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001774 | microglial cell activation | IEA | -- |
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0002224 | toll-like receptor signaling pathway | IEA,TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | IEA | -- |
Drugs & Compounds for TLR8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Imiquimod | Approved, Investigational | Pharma | Agonist, Target | TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist | 163 | |
| Pembrolizumab | Approved | Pharma | 1425 | |||
| Resiquimod | Investigational | Pharma | Target, agonist | Toll-like receptor 7 (TLR7) agonist | 0 | |
| Motesanib | Investigational | Pharma | antagonist | Inhibitor of Flk-1/Flt-4/PDGFR-/c-Kit, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Antibodies | Pharma | 8293 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| R848 |
|
Agonist |
|
(1) ApexBio Compounds for TLR8 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Resiquimod (R-848) | Immune response modifier | 144875-48-9 |
Transcripts for TLR8 Gene
mRNA/cDNA for TLR8 Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000218032 4216 nts (view in UCSC)
- ENST00000311912 3367 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TLR8 - Starting at $85 >
- * TLR8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TLR8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR8
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR8
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR8
- Browse OriGene Inhibitory RNA Products For TLR8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR8
Clone products for research
- Applied Biological Materials (abm): Clones for TLR8 - Starting at $45 >
- * TLR8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TLR8
- Addgene plasmids for TLR8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR8
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | - | - | - | ||||||||||
| SP3: |
Relevant External Links for TLR8 Gene
- GeneLoc Exon Structure for
- TLR8
Expression for TLR8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for TLR8 Gene
This gene is overexpressed in Whole Blood (x43.3).
This gene is overexpressed in Monocytes (36.3) and Blymphocyte (29.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR8 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR8
SOURCE GeneReport for Unigene cluster for TLR8 Gene:
Hs.660543mRNA Expression by UniProt/SwissProt for TLR8 Gene:
Q9NR97-TLR8_HUMAN
Tissue specificity:
Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.
Evidence on tissue expression from TISSUES for TLR8 Gene
- Liver(4.5)
- Spleen(3.3)
- Blood(3.2)
- Lymph node(3)
- Bone marrow(2.7)
- Intestine(2.7)
- Lung(2.6)
- Heart(2.3)
- Kidney(2.1)
- Skin(2.1)
- Nervous system(2)
Primer products for research
-
OriGene qPCR primer pairs for TLR8
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR8 Gene
Orthologs for TLR8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TLR8 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TLR8 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | TLR8 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tlr8 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tlr8 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TLR8 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100495962 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100332583 30 |
|
||
| TLR8 (3 of 3) 31 |
|
OneToMany | |||
| tlr8a 31 |
|
OneToMany | |||
| tlr8b 31 |
|
OneToMany |
- Species where no ortholog for TLR8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TLR8 Gene
- ENSEMBL:
- Gene Tree for TLR8 (if available)
- TreeFam:
- Gene Tree for TLR8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TLR8: view image
Paralogs for TLR8 Gene
Paralogs for TLR8 Gene
(2) SIMAP similar genes for TLR8 Gene using alignment to 3 proteins:
- TLR8_HUMAN
- Q495P6_HUMAN
- Q495P7_HUMAN
Variants for TLR8 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR8 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs151096932 | Likely Benign: not provided | 12,919,092(+) |
A/G NM_138636.5(TLR8):c.52A>G (p.Ile18Val) |
MISSENSE | |
| rs1569113445 | Association: Osteoarthritis | 12,906,527(+) |
G/C NM_138636.5(TLR8):c.-180G>C |
||
| rs1569113447 | Association: Osteoarthritis | 12,906,538(+) |
T/A NM_138636.5(TLR8):c.-169T>A |
||
| rs370464823 | Likely Benign: not provided | 12,920,267(+) |
C/T NM_138636.5(TLR8):c.1227C>T (p.Ile409=) |
SYNONYMOUS | |
| rs5744079 | Benign: not provided | 12,919,601(+) |
C/T NM_138636.5(TLR8):c.561C>T (p.Cys187=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3573586 | CNV | loss | 25503493 |
Residual Variation Intolerance Score:
20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLR8 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR8 Gene
Disorders for TLR8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| superficial basal cell carcinoma |
|
|
| anogenital venereal wart |
|
|
| crimean-congo hemorrhagic fever |
|
|
| viral infectious disease |
|
|
| chikungunya |
|
|
Search TLR8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TLR8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TLR8 Gene
Publications for TLR8 Gene
- Three novel mammalian toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X … Beutler B (European cytokine network 2000) 2 3 4 23
- Toll-like receptor 8 polymorphism and coronary artery disease. (PMID: 18985439) Chen Z … Tang C (Molecular biology reports 2009) 3 23 41
- Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. (PMID: 18927625) Davila S … Seielstad M (PLoS genetics 2008) 3 23 41
- A functional toll-like receptor 8 variant is associated with HIV disease restriction. (PMID: 18605904) Oh DY … Schumann RR (The Journal of infectious diseases 2008) 3 23 41
- Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PMID: 17964520) Cheng PL … Lin TM (Translational research : the journal of laboratory and clinical medicine 2007) 3 23 41
ExternalLinks
Products for TLR8 Gene
- Custom Antibody ServicesOriGene Antibodies for TLR8
- AM08388PU-N
- AP07372PU-N
- AP07644PU-N
- CF810174
- CF810175
- CF810191
- DDX0480A488-100
- DDX0480A546-100
- DDX0480A647-100
- DDX0480B-100
- DDX0480P-100
- DDX0481A488-100
- DDX0481A546-100
- DDX0481P-100
- DDX0482A488-100
- DDX0482P-100
- DDX0483A488-100
- DDX0483A546-100
- DDX0483A647-100
- DDX0483B-100
- DDX0483P-100
- SP2079P
- TA306159
- TA319918
- TA319919
- TA322065
- TA322066
- TA327055
- TA349553
- TA810174
- TA810174S
- TA810175
- TA810175S
- TA810191
- TA810191S
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TLR8
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR8
- Origene Custom Protein Services for TLR8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR8
- Browse OriGene Inhibitory RNA Products For TLR8
- OriGene qPCR primer pairs for TLR8
- OriGene CRISPR knockouts for TLR8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TLR8
- Sino Biological Human cDNA Clone for TLR8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for TLR8
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TLR8
- Novus Biologicals proteins and lysates for TLR8
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TLR8
- Abcam proteins for TLR8
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for TLR8
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TLR8 (AFLGC-TLR8)
- ApexBio compounds for TLR8
- VectorBuilder Custom and pre-made DNA vectors for TLR8 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TLR8 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TLR8 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TLR8 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TLR8
- Addgene plasmids for TLR8
- antibodies-online: Show 70 available TLR8 Antibodies ranked by validation data
- Compare Top TLR8 Antibodies
- Recommended
- 142 WB Antibodies (anti-human)
- 26 FACS Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 89 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 21 available TLR8 Elisa Kits ranked by validation data
- Compare Top TLR8 Elisa Kits
- antibodies-online: Show 13 available TLR8 Proteins ranked by validation data
- Compare Top TLR8 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TLR8
- Search Santa Cruz Biotechnology (SCBT) for TLR8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TLR8
- Horizon Cell Lines for TLR8
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TLR8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR8
Sources for TLR8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB