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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
TLR8 (Toll Like Receptor 8) is a Protein Coding gene. Diseases associated with TLR8 include Superficial Basal Cell Carcinoma and Crimean-Congo Hemorrhagic Fever. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include RNA binding and drug binding. An important paralog of this gene is TLR7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IDA | 16123302 |
GO:0003723 | RNA binding | TAS | 16123302 |
GO:0003725 | double-stranded RNA binding | IDA | 16111635 |
GO:0003727 | single-stranded RNA binding | IDA | 14976262 |
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0009897 | external side of plasma membrane | IDA | 24942581 |
GO:0010008 | endosome membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Toll-like Receptor Signaling Pathway | ||
3 | Toll-Like receptor Signaling Pathways | ||
4 | NF-KappaB Family Pathway |
NF-KappaB (p50-p65) Pathway
.72
|
NF-KappaB Family Pathway
.72
|
5 | TRAF Pathway |
TRAF Pathway
.42
|
Toll-Like Receptors Pathway
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001774 | microglial cell activation | IEA | -- |
GO:0001932 | regulation of protein phosphorylation | IEA | -- |
GO:0002224 | toll-like receptor signaling pathway | IEA,TAS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Imiquimod | Approved, Investigational | Pharma | Agonist, Target, agonist | TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist | 163 | |
Resiquimod | Investigational | Pharma | Target, agonist | Toll-like receptor 7 (TLR7) agonist | 0 | |
Motesanib | Investigational | Pharma | antagonist | Inhibitor of Flk-1/Flt-4/PDGFR-/c-Kit, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
Resiquimod (R-848) | Pharma | Immune response modifier | 0 | |||
VTX-1463 | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
R848 |
|
Agonist |
|
Compound | Action | Cas Number |
---|---|---|
Resiquimod (R-848) | Immune response modifier | 144875-48-9 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | - | - | - | ||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TLR8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TLR8 30 |
|
||
Dog (Canis familiaris) |
Mammalia | TLR8 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tlr8 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tlr8 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TLR8 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100495962 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100332583 30 |
|
||
TLR8 (3 of 3) 31 |
|
OneToMany | |||
tlr8a 31 |
|
OneToMany | |||
tlr8b 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
739927 | Likely Benign: not provided | 12,919,092(+) | A/G | MISSENSE_VARIANT | |
754403 | Likely Benign: not provided | 12,920,267(+) | C/T | SYNONYMOUS_VARIANT | |
773100 | Benign: not provided | 12,921,287(+) | A/G | SYNONYMOUS_VARIANT | |
784429 | Benign: not provided | 12,919,601(+) | C/T | SYNONYMOUS_VARIANT | |
788047 | Benign: not provided | 12,921,184(+) | G/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3573586 | CNV | loss | 25503493 |
Disorder | Aliases | PubMed IDs |
---|---|---|
superficial basal cell carcinoma |
|
|
crimean-congo hemorrhagic fever |
|
|
viral infectious disease |
|
|
chikungunya |
|
|
dengue hemorrhagic fever |
|
|