The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, a... See more...

Aliases for TLR8 Gene

Aliases for TLR8 Gene

  • Toll Like Receptor 8 2 3 5
  • Toll-Like Receptor 8 2 3 4
  • CD288 2 3
  • CD288 Antigen 4
  • TLR8 5

External Ids for TLR8 Gene

Previous GeneCards Identifiers for TLR8 Gene

  • GC0XP012117
  • GC0XP011690
  • GC0XP012221
  • GC0XP012286
  • GC0XP012684
  • GC0XP012834
  • GC0XP010691

Summaries for TLR8 Gene

Entrez Gene Summary for TLR8 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR8 Gene

TLR8 (Toll Like Receptor 8) is a Protein Coding gene. Diseases associated with TLR8 include Superficial Basal Cell Carcinoma and Crimean-Congo Hemorrhagic Fever. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include RNA binding and drug binding. An important paralog of this gene is TLR7.

UniProtKB/Swiss-Prot Summary for TLR8 Gene

  • Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).

Gene Wiki entry for TLR8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR8 Gene

Genomics for TLR8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLR8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ012905 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 600.7 +2.4 2415 5.7 SPI1 TLR8 TLR8-AS1 piR-48209-736 TMSB4X
GH0XJ012945 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 30.5 +45.7 45735 13.1 SP1 CREB1 GATAD2A CTCF ZBTB33 TEAD4 PRDM10 TFE3 LEF1 IKZF1 TLR8 TMSB4X OFD1 TLR8-AS1 TLR7 ATXN3L piR-30444-337 lnc-TMSB4X-5
GH0XJ013073 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +178.5 178457 22.6 CEBPG SP1 POLR2A JUND STAT3 ZNF143 RELA SMAD5 NR2C1 RAD21 piR-32214-702 FAM9C TMSB4X TLR8 TLR7 ENSG00000261030 piR-45605-023 lnc-TMSB4X-1 LOC105373133 ATXN3L
GH0XJ012790 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 -114.8 -114819 2.8 HNRNPL PRDM10 POLR2A LARP7 ZIC2 RBFOX2 PATZ1 EZH2 ZNF341 ZFX PRPS2 TLR8 TLR8-AS1 piR-43105-682 TLR7
GH0XJ013024 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 11.7 +121.5 121523 6.4 CREB1 ZHX2 FOXA1 RELA ZNF24 REST IKZF2 ATF7 EED ARID3A FAM9C TMSB4X TLR8-AS1 TLR8 LOC105373133 lnc-TMSB4X-10 RF00017-8164
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLR8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR8

Top Transcription factor binding sites by QIAGEN in the TLR8 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • FAC1
  • IRF-7A
  • Sox5
  • STAT1

Genomic Locations for TLR8 Gene

Genomic Locations for TLR8 Gene
chrX:12,906,620-12,923,169
(GRCh38/hg38)
Size:
16,550 bases
Orientation:
Plus strand
chrX:12,924,739-12,941,288
(GRCh37/hg19)
Size:
16,550 bases
Orientation:
Plus strand

Genomic View for TLR8 Gene

Genes around TLR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR8 Gene

Proteins for TLR8 Gene

  • Protein details for TLR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR97-TLR8_HUMAN
    Recommended name:
    Toll-like receptor 8
    Protein Accession:
    Q9NR97
    Secondary Accessions:
    • B3Y654
    • D1CS70
    • D1CS76
    • Q495P4
    • Q6UXL6
    • Q9NYG9

    Protein attributes for TLR8 Gene

    Size:
    1041 amino acids
    Molecular mass:
    119828 Da
    Quaternary structure:
    • Homodimer (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:29155428). Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (By similarity). Interacts with BTK (PubMed:17932028). Interacts with SMPDL3B (By similarity).

    Three dimensional structures from OCA and Proteopedia for TLR8 Gene

    Alternative splice isoforms for TLR8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR8 Gene

Post-translational modifications for TLR8 Gene

  • Ubiquitinated by RNF216; leading to degradation by the proteasome.
  • Proteolytic processing occurs in monocytes and monocyte-derived macrophages by both furin-like proprotein convertase and cathepsins (PubMed:25297876). The cleavage is necessary for dimer formation and subsequent activation (PubMed:26929371).
  • Glycosylation at Asn29, Asn42, Asn80, Asn88, Asn115, Asn160, Asn247, Asn285, Asn293, Asn358, Asn362, Asn395, Asn416, Asn443, Asn511, Asn546, Asn582, Asn590, Asn640, Asn680, and Asn752
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR8 Gene

Antibody Products

  • Abcam antibodies for TLR8

No data available for DME Specific Peptides for TLR8 Gene

Domains & Families for TLR8 Gene

Gene Families for TLR8 Gene

Protein Domains for TLR8 Gene

InterPro:
Blocks:
  • Cysteine-rich flanking region, C-terminal
  • TIR domain
ProtoNet:

Suggested Antigen Peptide Sequences for TLR8 Gene

GenScript: Design optimal peptide antigens:
  • TLR8 (D1CS76_HUMAN)
  • Toll-like receptor 8 (Q495P6_HUMAN)
  • Toll-like receptor 8 (Q495P7_HUMAN)
  • Toll-like receptor 8 (TLR8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NR97

UniProtKB/Swiss-Prot:

TLR8_HUMAN :
  • Belongs to the Toll-like receptor family.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR8: view

Function for TLR8 Gene

Molecular function for TLR8 Gene

UniProtKB/Swiss-Prot Function:
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by RNAs having enough uridines.

Phenotypes From GWAS Catalog for TLR8 Gene

Gene Ontology (GO) - Molecular Function for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16123302
GO:0003723 RNA binding TAS 16123302
GO:0003725 double-stranded RNA binding IDA 16111635
GO:0003727 single-stranded RNA binding IDA 14976262
GO:0004888 transmembrane signaling receptor activity IEA --
genes like me logo Genes that share ontologies with TLR8: view
genes like me logo Genes that share phenotypes with TLR8: view

Animal Models for TLR8 Gene

MGI Knock Outs for TLR8:

Animal Model Products

  • Taconic Biosciences Mouse Models for TLR8

CRISPR Products

miRNA for TLR8 Gene

miRTarBase miRNAs that target TLR8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR8 Gene

Localization for TLR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR8 Gene

Endosome membrane. Single-pass type I membrane protein. Note=Endosomal localization confers distinctive proteolytic processing. {ECO:0000269 PubMed:25297876}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR8 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 5
lysosome 5
golgi apparatus 4
extracellular 3
cytoskeleton 3
mitochondrion 3
peroxisome 3
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IBA 21873635
GO:0009897 external side of plasma membrane IDA 24942581
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with TLR8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR8 Gene

Pathways & Interactions for TLR8 Gene

genes like me logo Genes that share pathways with TLR8: view

Pathways by source for TLR8 Gene

1 Tocris pathway for TLR8 Gene
8 Qiagen pathways for TLR8 Gene
  • Colorectal Cancer Metastasis
  • NF-KappaB (p50-p65) Pathway
  • NF-KappaB Family Pathway
  • Phagocytosis of Microbes
  • Tec Kinases Signaling
1 Cell Signaling Technology pathway for TLR8 Gene
1 GeneTex pathway for TLR8 Gene

SIGNOR curated interactions for TLR8 Gene

Activates:

Gene Ontology (GO) - Biological Process for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002224 toll-like receptor signaling pathway IEA,TAS --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TLR8: view

Drugs & Compounds for TLR8 Gene

(6) Drugs for TLR8 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imiquimod Approved, Investigational Pharma Agonist, Target, agonist TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist 163
Resiquimod Investigational Pharma Target, agonist Toll-like receptor 7 (TLR7) agonist 0
Motesanib Investigational Pharma antagonist Inhibitor of Flk-1/Flt-4/PDGFR-/c-Kit, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Resiquimod (R-848) Pharma Immune response modifier 0
VTX-1463 Pharma 0

(3) Additional Compounds for TLR8 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
R848
Agonist

(1) ApexBio Compounds for TLR8 Gene

Compound Action Cas Number
Resiquimod (R-848) Immune response modifier 144875-48-9
genes like me logo Genes that share compounds with TLR8: view

Drug Products

Transcripts for TLR8 Gene

mRNA/cDNA for TLR8 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR8

Alternative Splicing Database (ASD) splice patterns (SP) for TLR8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: - -
SP2: - - -
SP3:

Relevant External Links for TLR8 Gene

GeneLoc Exon Structure for
TLR8

Expression for TLR8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR8 Gene

This gene is overexpressed in Whole Blood (x43.3).

Protein differential expression in normal tissues from HIPED for TLR8 Gene

This gene is overexpressed in Monocytes (36.3) and Blymphocyte (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR8 Gene



Protein tissue co-expression partners for TLR8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR8

SOURCE GeneReport for Unigene cluster for TLR8 Gene:

Hs.660543

mRNA Expression by UniProt/SwissProt for TLR8 Gene:

Q9NR97-TLR8_HUMAN
Tissue specificity: Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.

Evidence on tissue expression from TISSUES for TLR8 Gene

  • Liver(4.6)
  • Spleen(3.9)
  • Blood(3.9)
  • Lymph node(3.7)
  • Intestine(3.5)
  • Bone marrow(3.4)
  • Lung(3.3)
  • Heart(3.2)
  • Nervous system(3)
  • Kidney(2.9)
  • Skin(2.8)
  • Muscle(2.7)
  • Bone(2.4)
  • Stomach(2.4)
  • Pancreas(2.3)
  • Eye(2.2)
  • Urine(2.1)
  • Saliva(2.1)
genes like me logo Genes that share expression patterns with TLR8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR8 Gene

Orthologs for TLR8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TLR8 30 31
  • 99.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TLR8 30
  • 80.71 (n)
Dog
(Canis familiaris)
Mammalia TLR8 30 31
  • 80.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tlr8 30 17 31
  • 76.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tlr8 30
  • 76.49 (n)
Oppossum
(Monodelphis domestica)
Mammalia TLR8 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 23 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100495962 30
  • 58.96 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100332583 30
  • 51.7 (n)
TLR8 (3 of 3) 31
  • 43 (a)
OneToMany
tlr8a 31
  • 42 (a)
OneToMany
tlr8b 31
  • 40 (a)
OneToMany
Species where no ortholog for TLR8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TLR8 Gene

ENSEMBL:
Gene Tree for TLR8 (if available)
TreeFam:
Gene Tree for TLR8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLR8: view image

Paralogs for TLR8 Gene

(2) SIMAP similar genes for TLR8 Gene using alignment to 3 proteins:

  • TLR8_HUMAN
  • Q495P6_HUMAN
  • Q495P7_HUMAN
genes like me logo Genes that share paralogs with TLR8: view

Variants for TLR8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR8 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
739927 Likely Benign: not provided 12,919,092(+) A/G MISSENSE_VARIANT
754403 Likely Benign: not provided 12,920,267(+) C/T SYNONYMOUS_VARIANT
773100 Benign: not provided 12,921,287(+) A/G SYNONYMOUS_VARIANT
784429 Benign: not provided 12,919,601(+) C/T SYNONYMOUS_VARIANT
788047 Benign: not provided 12,921,184(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TLR8 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLR8 Gene

Variant ID Type Subtype PubMed ID
esv3573586 CNV loss 25503493

Variation tolerance for TLR8 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR8 Gene

Human Gene Mutation Database (HGMD)
TLR8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLR8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR8 Gene

Disorders for TLR8 Gene

MalaCards: The human disease database

(44) MalaCards diseases for TLR8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
superficial basal cell carcinoma
  • multicentric basal cell carcinoma
crimean-congo hemorrhagic fever
  • chf congo virus
viral infectious disease
  • viral disease
chikungunya
  • chikungunya fever
dengue hemorrhagic fever
  • dengue haemorrhagic fever
- elite association - COSMIC cancer census association via MalaCards
Search TLR8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLR8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TLR8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR8 Gene

Publications for TLR8 Gene

  1. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X … Beutler B (European cytokine network 2000) 2 3 4 23
  2. Toll-like receptor 8 polymorphism and coronary artery disease. (PMID: 18985439) Chen Z … Tang C (Molecular biology reports 2009) 3 23 41
  3. A functional toll-like receptor 8 variant is associated with HIV disease restriction. (PMID: 18605904) Oh DY … Schumann RR (The Journal of infectious diseases 2008) 3 23 41
  4. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. (PMID: 18927625) Davila S … Seielstad M (PLoS genetics 2008) 3 23 41
  5. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PMID: 17964520) Cheng PL … Lin TM (Translational research : the journal of laboratory and clinical medicine 2007) 3 23 41

Products for TLR8 Gene

  • Addgene plasmids for TLR8

Sources for TLR8 Gene