Aliases for TLR8 Gene
External Ids for TLR8 Gene
Previous GeneCards Identifiers for TLR8 Gene
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
GeneCards Summary for TLR8 Gene
TLR8 (Toll Like Receptor 8) is a Protein Coding gene. Diseases associated with TLR8 include Superficial Basal Cell Carcinoma and Crimean-Congo Hemorrhagic Fever. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include RNA binding and drug binding. An important paralog of this gene is TLR7.
UniProtKB/Swiss-Prot Summary for TLR8 Gene
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).