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Aliases for TLR8 Gene

Aliases for TLR8 Gene

  • Toll Like Receptor 8 2 3 5
  • Toll-Like Receptor 8 2 3
  • CD288 Antigen 4
  • CD288 3

External Ids for TLR8 Gene

Previous GeneCards Identifiers for TLR8 Gene

  • GC0XP012117
  • GC0XP011690
  • GC0XP012221
  • GC0XP012286
  • GC0XP012684
  • GC0XP012834
  • GC0XP010691

Summaries for TLR8 Gene

Entrez Gene Summary for TLR8 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR8 Gene

TLR8 (Toll Like Receptor 8) is a Protein Coding gene. Diseases associated with TLR8 include Crimean-Congo Hemorrhagic Fever and Superficial Basal Cell Carcinoma. Among its related pathways are MAPK Pathway and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding and drug binding. An important paralog of this gene is TLR7.

UniProtKB/Swiss-Prot for TLR8 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Wiki entry for TLR8 Gene

Additional gene information for TLR8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR8 Gene

Genomics for TLR8 Gene

GeneHancer (GH) Regulatory Elements for TLR8 Gene

Promoters and enhancers for TLR8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ012905 Promoter/Enhancer 0.7 EPDnew Ensembl 650.7 -0.3 -321 1 TLR8 TLR8-AS1 GC0XP012877 GC0XP012878
GH0XJ012907 Enhancer 0.2 Ensembl 650.7 +1.5 1481 1 TLR8 TLR8-AS1
GH0XJ012945 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 30.5 +45.7 45735 13.1 HDGF PKNOX1 FOXA2 SMAD1 ARNT FEZF1 IRF4 YY1 POLR2B ZNF766 TLR8 OFD1 TMSB4X TLR8-AS1 TLR7 ATXN3L GC0XP012957
GH0XJ013073 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +178.5 178457 22.6 HDGF PKNOX1 ATF1 SMAD1 YBX1 IRF4 ZNF121 ZNF766 ZNF207 ZNF143 FAM9C TMSB4X TLR8 TLR7 ENSG00000261030 PIR38604 LOC105373133
GH0XJ012790 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.8 -114.8 -114828 2 HDGF SIN3A POLR2B GLIS2 RUNX3 ZNF263 SP3 SP5 MAFF ZNF610 PRPS2 OFD1 TLR8 TLR8-AS1 PSMA6P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLR8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLR8 gene promoter:
  • STAT1
  • IRF-7A
  • FAC1
  • CHOP-10
  • C/EBPalpha
  • Sox5

Genomic Locations for TLR8 Gene

Genomic Locations for TLR8 Gene
16,550 bases
Plus strand
16,550 bases
Plus strand

Genomic View for TLR8 Gene

Genes around TLR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR8 Gene

Proteins for TLR8 Gene

  • Protein details for TLR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Toll-like receptor 8
    Protein Accession:
    Secondary Accessions:
    • B3Y654
    • D1CS70
    • D1CS76
    • Q495P4
    • Q6UXL6
    • Q9NYG9

    Protein attributes for TLR8 Gene

    1041 amino acids
    Molecular mass:
    119828 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Homodimer. Interacts with BTK. Interacts with SMPDL3B (By similarity).

    Three dimensional structures from OCA and Proteopedia for TLR8 Gene

    Alternative splice isoforms for TLR8 Gene


neXtProt entry for TLR8 Gene

Post-translational modifications for TLR8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLR8 Gene

No data available for DME Specific Peptides for TLR8 Gene

Domains & Families for TLR8 Gene

Gene Families for TLR8 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TLR8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Toll-like receptor family.
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR8: view

Function for TLR8 Gene

Molecular function for TLR8 Gene

UniProtKB/Swiss-Prot Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Phenotypes From GWAS Catalog for TLR8 Gene

Gene Ontology (GO) - Molecular Function for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16123302
GO:0003723 RNA binding TAS 16123302
GO:0003725 double-stranded RNA binding IDA 16111635
GO:0003727 single-stranded RNA binding IDA 14976262
GO:0004888 transmembrane signaling receptor activity IEA --
genes like me logo Genes that share ontologies with TLR8: view
genes like me logo Genes that share phenotypes with TLR8: view

Animal Models for TLR8 Gene

MGI Knock Outs for TLR8:

Animal Model Products

  • Taconic Biosciences Mouse Models for TLR8

miRNA for TLR8 Gene

miRTarBase miRNAs that target TLR8

Clone Products

  • Addgene plasmids for TLR8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR8 Gene

Localization for TLR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR8 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
lysosome 5
endosome 5
golgi apparatus 4
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009897 external side of plasma membrane IDA 24942581
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with TLR8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR8 Gene

Pathways & Interactions for TLR8 Gene

genes like me logo Genes that share pathways with TLR8: view

Gene Ontology (GO) - Biological Process for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002224 toll-like receptor signaling pathway IEA,TAS --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TLR8: view

No data available for SIGNOR curated interactions for TLR8 Gene

Drugs & Compounds for TLR8 Gene

(6) Drugs for TLR8 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imiquimod Approved, Investigational Pharma Agonist, agonist, Target TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist 148
Resiquimod Investigational Pharma agonist, Target Toll-like receptor 7 (TLR7) agonist 0
Motesanib Investigational Pharma antagonist Inhibitor of Flk-1/Flt-4/PDGFR-/c-Kit, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Resiquimod (R-848) Pharma Immune response modifier 0
VTX-1463 Pharma 0

(3) Additional Compounds for TLR8 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TLR8 Gene

Compound Action Cas Number
Resiquimod (R-848) Immune response modifier 144875-48-9
genes like me logo Genes that share compounds with TLR8: view

Drug Products

Transcripts for TLR8 Gene

mRNA/cDNA for TLR8 Gene

Unigene Clusters for TLR8 Gene

Toll-like receptor 8:
Representative Sequences:

Clone Products

  • Addgene plasmids for TLR8

Alternative Splicing Database (ASD) splice patterns (SP) for TLR8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: - -
SP2: - - -

Relevant External Links for TLR8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLR8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR8 Gene

This gene is overexpressed in Whole Blood (x43.3).

Protein differential expression in normal tissues from HIPED for TLR8 Gene

This gene is overexpressed in Monocytes (36.3) and Blymphocyte (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR8 Gene

Protein tissue co-expression partners for TLR8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLR8 Gene:


SOURCE GeneReport for Unigene cluster for TLR8 Gene:


mRNA Expression by UniProt/SwissProt for TLR8 Gene:

Tissue specificity: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.

Evidence on tissue expression from TISSUES for TLR8 Gene

  • Liver(4.3)
  • Spleen(3.1)
  • Blood(2.9)
  • Lymph node(2.5)
  • Lung(2)
genes like me logo Genes that share expression patterns with TLR8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR8 Gene

Orthologs for TLR8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLR8 34 33
  • 99.42 (n)
(Bos Taurus)
Mammalia TLR8 33
  • 80.71 (n)
(Canis familiaris)
Mammalia TLR8 34 33
  • 80.66 (n)
(Mus musculus)
Mammalia Tlr8 16 34 33
  • 76.73 (n)
(Rattus norvegicus)
Mammalia Tlr8 33
  • 76.49 (n)
(Monodelphis domestica)
Mammalia TLR8 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495962 33
  • 58.96 (n)
(Danio rerio)
Actinopterygii LOC100332583 33
  • 51.7 (n)
TLR8 (3 of 3) 34
  • 43 (a)
tlr8a 34
  • 42 (a)
tlr8b 34
  • 40 (a)
Species where no ortholog for TLR8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR8 Gene

Gene Tree for TLR8 (if available)
Gene Tree for TLR8 (if available)
Evolutionary constrained regions (ECRs) for TLR8: view image

Paralogs for TLR8 Gene

Paralogs for TLR8 Gene

(2) SIMAP similar genes for TLR8 Gene using alignment to 3 proteins:

  • Q495P6_HUMAN
  • Q495P7_HUMAN
genes like me logo Genes that share paralogs with TLR8: view

Variants for TLR8 Gene

Sequence variations from dbSNP and Humsavar for TLR8 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000037346 -- 12,918,335(+) G/A intron_variant
rs1000317624 -- 12,911,866(+) T/G intron_variant
rs1000650274 -- 12,914,161(+) T/C intron_variant
rs1000732818 -- 12,923,631(+) C/T downstream_transcript_variant
rs1001395926 -- 12,915,743(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLR8 Gene

Variant ID Type Subtype PubMed ID
esv3573586 CNV loss 25503493

Variation tolerance for TLR8 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR8 Gene

Disorders for TLR8 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TLR8 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
crimean-congo hemorrhagic fever
  • chf congo virus
superficial basal cell carcinoma
  • multicentric basal cell carcinoma
  • chikungunya fever
viral infectious disease
  • viral disease
- elite association - COSMIC cancer census association via MalaCards
Search TLR8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLR8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TLR8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR8 Gene

Publications for TLR8 Gene

  1. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X … Beutler B (European cytokine network 2000) 2 3 4 22 58
  2. Toll-like receptor 8 polymorphism and coronary artery disease. (PMID: 18985439) Chen Z … Tang C (Molecular biology reports 2009) 3 22 44 58
  3. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. (PMID: 18927625) Davila S … Seielstad M (PLoS genetics 2008) 3 22 44 58
  4. A functional toll-like receptor 8 variant is associated with HIV disease restriction. (PMID: 18605904) Oh DY … Schumann RR (The Journal of infectious diseases 2008) 3 22 44 58
  5. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PMID: 17964520) Cheng PL … Lin TM (Translational research : the journal of laboratory and clinical medicine 2007) 3 22 44 58

Products for TLR8 Gene

  • Addgene plasmids for TLR8

Sources for TLR8 Gene

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