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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs)... See more...
Aliases for TLR7 Gene
Aliases for TLR7 Gene
External Ids for TLR7 Gene
- HGNC: 15631
- NCBI Entrez Gene: 51284
- Ensembl: ENSG00000196664
- OMIM®: 300365
- UniProtKB/Swiss-Prot: Q9NYK1
Previous GeneCards Identifiers for TLR7 Gene
- GC0XP012078
- GC0XP011651
- GC0XP012181
- GC0XP012246
- GC0XP012644
- GC0XP012795
- GC0XP010651
- GC0XP012885
Summaries for TLR7 Gene
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]
GeneCards Summary for TLR7 Gene
TLR7 (Toll Like Receptor 7) is a Protein Coding gene. Diseases associated with TLR7 include Immunodeficiency 74, Covid19-Related, X-Linked and Superficial Basal Cell Carcinoma. Among its related pathways are Phagocytosis of Microbes and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and double-stranded RNA binding. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot Summary for TLR7 Gene
-
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:27742543).
-
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.
Additional gene information for TLR7 Gene
- HGNC (15631)
- NCBI Entrez Gene (51284)
- Ensembl (ENSG00000196664)
- OMIM® (300365)
- UniProtKB/Swiss-Prot (Q9NYK1)
- Open Targets Platform(ENSG00000196664)
- Monarch Initiative
- Search for TLR7 at DataMed
- Search for TLR7 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR7 Gene
Genomics for TLR7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TLR7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TLR7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR7
- Top Transcription factor binding sites by QIAGEN in the TLR7 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- FOXO4
- IRF-1
- S8
- STAT1
- STAT3
Genomic Locations for TLR7 Gene
Latest Assembly
- chrX:12,867,072-12,890,361
- (GRCh38/hg38)
- Size:
- 23,290 bases
- Orientation:
- Plus strand
Previous Assembly
- chrX:12,885,191-12,908,480
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 23,290 bases
- Orientation:
- Plus strand
- chrX:12,885,202-12,908,499
- (GRCh37/hg19 by Ensembl)
- Size:
- 23,298 bases
- Orientation:
- Plus strand
Genomic View for TLR7 Gene
Genes around TLR7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by HGNC
- Xp22.2 by Entrez Gene
- Xp22.2 by Ensembl
TLR7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLR7 Gene
Proteins for TLR7 Gene
-
Protein details for TLR7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYK1-TLR7_HUMAN
- Recommended name:
- Toll-like receptor 7
- Protein Accession:
- Q9NYK1
- D1CS69
- Q9NR98
Protein attributes for TLR7 Gene
- Size:
- 1049 amino acids
- Molecular mass:
- 120922 Da
- Quaternary structure:
-
- Homodimer (PubMed:27742543). Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (By similarity). Interacts with SMPDL3B (By similarity).
Protein Expression for TLR7 Gene
Post-translational modifications for TLR7 Gene
Other Protein References for TLR7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences TLR7 / CD287 Antibody (LS-B1420) and TLR7 / CD287 Antibody (LS-B4828)
- G Biosciences Immunotag™ TLR7 Antibody
- NSJ Bioreagents TLR7 Antibody
- Novus Biologicals Antibodies for TLR7
-
Abcam antibodies for TLR7
- Invitrogen Antibodies for TLR7 (AFLGC-TLR7)
- antibodies-online: Show 66 available TLR7 Antibodies ranked by validation data
- Compare Top TLR7 Antibodies
-
Recommended
- 194 WB Antibodies (anti-human)
- 29 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 103 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 2 IHC (fro) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR7
Protein products for research
-
OriGene Purified Proteins for TLR7
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR7
- Origene Custom Protein Services for TLR7
- Novus Biologicals proteins for TLR7
-
Abcam proteins for TLR7
No data available for DME Specific Peptides for TLR7 Gene
Domains & Families for TLR7 Gene
Gene Families for TLR7 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted membrane proteins
Protein Domains for TLR7 Gene
- InterPro:
- Blocks:
-
- Cysteine-rich flanking region, N-terminal
- Cysteine-rich flanking region, C-terminal
- TIR domain
- ProtoNet:
Suggested Antigen Peptide Sequences for TLR7 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ94489, Homo sapiens toll-like receptor 7 (TLR7), mRNA (B2R9N9_HUMAN)
- TLR7 (D1CS68_HUMAN)
- TLR7 (D1CS69_HUMAN)
- Toll-like receptor 7 (TLR7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NYK1UniProtKB/Swiss-Prot:
TLR7_HUMAN :- Contains two binding domains, first site for small ligands and second site for ssRNA.
- Belongs to the Toll-like receptor family.
- Domain:
-
- Contains two binding domains, first site for small ligands and second site for ssRNA.
- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR7 Gene
Molecular function for TLR7 Gene
- UniProtKB/Swiss-Prot Function:
- Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:27742543).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by guanosine analogs including deoxyguanosine, 7-thia-8-oxoguanosine or 7-deazaguanosine in a RNA-independent manner.
Phenotypes From GWAS Catalog for TLR7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003725 | double-stranded RNA binding | IDA | 16111635 |
| GO:0003727 | single-stranded RNA binding | ISS | -- |
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:0008144 | drug binding | IEA | -- |
Phenotypes for TLR7 Gene
- MGI mutant phenotypes for TLR7:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for TLR7:
Animal Models for TLR7 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TLR7 - Starting at $85 >
- * TLR7 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TLR7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR7
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR7
miRNA for TLR7 Gene
- miRTarBase miRNAs that target TLR7
-
- hsa-miR-758-3p (MIRT438602)
- hsa-miR-586 (MIRT449486)
- hsa-miR-8087 (MIRT449487)
- hsa-miR-1228-3p (MIRT684065)
- hsa-miR-5089-5p (MIRT684066)
- hsa-miR-5589-5p (MIRT684067)
- hsa-miR-4731-5p (MIRT684068)
- hsa-miR-6778-3p (MIRT684069)
- hsa-miR-6506-5p (MIRT684070)
- hsa-miR-619-5p (MIRT684071)
- hsa-miR-150-5p (MIRT684072)
- hsa-miR-7107-5p (MIRT684073)
- hsa-miR-1234-3p (MIRT684074)
- hsa-miR-6747-3p (MIRT684075)
- hsa-miR-186-3p (MIRT684076)
- hsa-miR-520h (MIRT684077)
- hsa-miR-520g-3p (MIRT684078)
- hsa-miR-512-3p (MIRT684079)
- hsa-miR-520e (MIRT684080)
- hsa-miR-520d-3p (MIRT684081)
- hsa-miR-520c-3p (MIRT684082)
- hsa-miR-520b (MIRT684083)
- hsa-miR-520a-3p (MIRT684084)
- hsa-miR-373-3p (MIRT684085)
- hsa-miR-372-3p (MIRT684086)
- hsa-miR-302e (MIRT684087)
- hsa-miR-302d-3p (MIRT684088)
- hsa-miR-302c-3p (MIRT684089)
- hsa-miR-302b-3p (MIRT684090)
- hsa-miR-302a-3p (MIRT684091)
- hsa-miR-93-5p (MIRT684092)
- hsa-miR-526b-3p (MIRT684093)
- hsa-miR-519d-3p (MIRT684094)
- hsa-miR-20b-5p (MIRT684095)
- hsa-miR-20a-5p (MIRT684096)
- hsa-miR-17-5p (MIRT684097)
- hsa-miR-106b-5p (MIRT684098)
- hsa-miR-106a-5p (MIRT684099)
- hsa-miR-19a-3p (MIRT734729)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR7
- Browse OriGene Inhibitory RNA Products For TLR7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR7
Clone products for research
- Applied Biological Materials (abm): Clones for TLR7 - Starting at $45 >
- * TLR7 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TLR7
- Addgene plasmids for TLR7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR7
Cell Lines for research
-
Horizon Cell Lines for TLR7
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TLR7 Gene
Localization for TLR7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR7 Gene
- Endoplasmic reticulum membrane. Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250 UniProtKB:P58681}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| lysosome | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| extracellular | 3 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005737 | cytoplasm | IDA | 19740627 |
| GO:0005764 | lysosome | ISS | -- |
| GO:0005768 | endosome | ISS | -- |
| GO:0005783 | endoplasmic reticulum | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR7 Gene
Pathways & Interactions for TLR7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-like Receptor Signaling Pathway | ||
| 3 | Toll-Like receptor Signaling Pathways | ||
| 4 | Measles |
.35
|
.33
|
| 5 | Th17 Differentiation Pathway | ||
Pathways by source for TLR7 Gene
4 BioSystems pathways for TLR7 Gene
9 Reactome pathways for TLR7 Gene
5 KEGG pathways for TLR7 Gene
1 GeneGo (Thomson Reuters) pathway for TLR7 Gene
- Immune response TLR signaling pathways
1 Tocris pathway for TLR7 Gene
8 Qiagen pathways for TLR7 Gene
- Colorectal Cancer Metastasis
- NF-KappaB (p50-p65) Pathway
- NF-KappaB Family Pathway
- Phagocytosis of Microbes
- Tec Kinases Signaling
1 Cell Signaling Technology pathway for TLR7 Gene
1 GeneTex pathway for TLR7 Gene
Interacting Proteins for TLR7 Gene
GPS-Prot Interaction Network for TLR7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001774 | microglial cell activation | IEA | -- |
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | IEA | -- |
Drugs & Compounds for TLR7 Gene
(30) Drugs for TLR7 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Imiquimod | Approved, Investigational | Pharma | Agonist, Target | TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist | 163 | |
| Hydroxychloroquine | Approved | Pharma | Target, antagonist, inhibitor | Autophagy inhibitor | 474 | |
| Edetic Acid | Approved, Vet_approved | Pharma | 165 | |||
| Pentetic acid | Approved | Pharma | 165 | |||
| Resiquimod | Investigational | Pharma | Target, agonist | Toll-like receptor 7 (TLR7) agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| R848 |
|
Agonist |
|
(5) Tocris Compounds for TLR7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Imiquimod | Toll-like receptor 7 (TLR7) agonist | 99011-02-6 |
| Pam3CSK4 | TLR1/2 agonist; induces cytokine production | 112208-00-1 |
| Poly(I:C) | TLR3 agonist | 24939-03-5 |
| Resiquimod | Toll-like receptor 7 (TLR7) agonist | 144875-48-9 |
| RWJ 21757 | Toll-like receptor 7 (TLR7) agonist | 121288-39-9 |
(5) ApexBio Compounds for TLR7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Hydroxychloroquine Sulfate | 747-36-4 | |
| Imiquimod | TLR-7 agonist,immunomodulator with antiviral and antitumor activity | 99011-02-6 |
| Imiquimod hydrochloride | Toll-like receptor 7 agonist | 99011-78-6 |
| Imiquimod maleate | Immune response modifier | 896106-16-4 |
| Resiquimod (R-848) | Immune response modifier | 144875-48-9 |
Transcripts for TLR7 Gene
mRNA/cDNA for TLR7 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380659 5003 nts (view in UCSC)
- ENST00000484204 299 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TLR7 - Starting at $85 >
- * TLR7 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TLR7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR7
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR7
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR7
- Browse OriGene Inhibitory RNA Products For TLR7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR7
Clone products for research
- Applied Biological Materials (abm): Clones for TLR7 - Starting at $45 >
- * TLR7 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TLR7
- Addgene plasmids for TLR7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR7
Relevant External Links for TLR7 Gene
- GeneLoc Exon Structure for
- TLR7
Expression for TLR7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
-
Kidney (Urinary System)
- Podocytes Podocyte Layer
-
Epithelial Cells
- Podocytes Podocyte Layer
This gene is overexpressed in Testis (58.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR7 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR7
SOURCE GeneReport for Unigene cluster for TLR7 Gene:
Hs.659215mRNA Expression by UniProt/SwissProt for TLR7 Gene:
Q9NYK1-TLR7_HUMAN
Tissue specificity:
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Evidence on tissue expression from TISSUES for TLR7 Gene
- Spleen(3.6)
- Lymph node(3.6)
- Blood(3.5)
- Liver(2.9)
- Nervous system(2.7)
- Bone marrow(2.6)
- Kidney(2.6)
- Intestine(2.6)
- Heart(2.5)
- Lung(2.4)
- Skin(2.4)
- Muscle(2.1)
- Pancreas(2)
Primer products for research
-
OriGene qPCR primer pairs for TLR7
-
OriGene qPCR primer pairs and template standards for TLR7
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR7 Gene
Orthologs for TLR7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TLR7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TLR7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TLR7 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tlr7 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tlr7 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TLR7 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | TLR7 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TLR7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tlr7 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tlr7 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7896 32 |
|
|
- Species where no ortholog for TLR7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TLR7 Gene
- ENSEMBL:
- Gene Tree for TLR7 (if available)
- TreeFam:
- Gene Tree for TLR7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TLR7: view image
Paralogs for TLR7 Gene
Paralogs for TLR7 Gene
(2) SIMAP similar genes for TLR7 Gene using alignment to 3 proteins:
- TLR7_HUMAN
- B2R9N9_HUMAN
- D1CS68_HUMAN
Variants for TLR7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR7 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 977232 | Pathogenic: Immunodeficiency 74, covid19-related, x-linked | 12,887,636(+) |
CAACT/C NM_016562.4(TLR7):c.2129_2132del (p.Gln710fs) |
FRAMESHIFT | |
| 977233 | Pathogenic: Immunodeficiency 74, covid19-related, x-linked | 12,887,891(+) |
G/T NM_016562.4(TLR7):c.2383G>T (p.Val795Phe) |
MISSENSE | |
| rs140749805 | Benign: not provided | 12,885,869(+) |
A/C NM_016562.4(TLR7):c.361A>C (p.Arg121=) |
SYNONYMOUS | |
| rs149314023 | Benign: not provided | 12,886,163(+) |
G/A NM_016562.4(TLR7):c.655G>A (p.Val219Ile) |
MISSENSE | |
| rs200805413 | Likely Benign: not provided | 12,888,511(+) |
C/G NM_016562.4(TLR7):c.3003C>G (p.Leu1001=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.95;
19.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLR7 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLR7 Gene
Disorders for TLR7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 74, covid19-related, x-linked |
|
|
| superficial basal cell carcinoma |
|
|
| hand, foot and mouth disease |
|
|
| anogenital venereal wart |
|
|
| penile disease |
|
|
Search TLR7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TLR7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TLR7 Gene
Publications for TLR7 Gene
- Three novel mammalian toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X … Beutler B (European cytokine network 2000) 2 3 4 23
- A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. (PMID: 19114863) Oh DY … Schumann RR (AIDS (London, England) 2009) 3 23 41
- Toll-like receptor polymorphisms and age-related macular degeneration. (PMID: 18385087) Edwards AO … Tosakulwong N (Investigative ophthalmology & visual science 2008) 3 23 41
- Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. (PMID: 18088248) Schott E … Berg T (Journal of viral hepatitis 2008) 3 23 41
- Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PMID: 17964520) Cheng PL … Lin TM (Translational research : the journal of laboratory and clinical medicine 2007) 3 23 41
ExternalLinks
Products for TLR7 Gene
- Custom Antibody ServicesOriGene Antibodies for TLR7
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- antibodies-online: Show 66 available TLR7 Antibodies ranked by validation data
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- 194 WB Antibodies (anti-human)
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- 1 IF Antibody (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- antibodies-online: Show 34 available TLR7 Elisa Kits ranked by validation data
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- antibodies-online: Show 13 available TLR7 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for TLR7
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Sources for TLR7 Gene
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