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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
TLR7 (Toll Like Receptor 7) is a Protein Coding gene. Diseases associated with TLR7 include Superficial Basal Cell Carcinoma and Anogenital Venereal Wart. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and double-stranded RNA binding. An important paralog of this gene is TLR8.
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ012866 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE | 606.5 | +0.7 | 654 | 2.9 | RELA POLR2A RCOR1 PKNOX1 EED SIN3A ARID3A ELK1 DPF2 RUNX3 | TLR7 TLR8 | |
GH0XJ012842 | Enhancer | 0.8 | ENCODE | 13.9 | -23.0 | -22968 | 2.7 | GATAD2A NFKBIZ RCOR2 RELA RXRB IRF2 IKZF2 POLR2A YY1 PKNOX1 | MRPL35P4 lnc-FAM9C-5 TLR7 piR-43105-683 lnc-FAM9C-6 PRPS2 | |
GH0XJ012889 | Enhancer | 0.8 | ENCODE | 12.9 | +24.4 | 24398 | 4.1 | SP1 STAT3 RELA TCF12 IKZF2 RCOR1 TRIM22 YY1 PKNOX1 EED | TLR7 TLR8-AS1 TLR8 | |
GH0XJ012894 | Enhancer | 0.8 | FANTOM5 ENCODE | 12.9 | +27.3 | 27299 | 0.4 | CTCF ZNF143 RAD21 TRIM22 IRF3 RUNX3 SMC3 NBN ZNF654 RB1 | TLR7 TLR8-AS1 TLR8 | |
GH0XJ013262 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 7.3 | +396.8 | 396829 | 2.2 | STAT3 RELA TRIM22 POLR2A PKNOX1 ARID3A RELB ZBTB40 NBN BCOR | lnc-TMSB4X-8 TLR7 lnc-ATXN3L-2 lnc-TMSB4X-7 ATXN3L RF00017-8164 FAM9C |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003725 | double-stranded RNA binding | IDA | 16111635 |
GO:0003727 | single-stranded RNA binding | ISS | -- |
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005515 | protein binding | IEA | -- |
GO:0008144 | drug binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005737 | cytoplasm | IDA | 19740627 |
GO:0005764 | lysosome | ISS | -- |
GO:0005768 | endosome | ISS | -- |
GO:0005783 | endoplasmic reticulum | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Toll-like Receptor Signaling Pathway | ||
3 | Toll-Like receptor Signaling Pathways | ||
4 | Measles |
.35
|
.33
|
5 | Th17 Differentiation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001774 | microglial cell activation | IEA | -- |
GO:0001932 | regulation of protein phosphorylation | IEA | -- |
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Imiquimod | Approved, Investigational | Pharma | Agonist, Target, agonist | TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist | 163 | |
Hydroxychloroquine | Approved | Pharma | Target, antagonist, inhibitor | Autophagy inhibitor | 431 | |
Edetic Acid | Approved, Vet_approved | Pharma | 148 | |||
Pentetic acid | Approved | Pharma | 148 | |||
Resiquimod | Investigational | Pharma | Target, agonist | Toll-like receptor 7 (TLR7) agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
R848 |
|
Agonist |
|
Compound | Action | Cas Number |
---|---|---|
Imiquimod | Toll-like receptor 7 (TLR7) agonist | 99011-02-6 |
Pam3CSK4 | TLR1/2 agonist; induces cytokine production | 112208-00-1 |
Poly(I:C) | TLR3 agonist | 24939-03-5 |
Resiquimod | Toll-like receptor 7 (TLR7) agonist | 144875-48-9 |
RWJ 21757 | Toll-like receptor 7 (TLR7) agonist | 121288-39-9 |
Compound | Action | Cas Number |
---|---|---|
Hydroxychloroquine Sulfate | 747-36-4 | |
Imiquimod | TLR-7 agonist,immunomodulator with antiviral and antitumor activity | 99011-02-6 |
Imiquimod hydrochloride | Toll-like receptor 7 agonist | 99011-78-6 |
Imiquimod maleate | Immune response modifier | 896106-16-4 |
Resiquimod (R-848) | Immune response modifier | 144875-48-9 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TLR7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TLR7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TLR7 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tlr7 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tlr7 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TLR7 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | TLR7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TLR7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tlr7 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tlr7 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7896 32 |
|
|
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711171 | Benign: not provided | 12,886,173(+) | T/A | MISSENSE_VARIANT | |
714912 | Benign: not provided | 12,885,869(+) | A/C | SYNONYMOUS_VARIANT | |
725307 | Likely Benign: not provided | 12,885,955(+) | C/T | SYNONYMOUS_VARIANT | |
753150 | Likely Benign: not provided | 12,886,321(+) | G/A | SYNONYMOUS_VARIANT | |
757725 | Likely Benign: not provided | 12,888,511(+) | C/G | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
superficial basal cell carcinoma |
|
|
anogenital venereal wart |
|
|
hand, foot and mouth disease |
|
|
mouth disease |
|
|
viral infectious disease |
|