Aliases for TLR7 Gene
External Ids for TLR7 Gene
Previous GeneCards Identifiers for TLR7 Gene
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
GeneCards Summary for TLR7 Gene
TLR7 (Toll Like Receptor 7) is a Protein Coding gene. Diseases associated with TLR7 include Superficial Basal Cell Carcinoma and Hand, Foot And Mouth Disease. Among its related pathways are Th1 Differentiation Pathway and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and double-stranded RNA binding. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot Summary for TLR7 Gene
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.