Aliases for TLR5 Gene
External Ids for TLR5 Gene
Previous HGNC Symbols for TLR5 Gene
Previous GeneCards Identifiers for TLR5 Gene
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
GeneCards Summary for TLR5 Gene
TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Systemic Lupus Erythematosus 1 and Melioidosis. Among its related pathways are Phagocytosis of Microbes and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and interleukin-1 receptor binding. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot Summary for TLR5 Gene
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).