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Aliases for TLR5 Gene

Aliases for TLR5 Gene

  • Toll Like Receptor 5 2 3 5
  • Toll/Interleukin-1 Receptor-Like Protein 3 2 3 4
  • Systemic Lupus Erythematosus Susceptibility 1 2 3
  • Toll-Like Receptor 5 2 3
  • TIL3 3 4
  • MELIOS 3
  • SLEB1 3
  • SLE1 3

External Ids for TLR5 Gene

Previous HGNC Symbols for TLR5 Gene

  • SLEB1

Previous GeneCards Identifiers for TLR5 Gene

  • GC01M221867
  • GC01M219203
  • GC01M9A0154
  • GC01M9A1397
  • GC01M9A1373
  • GC01M8T1373
  • GC01M221350
  • GC01M223283
  • GC01M193957

Summaries for TLR5 Gene

Entrez Gene Summary for TLR5 Gene

  • This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

GeneCards Summary for TLR5 Gene

TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Melioidosis and Systemic Lupus Erythematosus 1. Among its related pathways are Bacterial infections in CF airways and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and interleukin-1 receptor binding. An important paralog of this gene is TLR8.

UniProtKB/Swiss-Prot for TLR5 Gene

  • Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Wiki entry for TLR5 Gene

Additional gene information for TLR5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR5 Gene

Genomics for TLR5 Gene

GeneHancer (GH) Regulatory Elements for TLR5 Gene

Promoters and enhancers for TLR5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I223142 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.1 -72 2.4 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 POLR2B ZNF213 ZNF416 ZNF143 ENSG00000236846 TLR5 CICP13 CICP5 ENSG00000272750 TAF1A LOC100287497 FBXO28
GH01I223133 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.4 +8.7 8732 2.5 PKNOX1 SIN3A ZNF2 ZNF48 YY1 ZNF143 KLF13 SP3 SP5 REST TLR5 PIR45603
GH01I223176 Enhancer 1.3 FANTOM5 Ensembl ENCODE 17.2 -34.2 -34159 1.9 ELF3 FOXA2 ARID4B THRB ZNF48 RAD21 RARA YY1 IKZF2 THAP11 TLR5 ENSG00000236846 ENSG00000226601 GC01M223148
GH01I223175 Enhancer 1.1 FANTOM5 Ensembl ENCODE 16.7 -32.5 -32496 1.2 MEIS2 CTCF PKNOX1 RXRA MAX REST RAD21 YY1 NFIC ARID2 TLR5 ENSG00000236846 ENSG00000226601 GC01M223148
GH01I223189 Enhancer 1.3 FANTOM5 Ensembl ENCODE 12.6 -47.1 -47092 1.4 HDGF PKNOX1 RB1 BMI1 BATF IRF4 ZNF143 ATF7 ETV6 IKZF2 GC01P223191 TLR5 CICP5 CICP13 ENSG00000272750 ENSG00000236846 ENSG00000226601
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLR5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLR5 gene promoter:

Genomic Locations for TLR5 Gene

Genomic Locations for TLR5 Gene
33,879 bases
Minus strand

Genomic View for TLR5 Gene

Genes around TLR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR5 Gene

Proteins for TLR5 Gene

  • Protein details for TLR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Toll-like receptor 5
    Protein Accession:
    Secondary Accessions:
    • B1AZ05
    • B3Y633
    • B9VJ63
    • D1CS80
    • D3DTB8
    • O15456
    • Q32MI2
    • Q32MI3

    Protein attributes for TLR5 Gene

    858 amino acids
    Molecular mass:
    97834 Da
    Quaternary structure:
    • Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand.

    Three dimensional structures from OCA and Proteopedia for TLR5 Gene

neXtProt entry for TLR5 Gene

Post-translational modifications for TLR5 Gene

  • Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
  • Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • Glycosylation at posLast=3737, posLast=4646, posLast=245245, posLast=342342, isoforms=422, isoforms=595, and posLast=598598

No data available for DME Specific Peptides for TLR5 Gene

Domains & Families for TLR5 Gene

Gene Families for TLR5 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Toll-like receptor family.
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR5: view

Function for TLR5 Gene

Molecular function for TLR5 Gene

GENATLAS Biochemistry:
Drosophila transmembrane receptor Toll homolog 5,specifically expressed in ovary and peripheral monocytes
UniProtKB/Swiss-Prot Function:
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Ontology (GO) - Molecular Function for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005149 interleukin-1 receptor binding IPI 12925853
genes like me logo Genes that share ontologies with TLR5: view
genes like me logo Genes that share phenotypes with TLR5: view

Animal Models for TLR5 Gene

MGI Knock Outs for TLR5:

Clone Products

  • Addgene plasmids for TLR5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR5 Gene

Localization for TLR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR5 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
golgi apparatus 2
endosome 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLR5: view

Pathways & Interactions for TLR5 Gene

genes like me logo Genes that share pathways with TLR5: view

Interacting Proteins for TLR5 Gene

SIGNOR curated interactions for TLR5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA --
GO:0008584 male gonad development IEA --
genes like me logo Genes that share ontologies with TLR5: view

Drugs & Compounds for TLR5 Gene

(6) Drugs for TLR5 Gene - From: ClinicalTrials, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FLAGELLIN Pharma Agonist 0
Pharmaceutical Solutions Pharma 9000

(5) Additional Compounds for TLR5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TLR5: view

Transcripts for TLR5 Gene

Unigene Clusters for TLR5 Gene

Toll-like receptor 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for TLR5

Alternative Splicing Database (ASD) splice patterns (SP) for TLR5 Gene

No ASD Table

Relevant External Links for TLR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR5 Gene

This gene is overexpressed in Whole Blood (x20.5).

Protein differential expression in normal tissues from HIPED for TLR5 Gene

This gene is overexpressed in Ovary (12.1), Platelet (10.6), Cardia (9.7), Adrenal (8.3), Prostate (6.4), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLR5 Gene:


SOURCE GeneReport for Unigene cluster for TLR5 Gene:


mRNA Expression by UniProt/SwissProt for TLR5 Gene:

Tissue specificity: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Evidence on tissue expression from TISSUES for TLR5 Gene

  • Blood(4.5)
  • Nervous system(4.3)
  • Intestine(2.7)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Lung(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with TLR5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR5 Gene

Orthologs for TLR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLR5 33
  • 99.18 (n)
(Bos Taurus)
Mammalia TLR5 33 34
  • 83.26 (n)
(Mus musculus)
Mammalia Tlr5 33 16 34
  • 76.07 (n)
(Rattus norvegicus)
Mammalia Tlr5 33
  • 75.14 (n)
(Canis familiaris)
Mammalia TLR5 33 34
  • 67.71 (n)
(Monodelphis domestica)
Mammalia TLR5 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TLR5 34
  • 54 (a)
(Gallus gallus)
Aves TLR5 33 34
  • 59.8 (n)
(Anolis carolinensis)
Reptilia TLR5 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496647 33
  • 54.13 (n)
(Danio rerio)
Actinopterygii tlr5b 33 34
  • 47.15 (n)
tlr5a 34
  • 35 (a)
Species where no ortholog for TLR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR5 Gene

Gene Tree for TLR5 (if available)
Gene Tree for TLR5 (if available)

Paralogs for TLR5 Gene

Paralogs for TLR5 Gene

genes like me logo Genes that share paralogs with TLR5: view

Variants for TLR5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR5 Gene

A nonsense TLR5 polymorphism, resulting in p.Arg392Ter, confers resistance to melioidosis [MIM:615557], an infection caused by the Gram-negative, flagellated soil saprophyte Burkholderia pseudomallei. Carriers of this hypofunctional TLR5 variant may generate impaired inflammatory responses during melioidosis infection that result in reduced organ failure and lower mortality.
Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus.

Sequence variations from dbSNP and Humsavar for TLR5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs2072493 risk-factor, Legionellosis 223,111,257(-) T/A/C coding_sequence_variant, missense_variant
rs5744168 risk-factor, protective, Legionellosis, Systemic lupus erythematosus, resistance to, 1, Melioidosis, resistance to 223,111,858(-) G/A coding_sequence_variant, stop_gained
rs5744171 benign, not specified 223,111,573(-) G/T coding_sequence_variant, missense_variant
rs5744175 benign, not specified 223,111,102(-) T/A coding_sequence_variant, missense_variant
rs5744177 benign, not specified 223,110,495(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TLR5 Gene

Variant ID Type Subtype PubMed ID
nsv832659 CNV gain 17160897
esv3578454 CNV loss 25503493
esv1122523 CNV insertion 17803354

Variation tolerance for TLR5 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for TLR5 Gene

MalaCards: The human disease database

(18) MalaCards diseases for TLR5 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • melioidosis, susceptibility to
systemic lupus erythematosus 1
  • systemic lupus erythematosus, susceptibility to, 1
legionnaire disease
  • legionnaire disease, susceptibility to
  • pontiac fever
lupus erythematosus
  • systemic lupus erythematosus
- elite association - COSMIC cancer census association via MalaCards
Search TLR5 in MalaCards View complete list of genes associated with diseases


  • Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for TLR5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TLR5: view

No data available for Genatlas for TLR5 Gene

Publications for TLR5 Gene

  1. A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. (PMID: 16027372) Hawn TR … Aderem A (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 22 44 58
  2. A history of recurrent positive selection at the toll-like receptor 5 in primates. (PMID: 19179655) Wlasiuk G … Nachman MW (Molecular biology and evolution 2009) 3 4 22 58
  3. Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus. (PMID: 19473567) Sánchez E … Martin J (Clinical and experimental rheumatology 2009) 3 22 44 58
  4. Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (PMID: 18809506) Moura SB … Magalhães Queiroz DM (Microbes and infection 2008) 3 22 44 58
  5. Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus. (PMID: 17516623) Demirci FY … Kamboh MI (The Journal of rheumatology 2007) 3 22 44 58

Products for TLR5 Gene

Sources for TLR5 Gene

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