Aliases for TLR5 Gene
Aliases for TLR5 Gene
External Ids for TLR5 Gene
- HGNC: 11851
- Entrez Gene: 7100
- Ensembl: ENSG00000187554
- OMIM: 603031
- UniProtKB: O60602
Previous HGNC Symbols for TLR5 Gene
- SLEB1
Previous GeneCards Identifiers for TLR5 Gene
- GC01M221867
- GC01M219203
- GC01M9A0154
- GC01M9A1397
- GC01M9A1373
- GC01M8T1373
- GC01M221350
- GC01M223283
- GC01M193957
Summaries for TLR5 Gene
-
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
GeneCards Summary for TLR5 Gene
TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Melioidosis and Systemic Lupus Erythematosus 1. Among its related pathways are Bacterial infections in CF airways and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and interleukin-1 receptor binding. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot for TLR5 Gene
-
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Additional gene information for TLR5 Gene
- Monarch Initiative
- Search for TLR5 at DataMed
- Search for TLR5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR5 Gene
Genomics for TLR5 Gene
GeneHancer (GH) Regulatory Elements for TLR5 Gene
Promoters and enhancers for TLR5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TLR5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TLR5 gene promoter:
Regulatory Element Products
Genomic Locations for TLR5 Gene
Genomic Locations for TLR5 Gene
- chr1:223,109,404-223,143,282
- (GRCh38/hg38)
- Size:
- 33,879 bases
- Orientation:
- Minus strand
- chr1:223,282,748-223,316,624
- (GRCh37/hg19)
Genomic View for TLR5 Gene
Genes around TLR5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q41 by Ensembl
- 1q41 by Entrez Gene
- 1q41 by HGNC
TLR5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLR5 Gene
Proteins for TLR5 Gene
-
Protein details for TLR5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60602-TLR5_HUMAN
- Recommended name:
- Toll-like receptor 5
- Protein Accession:
- O60602
- B1AZ05
- B3Y633
- B9VJ63
- D1CS80
- D3DTB8
- O15456
- Q32MI2
- Q32MI3
Protein attributes for TLR5 Gene
- Size:
- 858 amino acids
- Molecular mass:
- 97834 Da
- Quaternary structure:
-
- Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand.
Protein Expression for TLR5 Gene
Post-translational modifications for TLR5 Gene
- Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
- Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
- Glycosylation at posLast=3737, posLast=4646, posLast=245245, posLast=342342, isoforms=422, isoforms=595, and posLast=598598
Other Protein References for TLR5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Abcam antibodies for TLR5
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Cloud-Clone Corp. Antibodies for TLR5
- Invitrogen Antibodies for TLR5
- antibodies-online: Search results for 261 available TLR5 Antibodies ranked by validation data
- Compare Top TLR5 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 35 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-mouse)
- 10 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 120 WB Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 28 FACS Antibodies (anti-human)
- 183 WB Antibodies (anti-human)
- GeneTex TLR5 antibody for TLR5
-
Custom Antibody ServicesProSci Antibodies for TLR5
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR5
Protein Products
-
OriGene Purified Proteins for TLR5
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR5
- Origene Custom Protein Services for TLR5
-
Cloud-Clone Corp. Proteins for TLR5
- Search GeneTex for Proteins for TLR5
-
Abcam proteins for TLR5
Assay Products
-
Cloud-Clone Corp. Assay Kits for TLR5
No data available for DME Specific Peptides for TLR5 Gene
Domains & Families for TLR5 Gene
Gene Families for TLR5 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for TLR5 Gene
Suggested Antigen Peptide Sequences for TLR5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60602- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR5 Gene
Molecular function for TLR5 Gene
- GENATLAS Biochemistry:
- Drosophila transmembrane receptor Toll homolog 5,specifically expressed in ovary and peripheral monocytes
- UniProtKB/Swiss-Prot Function:
- Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005149 | interleukin-1 receptor binding | IPI | 12925853 |
Phenotypes for TLR5 Gene
- MGI mutant phenotypes for TLR5:
-
inferred from 4 alleles
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for TLR5:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Strongly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLR5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TLR5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR5 gene
- Search ViGene Biosciences for TLR5
CRISPR Products
-
OriGene CRISPR knockouts for TLR5
- genomics-online: gRNA clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
- Applied Biological Materials CRISPR for TLR5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR5
- GenScript: Design CRISPR guide RNA sequences for TLR5
miRNA for TLR5 Gene
- miRTarBase miRNAs that target TLR5
-
- hsa-mir-6734-5p (MIRT451788)
- hsa-mir-6780b-5p (MIRT451789)
- hsa-mir-542-3p (MIRT451790)
- hsa-mir-4725-3p (MIRT451791)
- hsa-mir-4271 (MIRT451792)
- hsa-mir-6738-5p (MIRT451793)
- hsa-mir-5194 (MIRT451794)
- hsa-mir-1914-3p (MIRT451795)
- hsa-mir-423-5p (MIRT451796)
- hsa-mir-3184-5p (MIRT451797)
- hsa-mir-4645-3p (MIRT451798)
- hsa-mir-3185 (MIRT451799)
- hsa-mir-6783-5p (MIRT451800)
- hsa-mir-297 (MIRT784393)
- hsa-mir-4455 (MIRT785923)
- hsa-mir-4783-5p (MIRT786758)
- hsa-mir-511-3p (MIRT787119)
- hsa-mir-567 (MIRT787728)
- hsa-mir-574-5p (MIRT787887)
- hsa-mir-6867-5p (MIRT789224)
- hsa-mir-933 (MIRT789965)
miRNA Products
- Search ViGene Biosciences for TLR5
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for TLR5
- Browse OriGene Inhibitory RNA Products For TLR5
- genomics-online: shRNA clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR5 gene
Clone Products
- Sino Biological Human cDNA Clone for TLR5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TLR5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLR5
- Applied Biological Materials Clones for TLR5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TLR5
Cell Line Products
-
Horizon Cell Lines for TLR5
-
ViGene Biosciences adenoviral particle packaged cDNA for TLR5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TLR5 gene
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ViGene Biosciences ready-to-package AAV shRNAs for TLR5 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR5 Gene
Localization for TLR5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR5 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 2 |
| golgi apparatus | 2 |
| endosome | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
- Golgi apparatus (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TLR5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Diseases associated with the TLR signaling cascade | ||
| 2 | Activated TLR4 signalling | ||
| 3 | Toll-like receptor signaling pathway | ||
| 4 | Bacterial infections in CF airways | ||
| 5 | Development Slit-Robo signaling | ||
Pathways by source for TLR5 Gene
1 GeneTex pathway for TLR5 Gene
4 BioSystems pathways for TLR5 Gene
11 Reactome pathways for TLR5 Gene
5 GeneGo (Thomson Reuters) pathways for TLR5 Gene
3 R&D Systems pathways for TLR5 Gene
1 Tocris pathway for TLR5 Gene
8 Qiagen pathways for TLR5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0008584 | male gonad development | IEA | -- |
Transcripts for TLR5 Gene
mRNA/cDNA for TLR5 Gene
- (9) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (29) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TLR5
- genomics-online: gRNA clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
- Applied Biological Materials CRISPR for TLR5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR5
- GenScript: Design CRISPR guide RNA sequences for TLR5
miRNA Products
- Search ViGene Biosciences for TLR5
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for TLR5
- Browse OriGene Inhibitory RNA Products For TLR5
- genomics-online: shRNA clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR5 gene
Clone Products
- Sino Biological Human cDNA Clone for TLR5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TLR5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLR5
- Applied Biological Materials Clones for TLR5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TLR5
Expression for TLR5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for TLR5 Gene
This gene is overexpressed in Whole Blood (x20.5).
This gene is overexpressed in Ovary (12.1), Platelet (10.6), Cardia (9.7), Adrenal (8.3), Prostate (6.4), and Testis (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR5 Gene
NURSA nuclear receptor signaling pathways regulating expression of TLR5 Gene:
TLR5SOURCE GeneReport for Unigene cluster for TLR5 Gene:
Hs.604542mRNA Expression by UniProt/SwissProt for TLR5 Gene:
O60602-TLR5_HUMAN
Tissue specificity:
Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
Evidence on tissue expression from TISSUES for TLR5 Gene
- Blood(4.5)
- Nervous system(4.3)
- Intestine(2.7)
- Lymph node(2.6)
- Spleen(2.6)
- Lung(2.4)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for TLR5
- genomics-online: primer clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR5 Gene
Orthologs for TLR5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TLR5 33 |
|
||
| cow (Bos Taurus) |
Mammalia | TLR5 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tlr5 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tlr5 33 |
|
||
| dog (Canis familiaris) |
Mammalia | TLR5 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TLR5 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TLR5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TLR5 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TLR5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496647 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tlr5b 33 34 |
|
||
| tlr5a 34 |
|
OneToMany |
- Species where no ortholog for TLR5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TLR5 Gene
Variants for TLR5 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TLR5 Gene
- TLR5_HUMAN-O60602
- A nonsense TLR5 polymorphism, resulting in p.Arg392Ter, confers resistance to melioidosis [MIM:615557], an infection caused by the Gram-negative, flagellated soil saprophyte Burkholderia pseudomallei. Carriers of this hypofunctional TLR5 variant may generate impaired inflammatory responses during melioidosis infection that result in reduced organ failure and lower mortality.
- TLR5_HUMAN-O60602
- Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus.
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2072493 | risk-factor, Legionellosis | 223,111,257(-) | T/A/C | coding_sequence_variant, missense_variant | |
| rs5744168 | risk-factor, protective, Legionellosis, Systemic lupus erythematosus, resistance to, 1, Melioidosis, resistance to | 223,111,858(-) | G/A | coding_sequence_variant, stop_gained | |
| rs5744171 | benign, not specified | 223,111,573(-) | G/T | coding_sequence_variant, missense_variant | |
| rs5744175 | benign, not specified | 223,111,102(-) | T/A | coding_sequence_variant, missense_variant | |
| rs5744177 | benign, not specified | 223,110,495(-) | T/C | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv832659 | CNV | gain | 17160897 |
| esv3578454 | CNV | loss | 25503493 |
| esv1122523 | CNV | insertion | 17803354 |
Residual Variation Intolerance Score:
87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.28;
76.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLR5 Gene
Disorders for TLR5 Gene
(18) MalaCards diseases for TLR5 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melioidosis |
|
|
| systemic lupus erythematosus 1 |
|
|
| legionnaire disease |
|
|
| legionellosis |
|
|
| lupus erythematosus |
|
|
Search TLR5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TLR5_HUMAN- Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for TLR5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for TLR5 Gene
Publications for TLR5 Gene
- A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. (PMID: 16027372) Hawn TR … Aderem A (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 22 44 58
- A history of recurrent positive selection at the toll-like receptor 5 in primates. (PMID: 19179655) Wlasiuk G … Nachman MW (Molecular biology and evolution 2009) 3 4 22 58
- Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus. (PMID: 19473567) Sánchez E … Martin J (Clinical and experimental rheumatology 2009) 3 22 44 58
- Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (PMID: 18809506) Moura SB … Magalhães Queiroz DM (Microbes and infection 2008) 3 22 44 58
- Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus. (PMID: 17516623) Demirci FY … Kamboh MI (The Journal of rheumatology 2007) 3 22 44 58
Products for TLR5 Gene
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- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TLR5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLR5
- VectorBuilder custom plasmid, inducible vectors for TLR5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLR5
- antibodies-online: Search results for 261 available TLR5 Antibodies ranked by validation data
- Compare Top TLR5 Antibodies
- Recommended
- 183 WB Antibodies (anti-human)
- 28 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 120 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 10 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 13 available TLR5 Elisa Kits ranked by validation data
- Compare Top TLR5 Elisa Kits
- Recommended
- antibodies-online: Search results for 18 available TLR5 Proteins ranked by validation data
- Compare Top TLR5 Proteins
- GeneTex TLR5 antibody for TLR5
- Search GeneTex for Proteins for TLR5
- ViGene Biosciences adenoviral particle packaged cDNA for TLR5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TLR5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TLR5 gene
- Search ViGene Biosciences for TLR5
- Santa Cruz Biotechnology (SCBT) Antibodies for TLR5
- Search Santa Cruz Biotechnology (SCBT) for TLR5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TLR5
- Custom Antibody ServicesProSci Antibodies for TLR5
- Search for TLR5 Proteins at ProSci
- Horizon Cell Lines for TLR5
- genomics-online: cdna clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
- orf clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
- genomics-online: gRNA clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
- genomics-online: primer clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
- genomics-online: shRNA clones - Search results for 102 available TLR5 gene related products
- Overview of 102 available TLR5 gene related products
Sources for TLR5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew