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This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Melioidosis and Systemic Lupus Erythematosus 1. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and interleukin-1 receptor binding. An important paralog of this gene is TLR3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005149 | interleukin-1 receptor binding | IPI | 12925853 |
GO:0005515 | protein binding | IPI | 30158114 |
GO:0038023 | signaling receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Diseases associated with the TLR signaling cascade | ||
2 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
|
|
3 | Activated TLR4 signalling | ||
4 | Toll-like Receptor Signaling Pathway | ||
5 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001819 | positive regulation of cytokine production | IEA | -- |
GO:0002224 | toll-like receptor signaling pathway | IBA | 21873635 |
GO:0002376 | immune system process | IEA | -- |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
GO:0006954 | inflammatory response | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TLR5 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TLR5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tlr5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tlr5 30 |
|
||
Dog (Canis familiaris) |
Mammalia | TLR5 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TLR5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TLR5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TLR5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TLR5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496647 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tlr5b 30 31 |
|
OneToMany | |
tlr5a 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709716 | Benign: not provided | 223,112,165(-) | T/G | SYNONYMOUS_VARIANT | |
709717 | Benign: not provided | 223,112,698(-) | G/C | MISSENSE_VARIANT | |
723575 | Likely Benign: not provided | 223,111,371(-) | T/C | MISSENSE_VARIANT | |
723576 | Likely Benign: not provided | 223,111,389(-) | G/A | MISSENSE_VARIANT | |
775671 | Benign: not provided | 223,111,700(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1122523 | CNV | insertion | 17803354 |
esv3578454 | CNV | loss | 25503493 |
nsv832659 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
melioidosis |
|
|
systemic lupus erythematosus 1 |
|
|
legionnaire disease |
|
|
legionellosis |
|
|
lupus erythematosus |
|
|