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This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacteria... See more...
Aliases for TLR5 Gene
Aliases for TLR5 Gene
External Ids for TLR5 Gene
- HGNC: 11851
- Entrez Gene: 7100
- Ensembl: ENSG00000187554
- OMIM: 603031
- UniProtKB: O60602
Previous HGNC Symbols for TLR5 Gene
- SLEB1
Previous GeneCards Identifiers for TLR5 Gene
- GC01M221867
- GC01M219203
- GC01M9A0154
- GC01M9A1397
- GC01M9A1373
- GC01M8T1373
- GC01M221350
- GC01M223283
- GC01M193957
Summaries for TLR5 Gene
-
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
GeneCards Summary for TLR5 Gene
TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Melioidosis and Systemic Lupus Erythematosus 1. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and interleukin-1 receptor binding. An important paralog of this gene is TLR3.
UniProtKB/Swiss-Prot Summary for TLR5 Gene
-
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).
Additional gene information for TLR5 Gene
- HGNC(11851)
- Entrez Gene(7100)
- Ensembl(ENSG00000187554)
- OMIM(603031)
- UniProtKB(O60602)
- Open Targets Platform(ENSG00000187554)
- Monarch Initiative
- Search for TLR5 at DataMed
- Search for TLR5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR5 Gene
Genomics for TLR5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TLR5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TLR5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR5
- Top Transcription factor binding sites by QIAGEN in the TLR5 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- Cart-1
- Ik-3
- Lhx3a
- LHX3b
- NF-kappaB1
- Sp1
Genomic Locations for TLR5 Gene
Genomic Locations for TLR5 Gene
- chr1:223,108,401-223,143,281
- (GRCh38/hg38)
- Size:
- 34,881 bases
- Orientation:
- Minus strand
- chr1:223,282,748-223,316,624
- (GRCh37/hg19)
- Size:
- 33,877 bases
- Orientation:
- Minus strand
Genomic View for TLR5 Gene
Genes around TLR5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q41 by HGNC
- 1q41 by Entrez Gene
- 1q41 by Ensembl
TLR5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLR5 Gene
Proteins for TLR5 Gene
-
Protein details for TLR5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60602-TLR5_HUMAN
- Recommended name:
- Toll-like receptor 5
- Protein Accession:
- O60602
- B1AZ05
- B3Y633
- B9VJ63
- D1CS80
- D3DTB8
- O15456
- Q32MI2
- Q32MI3
Protein attributes for TLR5 Gene
- Size:
- 858 amino acids
- Molecular mass:
- 97834 Da
- Quaternary structure:
-
- Homodimer (PubMed:22173220). Interacts with MYD88 (via TIR domain) (PubMed:20855887). Interacts with TICAM1 (via TIR domain) (PubMed:20855887). Interacts with UNC93B1; this interaction is essential for proper TLR5 localization to the plasma membrane (PubMed:24778236).
Protein Expression for TLR5 Gene
Post-translational modifications for TLR5 Gene
- Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
- Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
-
Glycosylation at Asn37, Asn46, Asn245, Asn342, Asn422, Asn595, and Asn598
- NX_O60602 (NX_O60602-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TLR5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TLR5 Antibody
- NSJ Bioreagents TLR5 Antibody
-
Custom Antibody ServicesOriGene Antibodies for TLR5
- Novus Biologicals Antibodies for TLR5
-
Abcam antibodies for TLR5
- Invitrogen Antibodies for TLR5 (AFLGC-TLR5)
- antibodies-online: Show 68 available TLR5 Antibodies ranked by validation data
- Compare Top TLR5 Antibodies
-
Recommended
- 192 WB Antibodies (anti-human)
- 24 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 125 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Biorbyt antibodies for TLR5
-
Custom Antibody ServicesProSci Antibodies for TLR5
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR5
- Origene Custom Protein Services for TLR5
-
Abcam proteins for TLR5
Assay Products
No data available for DME Specific Peptides for TLR5 Gene
Domains & Families for TLR5 Gene
Gene Families for TLR5 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for TLR5 Gene
- InterPro:
- Blocks:
-
- Leucine-rich repeat signature
- Cysteine-rich flanking region, C-terminal
- TIR domain
- ProtoNet:
Suggested Antigen Peptide Sequences for TLR5 Gene
- GenScript: Design optimal peptide antigens:
-
- Toll-like receptor 5 (B9VJ61_HUMAN)
- Toll-like receptor 5 (B9VJ63_HUMAN)
- Toll-like receptor 5 (B9VJ65_HUMAN)
- Toll-like receptor 5 (B9VJ68_HUMAN)
- Toll-like receptor 5 (B9VJ69_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60602- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR5 Gene
Molecular function for TLR5 Gene
- UniProtKB/Swiss-Prot Function:
- Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).
- GENATLAS Biochemistry:
- Drosophila transmembrane receptor Toll homolog 5,specifically expressed in ovary and peripheral monocytes
Phenotypes From GWAS Catalog for TLR5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005149 | interleukin-1 receptor binding | IPI | 12925853 |
| GO:0005515 | protein binding | IPI | 30158114 |
| GO:0038023 | signaling receptor activity | IBA | 21873635 |
Phenotypes for TLR5 Gene
- MGI mutant phenotypes for TLR5:
-
inferred from 4 alleles
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- hematopoietic system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for TLR5:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased viability in esophageal squamous lineage
- No cells
Animal Models for TLR5 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for TLR5
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TLR5 - Select products 50% OFF >
- * TLR5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TLR5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR5
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR5
miRNA for TLR5 Gene
- miRTarBase miRNAs that target TLR5
-
- hsa-miR-6734-5p (MIRT451788)
- hsa-miR-6780b-5p (MIRT451789)
- hsa-miR-542-3p (MIRT451790)
- hsa-miR-4725-3p (MIRT451791)
- hsa-miR-4271 (MIRT451792)
- hsa-miR-6738-5p (MIRT451793)
- hsa-miR-5194 (MIRT451794)
- hsa-miR-1914-3p (MIRT451795)
- hsa-miR-423-5p (MIRT451796)
- hsa-miR-3184-5p (MIRT451797)
- hsa-miR-4645-3p (MIRT451798)
- hsa-miR-3185 (MIRT451799)
- hsa-miR-6783-5p (MIRT451800)
- hsa-miR-297 (MIRT784393)
- hsa-miR-4455 (MIRT785923)
- hsa-miR-4783-5p (MIRT786758)
- hsa-miR-511-3p (MIRT787119)
- hsa-miR-567 (MIRT787728)
- hsa-miR-574-5p (MIRT787887)
- hsa-miR-6867-5p (MIRT789224)
- hsa-miR-933 (MIRT789965)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR5
- Browse OriGene Inhibitory RNA Products For TLR5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR5
Clone Products
- Applied Biological Materials (abm): Clones for TLR5 - Select products 50% OFF >
- * TLR5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TLR5
- Addgene plasmids for TLR5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR5
Cell Line Products
-
Horizon Cell Lines for TLR5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR5 Gene
Localization for TLR5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR5 Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 4 |
| cytosol | 4 |
| extracellular | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| lysosome | 3 |
| golgi apparatus | 3 |
| peroxisome | 2 |
- Cytosol (2)
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TLR5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Diseases associated with the TLR signaling cascade | ||
| 2 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
|
|
| 3 | Activated TLR4 signalling | ||
| 4 | Toll-like Receptor Signaling Pathway | ||
| 5 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
Pathways by source for TLR5 Gene
5 BioSystems pathways for TLR5 Gene
11 Reactome pathways for TLR5 Gene
6 KEGG pathways for TLR5 Gene
5 GeneGo (Thomson Reuters) pathways for TLR5 Gene
- Bacterial infections in CF airways
- Immune response Bacterial infections in normal airways
- Immune response TLR signaling pathways
- Mucin expression in CF via IL-6, IL-17 signaling pathways
- Mucin expression in CF via TLRs, EGFR signaling pathways
6 R&D Systems pathways for TLR5 Gene
1 Tocris pathway for TLR5 Gene
8 Qiagen pathways for TLR5 Gene
- Colorectal Cancer Metastasis
- NF-KappaB (p50-p65) Pathway
- NF-KappaB Family Pathway
- Phagocytosis of Microbes
- Tec Kinases Signaling
1 GeneTex pathway for TLR5 Gene
Interacting Proteins for TLR5 Gene
Selected Interacting proteins:
O60602-TLR5_HUMAN
ENSP00000440643
for TLR5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TLR5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001819 | positive regulation of cytokine production | IEA | -- |
| GO:0002224 | toll-like receptor signaling pathway | IBA | 21873635 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
| GO:0006954 | inflammatory response | IBA | 21873635 |
Transcripts for TLR5 Gene
mRNA/cDNA for TLR5 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000407096 459 nts (view in UCSC)
- ENST00000465726 435 nts (view in UCSC)
- ENST00000484766 487 nts (view in UCSC)
- ENST00000540964 4088 nts (view in UCSC)
- ENST00000642471 510 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TLR5 - Select products 50% OFF >
- * TLR5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TLR5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR5
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR5
- Browse OriGene Inhibitory RNA Products For TLR5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR5
Clone Products
- Applied Biological Materials (abm): Clones for TLR5 - Select products 50% OFF >
- * TLR5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TLR5
- Addgene plasmids for TLR5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR5
Relevant External Links for TLR5 Gene
- GeneLoc Exon Structure for
- TLR5
Expression for TLR5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for TLR5 Gene
This gene is overexpressed in Whole Blood (x20.5).
This gene is overexpressed in Ovary (12.1), Platelet (10.6), Cardia (9.7), Adrenal (8.3), Prostate (6.4), and Testis (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR5
SOURCE GeneReport for Unigene cluster for TLR5 Gene:
Hs.604542mRNA Expression by UniProt/SwissProt for TLR5 Gene:
O60602-TLR5_HUMAN
Tissue specificity:
Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781).
Evidence on tissue expression from TISSUES for TLR5 Gene
- Blood(4.7)
- Nervous system(4.7)
- Lymph node(3.8)
- Spleen(3.7)
- Intestine(3.5)
- Liver(3.3)
- Lung(3.2)
- Kidney(3.2)
- Heart(3.2)
- Bone marrow(3.1)
- Skin(3)
- Stomach(2.8)
- Muscle(2.8)
- Thyroid gland(2.6)
- Bone(2.4)
- Pancreas(2.4)
- Gall bladder(2.3)
- Adrenal gland(2.3)
- Eye(2.3)
- Urine(2.2)
- Saliva(2.1)
Primer Products
-
OriGene qPCR primer pairs for TLR5
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR5 Gene
Orthologs for TLR5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TLR5 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | TLR5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tlr5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tlr5 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | TLR5 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TLR5 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TLR5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TLR5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TLR5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496647 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tlr5b 30 31 |
|
OneToMany | |
| tlr5a 31 |
|
OneToMany |
- Species where no ortholog for TLR5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TLR5 Gene
- ENSEMBL:
- Gene Tree for TLR5 (if available)
- TreeFam:
- Gene Tree for TLR5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TLR5: view image
Paralogs for TLR5 Gene
Variants for TLR5 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TLR5 Gene
- TLR5_HUMAN-O60602
- Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus.
- TLR5_HUMAN-O60602
- A nonsense TLR5 polymorphism, resulting in p.Arg392Ter, confers resistance to melioidosis [MIM:615557], an infection caused by the Gram-negative, flagellated soil saprophyte Burkholderia pseudomallei. Carriers of this hypofunctional TLR5 variant may generate impaired inflammatory responses during melioidosis infection that result in reduced organ failure and lower mortality.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR5 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709716 | Benign: not provided | 223,112,165(-) | T/G | SYNONYMOUS_VARIANT | |
| 709717 | Benign: not provided | 223,112,698(-) | G/C | MISSENSE_VARIANT | |
| 723575 | Likely Benign: not provided | 223,111,371(-) | T/C | MISSENSE_VARIANT | |
| 723576 | Likely Benign: not provided | 223,111,389(-) | G/A | MISSENSE_VARIANT | |
| 775671 | Benign: not provided | 223,111,700(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1122523 | CNV | insertion | 17803354 |
| esv3578454 | CNV | loss | 25503493 |
| nsv832659 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.28;
76.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLR5 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for TLR5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melioidosis |
|
|
| systemic lupus erythematosus 1 |
|
|
| legionnaire disease |
|
|
| legionellosis |
|
|
| lupus erythematosus |
|
|
Search TLR5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TLR5_HUMAN- Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for TLR5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TLR5 Gene
Publications for TLR5 Gene
- A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. (PMID: 16027372) Hawn TR … Aderem A (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 23 41
- A family of human receptors structurally related to Drosophila Toll. (PMID: 9435236) Rock FL … Bazan JF (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 23
- A history of recurrent positive selection at the toll-like receptor 5 in primates. (PMID: 19179655) Wlasiuk G … Nachman MW (Molecular biology and evolution 2009) 3 4 23
- Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. (PMID: 20016852) Hawn TR … Hooton TM (PloS one 2009) 3 23 41
- Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus. (PMID: 19473567) Sánchez E … Martin J (Clinical and experimental rheumatology 2009) 3 23 41
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Products for TLR5 Gene
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