TLR5 Gene (Protein Coding)

Toll Like Receptor 5

GC01M223109
GIFtS:
48
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacteria... See more...

Aliases for TLR5 Gene

Aliases for TLR5 Gene

  • Toll Like Receptor 5 2 3 5
  • Toll/Interleukin-1 Receptor-Like Protein 3 2 3 4
  • Toll-Like Receptor 5 2 3 4
  • TIL3 2 3 4
  • Systemic Lupus Erythematosus Susceptibility 1 2 3
  • MGC126430 2
  • MGC126431 2
  • FLJ10052 2
  • MELIOS 3
  • SLEB1 3
  • SLE1 3
  • TLR5 5

External Ids for TLR5 Gene

Previous HGNC Symbols for TLR5 Gene

  • SLEB1

Previous GeneCards Identifiers for TLR5 Gene

  • GC01M221867
  • GC01M219203
  • GC01M9A0154
  • GC01M9A1397
  • GC01M9A1373
  • GC01M8T1373
  • GC01M221350
  • GC01M223283
  • GC01M193957

Summaries for TLR5 Gene

Entrez Gene Summary for TLR5 Gene

  • This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

GeneCards Summary for TLR5 Gene

TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Systemic Lupus Erythematosus 1 and Melioidosis. Among its related pathways are Phagocytosis of Microbes and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and interleukin-1 receptor binding. An important paralog of this gene is TLR8.

UniProtKB/Swiss-Prot Summary for TLR5 Gene

  • Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).

Gene Wiki entry for TLR5 Gene

Additional gene information for TLR5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR5 Gene

Genomics for TLR5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TLR5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLR5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR5

Top Transcription factor binding sites by QIAGEN in the TLR5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Cart-1
  • Ik-3
  • Lhx3a
  • LHX3b
  • NF-kappaB1
  • Sp1

Genomic Locations for TLR5 Gene

Latest Assembly
chr1:223,108,401-223,143,281
(GRCh38/hg38)
Size:
34,881 bases
Orientation:
Minus strand

Previous Assembly
chr1:223,282,746-223,316,590
(GRCh37/hg19 by Entrez Gene)
Size:
33,845 bases
Orientation:
Minus strand

chr1:223,282,748-223,316,624
(GRCh37/hg19 by Ensembl)
Size:
33,877 bases
Orientation:
Minus strand

Genomic View for TLR5 Gene

Genes around TLR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TLR5 Gene

Proteins for TLR5 Gene

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  3. Assay products for research

  • Protein details for TLR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60602-TLR5_HUMAN
    Recommended name:
    Toll-like receptor 5
    Protein Accession:
    O60602
    Secondary Accessions:
    • B1AZ05
    • B3Y633
    • B9VJ63
    • D1CS80
    • D3DTB8
    • O15456
    • Q32MI2
    • Q32MI3

    Protein attributes for TLR5 Gene

    Size:
    858 amino acids
    Molecular mass:
    97834 Da
    Quaternary structure:
    • Homodimer (PubMed:22173220). Interacts with MYD88 (via TIR domain) (PubMed:20855887). Interacts with TICAM1 (via TIR domain) (PubMed:20855887). Interacts with UNC93B1; this interaction is essential for proper TLR5 localization to the plasma membrane (PubMed:24778236).

    Three dimensional structures from OCA and Proteopedia for TLR5 Gene

neXtProt entry for TLR5 Gene

Protein Expression for TLR5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TLR5 Gene

  • Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
  • Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • Glycosylation at Asn37, Asn46, Asn245, Asn342, Asn422, Asn595, and Asn598
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for TLR5

No data available for DME Specific Peptides for TLR5 Gene

Domains & Families for TLR5 Gene

Gene Families for TLR5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TLR5 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, C-terminal
  • TIR domain
ProtoNet:

Suggested Antigen Peptide Sequences for TLR5 Gene

GenScript: Design optimal peptide antigens:
  • Toll-like receptor 5 (B9VJ61_HUMAN)
  • Toll-like receptor 5 (B9VJ63_HUMAN)
  • Toll-like receptor 5 (B9VJ65_HUMAN)
  • Toll-like receptor 5 (B9VJ68_HUMAN)
  • Toll-like receptor 5 (B9VJ69_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60602

UniProtKB/Swiss-Prot:

TLR5_HUMAN :
  • Belongs to the Toll-like receptor family.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR5: view

Function for TLR5 Gene

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  2. CRISPR products for research
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  6. Cell Lines for research

Molecular function for TLR5 Gene

UniProtKB/Swiss-Prot Function:
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).
GENATLAS Biochemistry:
Drosophila transmembrane receptor Toll homolog 5,specifically expressed in ovary and peripheral monocytes

Phenotypes From GWAS Catalog for TLR5 Gene

Gene Ontology (GO) - Molecular Function for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005149 interleukin-1 receptor binding IPI 12925853
GO:0005515 protein binding IEA,IPI 30158114
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with TLR5: view
genes like me logo Genes that share phenotypes with TLR5: view

Animal Models for TLR5 Gene

MGI Knock Outs for TLR5:

Animal Models for research

  • Taconic Biosciences Mouse Models for TLR5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR5 Gene

Localization for TLR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR5 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 3
endosome 3
cytosol 3
golgi apparatus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLR5: view

Pathways & Interactions for TLR5 Gene

genes like me logo Genes that share pathways with TLR5: view

Pathways by source for TLR5 Gene

5 GeneGo (Thomson Reuters) pathways for TLR5 Gene
  • Bacterial infections in CF airways
  • Immune response Bacterial infections in normal airways
  • Immune response TLR signaling pathways
  • Mucin expression in CF via IL-6, IL-17 signaling pathways
  • Mucin expression in CF via TLRs, EGFR signaling pathways
1 Tocris pathway for TLR5 Gene
8 Qiagen pathways for TLR5 Gene
  • Colorectal Cancer Metastasis
  • NF-KappaB (p50-p65) Pathway
  • NF-KappaB Family Pathway
  • Phagocytosis of Microbes
  • Tec Kinases Signaling
1 GeneTex pathway for TLR5 Gene

SIGNOR curated interactions for TLR5 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IEA --
GO:0002224 toll-like receptor signaling pathway IEA,IBA 21873635
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA,TAS --
GO:0006954 inflammatory response IEA,IBA 21873635
genes like me logo Genes that share ontologies with TLR5: view

Drugs & Compounds for TLR5 Gene

Products:

  1. Drug products for research

(7) Drugs for TLR5 Gene - From: PharmGKB, ClinicalTrials, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ustekinumab Approved, Investigational Pharma 151
FLAGELLIN Pharma Agonist 0
Pharmaceutical Solutions Pharma 12798

(5) Additional Compounds for TLR5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TLR5: view

Transcripts for TLR5 Gene

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mRNA/cDNA for TLR5 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR5

Alternative Splicing Database (ASD) splice patterns (SP) for TLR5 Gene

No ASD Table

Relevant External Links for TLR5 Gene

GeneLoc Exon Structure for
TLR5

Expression for TLR5 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLR5 Gene

mRNA expression in normal human tissues for TLR5 Gene
mRNA expression by BioGPS for TLR5 GenemRNA expression by GTEx for TLR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR5 Gene

This gene is overexpressed in Whole Blood (x20.5).

Protein differential expression in normal tissues from HIPED for TLR5 Gene

This gene is overexpressed in Ovary (12.1), Platelet (10.6), Cardia (9.7), Adrenal (8.3), Prostate (6.4), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR5

SOURCE GeneReport for Unigene cluster for TLR5 Gene:

Hs.604542

mRNA Expression by UniProt/SwissProt for TLR5 Gene:

O60602-TLR5_HUMAN
Tissue specificity: Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781).

Evidence on tissue expression from TISSUES for TLR5 Gene

  • Blood(4.6)
  • Nervous system(4.5)
  • Lymph node(3)
  • Intestine(3)
  • Spleen(2.9)
  • Lung(2.7)
  • Kidney(2.6)
  • Liver(2.6)
  • Stomach(2.4)
  • Heart(2.3)
  • Bone marrow(2.3)
  • Skin(2.3)
  • Thyroid gland(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with TLR5: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR5 Gene

Orthologs for TLR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TLR5 30
  • 99.18 (n)
Cow
(Bos Taurus)
 Mammalia TLR5 30 31
  • 83.26 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tlr5 30 17 31
  • 76.07 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tlr5 30
  • 75.14 (n)
Dog
(Canis familiaris)
 Mammalia TLR5 30 31
  • 67.71 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TLR5 31
  • 64 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TLR5 31
  • 54 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TLR5 30 31
  • 59.8 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TLR5 31
  • 48 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100496647 30
  • 54.13 (n)
Zebrafish
(Danio rerio)
 Actinopterygii tlr5b 30 31
  • 47.15 (n)
 OneToMany
tlr5a 31
  • 35 (a)
 OneToMany
Species where no ortholog for TLR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TLR5 Gene

ENSEMBL:
Gene Tree for TLR5 (if available)
TreeFam:
Gene Tree for TLR5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLR5: view image

Paralogs for TLR5 Gene

Paralogs for TLR5 Gene

genes like me logo Genes that share paralogs with TLR5: view

Variants for TLR5 Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for TLR5 Gene

TLR5_HUMAN-O60602
Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus.
TLR5_HUMAN-O60602
A nonsense TLR5 polymorphism, resulting in p.Arg392Ter, confers resistance to melioidosis [MIM:615557], an infection caused by the Gram-negative, flagellated soil saprophyte Burkholderia pseudomallei. Carriers of this hypofunctional TLR5 variant may generate impaired inflammatory responses during melioidosis infection that result in reduced organ failure and lower mortality.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs138917078 Likely Benign: not provided 223,111,371(-) T/C
NM_003268.6(TLR5):c.1661A>G (p.Asp554Gly) 		MISSENSE
rs140469324 Likely Benign: not provided 223,111,389(-) G/A
NM_003268.6(TLR5):c.1643C>T (p.Ala548Val) 		MISSENSE
rs2072493 Risk Factor: Legionellosis. - 223,111,257(-) T/Cp.Asn592Ser
NM_003268.6(TLR5):c.1775A>G (p.Asn592Ser) 		MISSENSE
rs5744166 Benign: not provided. - 223,112,698(-) G/Cp.Pro112Ala
NM_003268.6(TLR5):c.334C>G (p.Pro112Ala) 		MISSENSE
rs5744167 Benign: not provided. - 223,112,604(-) T/Gp.Asn143Thr
NM_003268.6(TLR5):c.428A>C (p.Asn143Thr) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TLR5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TLR5 Gene

Variant ID Type Subtype PubMed ID
esv1122523 CNV insertion 17803354
esv3578454 CNV loss 25503493
nsv832659 CNV gain 17160897

Variation tolerance for TLR5 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR5 Gene

Human Gene Mutation Database (HGMD)
TLR5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLR5

SNP Genotyping and Copy Number Assays for research

Disorders for TLR5 Gene

MalaCards: The human disease database

(34) MalaCards diseases for TLR5 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
systemic lupus erythematosus 1
  • systemic lupus erythematosus, susceptibility to, 1
melioidosis
  • melioidosis, susceptibility to
legionnaire disease
  • legionnaire disease, susceptibility to
legionellosis
  • legionella infection
lupus erythematosus
  • lupus
- elite association - COSMIC cancer census association via MalaCards
Search TLR5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TLR5_HUMAN
  • Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for TLR5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TLR5: view

No data available for Genatlas for TLR5 Gene

Publications for TLR5 Gene

  1. A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. (PMID: 16027372) Hawn TR … Aderem A (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 23 41 74
  2. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. (PMID: 14623910) Hawn TR … Aderem A (The Journal of experimental medicine 2003) 3 4 23 74
  3. A family of human receptors structurally related to Drosophila Toll. (PMID: 9435236) Rock FL … Bazan JF (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 23
  4. Impaired TLR5 functionality is associated with survival in melioidosis. (PMID: 23447684) West TE … Skerrett SJ (Journal of immunology (Baltimore, Md. : 1950) 2013) 3 4 74
  5. A history of recurrent positive selection at the toll-like receptor 5 in primates. (PMID: 19179655) Wlasiuk G … Nachman MW (Molecular biology and evolution 2009) 3 4 23

ExternalLinks

View latest publications for TLR5 gene in Mastermind

Products for TLR5 Gene

  • Addgene plasmids for TLR5

Sources for TLR5 Gene