Aliases for TLR3 Gene
External Ids for TLR3 Gene
Previous GeneCards Identifiers for TLR3 Gene
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TLR3 Gene
TLR3 (Toll Like Receptor 3) is a Protein Coding gene. Diseases associated with TLR3 include Encephalopathy, Acute, Infection-Induced 2 and Human Immunodeficiency Virus Type 1. Among its related pathways are TLR3 deficiency - HSE and IKK complex recruitment mediated by RIP1. Gene Ontology (GO) annotations related to this gene include identical protein binding and transmembrane signaling receptor activity. An important paralog of this gene is TLR7.
UniProtKB/Swiss-Prot Summary for TLR3 Gene
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.