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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recog... See more...
Aliases for TLR2 Gene
Aliases for TLR2 Gene
External Ids for TLR2 Gene
- HGNC: 11848
- Entrez Gene: 7097
- Ensembl: ENSG00000137462
- OMIM: 603028
- UniProtKB: O60603
Previous GeneCards Identifiers for TLR2 Gene
- GC04P155458
- GC04P154997
- GC04P155183
- GC04P155186
- GC04P154966
- GC04P154824
- GC04P154606
- GC04P150336
- GC04P154612
Summaries for TLR2 Gene
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for TLR2 Gene
TLR2 (Toll Like Receptor 2) is a Protein Coding gene. Diseases associated with TLR2 include Leprosy 3 and Colorectal Cancer. Among its related pathways are Antigen processing-Cross presentation and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR6.
UniProtKB/Swiss-Prot Summary for TLR2 Gene
-
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).
-
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.
Additional gene information for TLR2 Gene
- HGNC(11848)
- Entrez Gene(7097)
- Ensembl(ENSG00000137462)
- OMIM(603028)
- UniProtKB(O60603)
- Open Targets Platform(ENSG00000137462)
- Monarch Initiative
- Search for TLR2 at DataMed
- Search for TLR2 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR2 Gene
Genomics for TLR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TLR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TLR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR2
- Top Transcription factor binding sites by QIAGEN in the TLR2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CREB
- deltaCREB
- IRF-7A
- PPAR-gamma1
- PPAR-gamma2
- STAT3
Genomic Locations for TLR2 Gene
Genomic Locations for TLR2 Gene
- chr4:153,684,070-153,710,643
- (GRCh38/hg38)
- Size:
- 26,574 bases
- Orientation:
- Plus strand
- chr4:154,605,441-154,627,243
- (GRCh37/hg19)
- Size:
- 21,803 bases
- Orientation:
- Plus strand
Genomic View for TLR2 Gene
Genes around TLR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q31.3 by HGNC
- 4q31.3 by Entrez Gene
- 4q31.3 by Ensembl
TLR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLR2 Gene
Proteins for TLR2 Gene
-
Protein details for TLR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60603-TLR2_HUMAN
- Recommended name:
- Toll-like receptor 2
- Protein Accession:
- O60603
- B3Y612
- D1CS45
- D1CS48
- D1CS49
- O15454
- Q8NI00
Protein attributes for TLR2 Gene
- Size:
- 784 amino acids
- Molecular mass:
- 89838 Da
- Quaternary structure:
-
- Interacts with LY96, TLR1 and TLR6 (via extracellular domain) (PubMed:17889651). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with TICAM1 (PubMed:12471095). Interacts with CNPY3 (By similarity). Interacts with ATG16L1 (PubMed:23376921). Interacts with PPP1R11 (By similarity). Interacts with TICAM2 (PubMed:25385819).
- (Microbial infection) Interacts with M.tuberculosis EsxA.
- (Microbial infection) Interacts with M.bovis MPB83.
- (Microbial infection) Interacts with Staphylococcus aureus protein SSL5.
Protein Expression for TLR2 Gene
Post-translational modifications for TLR2 Gene
- Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
- Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation (PubMed:27805901). Deubiquitinated by USP2 (By similarity).
-
Glycosylation at Asn114, Asn199, Asn414, and Asn442
- NX_O60603 (NX_O60603-1)
-
Ubiquitination at Lys754
- NX_O60603 (NX_O60603-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- TLR2_HUMAN (1816)
Other Protein References for TLR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-TLR2 antibody [N1N2], N-term and Anti-TLR2 antibody
- NSJ Bioreagents TLR2 Antibody (Toll Like Receptor 2) (Mouse Monoclonal)
-
BioLegend
- CD282 (TLR2) Antibody (309707)
- CD282 (TLR2) Antibody (309706)
- CD282 (TLR2) Antibody (309702)
- CD282 (TLR2) Antibody (309705)
- CD282 (TLR2) Antibody (309708)
- CD282 (TLR2) Antibody (309712)
- CD282 (TLR2) Antibody (309714)
- CD282 (TLR2) Antibody (392308)
- CD282 (TLR2) Antibody (392303)
- CD282 (TLR2) Antibody (392302)
- CD282 (TLR2) Antibody (392307)
- CD282 (TLR2) Antibody (392306)
- CD282 (TLR2) Antibody (392305)
- CD282 (TLR2) Antibody (392304)
-
Custom Antibody ServicesOriGene Antibodies for TLR2
- AB0098-200
- AM00193PU-N
- AM01267BT-S
- AM01267FC-N
- AM01267PU-S
- AM01267RP-N
- AM01267RP-T
- AM01317FC-N
- AM01317PU-N
- AM01317RP-N
- AM06467SU-N
- AM08191AC-N
- AM08191BT-N
- AM08191FC-N
- AM08191LE-N
- AM08191PU-N
- AM08191RP-N
- AM20374FC-N
- AM20374PU-S
- AM26199FC-N
- AM26199PU-N
- AM26265BT-N
- AM26265FC-N
- AM26265PU-N
- AM26315PU-N
- AM26329FC-N
- AM26329PU-N
- AM26329RP-N
- AM26329RP-S
- AM32233BT-N
- AM32233PU-N
- AP07367PU-N
- AP11525PU-N
- AP11527PU-N
- DM3601P
- SM1825BS
- TA306125
- TA320478
- TA320479
- TA320480
- TA320481
- TA322878
- TA329156
- TA336413
- TA336461
- TA336462
- TA337143
- TA349550
- Novus Biologicals Antibodies for TLR2
-
Abcam antibodies for TLR2
- Invitrogen Antibodies for TLR2 (AFLGC-Tlr2)
-
Custom Antibody ServicesProSci Antibodies for TLR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR2
- Sino Biological Antibodies for TLR2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR2
- Origene Custom Protein Services for TLR2
- Sino Biological Recombinant Proteins for TLR2
- Sino Biological Cell Lysates for TLR2
- ProSpec Recombinant Proteins for TLR2
- antibodies-online: Search results for available TLR2 related products ranked by validation data
-
Abcam proteins for TLR2
Assay Products
- RayBiotech Human TLR-2 ELISA
- Novus Biologicals ELISA Kits for TLR2
- antibodies-online: Search results for available TLR2 related products ranked by validation data
-
Abcam assays for TLR2
No data available for DME Specific Peptides for TLR2 Gene
Domains & Families for TLR2 Gene
Gene Families for TLR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for TLR2 Gene
- InterPro:
- Blocks:
-
- Leucine-rich repeat signature
- Cysteine-rich flanking region, C-terminal
- TIR domain
- ProtoNet:
Suggested Antigen Peptide Sequences for TLR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Toll-like receptor 2 (C6KIA6_HUMAN)
- Toll-like receptor 2 (C6KIA9_HUMAN)
- Toll-like receptor (D1CS45_HUMAN)
- Toll-like receptor (D1CS48_HUMAN)
- Toll-like receptor (D1CS49_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60603UniProtKB/Swiss-Prot:
TLR2_HUMAN :- Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
- Belongs to the Toll-like receptor family.
- Domain:
-
- Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
- The ATG16L1-binding motif mediates interaction with ATG16L1.
- The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR2 Gene
Molecular function for TLR2 Gene
- UniProtKB/Swiss-Prot Function:
- Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};.
- GENATLAS Biochemistry:
- Drosophila transmembrane receptor Toll homolog 2,with two alternatively spliced isoforms,one expressed in lung,the other in heart,brain,muscle,mediator of liposaccharide (LPS) considered as a receptor,induced cellular signaling,involved in innate immunity through the recruitment of MYD88,against Gram positive bacteria
Enzyme Numbers (IUBMB) for TLR2 Gene
Phenotypes From GWAS Catalog for TLR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IDA | 11274165 |
| GO:0001540 | amyloid-beta binding | ISS | -- |
| GO:0001875 | lipopolysaccharide receptor activity | TAS | 11518816 |
| GO:0005515 | protein binding | IEA,IPI | 11441107 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for TLR2 Gene
- MGI mutant phenotypes for TLR2:
-
inferred from 5 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for TLR2:
Animal Models for TLR2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TLR2 - Select products 50% OFF >
- * TLR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR2
miRNA for TLR2 Gene
- miRTarBase miRNAs that target TLR2
-
- hsa-miR-146a-5p (MIRT000449)
- hsa-miR-105-5p (MIRT001127)
- hsa-miR-19a-3p (MIRT006646)
- hsa-miR-19b-3p (MIRT006647)
- mmu-miR-124-3p (MIRT015951)
- hsa-miR-335-5p (MIRT019178)
- hsa-miR-106b-5p (MIRT020445)
- hsa-miR-154-5p (MIRT052900)
- rno-miR-144-3p (MIRT731164)
- rno-miR-344b-1-3p (MIRT733038)
- hsa-miR-101-5p (MIRT734391)
- hsa-miR-143-3p (MIRT734783)
- hsa-miR-23a-5p (MIRT735134)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR2
- Browse OriGene Inhibitory RNA Products For TLR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR2
Clone Products
- Applied Biological Materials (abm): Clones for TLR2 - Select products 50% OFF >
- * TLR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TLR2
- Addgene plasmids for TLR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR2
Cell Line Products
-
Horizon Cell Lines for TLR2
No data available for Transcription Factor Targets and HOMER Transcription for TLR2 Gene
Localization for TLR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR2 Gene
- Membrane. Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane. Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. {ECO:0000269 PubMed:16880211}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| lysosome | 3 |
| peroxisome | 2 |
- Mitochondria (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 19740627 |
| GO:0005794 | Golgi apparatus | IDA | 16880211 |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 19509287 |
| GO:0009986 | cell surface | IEA,IDA | 12443841 |
Pathways & Interactions for TLR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Toll-like Receptor Signaling Pathway |
.37
|
|
| 4 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
|
|
| 5 | Defensins |
.81
.81
|
|
Pathways by source for TLR2 Gene
5 BioSystems pathways for TLR2 Gene
23 Reactome pathways for TLR2 Gene
20 KEGG pathways for TLR2 Gene
5 GeneGo (Thomson Reuters) pathways for TLR2 Gene
- Bacterial infections in CF airways
- Immune response Bacterial infections in normal airways
- Immune response TLR signaling pathways
- Mucin expression in CF via IL-6, IL-17 signaling pathways
- Mucin expression in CF via TLRs, EGFR signaling pathways
1 Tocris pathway for TLR2 Gene
11 Qiagen pathways for TLR2 Gene
- Colorectal Cancer Metastasis
- MSP-RON Signaling
- NF-KappaB (p50-p65) Pathway
- NF-KappaB Family Pathway
- NTHi-Induced Signaling
1 Cell Signaling Technology pathway for TLR2 Gene
1 GeneTex pathway for TLR2 Gene
Interacting Proteins for TLR2 Gene
Selected Interacting proteins:
O60603-TLR2_HUMAN
ENSP00000260010
for TLR2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TLR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001774 | microglial cell activation | IEA | -- |
| GO:0001775 | cell activation | IDA | 15294986 |
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002237 | response to molecule of bacterial origin | IEA | -- |
Drugs & Compounds for TLR2 Gene
(74) Drugs for TLR2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adapalene | Approved | Pharma | Target, antagonist | RAR尾 and RAR纬 agonist | 90 | |
| Lyme disease vaccine (recombinant OspA) | Approved, Withdrawn | Pharma | Target, other/unknown | 0 | ||
| Tuberculin purified protein derivative | Approved | Pharma | Target, ligand | 0 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3670 | ||
| Cyproterone Acetate | Approved, Investigational | Pharma | Androgen receptor antagonist | 47 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for TLR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Imiquimod | Toll-like receptor 7 (TLR7) agonist | 99011-02-6 |
| Pam3CSK4 | TLR1/2 agonist; induces cytokine production | 112208-00-1 |
| Poly(I:C) | TLR3 agonist | 24939-03-5 |
| Resiquimod | Toll-like receptor 7 (TLR7) agonist | 144875-48-9 |
| RWJ 21757 | Toll-like receptor 7 (TLR7) agonist | 121288-39-9 |
(1) ApexBio Compounds for TLR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Toll-like receptor modulator | TLR antagonist | 926927-42-6 |
Transcripts for TLR2 Gene
mRNA/cDNA for TLR2 Gene
- 8 REFSEQ mRNAs :
- 28 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000260010 4200 nts (view in UCSC)
- ENST00000642580 2979 nts (view in UCSC)
- ENST00000642700 2788 nts (view in UCSC)
- ENST00000643087 630 nts (view in UCSC)
- ENST00000643501 550 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TLR2 - Select products 50% OFF >
- * TLR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR2
- Browse OriGene Inhibitory RNA Products For TLR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR2
Clone Products
- Applied Biological Materials (abm): Clones for TLR2 - Select products 50% OFF >
- * TLR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TLR2
- Addgene plasmids for TLR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR2
Relevant External Links for TLR2 Gene
- GeneLoc Exon Structure for
- TLR2
Expression for TLR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for TLR2 Gene
This gene is overexpressed in Whole Blood (x30.2).
This gene is overexpressed in Monocytes (39.9), Peripheral blood mononuclear cells (16.1), and Milk (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR2
SOURCE GeneReport for Unigene cluster for TLR2 Gene:
Hs.519033mRNA Expression by UniProt/SwissProt for TLR2 Gene:
O60603-TLR2_HUMAN
Tissue specificity:
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Evidence on tissue expression from TISSUES for TLR2 Gene
- Blood(4.8)
- Lung(4.7)
- Spleen(4)
- Lymph node(3.8)
- Intestine(3.7)
- Bone marrow(3.6)
- Heart(3.5)
- Nervous system(3.4)
- Liver(3.4)
- Kidney(3.2)
- Skin(3.1)
- Muscle(2.9)
- Pancreas(2.7)
- Stomach(2.7)
- Bone(2.6)
- Adrenal gland(2.5)
- Eye(2.4)
- Saliva(2.3)
- Urine(2.2)
- Gall bladder(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for TLR2
-
OriGene qPCR primer pairs and template standards for TLR2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR2 Gene
Orthologs for TLR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TLR2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TLR2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TLR2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tlr2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tlr2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TLR2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TLR2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TLR2-2 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| TLR15 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485771 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tlr2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Toll-9 31 |
|
OneToMany |
- Species where no ortholog for TLR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TLR2 Gene
- ENSEMBL:
- Gene Tree for TLR2 (if available)
- TreeFam:
- Gene Tree for TLR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TLR2: view image
Paralogs for TLR2 Gene
Paralogs for TLR2 Gene
(4) SIMAP similar genes for TLR2 Gene using alignment to 8 proteins:
- TLR2_HUMAN
- C6KIA6_HUMAN
- C6KIA9_HUMAN
- D2JYJ0_HUMAN
- D2JYJ1_HUMAN
- D2JYJ2_HUMAN
- D2JYJ3_HUMAN
- D2JYJ4_HUMAN
Pseudogenes.org Pseudogenes for TLR2 Gene
Variants for TLR2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TLR2 Gene
- TLR2_HUMAN-O60603
- Genetic variations in TLR2 are associated with susceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR2 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710730 | Benign: not provided | 153,703,557(+) | T/C | MISSENSE_VARIANT | |
| 715599 | Benign: not provided | 153,704,643(+) | G/A | MISSENSE_VARIANT | |
| 716824 | Likely Benign: not provided | 153,703,178(+) | A/G | MISSENSE_VARIANT | |
| 719093 | Likely Benign: not provided | 153,703,396(+) | T/A | SYNONYMOUS_VARIANT | |
| 723333 | Likely Benign: not provided | 153,704,619(+) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.17;
51.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLR2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for TLR2 Gene
(232) MalaCards diseases for TLR2 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leprosy 3 |
|
|
| colorectal cancer |
|
|
| lepromatous leprosy |
|
|
| lyme disease |
|
|
| filariasis |
|
Search TLR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TLR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TLR2 Gene
Publications for TLR2 Gene
- Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (PMID: 19771452) Velez DR … Scott WK (Human genetics 2010) 3 23 41
- Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. (PMID: 20196868) Motsinger-Reif AA … Sterling TR (BMC medical genetics 2010) 3 23 41
- Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. (PMID: 20227302) Kastelijn EA … van den Bosch JM (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010) 3 23 41
- Genetic association of Toll-like-receptor 4 and tumor necrosis factor-alpha polymorphisms with Plasmodium falciparum blood infection levels. (PMID: 20307689) Basu M … Sengupta S (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2010) 3 23 41
- TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. (PMID: 20348497) Sam-Agudu NA … John CC (The American journal of tropical medicine and hygiene 2010) 3 23 41
ExternalLinks
Products for TLR2 Gene
- View all 29 R&D Systems TLR2 (TLR2) Products
- View all R&D Systems TLR2 (TLR2) Proteins and Enzymes
- View all 24 R&D Systems TLR2 (TLR2) Primary Antibodies
- View all R&D Systems TLR2 (TLR2) ELISAs
- View all 2 R&D Systems TLR2 (TLR2) Proteome Profiler Antibody Arrays
- View all R&D Systems TLR2 (TLR2) cDNA Clones
- Learn more about R&D Systems custom TLR2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for TLR2
- AB0098-200
- AM00193PU-N
- AM01267BT-S
- AM01267FC-N
- AM01267PU-S
- AM01267RP-N
- AM01267RP-T
- AM01317FC-N
- AM01317PU-N
- AM01317RP-N
- AM06467SU-N
- AM08191AC-N
- AM08191BT-N
- AM08191FC-N
- AM08191LE-N
- AM08191PU-N
- AM08191RP-N
- AM20374FC-N
- AM20374PU-S
- AM26199FC-N
- AM26199PU-N
- AM26265BT-N
- AM26265FC-N
- AM26265PU-N
- AM26315PU-N
- AM26329FC-N
- AM26329PU-N
- AM26329RP-N
- AM26329RP-S
- AM32233BT-N
- AM32233PU-N
- AP07367PU-N
- AP11525PU-N
- AP11527PU-N
- DM3601P
- SM1825BS
- TA306125
- TA320478
- TA320479
- TA320480
- TA320481
- TA322878
- TA329156
- TA336413
- TA336461
- TA336462
- TA337143
- TA349550
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR2
- Origene Custom Protein Services for TLR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLR2
- Browse OriGene Inhibitory RNA Products For TLR2
- OriGene qPCR primer pairs for TLR2
- OriGene qPCR primer pairs and template standards for TLR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TLR2
- Sino Biological Human cDNA Clone for TLR2
- Sino Biological Recombinant Proteins for TLR2
- Sino Biological Cell Lysates for TLR2
- Sino Biological Antibodies for TLR2
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TLR2
- Novus Biologicals proteins and lysates for TLR2
- Novus Biologicals ELISA Kits for TLR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TLR2
- Abcam proteins for TLR2
- Abcam assays for TLR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for TLR2
- VectorBuilder Custom and pre-made DNA vectors for TLR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TLR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TLR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TLR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TLR2
- Addgene plasmids for TLR2
- antibodies-online: Show 3 available TLR2 Antibodies ranked by validation data
- Compare Top TLR2 Antibodies
- antibodies-online: Search results for available TLR2 related products ranked by validation data
- antibodies-online: Search results for available TLR2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for TLR2
- Search Santa Cruz Biotechnology (SCBT) for TLR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TLR2
- Custom Antibody ServicesProSci Antibodies for TLR2
- Search for TLR2 Proteins at ProSci
- Horizon Cell Lines for TLR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TLR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TLR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TLR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR2
Sources for TLR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB