The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, a... See more...

Aliases for TLR10 Gene

Aliases for TLR10 Gene

  • Toll Like Receptor 10 2 3 5
  • Toll-Like Receptor 10 2 3 4
  • CD290 2 3
  • CD290 Antigen 4
  • EC 3.2.2.6 4
  • TLR10 5

External Ids for TLR10 Gene

Previous GeneCards Identifiers for TLR10 Gene

  • GC04P039119
  • GC04M038938
  • GC04M038609
  • GC04M038671
  • GC04M038597
  • GC04M038450
  • GC04M038098

Summaries for TLR10 Gene

Entrez Gene Summary for TLR10 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for TLR10 Gene

TLR10 (Toll Like Receptor 10) is a Protein Coding gene. Diseases associated with TLR10 include Melioidosis and Tonsillitis. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TLR1.

UniProtKB/Swiss-Prot Summary for TLR10 Gene

  • Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Gene Wiki entry for TLR10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLR10 Gene

Genomics for TLR10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLR10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J038803 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 612.5 -22.0 -21998 4 CTCF POLR2A BACH1 STAT3 ZNF143 RELA REST SMAD5 RAD21 TCF12 TLR1 TLR10 piR-36393-382 lnc-TLR1-1 TLR6 FAM114A1 MIR574 ENSG00000249685 ENSG00000249207 piR-43107-233
GH04J038779 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 600.7 +1.7 1661 3.5 CTCF POLR2A LARP7 ZNF143 REST SMAD5 RAD21 IKZF2 TRIM22 YY1 TLR10 lnc-TLR10-1 TLR1 TLR6 FAM114A1 MIR574 piR-48965-098 KLF3
GH04J038853 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 -73.4 -73448 5.7 CEBPG SP1 GATAD2A CTCF ZNF512 RFX1 LEF1 IKZF1 BACH1 JUND TLR6 TLR1 TLR10 FAM114A1 KLF3 KLHL5 piR-40110-530
GH04J038759 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.9 +21.0 21037 5.1 CTCF POLR2A RELA REST SMAD5 RAD21 TCF12 IKZF2 RCOR1 TRIM22 TLR1 TLR6 TLR10 FAM114A1 MIR574 ENSG00000271958 KLF3 RNA5SP158 piR-48965-098
GH04J038730 Enhancer 1 Ensembl ENCODE 11.2 +52.0 51989 1.6 SP1 GATAD2A CTCF TEAD4 KDM1A ZNF143 RELA REST RAD21 TCF12 FAM114A1 TLR10 TLR1 TLR6 MIR574 KLF3-AS1 ENSG00000271958 TMEM156 lnc-KLF3-6 lnc-KLF3-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLR10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLR10

Top Transcription factor binding sites by QIAGEN in the TLR10 gene promoter:
  • AML1a
  • FOXO4
  • GATA-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU3F2
  • POU3F2 (N-Oct-5a)

Genomic Locations for TLR10 Gene

Genomic Locations for TLR10 Gene
chr4:38,772,238-38,782,990
(GRCh38/hg38)
Size:
10,753 bases
Orientation:
Minus strand
chr4:38,773,860-38,784,611
(GRCh37/hg19)
Size:
10,752 bases
Orientation:
Minus strand

Genomic View for TLR10 Gene

Genes around TLR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR10 Gene

Proteins for TLR10 Gene

  • Protein details for TLR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXR5-TLR10_HUMAN
    Recommended name:
    Toll-like receptor 10
    Protein Accession:
    Q9BXR5
    Secondary Accessions:
    • A8K7L1
    • B3Y668
    • D1CS21
    • D1CS22
    • Q32MI7
    • Q32MI8
    • Q5FWG4
    • Q6UXL3

    Protein attributes for TLR10 Gene

    Size:
    811 amino acids
    Molecular mass:
    94564 Da
    Quaternary structure:
    • Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).

    Three dimensional structures from OCA and Proteopedia for TLR10 Gene

neXtProt entry for TLR10 Gene

Post-translational modifications for TLR10 Gene

  • Glycosylation at Asn33, Asn36, Asn140, Asn189, Asn236, Asn278, Asn330, Asn416, and Asn427
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TLR10 Gene

Domains & Families for TLR10 Gene

Gene Families for TLR10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TLR10 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, C-terminal
  • TIR domain
ProtoNet:

Suggested Antigen Peptide Sequences for TLR10 Gene

GenScript: Design optimal peptide antigens:
  • Toll-like receptor (D1CS19_HUMAN)
  • Toll-like receptor (D1CS20_HUMAN)
  • Toll-like receptor (D1CS21_HUMAN)
  • Toll-like receptor (D1CS22_HUMAN)
  • Toll-like receptor (D1CS24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BXR5

UniProtKB/Swiss-Prot:

TLR10_HUMAN :
  • The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
  • Belongs to the Toll-like receptor family.
Domain:
  • The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR10: view

Function for TLR10 Gene

Molecular function for TLR10 Gene

UniProtKB/Swiss-Prot Function:
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};.

Enzyme Numbers (IUBMB) for TLR10 Gene

Phenotypes From GWAS Catalog for TLR10 Gene

Gene Ontology (GO) - Molecular Function for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 11267672
GO:0005515 protein binding IPI 15728506
GO:0016787 hydrolase activity IEA --
GO:0038023 signaling receptor activity IBA 21873635
GO:0042802 identical protein binding IPI 15728506
genes like me logo Genes that share ontologies with TLR10: view

Phenotypes for TLR10 Gene

genes like me logo Genes that share phenotypes with TLR10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR10

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLR10 Gene

Localization for TLR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR10 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR10 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 3
peroxisome 3
nucleus 3
endoplasmic reticulum 3
endosome 3
cytosol 3
lysosome 3
cytoskeleton 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane TAS 11267672
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLR10: view

Pathways & Interactions for TLR10 Gene

genes like me logo Genes that share pathways with TLR10: view

Pathways by source for TLR10 Gene

1 Tocris pathway for TLR10 Gene
8 Qiagen pathways for TLR10 Gene
  • Colorectal Cancer Metastasis
  • NF-KappaB (p50-p65) Pathway
  • NF-KappaB Family Pathway
  • Phagocytosis of Microbes
  • Tec Kinases Signaling

Gene Ontology (GO) - Biological Process for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway IBA 21873635
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response NAS 11267672
genes like me logo Genes that share ontologies with TLR10: view

No data available for SIGNOR curated interactions for TLR10 Gene

Drugs & Compounds for TLR10 Gene

No Compound Related Data Available

Transcripts for TLR10 Gene

mRNA/cDNA for TLR10 Gene

5 REFSEQ mRNAs :
29 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLR10

Alternative Splicing Database (ASD) splice patterns (SP) for TLR10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7: - - - - -

Relevant External Links for TLR10 Gene

GeneLoc Exon Structure for
TLR10

Expression for TLR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR10 Gene

This gene is overexpressed in Spleen (x8.0) and Whole Blood (x5.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR10 Gene



Protein tissue co-expression partners for TLR10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLR10

SOURCE GeneReport for Unigene cluster for TLR10 Gene:

Hs.120551

mRNA Expression by UniProt/SwissProt for TLR10 Gene:

Q9BXR5-TLR10_HUMAN
Tissue specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Evidence on tissue expression from TISSUES for TLR10 Gene

  • Spleen(4.8)
  • Lymph node(3.9)
  • Blood(3.8)
  • Intestine(3.5)
  • Nervous system(3.1)
  • Bone marrow(2.9)
  • Heart(2.9)
  • Liver(2.9)
  • Skin(2.8)
  • Lung(2.8)
  • Kidney(2.8)
  • Muscle(2.7)
  • Stomach(2.5)
  • Eye(2.5)
  • Bone(2.4)
  • Pancreas(2.2)
  • Urine(2.1)
  • Saliva(2.1)
genes like me logo Genes that share expression patterns with TLR10: view

Primer Products

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR10 Gene

Orthologs for TLR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TLR10 30 31
  • 99.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TLR10 30 31
  • 87.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TLR10 30 31
  • 85.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tlr10 30
  • 77.75 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TLR10 31
  • 52 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 13 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves TLR1LA 31
  • 48 (a)
ManyToMany
TLR1LB 31
  • 46 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii tlr1 31
  • 33 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Toll-9 31
  • 18 (a)
OneToMany
Species where no ortholog for TLR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TLR10 Gene

ENSEMBL:
Gene Tree for TLR10 (if available)
TreeFam:
Gene Tree for TLR10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLR10: view image

Paralogs for TLR10 Gene

(6) SIMAP similar genes for TLR10 Gene using alignment to 10 proteins:

  • TLR10_HUMAN
  • D1CS19_HUMAN
  • D1CS20_HUMAN
  • D1CS24_HUMAN
  • D1CS26_HUMAN
  • D1CS27_HUMAN
  • D1CS28_HUMAN
  • D1CS29_HUMAN
  • D1CS30_HUMAN
  • D6RHW6_HUMAN
genes like me logo Genes that share paralogs with TLR10: view

Variants for TLR10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLR10 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
719668 Likely Benign: not provided 38,773,336(-) T/C MISSENSE_VARIANT
719669 Benign: not provided 38,774,085(-) G/A SYNONYMOUS_VARIANT
771360 Benign: not provided 38,773,881(-) G/A SYNONYMOUS_VARIANT
775956 Benign: not provided 38,773,784(-) G/A SYNONYMOUS_VARIANT
775957 Benign: not provided 38,774,483(-) G/A NONSENSE

Additional dbSNP identifiers (rs#s) for TLR10 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLR10 Gene

Variant ID Type Subtype PubMed ID
esv275476 CNV gain+loss 21479260

Variation tolerance for TLR10 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.63; 96.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR10 Gene

Human Gene Mutation Database (HGMD)
TLR10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLR10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR10 Gene

Disorders for TLR10 Gene

MalaCards: The human disease database

(40) MalaCards diseases for TLR10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melioidosis
  • melioidosis, susceptibility to
tonsillitis
  • chronic tonsillitis
q fever
  • infection due to coxiella burnetii
crimean-congo hemorrhagic fever
  • chf congo virus
scalp dermatosis
  • dermatosis of scalp
- elite association - COSMIC cancer census association via MalaCards
Search TLR10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLR10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TLR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR10 Gene

Publications for TLR10 Gene

  1. The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. (PMID: 18332149) Nyman T … Nordlund P (The Journal of biological chemistry 2008) 3 4 23
  2. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. (PMID: 18752252) Stevens VL … Rodriguez C (International journal of cancer 2008) 3 23 41
  3. Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases. (PMID: 18776592) Mailaparambil B … Heinzmann A (Disease markers 2008) 3 23 41
  4. Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk. (PMID: 16702361) Zhou XX … Zeng YX (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006) 3 23 41
  5. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. (PMID: 11267672) Chuang T … Ulevitch RJ (Biochimica et biophysica acta 2001) 2 3 4

Products for TLR10 Gene

Sources for TLR10 Gene