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TLR1 Gene(Protein Coding)

Toll Like Receptor 1

GCID:
GC04M038797
GIFtS:
57
Genes Participants
UDN Logo

Aliases for TLR1 Gene

Aliases for TLR1 Gene

  • Toll Like Receptor 1 2 3 5
  • Toll/Interleukin-1 Receptor-Like Protein 3 4
  • Toll-Like Receptor 1 2 3
  • TIL 3 4
  • CD281 Antigen 4
  • TIL. LPRS5 3
  • KIAA0012 4
  • Rsc786 3
  • CD281 3

External Ids for TLR1 Gene

Previous GeneCards Identifiers for TLR1 Gene

  • GC04P039090
  • GC04M038961
  • GC04M038632
  • GC04M038695
  • GC04M038620
  • GC04M038474
  • GC04M038122

Summaries for TLR1 Gene

Entrez Gene Summary for TLR1 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR1 Gene

TLR1 (Toll Like Receptor 1) is a Protein Coding gene. Diseases associated with TLR1 include Leprosy 5 and Lyme Disease. Among its related pathways are Bacterial infections in CF airways and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR1 Gene

  • Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Tocris Summary for TLR1 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

Gene Wiki entry for TLR1 Gene

Additional gene information for TLR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR1 Gene

Genomics for TLR1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TLR1 Gene

Promoters and enhancers for TLR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I038855 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 578.6 -0.5 -479 4 PKNOX1 ATF1 SMAD1 ARNT SIN3A IRF4 GTF3C2 TCF12 ZNF766 ZNF143 TLR6 TLR1 FAM114A1 KLF3 KLHL5
GH04I038803 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 577.2 +51.5 51517 3.4 PKNOX1 FOXA2 SMAD1 RB1 YBX1 ZBTB40 BATF KLF5 IRF4 RAD21 TLR1 TLR6 ZBTB12BP TLR10 MIR574 FAM114A1 ENSG00000249207 ENSG00000249685 HNRNPRP3 RFC1
GH04I038785 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 45.4 +70.7 70686 2.1 CBFB HLF ZBED1 JUNB EBF1 BATF ATF2 IRF4 RELA BCL11A TLR1 TLR6 MIR574 FAM114A1 KLF3 TLR10
GH04I038779 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 26.4 +75.4 75430 3.6 HDGF PKNOX1 SMAD1 BMI1 IRF4 RAD21 ZNF143 ATF7 IKZF2 BCLAF1 TLR10 TLR1 TLR6 FAM114A1 MIR574 RNA5SP158
GH04I038759 Enhancer 1.3 FANTOM5 Ensembl ENCODE 30 +94.9 94885 5.1 HDGF SMAD1 BMI1 YBX1 RAD21 ZNF143 ATF7 ETV6 BCLAF1 IKZF2 TLR1 TLR6 TLR10 MIR574 FAM114A1 ENSG00000271958 KLF3 RNA5SP158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLR1 gene promoter:

Genomic Locations for TLR1 Gene

Genomic Locations for TLR1 Gene
chr4:38,787,555-38,856,817
(GRCh38/hg38)
Size:
69,263 bases
Orientation:
Minus strand
chr4:38,792,298-38,858,438
(GRCh37/hg19)

Genomic View for TLR1 Gene

Genes around TLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TLR1 Gene

Proteins for TLR1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15399-TLR1_HUMAN
    Recommended name:
    Toll-like receptor 1
    Protein Accession:
    Q15399
    Secondary Accessions:
    • D1CS39
    • D1CS41
    • O15452
    • Q32MK3
    • Q32MK4
    • Q9UG90

    Protein attributes for TLR1 Gene

    Size:
    786 amino acids
    Molecular mass:
    90291 Da
    Quaternary structure:
    • Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211, PubMed:17889651). The activation cluster TLR2:TLR1:CD14 forms in response to triacylated lipopeptides (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity).
    SequenceCaution:
    • Sequence=BAA02801.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TLR1 Gene

neXtProt entry for TLR1 Gene

Protein Expression for TLR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TLR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLR1 Gene

Domains & Families for TLR1 Gene

Gene Families for TLR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TLR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TLR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15399

UniProtKB/Swiss-Prot:

TLR1_HUMAN :
  • Belongs to the Toll-like receptor family.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR1: view

Function for TLR1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TLR1 Gene

GENATLAS Biochemistry:
Drosophila transmembrane receptor Toll homolog 1,ubiquitously expressed,with at least two alternatively spliced isoforms,tissue specific,maybe involved in morphogenesis and immune defense
UniProtKB/Swiss-Prot Function:
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Phenotypes From GWAS Catalog for TLR1 Gene

Gene Ontology (GO) - Molecular Function for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10426995
GO:0004888 transmembrane signaling receptor activity NAS 11081518
GO:0005515 protein binding IPI 16880211
GO:0035663 Toll-like receptor 2 binding IPI 16880211
GO:0046982 protein heterodimerization activity IDA 17889651
genes like me logo Genes that share ontologies with TLR1: view
genes like me logo Genes that share phenotypes with TLR1: view

Animal Models for TLR1 Gene

MGI Knock Outs for TLR1:

Animal Model Products

miRNA for TLR1 Gene

miRTarBase miRNAs that target TLR1

Clone Products

  • Addgene plasmids for TLR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR1 Gene

Localization for TLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR1 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000269 PubMed:16880211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
extracellular 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9435236
GO:0016020 membrane NAS 11081518
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR1 Gene

Pathways & Interactions for TLR1 Gene

genes like me logo Genes that share pathways with TLR1: view

Gene Ontology (GO) - Biological Process for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001775 cell activation IDA 15294986
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with TLR1: view

No data available for SIGNOR curated interactions for TLR1 Gene

Drugs & Compounds for TLR1 Gene

Products:

  1. Drug

(12) Drugs for TLR1 Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pam3CSK4 Pharma TLR1/2 agonist; induces cytokine production 0
Poly(I:C) Pharma TLR3 agonist 0
CU CPT 22 Pharma 0
CU CPT 4a Pharma 0
Pam2CSK4 Pharma 0

(2) Additional Compounds for TLR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TLR1 Gene

Compound Action Cas Number
Imiquimod Toll-like receptor 7 (TLR7) agonist 99011-02-6
Pam3CSK4 TLR1/2 agonist; induces cytokine production 112208-00-1
Poly(I:C) TLR3 agonist 24939-03-5
Resiquimod Toll-like receptor 7 (TLR7) agonist 144875-48-9
RWJ 21757 Toll-like receptor 7 (TLR7) agonist 121288-39-9

(9) ApexBio Compounds for TLR1 Gene

Compound Action Cas Number
CU CPT 22 1416324-85-0
CU CPT 4a 1279713-77-7
Pam2CSK4 868247-72-7
Pam2CSK4 Biotin
Pam3CSK4 112208-00-1
Pam3CSK4 Biotin
Poly(I:C) 24939-03-5
RWJ 21757 121288-39-9
Toll-like receptor modulator TLR antagonist 926927-42-6
genes like me logo Genes that share compounds with TLR1: view

Drug Products

Transcripts for TLR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TLR1 Gene

(8) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLR1 Gene

Toll-like receptor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TLR1

Alternative Splicing Database (ASD) splice patterns (SP) for TLR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - - - - -

Relevant External Links for TLR1 Gene

GeneLoc Exon Structure for
TLR1
ECgene alternative splicing isoforms for
TLR1

Expression for TLR1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLR1 Gene

mRNA expression in normal human tissues for TLR1 Gene
mRNA expression by GTEx for TLR1 GenemRNA expression by BioGPS for TLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR1 Gene

This gene is overexpressed in Whole Blood (x26.6).

Protein differential expression in normal tissues from HIPED for TLR1 Gene

This gene is overexpressed in Monocytes (58.7) and CD8 Tcells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR1 Gene



Protein tissue co-expression partners for TLR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLR1 Gene:

TLR1

SOURCE GeneReport for Unigene cluster for TLR1 Gene:

Hs.654532

mRNA Expression by UniProt/SwissProt for TLR1 Gene:

Q15399-TLR1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Evidence on tissue expression from TISSUES for TLR1 Gene

  • Blood(4.6)
  • Bone marrow(4.4)
  • Liver(4.3)
  • Nervous system(4.3)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Intestine(2.4)
  • Lung(2)
genes like me logo Genes that share expression patterns with TLR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR1 Gene

Orthologs for TLR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TLR1 33 34
  • 99.24 (n)
dog
(Canis familiaris)
 Mammalia TLR1 33 34
  • 85.54 (n)
rat
(Rattus norvegicus)
 Mammalia Tlr1 33
  • 78.42 (n)
mouse
(Mus musculus)
 Mammalia Tlr1 33 16 34
  • 77.1 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 60 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves TLR1LA 34
  • 48 (a)
 ManyToMany
TLR1LB 34
  • 48 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 49 (a)
 ManyToMany
-- 34
  • 48 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia tlr1 33
  • 54.94 (n)
zebrafish
(Danio rerio)
 Actinopterygii tlr1 33 34
  • 48.05 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Toll-9 34
  • 18 (a)
 OneToMany
Species where no ortholog for TLR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR1 Gene

ENSEMBL:
Gene Tree for TLR1 (if available)
TreeFam:
Gene Tree for TLR1 (if available)

Paralogs for TLR1 Gene

Paralogs for TLR1 Gene

(3) SIMAP similar genes for TLR1 Gene using alignment to 14 proteins:

Pseudogenes.org Pseudogenes for TLR1 Gene

genes like me logo Genes that share paralogs with TLR1: view

Variants for TLR1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR1 Gene

TLR1_HUMAN-Q15399
Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIM:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy.

Sequence variations from dbSNP and Humsavar for TLR1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs4833095 risk-factor, Leprosy 5 38,798,089(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs55812771 benign, Latent Tuberculosis 38,797,285(-) A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs5743618 protective, Leprosy, protection against 38,797,027(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs773733396 benign, Latent Tuberculosis 38,797,418(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained
rs786201033 benign, Latent Tuberculosis 38,798,034(-) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TLR1 Gene

Variant ID Type Subtype PubMed ID
esv3600264 CNV loss 21293372
esv3600265 CNV loss 21293372
esv3893918 CNV loss 25118596
nsv594010 CNV loss 21841781
nsv966262 CNV duplication 23825009

Variation tolerance for TLR1 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR1 Gene

Human Gene Mutation Database (HGMD)
TLR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLR1

SNP Genotyping and Copy Number Assay Products

Disorders for TLR1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for TLR1 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leprosy 5
  • leprosy, susceptibility to, 5
lyme disease
  • bannwarth syndrome
melioidosis
  • melioidosis, susceptibility to
penicilliosis
ocular toxoplasmosis
  • toxoplasmosis ocular
- elite association - COSMIC cancer census association via MalaCards
Search TLR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TLR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR1 Gene

Publications for TLR1 Gene

  1. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (PMID: 19771452) Velez DR … Scott WK (Human genetics 2010) 3 22 44 58
  2. Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. (PMID: 19456232) Schuring RP … Oskam L (The Journal of infectious diseases 2009) 3 4 44 58
  3. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PMID: 19200604) Verstraelen H … Temmerman M (Journal of reproductive immunology 2009) 3 22 44 58
  4. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. (PMID: 20016852) Hawn TR … Hooton TM (PloS one 2009) 3 22 44 58
  5. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. (PMID: 18461142) Misch EA … Hawn TR (PLoS neglected tropical diseases 2008) 3 22 44 58

Products for TLR1 Gene

  • Addgene plasmids for TLR1

Sources for TLR1 Gene

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