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Aliases for TLNRD1 Gene

Aliases for TLNRD1 Gene

  • Talin Rod Domain Containing 1 2 3 5
  • Mesoderm Development Candidate 1 2 3 4
  • MESDC1 3 4
  • Talin Rod Domain-Containing Protein 1 3

External Ids for TLNRD1 Gene

Previous HGNC Symbols for TLNRD1 Gene

  • MESDC1

Summaries for TLNRD1 Gene

Entrez Gene Summary for TLNRD1 Gene

  • This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]

GeneCards Summary for TLNRD1 Gene

TLNRD1 (Talin Rod Domain Containing 1) is a Protein Coding gene. Diseases associated with TLNRD1 include Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 2.

UniProtKB/Swiss-Prot for TLNRD1 Gene

  • Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.

Additional gene information for TLNRD1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLNRD1 Gene

Genomics for TLNRD1 Gene

GeneHancer (GH) Regulatory Elements for TLNRD1 Gene

Promoters and enhancers for TLNRD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J080999 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 656.8 +0.5 479 4.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF766 TLNRD1 GC15M081000 PIR45812 ENSG00000277782 CFAP161 MESD
GH15J081022 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 46.1 +23.1 23056 2.8 HDGF PKNOX1 STAT5A BMI1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 GC15P081022 TLNRD1 MESD STARD5 GC15M081029 CFAP161
GH15J081291 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.1 +297.4 297438 14.7 HDGF PKNOX1 FOXA2 SMAD1 SIN3A IRF4 YY1 ZNF207 ZNF143 ATF7 IL16 PIR47037 PIR53519 TLNRD1 STARD5 TMC3 ENSG00000271725 PIR39910 GC15P081268
GH15J081029 Enhancer 1 FANTOM5 Ensembl 36.3 +29.1 29057 1.2 JUN MAX BACH1 ZNF280A ZNF316 NFATC1 FOS NFE2 TRIM24 MAFK GC15M081029 TLNRD1 MESD STARD5 GC15P081022 CFAP161
GH15J080984 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 18.9 -15.8 -15798 1.9 ZNF687 CBFA2T3 PAX8 PRDM6 NCOR1 EED IKZF1 CREB1 ZSCAN29 ZNF600 TLNRD1 MESD STARD5 GC15M080956
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLNRD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TLNRD1 Gene

Genomic Locations for TLNRD1 Gene
4,845 bases
Plus strand
3,051 bases
Plus strand

Genomic View for TLNRD1 Gene

Genes around TLNRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLNRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLNRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLNRD1 Gene

Proteins for TLNRD1 Gene

  • Protein details for TLNRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Talin rod domain-containing protein 1
    Protein Accession:

    Protein attributes for TLNRD1 Gene

    362 amino acids
    Molecular mass:
    37758 Da
    Quaternary structure:
    • May homodimerize. Interacts with F-actin.

neXtProt entry for TLNRD1 Gene

Post-translational modifications for TLNRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLNRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLNRD1 Gene

Domains & Families for TLNRD1 Gene

Gene Families for TLNRD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TLNRD1 Gene


Suggested Antigen Peptide Sequences for TLNRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLNRD1: view

No data available for UniProtKB/Swiss-Prot for TLNRD1 Gene

Function for TLNRD1 Gene

Molecular function for TLNRD1 Gene

UniProtKB/Swiss-Prot Function:
Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.
UniProtKB/Swiss-Prot Induction:
Down-regulated by microRNA MIR574-3p.

Phenotypes From GWAS Catalog for TLNRD1 Gene

Gene Ontology (GO) - Molecular Function for TLNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS,IEA --
genes like me logo Genes that share ontologies with TLNRD1: view
genes like me logo Genes that share phenotypes with TLNRD1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLNRD1 Gene

Localization for TLNRD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLNRD1 gene
Compartment Confidence
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber ISS --
genes like me logo Genes that share ontologies with TLNRD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TLNRD1 Gene

Pathways & Interactions for TLNRD1 Gene

SuperPathways for TLNRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TLNRD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TLNRD1 Gene

Drugs & Compounds for TLNRD1 Gene

No Compound Related Data Available

Transcripts for TLNRD1 Gene

mRNA/cDNA for TLNRD1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLNRD1 Gene

No ASD Table

Relevant External Links for TLNRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLNRD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLNRD1 Gene:


Evidence on tissue expression from TISSUES for TLNRD1 Gene

  • Skin(4.5)
  • Eye(4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLNRD1 Gene

Orthologs for TLNRD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLNRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MESDC1 34 33
  • 99.54 (n)
(Canis familiaris)
Mammalia MESDC1 34 33
  • 96.04 (n)
(Bos Taurus)
Mammalia MESDC1 34 33
  • 95.03 (n)
(Rattus norvegicus)
Mammalia Mesdc1 33
  • 91.16 (n)
(Mus musculus)
Mammalia Mesdc1 34 33
  • 90.88 (n)
Tlnrd1 16
(Monodelphis domestica)
Mammalia MESDC1 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MESDC1 34
  • 87 (a)
(Gallus gallus)
Aves MESDC1 34 33
  • 75.31 (n)
(Anolis carolinensis)
Reptilia MESDC1 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mesdc1 33
  • 77.68 (n)
MGC75847 33
(Danio rerio)
Actinopterygii MESDC1 34
  • 72 (a)
LOC100003148 33
  • 70.35 (n)
(Caenorhabditis elegans)
Secernentea Y18D10A.22 34
  • 5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 34
  • 7 (a)
Species where no ortholog for TLNRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLNRD1 Gene

Gene Tree for TLNRD1 (if available)
Gene Tree for TLNRD1 (if available)
Evolutionary constrained regions (ECRs) for TLNRD1: view image

Paralogs for TLNRD1 Gene

No data available for Paralogs for TLNRD1 Gene

Variants for TLNRD1 Gene

Sequence variations from dbSNP and Humsavar for TLNRD1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs758561889 likely-benign, Long QT syndrome 81,003,116(+) A/G coding_sequence_variant, missense_variant
rs1001066427 -- 81,003,631(+) C/T 3_prime_UTR_variant
rs1002230626 -- 81,003,992(+) T/A 3_prime_UTR_variant
rs1002361611 -- 80,999,372(+) G/A upstream_transcript_variant
rs1002412511 -- 80,999,137(+) T/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TLNRD1 Gene

Variant ID Type Subtype PubMed ID
esv28677 CNV loss 19812545
nsv1143787 CNV deletion 24896259
nsv1637 CNV deletion 18451855

Variation tolerance for TLNRD1 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLNRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLNRD1 Gene

Disorders for TLNRD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLNRD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autosomal dominant nocturnal frontal lobe epilepsy 2
  • enfl2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TLNRD1

genes like me logo Genes that share disorders with TLNRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLNRD1 Gene

Publications for TLNRD1 Gene

  1. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PMID: 11247670) Wines ME … Holdener BC (Genomics 2001) 2 3 4 58
  2. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. (PMID: 22179486) Tatarano S … Nakagawa M (International journal of oncology 2012) 3 4 58
  3. Central region of talin has a unique fold that binds vinculin and actin. (PMID: 20610383) Gingras AR … Critchley DR (The Journal of biological chemistry 2010) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for TLNRD1 Gene

Sources for TLNRD1 Gene

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