External Ids for TLN2 Gene
Previous GeneCards Identifiers for TLN2 Gene
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
GeneCards Summary for TLN2 Gene
TLN2 (Talin 2) is a Protein Coding gene. Diseases associated with TLN2 include Aromatase Excess Syndrome. Among its related pathways are Integrin Pathway and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TLN1.
UniProtKB/Swiss-Prot Summary for TLN2 Gene
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).