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Aliases for TLN2 Gene

Aliases for TLN2 Gene

  • Talin 2 2 3 5
  • KIAA0320 4
  • Talin-2 3
  • ILWEQ 3

External Ids for TLN2 Gene

Previous GeneCards Identifiers for TLN2 Gene

  • GC15P058780
  • GC15P055987
  • GC15P060518
  • GC15P060655
  • GC15P060726
  • GC15P062939
  • GC15P039762
  • GC15P062682

Summaries for TLN2 Gene

Entrez Gene Summary for TLN2 Gene

  • This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLN2 Gene

TLN2 (Talin 2) is a Protein Coding gene. Among its related pathways are EPH-Ephrin signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TLN1.

UniProtKB/Swiss-Prot for TLN2 Gene

  • As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

Additional gene information for TLN2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLN2 Gene

Genomics for TLN2 Gene

GeneHancer (GH) Regulatory Elements for TLN2 Gene

Promoters and enhancers for TLN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I062389 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 560.3 +0.8 779 3.4 ATF1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 POLR2B ZNF207 ZNF143 TLN2 GC15P069436
GH15I062647 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.1 +257.2 257174 1.2 KLF17 RAD21 RFX5 ZNF366 RCOR1 FOS DEK SMARCC1 USF2 CEBPB TLN2 MGC15885 LOC105370855
GH15I062603 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +213.5 213475 1.4 JUN MAX BRCA1 RAD21 RFX5 GTF3C2 GATA3 HNF4G RCOR1 FOSL2 TLN2 VPS13C MGC15885 GC15P069436
GH15I062605 Enhancer 1 Ensembl ENCODE dbSUPER 15.8 +216.3 216250 2.4 JUN CEBPB EP300 BRCA1 RFX5 SP1 JUND POLR2A STAT3 FOS TLN2 MGC15885 GC15P069436
GH15I062569 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.8 +179.6 179598 2.1 FOXA2 MLX ARID4B ZNF48 YY1 SLC30A9 RXRA SP5 MXD4 MIER2 TLN2 GC15P069436 MGC15885
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLN2 gene promoter:

Genomic Locations for TLN2 Gene

Genomic Locations for TLN2 Gene
454,106 bases
Plus strand

Genomic View for TLN2 Gene

Genes around TLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLN2 Gene

Proteins for TLN2 Gene

  • Protein details for TLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NLB8

    Protein attributes for TLN2 Gene

    2542 amino acids
    Molecular mass:
    271613 Da
    Quaternary structure:
    • Interacts directly with PIP5K1C.

neXtProt entry for TLN2 Gene

Post-translational modifications for TLN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TLN2 Gene

Domains & Families for TLN2 Gene

Gene Families for TLN2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLN2: view

No data available for UniProtKB/Swiss-Prot for TLN2 Gene

Function for TLN2 Gene

Molecular function for TLN2 Gene

UniProtKB/Swiss-Prot Function:
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

Phenotypes From GWAS Catalog for TLN2 Gene

Gene Ontology (GO) - Molecular Function for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS,IEA 10320934
GO:0005198 structural molecule activity NAS 10320934
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 10320934
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TLN2: view
genes like me logo Genes that share phenotypes with TLN2: view

Animal Models for TLN2 Gene

MGI Knock Outs for TLN2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLN2 Gene

Localization for TLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLN2 Gene

Cytoplasm. Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses (PubMed:12422219). {ECO:0000269 PubMed:12422219}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLN2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Focal adhesion sites (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IC --
genes like me logo Genes that share ontologies with TLN2: view

Pathways & Interactions for TLN2 Gene

genes like me logo Genes that share pathways with TLN2: view

Gene Ontology (GO) - Biological Process for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007016 cytoskeletal anchoring at plasma membrane IEA --
GO:0007043 cell-cell junction assembly TAS 15494027
GO:0007155 cell adhesion NAS,IEA 11907066
genes like me logo Genes that share ontologies with TLN2: view

No data available for SIGNOR curated interactions for TLN2 Gene

Drugs & Compounds for TLN2 Gene

No Compound Related Data Available

Transcripts for TLN2 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
SP1: - - -
SP2: - -

ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b · 54c
SP1: - -
SP2: - -
SP5: -
SP6: -
SP8: -

Relevant External Links for TLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLN2 Gene

This gene is overexpressed in Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLN2 Gene

Protein tissue co-expression partners for TLN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLN2 Gene:


SOURCE GeneReport for Unigene cluster for TLN2 Gene:


Evidence on tissue expression from TISSUES for TLN2 Gene

  • Nervous system(4.8)
  • Muscle(4.4)
  • Liver(4.3)
  • Heart(3)
  • Gall bladder(2.4)
  • Eye(2)
genes like me logo Genes that share expression patterns with TLN2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLN2 Gene

Orthologs for TLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLN2 33 34
  • 99.54 (n)
(Monodelphis domestica)
Mammalia TLN2 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia TLN2 34
  • 95 (a)
(Canis familiaris)
Mammalia TLN2 33 34
  • 91.77 (n)
(Bos Taurus)
Mammalia TLN2 33 34
  • 90.78 (n)
(Mus musculus)
Mammalia Tln2 33 16 34
  • 89.68 (n)
(Rattus norvegicus)
Mammalia Tln2 33
  • 89.64 (n)
(Gallus gallus)
Aves TLN2 33 34
  • 81.39 (n)
(Anolis carolinensis)
Reptilia TLN2 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tln2 33
  • 76.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2037 33
(Danio rerio)
Actinopterygii TLN2 (2 of 2) 34
  • 86 (a)
tln2a 33 34
  • 75.63 (n)
zgc63613 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007474 33
  • 55.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta rhea 33 34
  • 54.23 (n)
(Caenorhabditis elegans)
Secernentea Y71G12B.11 33
  • 48.24 (n)
tln-1 34
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5889 34
  • 58 (a)
Species where no ortholog for TLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLN2 Gene

Gene Tree for TLN2 (if available)
Gene Tree for TLN2 (if available)

Paralogs for TLN2 Gene

Paralogs for TLN2 Gene

(1) SIMAP similar genes for TLN2 Gene using alignment to 4 proteins: Pseudogenes for TLN2 Gene

genes like me logo Genes that share paralogs with TLN2: view

Variants for TLN2 Gene

Sequence variations from dbSNP and Humsavar for TLN2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000000141 -- 62,625,398(+) TTTTTTT/TTTTTTTT genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000001929 -- 62,495,768(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000004833 -- 62,664,710(+) T/C intron_variant
rs1000005509 -- 62,802,441(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000010437 -- 62,590,169(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLN2 Gene

Variant ID Type Subtype PubMed ID
esv1566775 CNV insertion 17803354
esv2054160 CNV deletion 18987734
esv2672262 CNV deletion 23128226
esv2749766 CNV deletion 23290073
esv2749767 CNV deletion 23290073
esv2749768 CNV deletion 23290073
esv2749769 CNV deletion 23290073
esv2913 CNV loss 18987735
esv3307559 CNV mobile element insertion 20981092
esv3403298 CNV insertion 20981092
esv3415480 CNV insertion 20981092
esv3581742 CNV loss 25503493
esv3636705 CNV loss 21293372
nsv1035441 CNV gain 25217958
nsv1044132 CNV gain 25217958
nsv1045036 CNV gain 25217958
nsv1070702 CNV deletion 25765185
nsv1116080 CNV deletion 24896259
nsv1134457 CNV deletion 24896259
nsv1153645 CNV deletion 26484159
nsv1561 CNV insertion 18451855
nsv1562 CNV insertion 18451855
nsv833032 CNV loss 17160897
nsv94552 CNV insertion 16902084

Variation tolerance for TLN2 Gene

Residual Variation Intolerance Score: 0.416% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLN2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLN2 Gene

Disorders for TLN2 Gene

Additional Disease Information for TLN2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLN2 Gene

Publications for TLN2 Gene

  1. Analysis of the mammalian talin2 gene TLN2. (PMID: 11527381) Monkley SJ … Critchley DR (Biochemical and biophysical research communications 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  3. Exome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly. (PMID: 27223613) Deng H … Guo Y (PloS one 2016) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. (PMID: 19109932) Xiao F … Wang XF (Brain research 2009) 3 22 58

Products for TLN2 Gene

Sources for TLN2 Gene

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