This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors t... See more...

Aliases for TLN2 Gene

Aliases for TLN2 Gene

  • Talin 2 2 3 5
  • KIAA0320 2 4
  • Talin-2 3 4
  • ILWEQ 2 3
  • TLN2 5

External Ids for TLN2 Gene

Previous GeneCards Identifiers for TLN2 Gene

  • GC15P058780
  • GC15P055987
  • GC15P060518
  • GC15P060655
  • GC15P060726
  • GC15P062939
  • GC15P039762
  • GC15P062682

Summaries for TLN2 Gene

Entrez Gene Summary for TLN2 Gene

  • This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLN2 Gene

TLN2 (Talin 2) is a Protein Coding gene. Diseases associated with TLN2 include Aromatase Excess Syndrome. Among its related pathways are Integrin Pathway and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TLN1.

UniProtKB/Swiss-Prot Summary for TLN2 Gene

  • As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLN2 Gene

Genomics for TLN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J062389 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 260.2 +0.6 582 3.8 ZNF207 MYC JUND ATF2 KLF9 POLR2A ZIC2 NONO ZNF592 SMAD5 TLN2 ENSG00000274340 lnc-C2CD4A-5 HSALNG0106427 piR-32023-088 TPM1
GH15J062757 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250 +367.7 367736 2.2 JUND CEBPA CHD4 YY1 CEBPB MAX SIN3A EP300 RXRA RFX5 TLN2 MIR190A HSALNG0106440 lnc-RPS27L-10 TPM1
GH15J062738 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 250 +349.2 349218 2.1 JUND BHLHE40 GATA2 POLR2A FOS EP300 CEBPB TLN2 lnc-RPS27L-10 HSALNG0106440 TPM1
GH15J062603 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +213.4 213378 2.2 BRCA1 CEBPB DEK MAX EP300 RXRA RAD21 RFX5 STAT3 TBP TLN2 VPS13C HSALNG0106434 MGC15885 lnc-C2CD4A-5 TPM1
GH15J062605 Enhancer 0.9 Ensembl ENCODE dbSUPER 15.8 +216.5 216478 3.2 JUND BRCA1 CEBPB EP300 RFX5 STAT3 MAFK BHLHE40 POLR2A FOS TLN2 HSALNG0106434 MGC15885 TPM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLN2

Top Transcription factor binding sites by QIAGEN in the TLN2 gene promoter:
  • AML1a
  • AREB6
  • CHOP-10
  • Hlf
  • POU2F1
  • POU2F1a
  • RP58
  • S8
  • SEF-1 (1)
  • TBP

Genomic Locations for TLN2 Gene

Latest Assembly
chr15:62,390,523-62,844,631
(GRCh38/hg38)
Size:
454,109 bases
Orientation:
Plus strand

Previous Assembly
chr15:62,939,510-63,136,830
(GRCh37/hg19 by Entrez Gene)
Size:
197,321 bases
Orientation:
Plus strand

chr15:62,682,725-63,136,830
(GRCh37/hg19 by Ensembl)
Size:
454,106 bases
Orientation:
Plus strand

Genomic View for TLN2 Gene

Genes around TLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLN2 Gene

Proteins for TLN2 Gene

  • Protein details for TLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4G6-TLN2_HUMAN
    Recommended name:
    Talin-2
    Protein Accession:
    Q9Y4G6
    Secondary Accessions:
    • A6NLB8

    Protein attributes for TLN2 Gene

    Size:
    2542 amino acids
    Molecular mass:
    271613 Da
    Quaternary structure:
    • Interacts directly with PIP5K1C.

    Three dimensional structures from OCA and Proteopedia for TLN2 Gene

neXtProt entry for TLN2 Gene

Post-translational modifications for TLN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TLN2 Gene

Domains & Families for TLN2 Gene

Gene Families for TLN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TLN2 Gene

GenScript: Design optimal peptide antigens:
  • Talin-2 (TLN2_HUMAN)
genes like me logo Genes that share domains with TLN2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TLN2 Gene

Function for TLN2 Gene

Molecular function for TLN2 Gene

UniProtKB/Swiss-Prot Function:
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

Phenotypes From GWAS Catalog for TLN2 Gene

Gene Ontology (GO) - Molecular Function for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,NAS 10320934
GO:0005178 integrin binding IBA 21873635
GO:0005198 structural molecule activity NAS 10320934
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 10320934
genes like me logo Genes that share ontologies with TLN2: view
genes like me logo Genes that share phenotypes with TLN2: view

Animal Models for TLN2 Gene

MGI Knock Outs for TLN2:
  • Tln2 Tln2<tm1.1Crit>
  • Tln2 Tln2<tm2Crit>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLN2 Gene

Localization for TLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLN2 Gene

Cytoplasm. Cell junction, focal adhesion. Cell junction, synapse. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses (PubMed:12422219). {ECO:0000269 PubMed:12422219}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLN2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 4
extracellular 2
mitochondrion 2
nucleus 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Focal adhesion sites (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0005925 focal adhesion IBA 21873635
genes like me logo Genes that share ontologies with TLN2: view

Pathways & Interactions for TLN2 Gene

PathCards logo

SuperPathways for TLN2 Gene

SuperPathway Contained pathways
1 Integrin Pathway
.67
.67
2 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.37
3 Focal Adhesion
4 Human T-cell leukemia virus 1 infection
5 Platelet activation
genes like me logo Genes that share pathways with TLN2: view

Pathways by source for TLN2 Gene

6 GeneGo (Thomson Reuters) pathways for TLN2 Gene
  • Cell adhesion Integrin inside-out signaling
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cytoskeleton remodeling FAK signaling
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Integrin outside-in signaling
6 Qiagen pathways for TLN2 Gene
  • Calpain Protease Regulates Cellular Mechanics
  • FAK1 Signaling
  • Integrin Pathway
  • MAPK Signaling
  • Paxillin Interactions

Gene Ontology (GO) - Biological Process for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007043 cell-cell junction assembly TAS 15494027
GO:0007155 cell adhesion IEA,NAS 11907066
GO:0098609 cell-cell adhesion IBA 21873635
genes like me logo Genes that share ontologies with TLN2: view

No data available for SIGNOR curated interactions for TLN2 Gene

Drugs & Compounds for TLN2 Gene

No Compound Related Data Available

Transcripts for TLN2 Gene

mRNA/cDNA for TLN2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLN2

Alternative Splicing Database (ASD) splice patterns (SP) for TLN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b · 54c
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:

Relevant External Links for TLN2 Gene

GeneLoc Exon Structure for
TLN2

Expression for TLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLN2 Gene

This gene is overexpressed in Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLN2 Gene



Protein tissue co-expression partners for TLN2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLN2

SOURCE GeneReport for Unigene cluster for TLN2 Gene:

Hs.569438

Evidence on tissue expression from TISSUES for TLN2 Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Liver(4.4)
  • Heart(3.3)
  • Gall bladder(2.4)
  • Kidney(2.4)
  • Intestine(2.3)
  • Lung(2.2)
  • Blood(2.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with TLN2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLN2 Gene

Orthologs for TLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TLN2 29 30
  • 99.54 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TLN2 30
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TLN2 30
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TLN2 29 30
  • 91.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TLN2 29 30
  • 90.78 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tln2 29 16 30
  • 89.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tln2 29
  • 89.64 (n)
Chicken
(Gallus gallus)
Aves TLN2 29 30
  • 81.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TLN2 30
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tln2 29
  • 76.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2037 29
Zebrafish
(Danio rerio)
Actinopterygii TLN2 (2 of 2) 30
  • 86 (a)
OneToMany
tln2a 29 30
  • 75.63 (n)
OneToMany
zgc63613 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007474 29
  • 55.25 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta rhea 29 30
  • 54.23 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y71G12B.11 29
  • 48.24 (n)
tln-1 30
  • 38 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 30
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5889 30
  • 58 (a)
OneToOne
Species where no ortholog for TLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TLN2 Gene

ENSEMBL:
Gene Tree for TLN2 (if available)
TreeFam:
Gene Tree for TLN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLN2: view image
Alliance of Genome Resources:
Additional Orthologs for TLN2

Paralogs for TLN2 Gene

Paralogs for TLN2 Gene

(1) SIMAP similar genes for TLN2 Gene using alignment to 4 proteins:

  • TLN2_HUMAN
  • G1UI21_HUMAN
  • H0YMT1_HUMAN
  • H0YN01_HUMAN

Pseudogenes.org Pseudogenes for TLN2 Gene

genes like me logo Genes that share paralogs with TLN2: view

Variants for TLN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLN2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
993318 Uncertain Significance: none provided 62,776,896(+) G/A
NM_015059.2(TLN2):c.5500G>A (p.Glu1834Lys)
MISSENSE
993319 Uncertain Significance: none provided 62,820,497(+) G/A
NM_015059.2(TLN2):c.6889G>A (p.Val2297Met)
MISSENSE
rs116474698 Benign: not provided 62,711,930(+) G/A
NM_015059.2(TLN2):c.2487G>A (p.Ala829=)
SYNONYMOUS
rs1262140430 Uncertain Significance: not provided 62,647,369(+) A/G
NM_015059.2(TLN2):c.59A>G (p.Gln20Arg)
MISSENSE
rs138463845 Likely Benign: not provided 62,819,579(+) G/A
NM_015059.2(TLN2):c.6835G>A (p.Gly2279Ser)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TLN2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TLN2 Gene

Variant ID Type Subtype PubMed ID
esv1566775 CNV insertion 17803354
esv2054160 CNV deletion 18987734
esv2672262 CNV deletion 23128226
esv2749766 CNV deletion 23290073
esv2749767 CNV deletion 23290073
esv2749768 CNV deletion 23290073
esv2749769 CNV deletion 23290073
esv2913 CNV loss 18987735
esv3307559 CNV mobile element insertion 20981092
esv3403298 CNV insertion 20981092
esv3415480 CNV insertion 20981092
esv3581742 CNV loss 25503493
esv3636705 CNV loss 21293372
nsv1035441 CNV gain 25217958
nsv1044132 CNV gain 25217958
nsv1045036 CNV gain 25217958
nsv1070702 CNV deletion 25765185
nsv1116080 CNV deletion 24896259
nsv1134457 CNV deletion 24896259
nsv1153645 CNV deletion 26484159
nsv1561 CNV insertion 18451855
nsv1562 CNV insertion 18451855
nsv833032 CNV loss 17160897
nsv94552 CNV insertion 16902084

Variation tolerance for TLN2 Gene

Residual Variation Intolerance Score: 0.416% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLN2 Gene

Human Gene Mutation Database (HGMD)
TLN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLN2
Leiden Open Variation Database (LOVD)
TLN2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLN2 Gene

Disorders for TLN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLN2 Gene - From: COP

Disorder Aliases PubMed IDs
aromatase excess syndrome
  • aexs
- elite association - COSMIC cancer census association via MalaCards
Search TLN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLN2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TLN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLN2 Gene

Publications for TLN2 Gene

  1. Analysis of the mammalian talin2 gene TLN2. (PMID: 11527381) Monkley SJ … Critchley DR (Biochemical and biophysical research communications 2001) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  3. Exome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly. (PMID: 27223613) Deng H … Guo Y (PloS one 2016) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. (PMID: 19109932) Xiao F … Wang XF (Brain research 2009) 3 22

Products for TLN2 Gene

Sources for TLN2 Gene