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Aliases for TLN1 Gene

Aliases for TLN1 Gene

  • Talin 1 2 3 5
  • Talin-1 3 3
  • TLN 3 4
  • KIAA1027 4
  • ILWEQ 3

External Ids for TLN1 Gene

Previous HGNC Symbols for TLN1 Gene

  • TLN

Previous GeneCards Identifiers for TLN1 Gene

  • GC09M036009
  • GC09M035866

Summaries for TLN1 Gene

Entrez Gene Summary for TLN1 Gene

  • This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

GeneCards Summary for TLN1 Gene

TLN1 (Talin 1) is a Protein Coding gene. Diseases associated with TLN1 include Leukocyte Adhesion Deficiency, Type I. Among its related pathways are Focal Adhesion and Signaling by moderate kinase activity BRAF mutants. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TLN2.

UniProtKB/Swiss-Prot for TLN1 Gene

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Gene Wiki entry for TLN1 Gene

Additional gene information for TLN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLN1 Gene

Genomics for TLN1 Gene

GeneHancer (GH) Regulatory Elements for TLN1 Gene

Promoters and enhancers for TLN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J035726 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.8 +2.0 1980 8.6 YBX1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D TLN1 CREB3 TMEM8B GBA2 PIGO ARHGEF39 TPM2 HMGB3P24 RN7SL22P MSMP
GH09J035679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.5 +46.3 46278 12.8 PKNOX1 ARID4B SIN3A POLR2B GLIS2 FOS SP3 REST SMARCB1 MIER3 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 RGP1 MSMP
GH09J035913 Enhancer 1.4 Ensembl ENCODE dbSUPER 19.8 -184.8 -184847 7.7 HDGF ARNT ARID4B NEUROD1 YBX1 ZBTB7B YY1 ZNF766 ZNF207 MCM3 PIGO ARHGEF39 RGP1 RECK TLN1 ENSG00000231393 GBA2 SPAAR CLTA NDUFA5P4
GH09J035616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.9 +113.1 113141 6.4 HDGF PKNOX1 ATF1 SMAD1 RB1 SIN3A STAT5A BATF RFX5 ETS1 CD72 ARHGEF39 RGP1 CCDC107 RN7SL22P SIT1 CA9 RECK FAM166B TLN1
GH09J035904 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -175.8 -175772 7.4 FOXA2 ZNF48 YY1 ZNF121 FOS DEK SP3 RXRA REST PPARG HRCT1 SPAAR TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLN1 gene promoter:

Genomic Locations for TLN1 Gene

Genomic Locations for TLN1 Gene
35,448 bases
Minus strand

Genomic View for TLN1 Gene

Genes around TLN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLN1 Gene

Proteins for TLN1 Gene

  • Protein details for TLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NMY0
    • Q86YD0
    • Q9NZQ2
    • Q9UHH8
    • Q9UPX3

    Protein attributes for TLN1 Gene

    2541 amino acids
    Molecular mass:
    269767 Da
    Quaternary structure:
    • Binds with high affinity to VCL and with low affinity to integrins (PubMed:15070891). Interacts with APBB1IP; this inhibits VCL binding. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP (PubMed:10320340, PubMed:12422220). Interacts with LAYN (By similarity). Interacts with SYNM (PubMed:18342854). Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1 (PubMed:21768292, PubMed:12473654).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL135.
    • Sequence=BAA82979.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TLN1 Gene

neXtProt entry for TLN1 Gene

Post-translational modifications for TLN1 Gene

  • Ubiquitination at isoforms=869, isoforms=428, isoforms=357, and isoforms=334
  • Modification sites at PhosphoSitePlus

Other Protein References for TLN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLN1 Gene

Domains & Families for TLN1 Gene

Gene Families for TLN1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TLN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLN1: view

No data available for UniProtKB/Swiss-Prot for TLN1 Gene

Function for TLN1 Gene

Molecular function for TLN1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Phenotypes From GWAS Catalog for TLN1 Gene

Gene Ontology (GO) - Molecular Function for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0003779 actin binding IEA --
GO:0005178 integrin binding IEA,IPI 12473654
GO:0005200 structural constituent of cytoskeleton NAS 10610730
GO:0005515 protein binding IPI 11279249
genes like me logo Genes that share ontologies with TLN1: view
genes like me logo Genes that share phenotypes with TLN1: view

Animal Models for TLN1 Gene

MGI Knock Outs for TLN1:

miRNA for TLN1 Gene

miRTarBase miRNAs that target TLN1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLN1 Gene

Localization for TLN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLN1 Gene

Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLN1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
cytoskeleton 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Focal adhesion sites (3)
  • Microtubule organizing center (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TLN1: view

Pathways & Interactions for TLN1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Signaling by moderate kinase activity BRAF mutants
3 Integrin alphaIIb beta3 signaling
4 Response to elevated platelet cytosolic Ca2+
5 Focal Adhesion
genes like me logo Genes that share pathways with TLN1: view

SIGNOR curated interactions for TLN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006936 muscle contraction TAS --
GO:0007016 cytoskeletal anchoring at plasma membrane NAS 10610730
GO:0007043 cell-cell junction assembly TAS 15494027
GO:0007044 cell-substrate junction assembly IEA --
genes like me logo Genes that share ontologies with TLN1: view

Drugs & Compounds for TLN1 Gene

No Compound Related Data Available

Transcripts for TLN1 Gene

mRNA/cDNA for TLN1 Gene

Unigene Clusters for TLN1 Gene

Talin 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLN1 Gene

No ASD Table

Relevant External Links for TLN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLN1 Gene

mRNA differential expression in normal tissues according to GTEx for TLN1 Gene

This gene is overexpressed in Artery - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for TLN1 Gene

This gene is overexpressed in Platelet (17.9) and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLN1 Gene

Protein tissue co-expression partners for TLN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLN1 Gene:


SOURCE GeneReport for Unigene cluster for TLN1 Gene:


Evidence on tissue expression from TISSUES for TLN1 Gene

  • Blood(4.7)
  • Nervous system(4.7)
  • Liver(4.6)
  • Intestine(4.2)
  • Skin(3.8)
  • Lung(3.7)
  • Heart(3.2)
  • Eye(2.9)
  • Pancreas(2.9)
  • Gall bladder(2.8)
  • Muscle(2.6)
  • Kidney(2.5)
  • Lymph node(2.4)
  • Thyroid gland(2.2)
  • Stomach(2.1)
  • Adrenal gland(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with TLN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLN1 Gene

Orthologs for TLN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLN1 34 33
  • 98.99 (n)
(Monodelphis domestica)
Mammalia TLN1 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia TLN1 34
  • 93 (a)
(Canis familiaris)
Mammalia TLN1 34 33
  • 92.56 (n)
(Bos Taurus)
Mammalia TLN1 34 33
  • 91.85 (n)
(Mus musculus)
Mammalia Tln1 16 34 33
  • 90.73 (n)
(Rattus norvegicus)
Mammalia Tln1 33
  • 90.61 (n)
(Gallus gallus)
Aves TLN1 34 33
  • 80.37 (n)
(Anolis carolinensis)
Reptilia TLN1 34
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18467 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15058 33
(Danio rerio)
Actinopterygii tln1 34 33
  • 75.43 (n)
sbcb854 33
fruit fly
(Drosophila melanogaster)
Insecta Talin 35
  • 46 (a)
(Caenorhabditis elegans)
Secernentea Y71G12B.11b 35
  • 41 (a)
Y71G12B.11a 35
  • 37 (a)
hipr-1 34
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.9312 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9312 33
Species where no ortholog for TLN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLN1 Gene

Gene Tree for TLN1 (if available)
Gene Tree for TLN1 (if available)
Evolutionary constrained regions (ECRs) for TLN1: view image

Paralogs for TLN1 Gene

Paralogs for TLN1 Gene

(1) SIMAP similar genes for TLN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLN1: view

Variants for TLN1 Gene

Sequence variations from dbSNP and Humsavar for TLN1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000049032 -- 35,722,738(-) A/G intron_variant
rs1000058902 -- 35,712,412(-) G/A intron_variant
rs1000074681 -- 35,719,301(-) A/C intron_variant
rs1000246790 -- 35,709,316(-) CAAAAAAACAAAAAAACAAAA/CAAAAAAACAAAA intron_variant
rs1000482863 -- 35,722,448(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLN1 Gene

Variant ID Type Subtype PubMed ID
esv25437 CNV loss 19812545
nsv1125318 OTHER inversion 24896259
nsv466385 CNV loss 19166990
nsv614166 CNV loss 21841781
nsv6528 CNV insertion 18451855
nsv819330 CNV loss 19587683

Variation tolerance for TLN1 Gene

Residual Variation Intolerance Score: 0.301% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLN1 Gene

Disorders for TLN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLN1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
leukocyte adhesion deficiency, type i
  • lad
- elite association - COSMIC cancer census association via MalaCards
Search TLN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLN1

genes like me logo Genes that share disorders with TLN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLN1 Gene

Publications for TLN1 Gene

  1. Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. (PMID: 10610730) Ben-Yosef T … Francomano CA (Genomics 1999) 2 3 4 22 58
  2. ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. (PMID: 19608030) Moulik M … Towbin JA (Journal of the American College of Cardiology 2009) 3 22 58
  3. Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin. (PMID: 18342854) Sun N … Robson RM (Experimental cell research 2008) 3 4 58
  4. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. (PMID: 17597073) Manevich E … Alon R (The Journal of biological chemistry 2007) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TLN1 Gene

Sources for TLN1 Gene

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