External Ids for TLN1 Gene
Previous HGNC Symbols for TLN1 Gene
Previous GeneCards Identifiers for TLN1 Gene
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
GeneCards Summary for TLN1 Gene
TLN1 (Talin 1) is a Protein Coding gene. Diseases associated with TLN1 include Leukocyte Adhesion Deficiency, Type I. Among its related pathways are Focal Adhesion and Signaling by moderate kinase activity BRAF mutants. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TLN2.
UniProtKB/Swiss-Prot for TLN1 Gene
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).