Aliases for TLK2 Gene
External Ids for TLK2 Gene
Previous GeneCards Identifiers for TLK2 Gene
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for TLK2 Gene
TLK2 (Tousled Like Kinase 2) is a Protein Coding gene. Diseases associated with TLK2 include Mental Retardation, Autosomal Dominant 57 and Pica Disease. Among its related pathways are DNA Damage Response and Chks in Checkpoint Regulation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TLK1.
UniProtKB/Swiss-Prot Summary for TLK2 Gene
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.