The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by block... See more...

Aliases for TLK1 Gene

Aliases for TLK1 Gene

  • Tousled Like Kinase 1 2 3 5
  • Serine/Threonine-Protein Kinase Tousled-Like 1 3 4
  • Tousled-Like Kinase 1 2 4
  • EC 2.7.11.1 4 51
  • PKU-Beta 3 4
  • KIAA0137 2 4
  • Serine Threonine Protein Kinase 3
  • SNARE Protein Kinase SNAK 3
  • EC 2.7.11 51
  • PKU-BETA 2
  • TLK1 5

External Ids for TLK1 Gene

Previous GeneCards Identifiers for TLK1 Gene

  • GC02M169900
  • GC02M170390
  • GC02M171812
  • GC02M172051
  • GC02M171674
  • GC02M171556
  • GC02M163735

Summaries for TLK1 Gene

Entrez Gene Summary for TLK1 Gene

  • The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TLK1 Gene

TLK1 (Tousled Like Kinase 1) is a Protein Coding gene. Diseases associated with TLK1 include Pica Disease and Spermatogenic Failure 5. Among its related pathways are ATM Pathway and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TLK2.

UniProtKB/Swiss-Prot Summary for TLK1 Gene

  • Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Gene Wiki entry for TLK1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLK1 Gene

Genomics for TLK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J171158 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.2 +71.5 71454 5.7 GATAD2A CTCF HNRNPL PRDM10 TFE3 ZNF512 LEF1 IKZF1 POLR2A BACH1 lnc-METTL8-4 TLK1 GORASP2 DCAF17 HAT1 METAP1D DAP3P2 SNODB933
GH02J171686 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 -457.2 -457187 3.4 CREB1 PRDM10 ZNF629 REST TFE3 SIX5 IKZF1 NFKBIZ SMAD2 ZNF692 DYNC1I2 DAP3P2 HAT1 CYBRD1 DCAF17 GORASP2 TLK1 piR-60885-064
GH02J171260 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.3 -30.0 -29987 3.8 GATAD2A TFE3 RXRB MTA1 IKZF2 SOX6 EED ZNF184 ZNF766 RELB TLK1 METTL8 LOC107983995 HSALNG0020332 lnc-TLK1-1 DCAF17
GH02J171271 Enhancer 1 Ensembl ENCODE 12.1 -40.8 -40787 2.2 CEBPG CREB1 GATAD2A IKZF1 ZHX2 JUND FOXA1 PRDM1 IRF2 CEBPA TLK1 METTL8 CYBRD1 METAP1D lnc-METTL8-2 LOC107983995 LOC105373737 lnc-TLK1-1 DCAF17
GH02J171182 Enhancer 0.7 Ensembl 15.7 +49.5 49513 0.8 LEF1 IKZF1 PKNOX1 HDAC1 MGA ZNF766 MTA3 CTBP1 ZNF316 USF1 TLK1 GORASP2 RF00017-3359 LOC112268427
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLK1

Top Transcription factor binding sites by QIAGEN in the TLK1 gene promoter:
  • FOXO3
  • FOXO3a
  • FOXO3b
  • HNF-1
  • HNF-1A
  • Nkx2-5
  • Pbx1a
  • Sox9

Genomic Locations for TLK1 Gene

Genomic Locations for TLK1 Gene
chr2:170,990,823-171,231,314
(GRCh38/hg38)
Size:
240,492 bases
Orientation:
Minus strand
chr2:171,847,333-172,087,824
(GRCh37/hg19)
Size:
240,492 bases
Orientation:
Minus strand

Genomic View for TLK1 Gene

Genes around TLK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLK1 Gene

Proteins for TLK1 Gene

  • Protein details for TLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKI8-TLK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase tousled-like 1
    Protein Accession:
    Q9UKI8
    Secondary Accessions:
    • B3KR15
    • B4DX87
    • Q14150
    • Q8N591
    • Q9NYH2
    • Q9Y4F6

    Protein attributes for TLK1 Gene

    Size:
    766 amino acids
    Molecular mass:
    86700 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.
    SequenceCaution:
    • Sequence=AAF03094.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA09486.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TLK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLK1 Gene

Selected DME Specific Peptides for TLK1 Gene

Q9UKI8:
  • EKKENYHKHACREYRIHK
  • RYLLLHLLGRGGFSEVYKAFDL
  • LEKYKERLN
  • ELHSLDPRRQELLEARF
  • AGTYWYLPPE
  • IKITDFGL
  • KPGNILL
  • GNDLDFYLKQ
  • LDHPRIVKLYDYFSLDTD
  • AVKIHQLNK
  • SQFKDHPTLN
  • IKITDFG
  • KERLNKC

Post-translational modifications for TLK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TLK1 Gene

Gene Families for TLK1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TLK1 Gene

Suggested Antigen Peptide Sequences for TLK1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33460 fis, clone BRAMY2000653, highly similar to Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (B3KR15_HUMAN)
  • cDNA FLJ34656 fis, clone KIDNE2018352, highly similar to Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (B3KRP1_HUMAN)
  • cDNA FLJ59778, highly similar to Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (B4DX87_HUMAN)
  • Tousled-like kinase 1 (TLK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKI8

UniProtKB/Swiss-Prot:

TLK1_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TLK1: view

Function for TLK1 Gene

Molecular function for TLK1 Gene

UniProtKB/Swiss-Prot Function:
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:9427565};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:9427565};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHEK1.
GENATLAS Biochemistry:
tousled-like kinase 1,nuclear serine/threonine kinase PKU beta,broadly expressed,autophosphorylating and dimerizing cell-cycle regulated displaying maximal activities during S phase,Arabidopsis thaliana homolog

Enzyme Numbers (IUBMB) for TLK1 Gene

Phenotypes From GWAS Catalog for TLK1 Gene

Gene Ontology (GO) - Molecular Function for TLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,TAS 9427565
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA,IDA 12660173
genes like me logo Genes that share ontologies with TLK1: view
genes like me logo Genes that share phenotypes with TLK1: view

Animal Models for TLK1 Gene

MGI Knock Outs for TLK1:
  • Tlk1 Tlk1<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for TLK1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLK1 Gene

Localization for TLK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLK1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 9427565
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TLK1: view

Pathways & Interactions for TLK1 Gene

genes like me logo Genes that share pathways with TLK1: view

Pathways by source for TLK1 Gene

2 Qiagen pathways for TLK1 Gene
  • ATM Pathway
  • Chks in Checkpoint Regulation
1 Cell Signaling Technology pathway for TLK1 Gene

SIGNOR curated interactions for TLK1 Gene

Activates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for TLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001672 regulation of chromatin assembly or disassembly IBA,IDA 12660173
GO:0006325 chromatin organization IEA --
GO:0006468 protein phosphorylation IEA,IDA 12660173
GO:0006886 intracellular protein transport IDA 10588641
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with TLK1: view

Drugs & Compounds for TLK1 Gene

(2) Drugs for TLK1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with TLK1: view

Transcripts for TLK1 Gene

mRNA/cDNA for TLK1 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLK1

Alternative Splicing Database (ASD) splice patterns (SP) for TLK1 Gene

No ASD Table

Relevant External Links for TLK1 Gene

GeneLoc Exon Structure for
TLK1

Expression for TLK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLK1 Gene

This gene is overexpressed in Heart (15.9) and Peripheral blood mononuclear cells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLK1 Gene



Protein tissue co-expression partners for TLK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLK1

SOURCE GeneReport for Unigene cluster for TLK1 Gene:

Hs.744917

mRNA Expression by UniProt/SwissProt for TLK1 Gene:

Q9UKI8-TLK1_HUMAN
Tissue specificity: Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.

Evidence on tissue expression from TISSUES for TLK1 Gene

  • Nervous system(4.6)
  • Kidney(2.4)
  • Liver(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with TLK1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLK1 Gene

Orthologs for TLK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TLK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TLK1 30 31
  • 99.87 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TLK1 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TLK1 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TLK1 30 31
  • 96.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TLK1 30 31
  • 95.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tlk1 30 17 31
  • 91.91 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TLK1 30 31
  • 87.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TLK1 31
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tlk1 30
  • 82.12 (n)
Str.902 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.22395 30
Zebrafish
(Danio rerio)
Actinopterygii tlk1b 31
  • 85 (a)
OneToMany
tlk1a 30 31
  • 74.52 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta BcDNA:GH07910 32
  • 72 (a)
tlk 31
  • 27 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000043 30
  • 56.27 (n)
Worm
(Caenorhabditis elegans)
Secernentea tlk-1 31
  • 34 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPS1 31
  • 15 (a)
OneToMany
Barley
(Hordeum vulgare)
Liliopsida Hv.12931 30
Corn
(Zea mays)
Liliopsida Zm.13254 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.566 31
  • 64 (a)
OneToMany
Species where no ortholog for TLK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TLK1 Gene

ENSEMBL:
Gene Tree for TLK1 (if available)
TreeFam:
Gene Tree for TLK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLK1: view image

Paralogs for TLK1 Gene

Paralogs for TLK1 Gene

(4) SIMAP similar genes for TLK1 Gene using alignment to 6 proteins:

  • TLK1_HUMAN
  • B3KRP1_HUMAN
  • C9JWT6_HUMAN
  • F8W7X8_HUMAN
  • Q53TE4_HUMAN
  • Q53TF9_HUMAN

Pseudogenes.org Pseudogenes for TLK1 Gene

genes like me logo Genes that share paralogs with TLK1: view

Variants for TLK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLK1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
VAR_041215 - p.Arg121Cys

Additional dbSNP identifiers (rs#s) for TLK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLK1 Gene

Variant ID Type Subtype PubMed ID
dgv1186e212 CNV loss 25503493
esv2660349 CNV deletion 23128226
esv2664440 CNV deletion 23128226
esv3310512 CNV novel sequence insertion 20981092
esv3349102 CNV duplication 20981092
esv3399332 CNV insertion 20981092
esv3593343 CNV gain 21293372
esv3593346 CNV loss 21293372
esv3593347 CNV loss 21293372
nsv3030 CNV insertion 18451855
nsv522291 CNV loss 19592680
nsv834456 CNV loss 17160897

Variation tolerance for TLK1 Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLK1 Gene

Human Gene Mutation Database (HGMD)
TLK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLK1 Gene

Disorders for TLK1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TLK1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search TLK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLK1

genes like me logo Genes that share disorders with TLK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLK1 Gene

Publications for TLK1 Gene

  1. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. (PMID: 12660173) Groth A … Hansen K (The EMBO journal 2003) 2 3 4
  2. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. (PMID: 11470414) Silljé HH … Nigg EA (Current biology : CB 2001) 3 4 23
  3. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. (PMID: 9427565) Yamakawa A … Date T (Gene 1997) 2 3 4
  4. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 41
  5. PKU-beta/TLK1 regulates myosin II activities, and is required for accurate equaled chromosome segregation. (PMID: 18838128) Hashimoto M … Date T (Mutation research 2008) 3 23

Products for TLK1 Gene

Sources for TLK1 Gene