Aliases for TLE7 Gene

Aliases for TLE7 Gene

  • TLE Family Member 7 2 3 5
  • Transducin Like Enhancer Of Split Family Member 7 2 3
  • Transducin-Like Enhancer Protein 7 3 4
  • Transducin-Like Enhancer Protein 2 3
  • Chico 3
  • TLE7 5

External Ids for TLE7 Gene

Summaries for TLE7 Gene

GeneCards Summary for TLE7 Gene

TLE7 (TLE Family Member 7) is a Protein Coding gene. An important paralog of this gene is TLE2.

Additional gene information for TLE7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLE7 Gene

Genomics for TLE7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLE7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J071440 Enhancer 0.6 ENCODE 600.7 +1.2 1161 0.1 CTCF REST ZNF444 NR2F1 RAD21 NR2F6 ZNF143 XRCC5 TARDBP TRIM22 TLE7 lnc-ZNF23-2 CALB2
GH16J071459 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 -19.4 -19445 3.4 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 SIX5 LEF1 SOX13 ZNF23 ENSG00000247324 lnc-ZNF19-2 IST1 DHX38 SF3B3 COG4 AP1G1 ATXN1L ZNF19
GH16J071425 Promoter/Enhancer 1.4 Ensembl ENCODE 0.4 +15.6 15553 1.8 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 SOX13 IKZF1 NFKBIZ KDM1A LINC02136 TRM-CAT2-1 ZNF23 ZNF19 DHX38 SF3B3 ENSG00000247324 PHLPP2 ATXN1L IST1
GH16J071358 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +82.4 82358 3 CTCF HNRNPL IKZF1 BACH1 LARP7 ZNF143 ZNF24 REST RAD21 POLR2A CALB2 ATXN1L LOC105371332 TLE7
GH16J071413 Enhancer 0.8 ENCODE 0.3 +29.1 29141 0.2 GATAD2A CTCF IKZF1 REST RAD21 TRIM22 BRCA1 EGR1 SMC3 MYC ENSG00000247324 ZNF23 CALB2 ZNF19 ENSG00000262120 lnc-CALB2-5 LINC02136 LOC105371332 TLE7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLE7 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TLE7 Gene

Genomic Locations for TLE7 Gene
12,075 bases
Minus strand

Genomic View for TLE7 Gene

Genes around TLE7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE7 Gene

Proteins for TLE7 Gene

  • Protein details for TLE7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transducin-like enhancer protein 7
    Protein Accession:

    Protein attributes for TLE7 Gene

    441 amino acids
    Molecular mass:
    48656 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLE7 Gene

Post-translational modifications for TLE7 Gene

No Post-translational modifications

Other Protein References for TLE7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLE7 Gene

Domains & Families for TLE7 Gene

Gene Families for TLE7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat Groucho/TLE family.
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE7: view

No data available for Suggested Antigen Peptide Sequences for TLE7 Gene

Function for TLE7 Gene

Phenotypes From GWAS Catalog for TLE7 Gene

Gene Ontology (GO) - Molecular Function for TLE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA 21873635
GO:0005515 protein binding IEA --
GO:0070491 repressing transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with TLE7: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLE7 Gene

Localization for TLE7 Gene

Gene Ontology (GO) - Cellular Components for TLE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with TLE7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TLE7 Gene

Pathways & Interactions for TLE7 Gene

PathCards logo

SuperPathways for TLE7 Gene

No Data Available

Interacting Proteins for TLE7 Gene

Gene Ontology (GO) - Biological Process for TLE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IBA 21873635
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with TLE7: view

No data available for Pathways by source and SIGNOR curated interactions for TLE7 Gene

Drugs & Compounds for TLE7 Gene

No Compound Related Data Available

Transcripts for TLE7 Gene

mRNA/cDNA for TLE7 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TLE7 Gene

No ASD Table

Relevant External Links for TLE7 Gene

GeneLoc Exon Structure for

Expression for TLE7 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE7 Gene

Orthologs for TLE7 Gene

Evolution for TLE7 Gene

Gene Tree for TLE7 (if available)
Gene Tree for TLE7 (if available)

No data available for Orthologs for TLE7 Gene

Paralogs for TLE7 Gene

Paralogs for TLE7 Gene

genes like me logo Genes that share paralogs with TLE7: view

Variants for TLE7 Gene

Additional dbSNP identifiers (rs#s) for TLE7 Gene

Additional Variant Information for TLE7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TLE7 Gene

Disorders for TLE7 Gene

Additional Disease Information for TLE7

No disorders were found for TLE7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE7 Gene

Publications for TLE7 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4

Products for TLE7 Gene

Sources for TLE7 Gene