Aliases for TLE6 Gene
External Ids for TLE6 Gene
Previous GeneCards Identifiers for TLE6 Gene
This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
GeneCards Summary for TLE6 Gene
TLE6 (TLE Family Member 6, Subcortical Maternal Complex Member) is a Protein Coding gene. Diseases associated with TLE6 include Preimplantation Embryonic Lethality 1 and Gestational Trophoblastic Neoplasm. Among its related pathways are Wnt signaling pathway. An important paralog of this gene is TLE2.
UniProtKB/Swiss-Prot Summary for TLE6 Gene
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.