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Aliases for TLE5 Gene

Aliases for TLE5 Gene

  • TLE Family Member 5, Transcriptional Modulator 2 3 4
  • Amino-Terminal Enhancer Of Split 2 3 4 5
  • AES 3 4 5
  • Gp130-Associated Protein GAM 3 4
  • Groucho-Related Protein 5 3 4
  • Grg-5 3 4
  • GRG5 3 4
  • GRG 3 4
  • Amino Enhancer Of Split 4
  • TLE Family Member 5 4
  • Protein ESP1 4
  • Protein GRG 4
  • AES-1 3
  • AES-2 3
  • ESP1 3

External Ids for TLE5 Gene

Previous HGNC Symbols for TLE5 Gene

  • AES

Summaries for TLE5 Gene

Entrez Gene Summary for TLE5 Gene

  • The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLE5 Gene

TLE5 (TLE Family Member 5, Transcriptional Modulator) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling by GPCR. An important paralog of this gene is TLE4.

UniProtKB/Swiss-Prot for TLE5 Gene

  • Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

Additional gene information for TLE5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE5 Gene

Genomics for TLE5 Gene

GeneHancer (GH) Regulatory Elements for TLE5 Gene

Promoters and enhancers for TLE5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J003059 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 621.4 +1.3 1254 4.8 ZFX ZKSCAN8 ZNF148 NKRF ZNF121 ZNF687 ZBTB7A SP7 MLLT1 ZNF639 TLE5 GNA11 TLE6 GC19M003048
GH19J003150 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -90.3 -90281 6 ZNF473 SP1 CC2D1A ZFX CBFA2T2 ZNF148 GTF2F1 ZNF687 CDC5L BACH1 LOC100996351 GC19P003153 GC19P003154 PIR47090 ZNF77 CACTIN GNA11 DOT1L ZNF555 LMNB2
GH19J002968 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 12.1 +91.4 91350 6.7 CC2D1A CBFA2T2 ZNF148 MLLT1 ZNF121 ZNF384 NFIB SP1 EGR1 SMARCA4 GC19M002962 NCLN TLE6 TLE2 TLE5 ZNF77 GNA11 ENSG00000253392 ZNF57 S1PR4
GH19J003164 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -102.4 -102385 1 PRDM12 CTCF ZNF18 CEBPB ZFP64 ZNF781 ZNF518A POLR2A HLF ZNF697 GC19M003162 GNA15 GNA11 TLE5 APBA3 S1PR4 FZR1 GC19M003161
GH19J003024 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 12.5 +37.8 37829 1.8 CBFA2T2 ZNF316 EZH2 HDAC2 NCOR1 ZFHX2 BCOR ZNF768 ZNF18 TCF12 GC19M003020 TLE6 TLE5 GNA11 TLE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLE5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TLE5 Gene

Genomic Locations for TLE5 Gene
chr19:3,052,910-3,063,107
(GRCh38/hg38)
Size:
10,198 bases
Orientation:
Minus strand
chr19:3,052,908-3,063,105
(GRCh37/hg19)
Size:
10,198 bases
Orientation:
Minus strand

Genomic View for TLE5 Gene

Genes around TLE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE5 Gene

Proteins for TLE5 Gene

  • Protein details for TLE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08117-TLE5_HUMAN
    Recommended name:
    TLE family member 5
    Protein Accession:
    Q08117
    Secondary Accessions:
    • B2RBL0
    • Q12808
    • Q14CJ1
    • Q96TG9
    • Q9UDY9

    Protein attributes for TLE5 Gene

    Size:
    197 amino acids
    Molecular mass:
    21970 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA. Interacts with PHF12. Interacts (via Q domain) with SIX3. Interacts with SIX6.
    SequenceCaution:
    • Sequence=AAC35517.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE5 Gene

Post-translational modifications for TLE5 Gene

Other Protein References for TLE5 Gene

No data available for DME Specific Peptides for TLE5 Gene

Domains & Families for TLE5 Gene

Gene Families for TLE5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TLE5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLE5 Gene

GenScript: Design optimal peptide antigens:
  • Protein GRG (AES_HUMAN)
  • cDNA FLJ37272 fis, clone BRAMY2012091, highly similar to Homo sapiens amino-terminal enhancer of split (AES), transcript variant 1, mRNA (Q14CJ1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08117

UniProtKB/Swiss-Prot:

TLE5_HUMAN :
  • Lacks the C-terminal WD repeats.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • Lacks the C-terminal WD repeats.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE5: view

Function for TLE5 Gene

Molecular function for TLE5 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

Phenotypes From GWAS Catalog for TLE5 Gene

Gene Ontology (GO) - Molecular Function for TLE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IPI 10660609
GO:0005515 protein binding IPI,IEA 10660609
GO:0070491 repressing transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with TLE5: view
genes like me logo Genes that share phenotypes with TLE5: view

Animal Models for TLE5 Gene

MGI Knock Outs for TLE5:
  • Tle5 Tle5<tm1Grid>

Animal Model Products

CRISPR Products

miRNA for TLE5 Gene

miRTarBase miRNAs that target TLE5

Clone Products

  • Applied Biological Materials (abm): Clones for TLE5 - Now 50% OFF >
  • * TLE5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TLE5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE5 Gene

Localization for TLE5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE5 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22952044
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with TLE5: view

Pathways & Interactions for TLE5 Gene

genes like me logo Genes that share pathways with TLE5: view

SIGNOR curated interactions for TLE5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TLE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 10660609
GO:0001501 skeletal system development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development TAS 8365415
genes like me logo Genes that share ontologies with TLE5: view

Drugs & Compounds for TLE5 Gene

No Compound Related Data Available

Transcripts for TLE5 Gene

mRNA/cDNA for TLE5 Gene

Unigene Clusters for TLE5 Gene

Amino-terminal enhancer of split:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TLE5 - Now 50% OFF >
  • * TLE5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TLE5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TLE5 Gene

No ASD Table

Relevant External Links for TLE5 Gene

GeneLoc Exon Structure for
TLE5
ECgene alternative splicing isoforms for
TLE5

Expression for TLE5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TLE5 Gene:

TLE5

SOURCE GeneReport for Unigene cluster for TLE5 Gene:

Hs.515053

mRNA Expression by UniProt/SwissProt for TLE5 Gene:

Q08117-TLE5_HUMAN
Tissue specificity: Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

Evidence on tissue expression from TISSUES for TLE5 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Lung(4.2)
  • Eye(3.7)
  • Pancreas(3.4)
  • Muscle(3.1)
  • Skin(3)
  • Heart(2.7)
  • Liver(2.6)
  • Intestine(2.5)
  • Spleen(2.3)
  • Adrenal gland(2.2)
  • Kidney(2.1)
  • Lymph node(2.1)
  • Stomach(2.1)
  • Thyroid gland(2.1)
  • Bone(2)
genes like me logo Genes that share expression patterns with TLE5: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE5 Gene

Orthologs for TLE5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLE5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AES 35 34
  • 98.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AES 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AES 35 34
  • 92.02 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aes 34
  • 86.7 (n)
mouse
(Mus musculus)
Mammalia Aes 35 34
  • 86.35 (n)
OneToOne
Tle5 17
platypus
(Ornithorhynchus anatinus)
Mammalia AES 35
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
ManyToMany
chicken
(Gallus gallus)
Aves AES 35 34
  • 83.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 2 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aes 34
  • 77.72 (n)
Str.1868 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68432 34
zebrafish
(Danio rerio)
Actinopterygii aes 34 35
  • 78.02 (n)
chico 35
  • 75 (a)
OneToMany
-- 34
Species where no ortholog for TLE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLE5 Gene

ENSEMBL:
Gene Tree for TLE5 (if available)
TreeFam:
Gene Tree for TLE5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLE5: view image

Paralogs for TLE5 Gene

Paralogs for TLE5 Gene

genes like me logo Genes that share paralogs with TLE5: view

Variants for TLE5 Gene

Sequence variations from dbSNP and Humsavar for TLE5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000001244 -- 3,053,303(-) G/C 3_prime_UTR_variant
rs1000241771 -- 3,057,245(-) T/C intron_variant
rs1000353466 -- 3,062,936(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000540271 -- 3,058,677(-) G/C intron_variant
rs1000691979 -- 3,063,331(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TLE5 Gene

Variant ID Type Subtype PubMed ID
dgv47n68 CNV loss 17160897
nsv1061420 CNV gain 25217958
nsv1071892 CNV deletion 25765185
nsv1136268 CNV deletion 24896259
nsv578420 CNV loss 21841781
nsv833709 CNV loss 17160897

Variation tolerance for TLE5 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE5 Gene

Disorders for TLE5 Gene

Additional Disease Information for TLE5

No disorders were found for TLE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE5 Gene

Publications for TLE5 Gene

  1. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PMID: 8365415) Miyasaka H … Li SS (European journal of biochemistry 1993) 2 3 4 23 58
  2. The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. (PMID: 16002402) Rave-Harel N … Mellon PL (The Journal of biological chemistry 2005) 3 23 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. Six3 and Six6 activity is modulated by members of the groucho family. (PMID: 12441302) López-Ríos J … Bovolenta P (Development (Cambridge, England) 2003) 3 4 58

Products for TLE5 Gene

Sources for TLE5 Gene

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