Aliases for TLE4 Gene

Aliases for TLE4 Gene

  • TLE Family Member 4, Transcriptional Corepressor 2 3 5
  • Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila) 2 3
  • Transducin Like Enhancer Of Split 4 2 3
  • Transducin-Like Enhancer Protein 4 3 4
  • Groucho-Related Protein 4 3 4
  • Grg-4 3 4
  • GRG4 3 4
  • Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1) 3
  • Enhancer Of Split Groucho 4 3
  • B Lymphocyte Gene 1 3
  • KIAA1261 4
  • E(SpI) 3
  • E(Spl) 3
  • BCE-1 3
  • BCE1 3
  • ESG4 3
  • ESG 3

External Ids for TLE4 Gene

Previous GeneCards Identifiers for TLE4 Gene

  • GC09P073246
  • GC09M074057
  • GC09P075756
  • GC09P077644
  • GC09P077643
  • GC09P079416
  • GC09P081376
  • GC09P082186
  • GC09P052018

Summaries for TLE4 Gene

GeneCards Summary for TLE4 Gene

TLE4 (TLE Family Member 4, Transcriptional Corepressor) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TLE1.

UniProtKB/Swiss-Prot Summary for TLE4 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Gene Wiki entry for TLE4 Gene

Additional gene information for TLE4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLE4 Gene

Genomics for TLE4 Gene

GeneHancer (GH) Regulatory Elements for TLE4 Gene

Promoters and enhancers for TLE4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J079570 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.1 1128 6.2 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G USF1 SP1 FOS TEAD4 NONHSAG052638.2 TLE4 lnc-PSAT1-3 LNCARSR
GH09J079609 Enhancer 2 VISTA UCNEbase FANTOM5 ENCODE CraniofacialAtlas dbSUPER 20.3 +39.2 39164 3.5 JUND REST ATF2 OSR2 BCL11A ZNF316 GATA3 TRIM24 CEBPG SPI1 TLE4 RF00994-1141 lnc-PSAT1-5
GH09J079659 Promoter/Enhancer 1.7 VISTA Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +90.2 90155 5.2 EP300 TCF12 RFX1 ESRRA WT1 TCF7L2 GATA3 MXI1 ZNF843 SCRT1 TLE4 RF00994-1141 lnc-PSAT1-5
GH09J079627 Enhancer 1.6 VISTA UCNEbase Ensembl ENCODE dbSUPER 11.3 +59.2 59228 6.8 EP300 RELA TRIM22 BCL11A ZNF384 ARNT MEF2B NBN BATF ELF1 TLE4 RF00994-1141 lnc-PSAT1-5
GH09J079692 Enhancer 1 Ensembl ENCODE dbSUPER 15.8 +126.6 126628 13.6 ZNF217 TEAD4 CTBP1 MAFF MAFK SPI1 BATF GATA3 PRDM6 TBX21 TLE4 lnc-PSAT1-5 RF00994-1141
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLE4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLE4

Top Transcription factor binding sites by QIAGEN in the TLE4 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Sox5
  • Sp1
  • TBP

Genomic Locations for TLE4 Gene

Genomic Locations for TLE4 Gene
chr9:79,571,773-79,726,882
(GRCh38/hg38)
Size:
155,110 bases
Orientation:
Plus strand
chr9:82,186,688-82,341,658
(GRCh37/hg19)
Size:
154,971 bases
Orientation:
Plus strand

Genomic View for TLE4 Gene

Genes around TLE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE4 Gene

Proteins for TLE4 Gene

  • Protein details for TLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04727-TLE4_HUMAN
    Recommended name:
    Transducin-like enhancer protein 4
    Protein Accession:
    Q04727
    Secondary Accessions:
    • F8W6T6
    • Q3ZCS1
    • Q5T1Y2
    • Q6PCB3
    • Q9BZ07
    • Q9BZ08
    • Q9BZ09
    • Q9NSL3
    • Q9ULF9

    Protein attributes for TLE4 Gene

    Size:
    773 amino acids
    Molecular mass:
    83755 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. Interacts with SIX3 and SIX6 (By similarity). Interacts with PAX2.
    SequenceCaution:
    • Sequence=BAA86575.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE4 Gene

Post-translational modifications for TLE4 Gene

Antibody Products

  • Abcam antibodies for TLE4

No data available for DME Specific Peptides for TLE4 Gene

Domains & Families for TLE4 Gene

Gene Families for TLE4 Gene

Protein Domains for TLE4 Gene

Blocks:
  • Groucho/transducin-like enhancer protein signature
  • Groucho/TLE N-terminal Q-rich domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLE4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61488, highly similar to Transducin-like enhancer protein 4 (A6NIY7_HUMAN)
  • cDNA FLJ32674 fis, clone TESTI1000142, highly similar to TRANSDUCIN-LIKE ENHANCER PROTEIN 4 (B3KQ29_HUMAN)
  • Putative protein BCE-1 (BCE1_HUMAN)
  • Transducin-like enhancer of split 4 (E(Sp1) homolog, Drosophila) (Q5JSY6_HUMAN)
  • Transducin-like enhancer of split 4 (E(Sp1) homolog, Drosophila) (Q5JSY7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04727

UniProtKB/Swiss-Prot:

TLE4_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE4: view

Function for TLE4 Gene

Molecular function for TLE4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Phenotypes From GWAS Catalog for TLE4 Gene

Gene Ontology (GO) - Molecular Function for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA --
GO:0003674 molecular_function ND --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IBA 21873635
GO:0005515 protein binding IEA,IPI 24676634
genes like me logo Genes that share ontologies with TLE4: view
genes like me logo Genes that share phenotypes with TLE4: view

Animal Models for TLE4 Gene

MGI Knock Outs for TLE4:
  • Tle4 Tle4<tm1.2Dasw>

Animal Model Products

  • Taconic Biosciences Mouse Models for TLE4

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE4 Gene

Localization for TLE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE4 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IBA 1303260
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA 21873635
GO:1990907 beta-catenin-TCF complex IDA 28296634
genes like me logo Genes that share ontologies with TLE4: view

Pathways & Interactions for TLE4 Gene

genes like me logo Genes that share pathways with TLE4: view

Pathways by source for TLE4 Gene

1 Cell Signaling Technology pathway for TLE4 Gene
1 GeneTex pathway for TLE4 Gene

SIGNOR curated interactions for TLE4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0016055 Wnt signaling pathway IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TLE4: view

Drugs & Compounds for TLE4 Gene

No Compound Related Data Available

Transcripts for TLE4 Gene

mRNA/cDNA for TLE4 Gene

18 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
28 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLE4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TLE4 Gene

GeneLoc Exon Structure for
TLE4

Expression for TLE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE4 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for TLE4 Gene

This gene is overexpressed in Testis (27.8), Ovary (24.1), and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLE4 Gene



Protein tissue co-expression partners for TLE4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLE4

SOURCE GeneReport for Unigene cluster for TLE4 Gene:

Hs.444213

mRNA Expression by UniProt/SwissProt for TLE4 Gene:

Q04727-TLE4_HUMAN
Tissue specificity: In all tissues examined, mostly in brain, and muscle.

Evidence on tissue expression from TISSUES for TLE4 Gene

  • Nervous system(4.7)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TLE4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE4 Gene

Orthologs for TLE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLE4 31 30
  • 99.5 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLE4 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLE4 31 30
  • 93.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TLE4 31 30
  • 92.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tle4 17 31 30
  • 92.32 (n)
rat
(Rattus norvegicus)
Mammalia Tle4 30
  • 91.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TLE4 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLE4 31 30
  • 86.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLE4 31
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tle4 30
  • 84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15157 30
zebrafish
(Danio rerio)
Actinopterygii tle2 31
  • 71 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta gro 31
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010324 30
  • 60.93 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-37 31
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8664 31
  • 57 (a)
ManyToMany
CSA.10712 31
  • 53 (a)
ManyToMany
Species where no ortholog for TLE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLE4 Gene

ENSEMBL:
Gene Tree for TLE4 (if available)
TreeFam:
Gene Tree for TLE4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLE4: view image

Paralogs for TLE4 Gene

Paralogs for TLE4 Gene

(6) SIMAP similar genes for TLE4 Gene using alignment to 15 proteins:

  • TLE4_HUMAN
  • B3KQ29_HUMAN
  • E7EQH3_HUMAN
  • F8W6T6_HUMAN
  • F8W9R0_HUMAN
  • F8WAY5_HUMAN
  • G8JLG4_HUMAN
  • H0Y5S0_HUMAN
  • H7C4E4_HUMAN
  • H7C4P7_HUMAN
  • H7C4W5_HUMAN
  • Q5JSY7_HUMAN
  • Q5JSY8_HUMAN
  • Q5JSZ1_HUMAN
  • Q5JSZ2_HUMAN

Pseudogenes.org Pseudogenes for TLE4 Gene

genes like me logo Genes that share paralogs with TLE4: view

Variants for TLE4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLE4 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
716285 Benign: not provided 79,708,207(+) A/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
716982 Benign: not provided 79,720,246(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
736665 Benign: not provided 79,718,779(+) C/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
786909 Benign: not provided 79,718,839(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
786910 Benign: not provided 79,722,492(+) A/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TLE4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLE4 Gene

Variant ID Type Subtype PubMed ID
esv3450741 CNV insertion 20981092
nsv1048899 CNV gain 25217958
nsv831634 CNV loss 17160897

Variation tolerance for TLE4 Gene

Residual Variation Intolerance Score: 8.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE4 Gene

Disorders for TLE4 Gene

Additional Disease Information for TLE4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TLE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE4 Gene

Publications for TLE4 Gene

  1. Mutations in PAX2 associate with adult-onset FSGS. (PMID: 24676634) Barua M … Pollak MR (Journal of the American Society of Nephrology : JASN 2014) 3 4 54
  2. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y … Zhang H (Genetic epidemiology 2011) 3 41 54
  3. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 41 54
  4. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. (PMID: 19714205) Hancock DB … London SJ (PLoS genetics 2009) 3 41 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for TLE4 Gene

Sources for TLE4 Gene