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Aliases for TLE3 Gene

Aliases for TLE3 Gene

  • Transducin Like Enhancer Of Split 3 2 3 5
  • Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 3 3 4
  • ESG3 3 4
  • Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1) 3
  • Transducin-Like Enhancer Of Split 3 Short Isoform 3
  • Transducin-Like Enhancer Protein 3 3
  • Enhancer Of Split Groucho 3 3
  • HsT18976 3
  • KIAA1547 4
  • GRG3 3
  • ESG 3

External Ids for TLE3 Gene

Previous GeneCards Identifiers for TLE3 Gene

  • GC15M066130
  • GC15M063439
  • GC15M067919
  • GC15M068057
  • GC15M068129
  • GC15M070341
  • GC15M047172

Summaries for TLE3 Gene

Entrez Gene Summary for TLE3 Gene

  • This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

GeneCards Summary for TLE3 Gene

TLE3 (Transducin Like Enhancer Of Split 3) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. An important paralog of this gene is TLE4.

UniProtKB/Swiss-Prot for TLE3 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Wiki entry for TLE3 Gene

Additional gene information for TLE3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE3 Gene

Genomics for TLE3 Gene

GeneHancer (GH) Regulatory Elements for TLE3 Gene

Promoters and enhancers for TLE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I070088 Promoter/Enhancer 3.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 589.5 +2.6 2585 13.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 TLE3 THAP10 LRRC49 GC15P070099 LOC105370877
GH15I070503 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 38.4 -408.6 -408560 7.1 PKNOX1 CLOCK FOXA2 SMAD1 NEUROD1 SIN3A FEZF1 ZNF2 E2F8 ZNF416 LINC02205 TLE3 RPL17P39 MIR629 PIR55212 GC15M070491
GH15I069758 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29.6 +338.1 338138 3.8 HDGF ZNF493 YBX1 FEZF1 IRF4 ZNF766 GLIS2 ZNF416 ATF7 FOS TLE3 LOC145694 NOX5 GC15P069737 GC15P069802
GH15I070478 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 33.1 -381.5 -381496 2.5 PKNOX1 ZNF493 BATF IRF4 ZNF143 RCOR1 ETV6 IKZF2 RUNX3 EGR2 TLE3 RPL17P39 MIR629 PIR51135 LINC02205
GH15I069725 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 32.8 +371.6 371641 1.9 CTCF KLF1 POLR2A IKZF1 MYC SP7 TLE3 GC15P069737 GC15M069642
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLE3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLE3 gene promoter:

Genomic Locations for TLE3 Gene

Genomic Locations for TLE3 Gene
chr15:70,047,790-70,098,176
(GRCh38/hg38)
Size:
50,387 bases
Orientation:
Minus strand
chr15:70,340,129-70,390,515
(GRCh37/hg19)

Genomic View for TLE3 Gene

Genes around TLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE3 Gene

Proteins for TLE3 Gene

  • Protein details for TLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04726-TLE3_HUMAN
    Recommended name:
    Transducin-like enhancer protein 3
    Protein Accession:
    Q04726
    Secondary Accessions:
    • B4DPT0
    • E9PD64
    • F8W964
    • Q6PI57
    • Q8IVV6
    • Q8WVR2
    • Q9HCM5

    Protein attributes for TLE3 Gene

    Size:
    772 amino acids
    Molecular mass:
    83417 Da
    Quaternary structure:
    • Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. Interacts with TBX18 (via engrailed homology 1 repressor motif), leading to decreased of TBX18 transcriptional activity.
    SequenceCaution:
    • Sequence=BAB13373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE3 Gene

neXtProt entry for TLE3 Gene

Post-translational modifications for TLE3 Gene

  • Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
  • Ubiquitination at posLast=3030 and isoforms=5, 7343
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TLE3

No data available for DME Specific Peptides for TLE3 Gene

Domains & Families for TLE3 Gene

Gene Families for TLE3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q04726

UniProtKB/Swiss-Prot:

TLE3_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE3: view

Function for TLE3 Gene

Molecular function for TLE3 Gene

GENATLAS Biochemistry:
transducin-like enhancer of split 3,with homology to Drosophila split Groucho (Notch signaling pathway)
UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Phenotypes From GWAS Catalog for TLE3 Gene

Gene Ontology (GO) - Molecular Function for TLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17577209
genes like me logo Genes that share ontologies with TLE3: view
genes like me logo Genes that share phenotypes with TLE3: view

Animal Models for TLE3 Gene

MGI Knock Outs for TLE3:

Animal Model Products

Clone Products

  • Addgene plasmids for TLE3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE3 Gene

Localization for TLE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE3 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA 1303260
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with TLE3: view

Pathways & Interactions for TLE3 Gene

genes like me logo Genes that share pathways with TLE3: view

Gene Ontology (GO) - Biological Process for TLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 8808280
GO:0009887 animal organ morphogenesis TAS 8808280
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TLE3: view

No data available for SIGNOR curated interactions for TLE3 Gene

Drugs & Compounds for TLE3 Gene

(13) Drugs for TLE3 Gene - From: ClinicalTrials and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Inhibition, inhibitor, Biomarker Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2040
Paclitaxel Approved, Vet_approved Pharma inhibitor, Biomarker, binder Tubulin and Bcl2 inhibitor, Taxanes 3027
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1828
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1828
Epirubicin Approved Pharma 426
genes like me logo Genes that share compounds with TLE3: view

Transcripts for TLE3 Gene

Unigene Clusters for TLE3 Gene

Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila):
Representative Sequences:

Clone Products

  • Addgene plasmids for TLE3

Alternative Splicing Database (ASD) splice patterns (SP) for TLE3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a ·
SP1:
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -
SP7: -
SP8: - -
SP9:
SP10: -
SP11: -
SP12:

ExUns: 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TLE3 Gene

GeneLoc Exon Structure for
TLE3
ECgene alternative splicing isoforms for
TLE3

Expression for TLE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLE3 Gene

mRNA differential expression in normal tissues according to GTEx for TLE3 Gene

This gene is overexpressed in Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for TLE3 Gene

This gene is overexpressed in Placenta (11.4), CD8 Tcells (8.4), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLE3 Gene



Protein tissue co-expression partners for TLE3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLE3 Gene:

TLE3

SOURCE GeneReport for Unigene cluster for TLE3 Gene:

Hs.287362

mRNA Expression by UniProt/SwissProt for TLE3 Gene:

Q04726-TLE3_HUMAN
Tissue specificity: Placenta and lung.

Evidence on tissue expression from TISSUES for TLE3 Gene

  • Nervous system(4.6)
  • Pancreas(4.3)
  • Liver(4.1)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with TLE3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE3 Gene

Orthologs for TLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE3 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia TLE3 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLE3 33 34
  • 99.87 (n)
oppossum
(Monodelphis domestica)
Mammalia TLE3 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLE3 33 34
  • 93.45 (n)
dog
(Canis familiaris)
Mammalia TLE3 33 34
  • 93.27 (n)
rat
(Rattus norvegicus)
Mammalia Tle3 33
  • 91.84 (n)
mouse
(Mus musculus)
Mammalia Tle3 33 16 34
  • 91.27 (n)
chicken
(Gallus gallus)
Aves TLE3 33 34
  • 83.94 (n)
lizard
(Anolis carolinensis)
Reptilia TLE3 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4386 33
zebrafish
(Danio rerio)
Actinopterygii gro2 34
  • 89 (a)
OneToMany
gro1 33 34
  • 80.31 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9672 33
fruit fly
(Drosophila melanogaster)
Insecta gro 34
  • 66 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8664 34
  • 55 (a)
ManyToMany
CSA.10712 34
  • 51 (a)
ManyToMany
Species where no ortholog for TLE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLE3 Gene

ENSEMBL:
Gene Tree for TLE3 (if available)
TreeFam:
Gene Tree for TLE3 (if available)

Paralogs for TLE3 Gene

Variants for TLE3 Gene

Sequence variations from dbSNP and Humsavar for TLE3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000100035 -- 70,096,379(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000105754 -- 70,058,486(-) A/C intron_variant
rs1000190526 -- 70,095,207(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000201626 -- 70,095,407(-) C/A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000266009 -- 70,058,567(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLE3 Gene

Variant ID Type Subtype PubMed ID
esv25961 CNV loss 19812545
esv2672644 CNV deletion 23128226
nsv473505 CNV novel sequence insertion 20440878
nsv476997 CNV novel sequence insertion 20440878
nsv827380 CNV gain 20364138
nsv951987 CNV deletion 24416366

Variation tolerance for TLE3 Gene

Residual Variation Intolerance Score: 3.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE3 Gene

Disorders for TLE3 Gene

Additional Disease Information for TLE3

No disorders were found for TLE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE3 Gene

Publications for TLE3 Gene

  1. Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development. (PMID: 26235987) Vivante A … Hildebrandt F (American journal of human genetics 2015) 3 4 58
  2. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. (PMID: 22304967) Hanson AJ … Lee E (Molecular cell 2012) 3 4 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TLE3 Gene

  • Addgene plasmids for TLE3

Sources for TLE3 Gene

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