This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternat... See more...

Aliases for TLE3 Gene

Aliases for TLE3 Gene

  • TLE Family Member 3, Transcriptional Corepressor 2 3 5
  • Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 3 3 4
  • Transducin Like Enhancer Of Split 3 2 3
  • Transducin-Like Enhancer Protein 3 3 4
  • ESG3 3 4
  • Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1) 3
  • Transducin-Like Enhancer Of Split 3 Short Isoform 3
  • Enhancer Of Split Groucho 3 3
  • HSALNG0106903 167
  • HSALNG0106901 167
  • Lnc-UACA-6 168
  • HsT18976 3
  • KIAA1547 4
  • GRG3 3
  • ESG 3

External Ids for TLE3 Gene

Previous GeneCards Identifiers for TLE3 Gene

  • GC15M066130
  • GC15M063439
  • GC15M067919
  • GC15M068057
  • GC15M068129
  • GC15M070341
  • GC15M047172

Summaries for TLE3 Gene

Entrez Gene Summary for TLE3 Gene

  • This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

GeneCards Summary for TLE3 Gene

TLE3 (TLE Family Member 3, Transcriptional Corepressor) is a Protein Coding gene. Diseases associated with TLE3 include Chromosome 1Q21.1 Duplication Syndrome. Among its related pathways are Signaling by Wnt and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is TLE4.

UniProtKB/Swiss-Prot Summary for TLE3 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Wiki entry for TLE3 Gene

Additional gene information for TLE3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLE3 Gene

Genomics for TLE3 Gene

GeneHancer (GH) Regulatory Elements for TLE3 Gene

Promoters and enhancers for TLE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J070088 Promoter/Enhancer 3.1 VISTA EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 539.4 +2.6 2585 13.2 HNRNPK ZNF217 EP300 CTCF ZSCAN5C TCF12 NRF1 MYC USF1 POLR2G TLE3 THAP10 LRRC49 lnc-UACA-5 lnc-RPLP1-8 LOC105370877
GH15J070503 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 38.3 -408.6 -408560 7.1 ZNF217 ZSCAN5C TCF12 SP1 JUND FOS ZNF639 ZNF10 ZIC2 ZBTB10 LINC02205 lnc-LRRC49-17 TLE3 ENSG00000212664 MIR629 LINC02204
GH15J069712 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 32.8 +376.2 376175 20 CTCF USF1 SP1 EP300 ZIC2 REST CUX1 RELA RCOR1 RAD21 lnc-TLE3-16 TLE3 MIR629 lnc-RPLP1-6 lnc-TLE3-15 DRAIC LINC00593 PCAT29
GH15J069760 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 29.6 +337.7 337712 3 ZBTB40 ZSCAN5C SP1 JUND FOS ZNF639 REST TCF7 ZNF623 TRIM28 TLE3 ENSG00000259426 NOX5 lnc-TLE3-15 piR-55194-146 DRAIC LINC00593 PCAT29
GH15J070480 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 33.1 -382.3 -382279 0.2 EP300 RELA BCL11A TCF12 CBFB MEF2B FOSL1 BATF IRF4 POU2F2 RF00017-1827 TLE3 MIR629 piR-57136 LINC02204
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLE3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLE3

Top Transcription factor binding sites by QIAGEN in the TLE3 gene promoter:
  • C/EBPalpha
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • Egr-3
  • GATA-1
  • HSF2
  • MZF-1

Genomic Locations for TLE3 Gene

Genomic Locations for TLE3 Gene
chr15:70,047,790-70,098,176
(GRCh38/hg38)
Size:
50,387 bases
Orientation:
Minus strand
chr15:70,340,129-70,390,515
(GRCh37/hg19)
Size:
50,387 bases
Orientation:
Minus strand

Genomic View for TLE3 Gene

Genes around TLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE3 Gene

Proteins for TLE3 Gene

  • Protein details for TLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04726-TLE3_HUMAN
    Recommended name:
    Transducin-like enhancer protein 3
    Protein Accession:
    Q04726
    Secondary Accessions:
    • B4DPT0
    • E9PD64
    • F8W964
    • Q6PI57
    • Q8IVV6
    • Q8WVR2
    • Q9HCM5

    Protein attributes for TLE3 Gene

    Size:
    772 amino acids
    Molecular mass:
    83417 Da
    Quaternary structure:
    • Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. Interacts with TBX18 (via engrailed homology 1 repressor motif), leading to decreased of TBX18 transcriptional activity.
    SequenceCaution:
    • Sequence=BAB13373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE3 Gene

neXtProt entry for TLE3 Gene

Post-translational modifications for TLE3 Gene

  • Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
  • Ubiquitination at Lys30
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TLE3 Gene

Domains & Families for TLE3 Gene

Protein Domains for TLE3 Gene

Blocks:
  • G-protein beta WD-40 repeat signature
  • Groucho/transducin-like enhancer protein signature
  • Groucho/TLE N-terminal Q-rich domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLE3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58232, highly similar to Transducin-like enhancer protein 3 (B4E2W3_HUMAN)
  • Transducin-like enhancer of split 3 short isoform (Q672R2_HUMAN)
  • Transducin-like enhancer of split 3 splice variant 2 (Q6PRX2_HUMAN)
  • Transducin-like enhancer of split 3 splice variant 1 (Q6PRX3_HUMAN)
  • Enhancer of split groucho-like protein 3 (TLE3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04726

UniProtKB/Swiss-Prot:

TLE3_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE3: view

Function for TLE3 Gene

Molecular function for TLE3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
GENATLAS Biochemistry:
transducin-like enhancer of split 3,with homology to Drosophila split Groucho (Notch signaling pathway)

Phenotypes From GWAS Catalog for TLE3 Gene

Gene Ontology (GO) - Molecular Function for TLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA 21873635
GO:0005515 protein binding IEA,IPI 17577209
GO:0070491 repressing transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with TLE3: view
genes like me logo Genes that share phenotypes with TLE3: view

Animal Models for TLE3 Gene

MGI Knock Outs for TLE3:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for TLE3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE3 Gene

Localization for TLE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE3 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IBA 21873635
GO:1990907 beta-catenin-TCF complex IDA 28296634
genes like me logo Genes that share ontologies with TLE3: view

Pathways & Interactions for TLE3 Gene

genes like me logo Genes that share pathways with TLE3: view

Pathways by source for TLE3 Gene

1 Qiagen pathway for TLE3 Gene
  • GSK3 Signaling
1 Cell Signaling Technology pathway for TLE3 Gene

Gene Ontology (GO) - Biological Process for TLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 8808280
GO:0009887 animal organ morphogenesis TAS 8808280
GO:0016055 Wnt signaling pathway IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with TLE3: view

No data available for SIGNOR curated interactions for TLE3 Gene

Drugs & Compounds for TLE3 Gene

(11) Drugs for TLE3 Gene - From: ClinicalTrials and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved, Investigational Pharma Inhibition, inhibitor, Biomarker Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2273
Paclitaxel Approved, Vet_approved Pharma inhibitor, Biomarker, binder Tubulin and Bcl2 inhibitor, Taxanes 3559
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 2036
Epirubicin Approved Pharma 468
Albumin-Bound Paclitaxel Pharma 3559
genes like me logo Genes that share compounds with TLE3: view

Transcripts for TLE3 Gene

mRNA/cDNA for TLE3 Gene

7 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
4 RNACentral transcripts :
2 LncBook transcripts :
3 LNCipedia transcripts :

CRISPR Products

Clone Products

  • Addgene plasmids for TLE3

Alternative Splicing Database (ASD) splice patterns (SP) for TLE3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a ·
SP1:
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -
SP7: -
SP8: - -
SP9:
SP10: -
SP11: -
SP12:

ExUns: 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TLE3 Gene

GeneLoc Exon Structure for
TLE3

Expression for TLE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLE3 Gene

mRNA differential expression in normal tissues according to GTEx for TLE3 Gene

This gene is overexpressed in Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for TLE3 Gene

This gene is overexpressed in Placenta (11.4), CD8 Tcells (8.4), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLE3 Gene



Protein tissue co-expression partners for TLE3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLE3

SOURCE GeneReport for Unigene cluster for TLE3 Gene:

Hs.287362

mRNA Expression by UniProt/SwissProt for TLE3 Gene:

Q04726-TLE3_HUMAN
Tissue specificity: Placenta and lung.

Evidence on tissue expression from TISSUES for TLE3 Gene

  • Nervous system(4.6)
  • Pancreas(4.3)
  • Liver(4.1)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with TLE3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE3 Gene

Orthologs for TLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE3 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia TLE3 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLE3 31 30
  • 99.87 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLE3 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLE3 31 30
  • 93.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TLE3 31 30
  • 93.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tle3 30
  • 91.84 (n)
mouse
(Mus musculus)
Mammalia Tle3 17 31 30
  • 91.27 (n)
chicken
(Gallus gallus)
Aves TLE3 31 30
  • 83.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLE3 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4386 30
zebrafish
(Danio rerio)
Actinopterygii gro2 31
  • 89 (a)
OneToMany
gro1 31 30
  • 80.31 (n)
OneToMany
-- 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9672 30
fruit fly
(Drosophila melanogaster)
Insecta gro 31
  • 66 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8664 31
  • 55 (a)
ManyToMany
CSA.10712 31
  • 51 (a)
ManyToMany
Species where no ortholog for TLE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLE3 Gene

ENSEMBL:
Gene Tree for TLE3 (if available)
TreeFam:
Gene Tree for TLE3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLE3: view image

Paralogs for TLE3 Gene

Paralogs for TLE3 Gene

(6) SIMAP similar genes for TLE3 Gene using alignment to 18 proteins:

  • TLE3_HUMAN
  • F5H7D6_HUMAN
  • F8W8S3_HUMAN
  • F8W964_HUMAN
  • H0YKH0_HUMAN
  • H0YKH5_HUMAN
  • H0YKN8_HUMAN
  • H0YKT5_HUMAN
  • H0YL70_HUMAN
  • H0YLI3_HUMAN
  • H0YLW9_HUMAN
  • H0YNI7_HUMAN
  • H0YNT2_HUMAN
  • H3BUH5_HUMAN
  • Q672R2_HUMAN
  • Q6PI57_HUMAN
  • Q6PRX2_HUMAN
  • Q6PRX3_HUMAN
genes like me logo Genes that share paralogs with TLE3: view

Variants for TLE3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLE3 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs1057864 - p.Ala229Val

Additional dbSNP identifiers (rs#s) for TLE3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLE3 Gene

Variant ID Type Subtype PubMed ID
esv25961 CNV loss 19812545
esv2672644 CNV deletion 23128226
nsv473505 CNV novel sequence insertion 20440878
nsv476997 CNV novel sequence insertion 20440878
nsv827380 CNV gain 20364138
nsv951987 CNV deletion 24416366

Variation tolerance for TLE3 Gene

Residual Variation Intolerance Score: 3.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE3 Gene

Disorders for TLE3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLE3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1q21.1 duplication syndrome
  • 1q21.1 microduplication syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TLE3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLE3

genes like me logo Genes that share disorders with TLE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLE3 Gene

Publications for TLE3 Gene

  1. Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development. (PMID: 26235987) Vivante A … Hildebrandt F (American journal of human genetics 2015) 3 4 54
  2. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. (PMID: 22304967) Hanson AJ … Lee E (Molecular cell 2012) 3 4 54
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for TLE3 Gene

Sources for TLE3 Gene