Aliases for TLE2 Gene

Aliases for TLE2 Gene

  • TLE Family Member 2, Transcriptional Corepressor 2 3 5
  • ESG2 2 3 4
  • Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 2 3 4
  • Transducin Like Enhancer Of Split 2 2 3
  • Transducin-Like Enhancer Protein 2 3 4
  • GRG2 2 3
  • ESG 2 3
  • Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1) 3
  • Enhancer Of Split Groucho 2 2
  • FLJ41188 2
  • TLE2 5

External Ids for TLE2 Gene

Previous GeneCards Identifiers for TLE2 Gene

  • GC19M003089
  • GC19M002937
  • GC19M002948
  • GC19M002765

Summaries for TLE2 Gene

GeneCards Summary for TLE2 Gene

TLE2 (TLE Family Member 2, Transcriptional Corepressor) is a Protein Coding gene. Diseases associated with TLE2 include Olfactory Groove Meningioma and Anterior Cranial Fossa Meningioma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is TLE1.

UniProtKB/Swiss-Prot Summary for TLE2 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Wiki entry for TLE2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLE2 Gene

Genomics for TLE2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLE2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J003046 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.4 382 2.5 GATAD2A PRDM10 ZNF629 ZNF512 LEF1 IKZF1 KDM1A ZNF692 PRDM1 DDX20 TLE2 TLE5 GIPC3 piR-32214-327 TLE6
GH19J003027 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 600.4 +18.7 18707 2.1 ZIC2 PATZ1 ZNF740 EZH2 ZNF341 UBTF ZNF10 ZBTB10 ZBTB26 ZFHX2 lnc-AES-2 TLE2 piR-35674-240 TLE6
GH19J002079 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.1 +958.7 958727 19 ZNF221 SP1 HNRNPL GATAD2A CTCF ATF7 ZNF629 TFE3 ZNF512 RFX1 MOB3A IZUMO4 CIRBP ZNF77 LMNB2 ZNF555 BTBD2 SF3A2 TLE2 MKNK2
GH19J002461 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20.1 +585.2 585239 2.8 ZNF221 BRCA1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 SOX13 IKZF1 LINC01775 SF3A2 TCF3 LOC100288123 ZNF77 ZNF555 SPPL2B DOT1L TLE2 ENSG00000267283
GH19J003150 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -105.8 -105753 6 ARHGAP35 SP1 PRDM10 ZNF629 LEF1 IKZF1 KDM1A ZNF692 POLR2A BACH1 LOC100996351 ZNF77 CACTIN GNA11 CACTIN-AS1 DOT1L ZNF555 SF3A2 LMNB2 SPPL2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLE2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLE2

Top Transcription factor binding sites by QIAGEN in the TLE2 gene promoter:
  • p53
  • STAT3

Genomic Locations for TLE2 Gene

Genomic Locations for TLE2 Gene
chr19:2,997,638-3,047,635
(GRCh38/hg38)
Size:
49,998 bases
Orientation:
Minus strand
chr19:2,997,636-3,047,633
(GRCh37/hg19)
Size:
49,998 bases
Orientation:
Minus strand

Genomic View for TLE2 Gene

Genes around TLE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE2 Gene

Proteins for TLE2 Gene

  • Protein details for TLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04725-TLE2_HUMAN
    Recommended name:
    Transducin-like enhancer protein 2
    Protein Accession:
    Q04725
    Secondary Accessions:
    • B4DE03
    • E9PEV7
    • F8WCH2
    • Q8WVY0
    • Q9Y6S0

    Protein attributes for TLE2 Gene

    Size:
    743 amino acids
    Molecular mass:
    79841 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.
    SequenceCaution:
    • Sequence=AK308137; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE2 Gene

Post-translational modifications for TLE2 Gene

No data available for DME Specific Peptides for TLE2 Gene

Domains & Families for TLE2 Gene

Gene Families for TLE2 Gene

Protein Domains for TLE2 Gene

InterPro:
Blocks:
  • G-protein beta WD-40 repeat signature
  • Groucho/TLE N-terminal Q-rich domain
  • Groucho/transducin-like enhancer protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for TLE2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61693, highly similar to Transducin-like enhancer protein 2 (B4DE62_HUMAN)
  • Enhancer of split groucho-like protein 2 (TLE2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04725

UniProtKB/Swiss-Prot:

TLE2_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE2: view

Function for TLE2 Gene

Molecular function for TLE2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
GENATLAS Biochemistry:
transducin-like enhancer of split 2,with homology to Drosophila split Groucho (Notch signaling pathway) mainly expressed in muscle,placenta

Phenotypes From GWAS Catalog for TLE2 Gene

Gene Ontology (GO) - Molecular Function for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 19460168
GO:0005515 protein binding IPI 17041588
GO:0070491 repressing transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with TLE2: view
genes like me logo Genes that share phenotypes with TLE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLE2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLE2 Gene

Localization for TLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE2 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005634 nucleus TAS,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA 21873635
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with TLE2: view

Pathways & Interactions for TLE2 Gene

genes like me logo Genes that share pathways with TLE2: view

Pathways by source for TLE2 Gene

1 R&D Systems pathway for TLE2 Gene
1 Qiagen pathway for TLE2 Gene
  • GSK3 Signaling
1 Cell Signaling Technology pathway for TLE2 Gene

SIGNOR curated interactions for TLE2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 8808280
GO:0009887 animal organ morphogenesis TAS 8808280
GO:0016055 Wnt signaling pathway IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 19460168
genes like me logo Genes that share ontologies with TLE2: view

Drugs & Compounds for TLE2 Gene

No Compound Related Data Available

Transcripts for TLE2 Gene

mRNA/cDNA for TLE2 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLE2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLE2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: -

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TLE2 Gene

GeneLoc Exon Structure for
TLE2

Expression for TLE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE2 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5) and Brain - Cerebellar Hemisphere (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLE2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLE2

SOURCE GeneReport for Unigene cluster for TLE2 Gene:

Hs.332173

mRNA Expression by UniProt/SwissProt for TLE2 Gene:

Q04725-TLE2_HUMAN
Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle.

Evidence on tissue expression from TISSUES for TLE2 Gene

  • Nervous system(4.7)
  • Muscle(2.6)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with TLE2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE2 Gene

Orthologs for TLE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TLE2 30 31
  • 96.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TLE2 30 31
  • 90.36 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TLE2 30 31
  • 89.55 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tle2 30 17 31
  • 84.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tle2 30
  • 84.8 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 72 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 69 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 38 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 74 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii zgc:136336 31
  • 43 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta gro 32
  • 78 (a)
Worm
(Caenorhabditis elegans)
Secernentea unc-37 32
  • 56 (a)
Species where no ortholog for TLE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TLE2 Gene

ENSEMBL:
Gene Tree for TLE2 (if available)
TreeFam:
Gene Tree for TLE2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLE2: view image

Paralogs for TLE2 Gene

Paralogs for TLE2 Gene

(7) SIMAP similar genes for TLE2 Gene using alignment to 8 proteins:

  • TLE2_HUMAN
  • B4DE62_HUMAN
  • K7EJR7_HUMAN
  • K7EK93_HUMAN
  • K7EMK7_HUMAN
  • K7EPD4_HUMAN
  • K7EPF3_HUMAN
  • K7ESD8_HUMAN

Pseudogenes.org Pseudogenes for TLE2 Gene

genes like me logo Genes that share paralogs with TLE2: view

Variants for TLE2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLE2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs199788562 - p.Ser381Gly

Additional dbSNP identifiers (rs#s) for TLE2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLE2 Gene

Variant ID Type Subtype PubMed ID
dgv47n68 CNV loss 17160897
esv3555871 CNV deletion 23714750
esv3643452 CNV loss 21293372
nsv1061420 CNV gain 25217958
nsv1071891 CNV deletion 25765185
nsv1072304 CNV deletion 25765185
nsv1112739 CNV deletion 24896259
nsv1126506 CNV deletion 24896259
nsv1144855 CNV deletion 24896259
nsv2391 CNV insertion 18451855
nsv578420 CNV loss 21841781
nsv833709 CNV loss 17160897

Variation tolerance for TLE2 Gene

Residual Variation Intolerance Score: 9.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE2 Gene

Disorders for TLE2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TLE2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
olfactory groove meningioma
  • meningioma of the olfactory groove
anterior cranial fossa meningioma
  • meningioma of the anterior fossa
- elite association - COSMIC cancer census association via MalaCards
Search TLE2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLE2

genes like me logo Genes that share disorders with TLE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLE2 Gene

Publications for TLE2 Gene

  1. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. (PMID: 19939918) He Z … Lan K (Journal of virology 2010) 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  5. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. (PMID: 11266540) Brantjes H … Clevers H (Nucleic acids research 2001) 3 4

Products for TLE2 Gene

Sources for TLE2 Gene