Aliases for TLE2 Gene
External Ids for TLE2 Gene
Previous GeneCards Identifiers for TLE2 Gene
GeneCards Summary for TLE2 Gene
TLE2 (TLE Family Member 2, Transcriptional Corepressor) is a Protein Coding gene. Diseases associated with TLE2 include Olfactory Groove Meningioma and Anterior Cranial Fossa Meningioma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is TLE1.
UniProtKB/Swiss-Prot Summary for TLE2 Gene
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).