Aliases for TLE1 Gene
Aliases for TLE1 Gene
External Ids for TLE1 Gene
- HGNC: 11837
- Entrez Gene: 7088
- Ensembl: ENSG00000196781
- OMIM: 600189
- UniProtKB: Q04724
Previous GeneCards Identifiers for TLE1 Gene
- GC09M075257
- GC09M076067
- GC09M077768
- GC09M079655
- GC09M081428
- GC09M083388
- GC09M084198
- GC09M054030
Summaries for TLE1 Gene
GeneCards Summary for TLE1 Gene
TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.
UniProtKB/Swiss-Prot for TLE1 Gene
-
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Additional gene information for TLE1 Gene
- Monarch Initiative
- Search for TLE1 at DataMed
- Search for TLE1 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE1 Gene
Genomics for TLE1 Gene
GeneHancer (GH) Regulatory Elements for TLE1 Gene
Promoters and enhancers for TLE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TLE1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TLE1 Gene
Genomic Locations for TLE1 Gene
- chr9:81,583,683-81,689,535
- (GRCh38/hg38)
- Size:
- 105,853 bases
- Orientation:
- Minus strand
- chr9:84,198,598-84,304,220
- (GRCh37/hg19)
Genomic View for TLE1 Gene
Genes around TLE1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.32 by Ensembl
- 9q21.32 by Entrez Gene
- 9q21.32 by HGNC
TLE1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLE1 Gene
Proteins for TLE1 Gene
-
Protein details for TLE1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q04724-TLE1_HUMAN
- Recommended name:
- Transducin-like enhancer protein 1
- Protein Accession:
- Q04724
- A8K495
- Q5T3G4
- Q969V9
Protein attributes for TLE1 Gene
- Size:
- 770 amino acids
- Molecular mass:
- 83201 Da
- Quaternary structure:
-
- Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Interacts with SIX3. Interacts with EFNB1.
Protein Expression for TLE1 Gene
Post-translational modifications for TLE1 Gene
- Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
- Ubiquitinated by XIAP/BIRC4.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TLE1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TLE1 (TLE1)
-
Custom Antibody ServicesOriGene Antibodies for TLE1
- CF800320
- TA800320
- CF800319
- TA800319
- CF800318
- TA800318
- CF800303
- TA800303
- CF800302
- TA800302
- CF800301
- TA800301
- CF800299
- TA800299
- CF800296
- TA800296
- CF800294
- TA800294
- TA700293
- TA700272
- TA700271
- TA700270
- TA700269
- TA700268
- TA600272
- TA600271
- TA600270
- TA600269
- TA600268
- TA590613
- TA332729
- TA800294S
- AP54266PU-N
- Novus Biologicals Antibodies for TLE1
-
Abcam antibodies for TLE1
- Invitrogen Antibodies for TLE1
- GeneTex TLE1 antibody for TLE1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLE1
- Sino Biological Antibodies for TLE1
Protein Products
-
OriGene Purified Proteins for TLE1
- Search Origene for MassSpec and Protein Over-expression Lysates for TLE1
- Origene Custom Protein Services for TLE1
- Search GeneTex for Proteins for TLE1
-
Abcam proteins for TLE1
Assay Products
- antibodies-online: Search results for available TLE1 related products ranked by validation data
No data available for DME Specific Peptides for TLE1 Gene
Domains & Families for TLE1 Gene
Gene Families for TLE1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TLE1 Gene
Suggested Antigen Peptide Sequences for TLE1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q04724UniProtKB/Swiss-Prot:
TLE1_HUMAN :- WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
- Belongs to the WD repeat Groucho/TLE family.
- Domain:
-
- WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
- Family:
-
- Belongs to the WD repeat Groucho/TLE family.
Function for TLE1 Gene
Molecular function for TLE1 Gene
- GENATLAS Biochemistry:
- transducin-like enhancer of split related,with homology to Drosophila split Groucho (Notch signaling pathway),negative regulator of CBFA2 (AML1)
- UniProtKB/Swiss-Prot Function:
- Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Phenotypes From GWAS Catalog for TLE1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001106 | RNA polymerase II transcription corepressor activity | IDA | 10748198 |
| GO:0005515 | protein binding | IPI | 9751710 |
| GO:0008134 | transcription factor binding | IPI | 8687460 |
| GO:0042802 | identical protein binding | IPI | 24596249 |
Phenotypes for TLE1 Gene
- GenomeRNAi human phenotypes for TLE1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased IL-8 secretion
- Increased cell number in S
- Synthetic lethal with vaccinia virus (VACV) infection
- Synthetic lethal with imatinib mesylate
- Increased G1 length, increased G2 length
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLE1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TLE1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLE1 gene
- Search ViGene Biosciences for TLE1
CRISPR Products
-
OriGene CRISPR knockouts for TLE1
- genomics-online: gRNA clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
- Applied Biological Materials CRISPR for TLE1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLE1
- GenScript: Design CRISPR guide RNA sequences for TLE1
miRNA for TLE1 Gene
- miRTarBase miRNAs that target TLE1
miRNA Products
- Search ViGene Biosciences for TLE1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TLE1
- Browse OriGene Inhibitory RNA Products For TLE1
- genomics-online: shRNA clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLE1 gene
Clone Products
- Sino Biological Human cDNA Clone for TLE1
- VectorBuilder custom plasmid, inducible vectors for TLE1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLE1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLE1
- Applied Biological Materials Clones for TLE1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TLE1
-
ViGene Biosciences adenoviral particle packaged cDNA for TLE1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TLE1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLE1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLE1 Gene
Localization for TLE1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLE1 Gene
- Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IMP,TAS | 22952044 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IMP | 22952044 |
Pathways & Interactions for TLE1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 3 | Signaling by Wnt |
.71
|
|
| 4 | Wnt / Hedgehog / Notch | ||
| 5 | Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling | ||
Pathways by source for TLE1 Gene
1 GeneTex pathway for TLE1 Gene
4 BioSystems pathways for TLE1 Gene
10 Reactome pathways for TLE1 Gene
1 GeneGo (Thomson Reuters) pathway for TLE1 Gene
1 R&D Systems pathway for TLE1 Gene
1 Qiagen pathway for TLE1 Gene
1 Cell Signaling Technology pathway for TLE1 Gene
Interacting Proteins for TLE1 Gene
Selected Interacting proteins:
Q04724-TLE1_HUMAN
ENSP00000365682
for TLE1 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8808280 |
| GO:0007275 | multicellular organism development | TAS | 8365415 |
Transcripts for TLE1 Gene
mRNA/cDNA for TLE1 Gene
- (20) REFSEQ mRNAs :
- (450) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TLE1
- genomics-online: gRNA clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
- Applied Biological Materials CRISPR for TLE1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLE1
- GenScript: Design CRISPR guide RNA sequences for TLE1
miRNA Products
- Search ViGene Biosciences for TLE1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TLE1
- Browse OriGene Inhibitory RNA Products For TLE1
- genomics-online: shRNA clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLE1 gene
Clone Products
- Sino Biological Human cDNA Clone for TLE1
- VectorBuilder custom plasmid, inducible vectors for TLE1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLE1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLE1
- Applied Biological Materials Clones for TLE1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 15c | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | - | ||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: | |||||||||||||||||||
| SP13: | |||||||||||||||||||
| SP14: |
Expression for TLE1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Lung (Respiratory System)
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Pancreas (23.5), Peripheral blood mononuclear cells (18.8), Uterus (8.7), and Fetal testis (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLE1 Gene
NURSA nuclear receptor signaling pathways regulating expression of TLE1 Gene:
TLE1SOURCE GeneReport for Unigene cluster for TLE1 Gene:
Hs.197320mRNA Expression by UniProt/SwissProt for TLE1 Gene:
Q04724-TLE1_HUMAN
Tissue specificity:
In all tissues examined, mostly in brain, liver and muscle.
Evidence on tissue expression from TISSUES for TLE1 Gene
- Nervous system(4.7)
- Intestine(4.4)
- Kidney(4.4)
- Eye(4)
- Lung(2.9)
Primer Products
-
OriGene qPCR primer pairs for TLE1
-
OriGene qPCR primer pairs and template standards for TLE1
- genomics-online: primer clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE1 Gene
Orthologs for TLE1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TLE1 34 |
|
OneToOne | |
| LOC464546 33 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | TLE1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | TLE1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TLE1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tle1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tle1 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | TLE1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TLE1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tle1 33 |
|
||
| Str.5824 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | gro 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-37 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8664 34 |
|
ManyToMany | |
| CSA.10712 34 |
|
ManyToMany |
- Species where no ortholog for TLE1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for TLE1 Gene
Variants for TLE1 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002732 | -- | 81,635,351(-) | T/A | intron_variant | |
| rs1000005639 | -- | 81,623,528(-) | C/G | intron_variant | |
| rs1000021105 | -- | 81,665,552(-) | C/T | intron_variant | |
| rs1000039521 | -- | 81,676,527(-) | A/G | intron_variant | |
| rs1000100098 | -- | 81,623,884(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2456414 | CNV | deletion | 19546169 |
| esv3545005 | CNV | deletion | 23714750 |
| nsv1043810 | CNV | gain | 25217958 |
| nsv521784 | CNV | gain | 19592680 |
| nsv821665 | CNV | loss | 15273396 |
| nsv831638 | CNV | loss | 17160897 |
| nsv8532 | CNV | loss | 18304495 |
Residual Variation Intolerance Score:
5.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.67;
31.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLE1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TLE1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE1 Gene
Disorders for TLE1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| synovium cancer |
|
|
| core binding factor acute myeloid leukemia |
|
|
| spindle cell liposarcoma |
|
|
| sarcoma, synovial |
|
|
| connective tissue cancer |
|
|
Search TLE1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TLE1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TLE1 Gene
Publications for TLE1 Gene
- Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PMID: 14651967) Hentschke M … Borgmeyer U (Biochemical and biophysical research communications 2003) 3 4 22 58
- Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. (PMID: 11731482) Dasen JS … Rosenfeld MG (Genes & development 2001) 3 4 22 58
- Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PMID: 10748198) Wang JC … Granner DK (The Journal of biological chemistry 2000) 3 4 22 58
- Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PMID: 9874198) Grbavec D … Stifani S (European journal of biochemistry 1998) 3 4 22 58
- Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PMID: 8365415) Miyasaka H … Li SS (European journal of biochemistry 1993) 2 3 22 58
Products for TLE1 Gene
- R&D Systems Antibodies for TLE1 (TLE1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TLE1
- AP54266PU-N
- TA800294S
- TA332729
- TA590613
- TA600268
- TA600269
- TA600270
- TA600271
- TA600272
- TA700268
- TA700269
- TA700270
- TA700271
- TA700272
- TA700293
- TA800294
- CF800294
- TA800296
- CF800296
- TA800299
- CF800299
- TA800301
- CF800301
- TA800302
- CF800302
- TA800303
- CF800303
- TA800318
- CF800318
- TA800319
- CF800319
- TA800320
- CF800320
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TLE1
- Search Origene for MassSpec and Protein Over-expression Lysates for TLE1
- Origene Custom Protein Services for TLE1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TLE1
- Browse OriGene Inhibitory RNA Products For TLE1
- OriGene qPCR primer pairs and template standards for TLE1
- OriGene qPCR primer pairs for TLE1
- OriGene CRISPR knockouts for TLE1
- OriGene ORF clones in human for TLE1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TLE1
- GenScript: Next-day shipping of latest version cDNA ORF clones for TLE1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TLE1
- GenScript Custom Assay Services for TLE1
- GenScript Custom overexpressing Cell Line Services for TLE1
- GenScript: Design CRISPR guide RNA sequences for TLE1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TLE1
- Sino Biological Human cDNA Clone for TLE1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Sino Biological Antibodies for TLE1
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TLE1
- Novus Biologicals lysates and proteins for TLE1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TLE1
- Abcam proteins for TLE1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLE1
- VectorBuilder custom plasmid, inducible vectors for TLE1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLE1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLE1
- antibodies-online: Search results for 103 available TLE1 Antibodies ranked by validation data
- Compare Top TLE1 Antibodies
- antibodies-online: Search results for available TLE1 related products ranked by validation data
- antibodies-online: Search results for 4 available TLE1 Proteins ranked by validation data
- Compare Top TLE1 Proteins
- GeneTex TLE1 antibody for TLE1
- Search GeneTex for Proteins for TLE1
- ViGene Biosciences adenoviral particle packaged cDNA for TLE1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TLE1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TLE1 gene
- Search ViGene Biosciences for TLE1
- Santa Cruz Biotechnology (SCBT) Antibodies for TLE1
- Search Santa Cruz Biotechnology (SCBT) for TLE1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TLE1
- Horizon Cell Lines for TLE1
- genomics-online: cdna clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
- orf clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
- genomics-online: gRNA clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
- genomics-online: primer clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
- genomics-online: shRNA clones - Search results for 133 available TLE1 gene related products
- Overview of 133 available TLE1 gene related products
Sources for TLE1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
