Aliases for TLE1 Gene
External Ids for TLE1 Gene
Previous GeneCards Identifiers for TLE1 Gene
GeneCards Summary for TLE1 Gene
TLE1 (TLE Family Member 1, Transcriptional Corepressor) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.
UniProtKB/Swiss-Prot Summary for TLE1 Gene
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.