TLE1 Gene (Protein Coding)

TLE Family Member 1, Transcriptional Corepressor

GC09M081583
GIFtS:
45

Aliases for TLE1 Gene

Aliases for TLE1 Gene

  • TLE Family Member 1, Transcriptional Corepressor 2 3 5
  • Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 1 3 4
  • Transducin Like Enhancer Of Split 1 2 3
  • Transducin-Like Enhancer Protein 1 3 4
  • ESG1 3 4
  • Enhancer Of Split Groucho 1 2
  • E(Sp1) Homolog 4
  • GRG1 3
  • ESG 3

External Ids for TLE1 Gene

Previous GeneCards Identifiers for TLE1 Gene

  • GC09M075257
  • GC09M076067
  • GC09M077768
  • GC09M079655
  • GC09M081428
  • GC09M083388
  • GC09M084198
  • GC09M054030

Summaries for TLE1 Gene

GeneCards Summary for TLE1 Gene

TLE1 (TLE Family Member 1, Transcriptional Corepressor) is a Protein Coding gene. Diseases associated with TLE1 include Glomus Tumor and Tibial Adamantinoma. Among its related pathways are Signaling by Wnt and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.

UniProtKB/Swiss-Prot Summary for TLE1 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Gene Wiki entry for TLE1 Gene

Additional gene information for TLE1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLE1 Gene

Genomics for TLE1 Gene

GeneHancer (GH) Regulatory Elements for TLE1 Gene

Promoters and enhancers for TLE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J081685 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.3 1285 5.7 EP300 FOXK2 ZNF217 CTCF POLR2G USF1 NCOR1 ZIC2 REST POLR2A LOC101927502 TLE1 RF00017-7652 RF00017-7651
GH09J081632 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 11.8 +52.4 52392 10.1 EP300 NCOR1 FOS KDM6A SKI TEAD1 ZBTB26 FOXA2 CEBPB MAFF LOC101927502 TLE1 RNU6-1035P piR-33614-275 lnc-SPATA31D4-7 RF00017-7651
GH09J081619 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 11.4 +65.0 64950 10.8 EP300 TCF12 USF1 FOS TCF7 ZBTB25 TEAD1 ZBTB26 ZSCAN9 FOXA2 TLE1 LOC101927502 piR-33614-275 lnc-SPATA31D4-7 RF00017-7651
GH09J081649 Enhancer 1 VISTA UCNEbase 11.4 +38.9 38889 2.8 EP300 POLR2A RBM22 SMARCA4 RAD21 EZH2 LOC101927502 TLE1 lnc-SPATA31D4-6 RF00017-7652 RF00017-7651
GH09J081656 Enhancer 0.9 ENCODE 11.9 +32.5 32466 0.3 EP300 ZNF217 TCF12 NCOR1 KDM6A TCF7 FOXA1 CUX1 ZBTB25 TGIF2 TLE1 LOC101927502 RNU6-1035P lnc-SPATA31D4-6 RF00017-7652 RF00017-7651
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLE1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLE1

Top Transcription factor binding sites by QIAGEN in the TLE1 gene promoter:
  • FOXI1
  • FOXO4
  • GATA-1
  • HFH-3
  • MZF-1
  • NF-kappaB1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • STAT5A

Genomic Locations for TLE1 Gene

Genomic Locations for TLE1 Gene
chr9:81,583,683-81,689,547
(GRCh38/hg38)
Size:
105,865 bases
Orientation:
Minus strand
chr9:84,198,598-84,304,220
(GRCh37/hg19)
Size:
105,623 bases
Orientation:
Minus strand

Genomic View for TLE1 Gene

Genes around TLE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TLE1 Gene

Proteins for TLE1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TLE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04724-TLE1_HUMAN
    Recommended name:
    Transducin-like enhancer protein 1
    Protein Accession:
    Q04724
    Secondary Accessions:
    • A8K495
    • Q5T3G4
    • Q969V9

    Protein attributes for TLE1 Gene

    Size:
    770 amino acids
    Molecular mass:
    83201 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Interacts with SIX3. Interacts with EFNB1.

    Three dimensional structures from OCA and Proteopedia for TLE1 Gene

neXtProt entry for TLE1 Gene

Protein Expression for TLE1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TLE1 Gene

  • Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
  • Ubiquitinated by XIAP/BIRC4.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLE1 Gene

Domains & Families for TLE1 Gene

Gene Families for TLE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TLE1 Gene

Blocks:
  • G-protein beta WD-40 repeat signature
  • Groucho/transducin-like enhancer protein signature
  • Groucho/TLE N-terminal Q-rich domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLE1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50374, weakly similar to Protein groucho (B4E345_HUMAN)
  • Enhancer of split groucho-like protein 1 (TLE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04724

UniProtKB/Swiss-Prot:

TLE1_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE1: view

Function for TLE1 Gene

Products:

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for TLE1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
GENATLAS Biochemistry:
transducin-like enhancer of split related,with homology to Drosophila split Groucho (Notch signaling pathway),negative regulator of CBFA2 (AML1)

Phenotypes From GWAS Catalog for TLE1 Gene

Gene Ontology (GO) - Molecular Function for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 10748198
GO:0005515 protein binding IPI,IEA 9751710
GO:0008134 transcription factor binding IPI 8687460
GO:0042802 identical protein binding IPI 24596249
GO:0070491 repressing transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with TLE1: view
genes like me logo Genes that share phenotypes with TLE1: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for TLE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLE1 Gene

Localization for TLE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE1 Gene

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP,IEA 22952044
GO:0005654 nucleoplasm TAS,IDA --
GO:0005667 transcription factor complex IBA 21873635
GO:0005829 cytosol IMP 22952044
GO:1990907 beta-catenin-TCF complex IDA 28296634
genes like me logo Genes that share ontologies with TLE1: view

Pathways & Interactions for TLE1 Gene

genes like me logo Genes that share pathways with TLE1: view

Pathways by source for TLE1 Gene

1 GeneGo (Thomson Reuters) pathway for TLE1 Gene
  • Development Notch Signaling Pathway
1 Qiagen pathway for TLE1 Gene
  • GSK3 Signaling
1 Cell Signaling Technology pathway for TLE1 Gene
1 GeneTex pathway for TLE1 Gene

SIGNOR curated interactions for TLE1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 8808280
GO:0007275 multicellular organism development TAS 8365415
GO:0009887 animal organ morphogenesis TAS 8808280
GO:0010628 positive regulation of gene expression IMP 15006356
genes like me logo Genes that share ontologies with TLE1: view

Drugs & Compounds for TLE1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TLE1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TLE1 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for TLE1

Alternative Splicing Database (ASD) splice patterns (SP) for TLE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TLE1 Gene

GeneLoc Exon Structure for
TLE1

Expression for TLE1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLE1 Gene

mRNA expression in normal human tissues for TLE1 Gene
mRNA expression by GTEx for TLE1 GenemRNA expression by BioGPS for TLE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLE1 Gene

This gene is overexpressed in Pancreas (23.5), Peripheral blood mononuclear cells (18.8), Uterus (8.7), and Fetal testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLE1 Gene



Protein tissue co-expression partners for TLE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLE1

SOURCE GeneReport for Unigene cluster for TLE1 Gene:

Hs.197320

mRNA Expression by UniProt/SwissProt for TLE1 Gene:

Q04724-TLE1_HUMAN
Tissue specificity: In all tissues examined, mostly in brain, liver and muscle.

Evidence on tissue expression from TISSUES for TLE1 Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Kidney(4.4)
  • Eye(4)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with TLE1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE1 Gene

Orthologs for TLE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TLE1 31
  • 100 (a)
 OneToOne
LOC464546 30
  • 99.48 (n)
oppossum
(Monodelphis domestica)
 Mammalia TLE1 31
  • 99 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 98 (a)
 OneToMany
-- 31
  • 85 (a)
 OneToMany
-- 31
  • 80 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia TLE1 31 30
  • 92.21 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TLE1 31
  • 91 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tle1 30
  • 90.41 (n)
mouse
(Mus musculus)
 Mammalia Tle1 17 31 30
  • 90.32 (n)
chicken
(Gallus gallus)
 Aves TLE1 31 30
  • 85.15 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TLE1 31
  • 96 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tle1 30
  • 82.23 (n)
Str.5824 30
fruit fly
(Drosophila melanogaster)
 Insecta gro 31 32
  • 66 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea unc-37 32
  • 59 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8664 31
  • 56 (a)
 ManyToMany
CSA.10712 31
  • 52 (a)
 ManyToMany
Species where no ortholog for TLE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TLE1 Gene

ENSEMBL:
Gene Tree for TLE1 (if available)
TreeFam:
Gene Tree for TLE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLE1: view image

Paralogs for TLE1 Gene

Paralogs for TLE1 Gene

(4) SIMAP similar genes for TLE1 Gene using alignment to 4 proteins:

  • TLE1_HUMAN
  • Q5T3G2_HUMAN
  • Q5T3G3_HUMAN
  • Q5T7A9_HUMAN
genes like me logo Genes that share paralogs with TLE1: view

Variants for TLE1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLE1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
775274 Benign: not provided 81,687,396(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TLE1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLE1 Gene

Variant ID Type Subtype PubMed ID
esv2456414 CNV deletion 19546169
esv3545005 CNV deletion 23714750
nsv1043810 CNV gain 25217958
nsv521784 CNV gain 19592680
nsv821665 CNV loss 15273396
nsv831638 CNV loss 17160897
nsv8532 CNV loss 18304495

Variation tolerance for TLE1 Gene

Residual Variation Intolerance Score: 5.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE1 Gene

Disorders for TLE1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for TLE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
glomus tumor
  • glomus neoplasm
tibial adamantinoma
  • tibial adamantinoma morphology
spindle cell synovial sarcoma
  • synovial sarcoma with spindle cell components
spindle cell liposarcoma
synovium cancer
  • malignant tumor of synovium
- elite association - COSMIC cancer census association via MalaCards
Search TLE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TLE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLE1 Gene

Publications for TLE1 Gene

  1. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PMID: 14651967) Hentschke M … Borgmeyer U (Biochemical and biophysical research communications 2003) 3 4 23 54
  2. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. (PMID: 11731482) Dasen JS … Rosenfeld MG (Genes & development 2001) 3 4 23 54
  3. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PMID: 10748198) Wang JC … Granner DK (The Journal of biological chemistry 2000) 3 4 23 54
  4. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PMID: 9874198) Grbavec D … Stifani S (European journal of biochemistry 1998) 3 4 23 54
  5. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PMID: 8365415) Miyasaka H … Li SS (European journal of biochemistry 1993) 2 3 23 54

ExternalLinks

View latest publications for TLE1 gene in Mastermind

Products for TLE1 Gene

  • Addgene plasmids for TLE1

Sources for TLE1 Gene